{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:09:01Z","timestamp":1791641341369,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,6,2]],"date-time":"2011-06-02T00:00:00Z","timestamp":1306972800000},"content-version":"vor","delay-in-days":244,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.micinf.2010.05.006","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T04:55:06Z","timestamp":1275540906000},"page":"819-827","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila"],"prefix":"10.1016","volume":"12","author":[{"given":"Mariana S.","family":"Frutuoso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana I.","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo S.F.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djalma S.L.","family":"Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiane","family":"S\u00f4nego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi S.","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Flavell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Q.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario S.","family":"Zamboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2010.05.006_bib1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev.micro.54.1.567","article-title":"Legionella pneumophila pathogesesis: a fateful journey from amoebae to macrophages","volume":"54","author":"Swanson","year":"2000","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.micinf.2010.05.006_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinf.2007.09.010","article-title":"Legionella spp. and Legionnaires\u2019 disease","volume":"56","author":"Diederen","year":"2008","journal-title":"J. Infect."},{"key":"10.1016\/j.micinf.2010.05.006_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/spid.2002.127206","article-title":"Legionella pneumophila pathogenesis and immunity","volume":"13","author":"Friedman","year":"2002","journal-title":"Semin. Pediatr. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.05.006_bib4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1164\/ajrccm.149.3.8118629","article-title":"Risk factors for nosocomial Legionella pneumophila pneumonia","volume":"149","author":"Carratala","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.micinf.2010.05.006_bib5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/00006454-198701000-00019","article-title":"Fatal Legionella pneumonitis in a neutropenic leukemic child","volume":"6","author":"Gutzeit","year":"1987","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.micinf.2010.05.006_bib6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0046-8177(81)80021-4","article-title":"The pathology of the Legionella pneumonias. A review of 74 cases and the literature","volume":"12","author":"Winn","year":"1981","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.micinf.2010.05.006_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1099\/jmm.0.46913-0","article-title":"Role of Toll-like receptor 2 in\u00a0recognition of Legionella pneumophila in a murine pneumonia model","volume":"56","author":"Fuse","year":"2007","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.micinf.2010.05.006_bib8","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1086\/504525","article-title":"Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophila","volume":"193","author":"Hawn","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.05.006_bib9","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.4049\/jimmunol.179.10.6981","article-title":"Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila","volume":"179","author":"Hawn","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2010.05.006_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1164\/ajrccm.149.1.8111597","article-title":"Intratracheal interferon-gamma augments pulmonary defenses in experimental legionellosis","volume":"149","author":"Skerrett","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.micinf.2010.05.006_bib11","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1128\/IAI.69.4.2017-2024.2001","article-title":"Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells","volume":"69","author":"Tateda","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.05.006_bib12","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.4049\/jimmunol.166.5.3355","article-title":"Early recruitment of neutrophils determines subsequent T1\/T2 host responses in a murine model of Legionella pneumophila pneumonia","volume":"166","author":"Tateda","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2010.05.006_bib13","first-page":"105","article-title":"Effects of polymorphonuclear leucocyte depletion on the pathogenesis of experimental Legionnaires\u2019 disease","volume":"69","author":"Fitzgeorge","year":"1988","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.micinf.2010.05.006_bib14","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1084\/jem.153.2.398","article-title":"Interaction of the legionnaires\u2019 disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. pneumophila to monocytes but does not inhibit intracellular multiplication","volume":"153","author":"Horwitz","year":"1981","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2010.05.006_bib15","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/infdis\/148.3.510","article-title":"The contribution of human neutrophils and serum to host defense against Legionella micdadei","volume":"148","author":"Weinbaum","year":"1983","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.05.006_bib16","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.4049\/jimmunol.181.10.7121","article-title":"A novel role for neutrophils as critical activators of NK cells","volume":"181","author":"Sporri","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2010.05.006_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1128\/IAI.66.1.65-69.1998","article-title":"In vivo regulation of replicative Legionella pneumophila lung infection by endogenous interleukin-12","volume":"66","author":"Brieland","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.05.006_bib18","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.4049\/jimmunol.140.11.3978","article-title":"IFN-gamma-activated human alveolar macrophages inhibit the intracellular multiplication of Legionella pneumophila","volume":"140","author":"Nash","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2010.05.006_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mib.2008.12.004","article-title":"Legionella pneumophila Dot\/Icm translocated substrates: a sum of parts","volume":"12","author":"Ensminger","year":"2009","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.micinf.2010.05.006_bib20","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.tim.2007.06.006","article-title":"Effector proteins translocated by Legionella pneumophila: strength in numbers","volume":"15","author":"Ninio","year":"2007","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micinf.2010.05.006_bib21","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1046\/j.1365-2958.2000.02176.x","article-title":"Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth","volume":"38","author":"Coers","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micinf.2010.05.006_bib22","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1128\/IAI.68.7.3971-3982.2000","article-title":"Identification and subcellular localization of the Legionella pneumophila IcmX protein: a factor essential for establishment of a replicative organelle in eukaryotic host cells","volume":"68","author":"Matthews","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.05.006_bib23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1365-2958.1998.00841.x","article-title":"Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake","volume":"28","author":"Roy","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micinf.2010.05.006_bib24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.immuni.2007.10.002","article-title":"Intracellular NOD-like receptors in host defense and disease","volume":"27","author":"Kanneganti","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2010.05.006_bib25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micinf.2010.05.006_bib26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-065X.2008.00734.x","article-title":"Function of Nod-like receptors in microbial recognition and host defense","volume":"227","author":"Franchi","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.micinf.2010.05.006_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1084\/jem.20051229","article-title":"Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo","volume":"203","author":"Masumoto","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2010.05.006_bib28","doi-asserted-by":"crossref","first-page":"514","DOI":"10.4049\/jimmunol.179.1.514","article-title":"Nod1\/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells","volume":"179","author":"Park","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2010.05.006_bib29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1371\/journal.ppat.0010034","article-title":"NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis","volume":"1","author":"Ferwerda","year":"2005","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micinf.2010.05.006_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/j.1469-0691.2008.02270.x","article-title":"Role of the cytoplasmic pattern recognition receptor Nod2 in Coxiella burnetii infection","author":"Benoit","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.micinf.2010.05.006_bib31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/01.RES.0000155721.83594.2c","article-title":"Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae","volume":"96","author":"Opitz","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.micinf.2010.05.006_bib32","doi-asserted-by":"crossref","first-page":"e1000379","DOI":"10.1371\/journal.ppat.1000379","article-title":"The NOD\/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection","volume":"5","author":"Shimada","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micinf.2010.05.006_bib33","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2958.1993.tb01092.x","article-title":"Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila","volume":"7","author":"Berger","year":"1993","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micinf.2010.05.006_bib34","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1046\/j.1365-2958.1999.01410.x","article-title":"Pore-forming activity is not sufficient for Legionella pneumophila phagosome trafficking and intracellular growth","volume":"32","author":"Zuckman","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micinf.2010.05.006_bib35","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1371\/journal.ppat.0020018","article-title":"Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity","volume":"2","author":"Ren","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micinf.2010.05.006_bib36","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/ni945","article-title":"An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid","volume":"4","author":"Chamaillard","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micinf.2010.05.006_bib37","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1126\/science.1104911","article-title":"Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract","volume":"307","author":"Kobayashi","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.micinf.2010.05.006_bib38","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/416194a","article-title":"RICK\/Rip2\/CARDIAK mediates signaling for receptors of the innate and adaptive immune systems","volume":"416","author":"Kobayashi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2010.05.006_bib39","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1073\/pnas.0900196106","article-title":"Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis","volume":"106","author":"Alves-Filho","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.micinf.2010.05.006_bib40","first-page":"220","article-title":"Legionella pneumophila: factors involved in the route and response to an intracellular niche","volume":"2","author":"Isberg","year":"1993","journal-title":"Infect. Agents Dis."},{"key":"10.1016\/j.micinf.2010.05.006_bib41","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1365-2958.2004.04435.x","article-title":"The Legionella IcmS-IcmW protein complex is important for Dot\/Icm-mediated protein translocation","volume":"55","author":"Ninio","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micinf.2010.05.006_bib42","doi-asserted-by":"crossref","first-page":"e1000220","DOI":"10.1371\/journal.ppat.1000220","article-title":"Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila","volume":"4","author":"Shin","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micinf.2010.05.006_bib43","doi-asserted-by":"crossref","first-page":"35217","DOI":"10.1074\/jbc.M604933200","article-title":"Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf","volume":"281","author":"Amer","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2010.05.006_bib44","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1128\/IAI.01382-08","article-title":"Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila","volume":"77","author":"Case","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.05.006_bib45","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1084\/jem.20051659","article-title":"Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection","volume":"203","author":"Molofsky","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2010.05.006_bib46","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ni1305","article-title":"The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection","volume":"7","author":"Zamboni","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micinf.2010.05.006_bib47","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1128\/IAI.02049-05","article-title":"MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of Legionnaires\u2019 disease","volume":"74","author":"Archer","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.05.006_bib48","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1073\/pnas.0406239101","article-title":"A C-terminal translocation signal required for Dot\/Icm-dependent delivery of the Legionella RalF protein to host cells","volume":"102","author":"Nagai","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.micinf.2010.05.006_bib49","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.immuni.2007.12.012","article-title":"The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands","volume":"28","author":"Kim","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2010.05.006_bib50","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1128\/IAI.00905-09","article-title":"Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis","volume":"78","author":"Silveira","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.05.006_bib51","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ni1131","article-title":"Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island","volume":"5","author":"Viala","year":"2004","journal-title":"Nat. Immunol."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457910001437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457910001437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:26:26Z","timestamp":1761143186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457910001437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S1286457910001437"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2010.05.006","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2010.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Institut Pasteur. Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}