{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:55:34Z","timestamp":1791204934970,"version":"4.1.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":4717,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.micinf.2010.10.015","type":"journal-article","created":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T04:29:01Z","timestamp":1288240141000},"page":"134-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Cell-mediated immunity in human brucellosis"],"prefix":"10.1016","volume":"13","author":[{"given":"Panagiotis","family":"Skendros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Pappas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Boura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2010.10.015_bib1","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1056\/NEJMra050570","article-title":"Brucellosis","volume":"352","author":"Pappas","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.micinf.2010.10.015_bib2","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s00018-006-6311-4","article-title":"Brucella as a biological weapon","volume":"63","author":"Pappas","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.micinf.2010.10.015_bib3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jhin.2005.02.018","article-title":"Spanish Co-operative Group for the study of laboratory-acquired brucellosis: a Spanish national survey","volume":"61","author":"Bouza","year":"2005","journal-title":"J. Hosp. Infect."},{"key":"10.1016\/j.micinf.2010.10.015_bib4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1365-2249.2006.03223.x","article-title":"CD80\/CD28 co-stimulation in human brucellosis","volume":"146","author":"Skendros","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1286-4579(00)01350-2","article-title":"Immunity and protection against Brucella abortus","volume":"3","author":"Golding","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2010.10.015_bib6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1615\/CritRevImmunol.v26.i5.30","article-title":"Host immune responses to the intracellular bacteria Brucella: does the bacteria instruct the host to facilitate chronic infection?","volume":"26","author":"Baldwin","year":"2006","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib7","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.micinf.2008.07.007","article-title":"Brucella: a Mr \u201cHide\u201d converted into Dr Jekyll","volume":"10","author":"Gorvel","year":"2008","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2010.10.015_bib8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/713608012","article-title":"T cell immunity to brucellosis","volume":"29","author":"Yingst","year":"2003","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.micinf.2010.10.015_bib9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.clim.2004.07.010","article-title":"Cellular bioterrorism: how Brucella corrupts macrophage physiology to promote invasion and proliferation","volume":"114","author":"Jimenez de Bagues","year":"2005","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.micpath.2003.09.003","article-title":"Impairment of Brucella growth in human macrophagic cells that produce nitric oxide","volume":"36","author":"Gross","year":"2004","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micinf.2010.10.015_bib11","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1128\/IAI.69.6.3817-3826.2001","article-title":"Human peripheral blood T cells, monocytes, and macrophages secrete macrophage inflammatory proteins 1alpha and 1beta following stimulation with heat-inactivated Brucella abortus","volume":"69","author":"Zaitseva","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib12","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1189\/jlb.0103015","article-title":"Smooth and rough lipopolysaccharide phenotypes of Brucella induce different intracellular trafficking and cytokine\/chemokine release in human monocytes","volume":"74","author":"Rittig","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.micinf.2010.10.015_bib13","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.4049\/jimmunol.156.8.2885","article-title":"Brucella species release a specific, protease-sensitive, inhibitor of TNF-alpha expression, active on human macrophage-like cells","volume":"156","author":"Caron","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib14","first-page":"124","article-title":"A case of Brucella spondylitis in a patient with psoriatic arthritis receiving infliximab","volume":"27","author":"Papagoras","year":"2009","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.micinf.2010.10.015_bib15","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1086\/588482","article-title":"An eternal microbe: Brucella DNA load persists for years after clinical cure","volume":"46","author":"Vrioni","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.10.015_bib16","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1128\/IAI.69.6.3995-4006.2001","article-title":"Intracellular survival of Brucella spp. in human monocytes involves conventional uptake but special phagosomes","volume":"69","author":"Rittig","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib17","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1128\/IAI.73.6.3702-3713.2005","article-title":"Opsonized virulent Brucella abortus replicates within nonacidic, endoplasmic reticulum-negative, LAMP-1-positive phagosomes in human monocytes","volume":"73","author":"Bellaire","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib18","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1073\/pnas.032514299","article-title":"The Brucella suis virB operon is induced intracellularly in macrophages","volume":"99","author":"Boschiroli","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.micinf.2010.10.015_bib19","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1128\/IAI.73.9.5524-5529.2005","article-title":"Identification of a new virulence factor, BvfA, in Brucella suis","volume":"73","author":"Lavigne","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1475-2859-5-13","article-title":"Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system","volume":"5","author":"Cardoso","year":"2006","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.micinf.2010.10.015_bib21","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1128\/IAI.71.4.2110-2119.2003","article-title":"Interactions between Brucella melitensis and human phagocytes: bacterial surface O Polysaccharide inhibits phagocytosis, bacterial killing, and subsequent host cell apoptosis","volume":"71","author":"Fernandez-Prada","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib22","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1128\/IAI.69.7.4407-4416.2001","article-title":"Deletion of wboA enhances activation of the lectin pathway of complement in Brucella abortus and Brucella melitensis","volume":"69","author":"Fernandez-Prada","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0147-9571(01)00029-7","article-title":"Study of interleukin-10 and interleukin-12 productions in response to lipopolysaccharides extracted from two different Brucella strains","volume":"25","author":"Kariminia","year":"2002","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.10.015_bib24","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.4049\/jimmunol.173.7.4635","article-title":"Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus","volume":"173","author":"Giambartolomei","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib25","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.1128\/IAI.69.8.4823-4830.2001","article-title":"Major outer membrane protein Omp25 of Brucella suis is involved in inhibition of tumor necrosis factor alpha production during infection of human macrophages","volume":"69","author":"Jubier-Maurin","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib26","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/IAI.00949-07","article-title":"Brucella abortus inhibits major histocompatibility complex class II expression and antigen processing through interleukin-6 secretion via Toll-like receptor 2","volume":"76","author":"Barrionuevo","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib27","doi-asserted-by":"crossref","first-page":"9892","DOI":"10.1074\/jbc.M805458200","article-title":"Brucella TIR Domain-containing protein mimics properties of the toll-like receptor adaptor protein TIRAP","volume":"284","author":"Radhakrishnan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2010.10.015_bib28","doi-asserted-by":"crossref","first-page":"956","DOI":"10.4049\/jimmunol.0902008","article-title":"Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL","volume":"184","author":"Sengupta","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.micpath.2008.10.011","article-title":"The IFN gamma-induced STAT1-CBP\/P300 association, required for a normal response to the cytokine, is disrupted in Brucella-infected macrophages","volume":"46","author":"Bouhet","year":"2009","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micinf.2010.10.015_bib30","doi-asserted-by":"crossref","first-page":"5607","DOI":"10.4049\/jimmunol.170.11.5607","article-title":"Subversion and utilization of the host cell cyclic adenosine 5\u2019-monophosphate\/protein kinase A pathway by Brucella during macrophage infection","volume":"170","author":"Gross","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib31","doi-asserted-by":"crossref","first-page":"5916","DOI":"10.1128\/IAI.00931-07","article-title":"Interaction of Brucella suis and Brucella abortus rough strains with human dendritic cells","volume":"75","author":"Billard","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib32","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1128\/IAI.00637-07","article-title":"Brucella suis prevents human dendritic cell maturation and antigen presentation through regulation of tumor necrosis factor alpha secretion","volume":"75","author":"Billard","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib33","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.micinf.2008.07.035","article-title":"Brucella lipoproteins mimic dendritic cell maturation induced by Brucella abortus","volume":"10","author":"Zwerdling","year":"2008","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2010.10.015_bib34","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1574-695X.2008.00441.x","article-title":"VirB type IV secretory system does not contribute to Brucella suis\u2019 avoidance of human dendritic cell maturation","volume":"53","author":"Billard","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.micinf.2010.10.015_bib35","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1128\/iai.62.3.910-914.1994","article-title":"Phagocytic cell function in active brucellosis","volume":"62","author":"Ocon","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib36","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1128\/IAI.01385-09","article-title":"Human brucellosis is characterized by an intense Th1 profile associated to a defective monocyte function","volume":"78","author":"Rodr\u00edguez-Zapata","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib37","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1258\/0004563053492801","article-title":"Effect of the treatment of brucellosis on leukocyte superoxide dismutase activity and plasma nitric oxide level","volume":"42","author":"Karabulut","year":"2005","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.micinf.2010.10.015_bib38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3109\/08923978209019455","article-title":"Peripheral blood monocyte phagocytosis in patients with chronic brucellosis","volume":"4","author":"Boura","year":"1982","journal-title":"J. Immunopharmacol."},{"key":"10.1016\/j.micinf.2010.10.015_bib39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/08923978909082146","article-title":"Monocyte locomotion in anergic chronic brucellosis patients: the in vivo effect of ascorbic acid","volume":"11","author":"Boura","year":"1989","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.micinf.2010.10.015_bib40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3109\/08923978909005367","article-title":"In vitro effect of interferon alpha-2b on T lymphocyte transformation and leukocyte migration inhibition in patients with chronic brucellosis","volume":"11","author":"Lagra","year":"1989","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.micinf.2010.10.015_bib41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3109\/08923979409019745","article-title":"Immunotherapy in chronic brucellosis. Effect of levamisole and interferon; mechanisms of action and clinical value","volume":"16","author":"Printzis","year":"1994","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.micinf.2010.10.015_bib42","first-page":"919","article-title":"Interferon-A 2a administration in chronic anergic brucellosis","volume":"42","author":"Boura","year":"1995","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.micinf.2010.10.015_bib43","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/205873929901200208","article-title":"Effect of bacterial extracts on the immunologic profile in chronic relapsing brucellosis patients","volume":"12","author":"Boura","year":"1999","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.micinf.2010.10.015_bib44","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1086\/375223","article-title":"Monocyte and lymphocyte apoptosis resistance in acute and chronic brucellosis and its possible implications in clinical management","volume":"36","author":"Tolomeo","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.10.015_bib45","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0140-6736(77)91181-3","article-title":"Brucellosis, immunodepression, and levamisole","volume":"1","author":"Renoux","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2010.10.015_bib46","first-page":"225","article-title":"Acquired immune suppression in chronic brucellosis","volume":"76","author":"Thornes","year":"1983","journal-title":"Ir. Med. J."},{"key":"10.1016\/j.micinf.2010.10.015_bib47","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0035-9203(02)90119-7","article-title":"Antigen-specific activation and proliferation of CD4+ and CD8+ T lymphocytes from brucellosis patients","volume":"96","author":"Moreno-Lafont","year":"2002","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2010.10.015_bib48","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jinf.2006.04.001","article-title":"Diminished percentage of CD4+ T-lymphocytes expressing interleukine-2 receptor alpha in chronic brucellosis","volume":"54","author":"Skendros","year":"2007","journal-title":"J. Infect."},{"key":"10.1016\/j.micinf.2010.10.015_bib49","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1086\/341449","article-title":"Diminished production of T\u00a0helper 1 cytokines correlates with T cell unresponsiveness to Brucella cytoplasmic proteins in chronic human brucellosis","volume":"186","author":"Giambartolomei","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.10.015_bib50","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jinf.2005.11.024","article-title":"Dominant Th1 cytokine production in early onset of human brucellosis followed by switching towards Th2 along prolongation of disease","volume":"53","author":"Rafiei","year":"2006","journal-title":"J. Infect."},{"key":"10.1016\/j.micinf.2010.10.015_bib51","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.micinf.2009.08.001","article-title":"Transforming growth factor beta production correlates with depressed lymphocytes function in humans with chronic brucellosis","volume":"11","author":"Elfaki","year":"2009","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2010.10.015_bib52","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.diagmicrobio.2005.02.016","article-title":"In vitro nonspecific mitogenic response of T-cell subsets in acute and chronic brucellosis","volume":"52","author":"Kinikli","year":"2005","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.10.015_bib53","first-page":"327346","article-title":"Chronic brucellosis patients retain low frequency of CD4+ T-lymphocytes expressing CD25 and CD28 after Escherichia coli LPS stimulation of PHA-cultured PBMCs","author":"Skendros","year":"2008","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0928-8244(03)00207-4","article-title":"Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers","volume":"39","author":"Demirdag","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.micinf.2010.10.015_bib55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.femsim.2005.04.001","article-title":"Determination of intracellular cytokines produced by Th1 and Th2 cells using flow cytometry in patients with brucellosis","volume":"45","author":"Akbulut","year":"2005","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.micinf.2010.10.015_bib56","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1128\/IAI.72.4.2303-2311.2004","article-title":"Impairment of intramacrophagic Brucella suis multiplication by human natural killer cells through a contact-dependent mechanism","volume":"72","author":"Dornand","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.10.015_bib57","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.4049\/jimmunol.177.8.5533","article-title":"Release of LL-37 by activated human Vgamma9Vdelta2 T cells: a microbicidal weapon against Brucella suis","volume":"177","author":"Dudal","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib58","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/eji.200838929","article-title":"Human CD4+ invariant NKT cells are involved in antibacterial immunity against Brucella suis through CD1d-dependent but CD4-independent mechanisms","volume":"39","author":"Bessoles","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib59","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10238-008-0021-1","article-title":"Gamma\/delta T cells in patients with acute brucellosis","volume":"9","author":"Kilic","year":"2009","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.micinf.2010.10.015_bib60","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/clind\/15.5.764","article-title":"Impaired activity of natural killer cells in patients with acute brucellosis","volume":"15","author":"Salmer\u00f3n","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.10.015_bib61","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1046\/j.1365-2249.2000.01331.x","article-title":"TNFA promoter polymorphism and susceptibility to brucellosis","volume":"121","author":"Caballero","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib62","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1080\/0036554021000026975","article-title":"Frequency analysis of the CCR5delta32 mutation in patients with brucellosis","volume":"34","author":"Skendros","year":"2002","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.10.015_bib63","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.micinf.2003.08.010","article-title":"Inducible nitric oxide synthase promoter polymorphism in human brucellosis","volume":"5","author":"Orozco","year":"2003","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2010.10.015_bib64","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2370.2003.00419.x","article-title":"Polymorphisms of the interferon gamma and interleukin 10 genes in human brucellosis","volume":"30","author":"Bravo","year":"2003","journal-title":"Eur. J. Immunogenet."},{"key":"10.1016\/j.micinf.2010.10.015_bib65","first-page":"1051","article-title":"HLA-B*39 allele confers susceptibility to osteoarticular complications in human brucellosis","volume":"30","author":"Bravo","year":"2003","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.micinf.2010.10.015_bib66","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.micinf.2005.06.010","article-title":"Variation in the NRAMP1 gene does not affect susceptibility or protection in human brucellosis","volume":"8","author":"Bravo","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2010.10.015_bib67","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jinf.2005.10.018","article-title":"TLR4 polymorphism in Iranian patients with brucellosis","volume":"53","author":"Rezazadeh","year":"2006","journal-title":"J. Infect."},{"key":"10.1016\/j.micinf.2010.10.015_bib68","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/00365540600786473","article-title":"Association of susceptibility to brucellosis and interleukin-4 promoter polymorphism","volume":"38","author":"Rezazadeh","year":"2006","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.10.015_bib69","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/08820130600634568","article-title":"Polymorphism in the promoter region of the CD14 gene and susceptibility to Brucellosis","volume":"35","author":"Haidari","year":"2006","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.micinf.2010.10.015_bib70","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1099\/jmm.0.46383-0","article-title":"Association between the Phe206Leu polymorphism of L-selectin and brucellosis","volume":"55","author":"Rafiei","year":"2006","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.micinf.2010.10.015_bib71","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1399-0039.2006.00668.x","article-title":"Association of interleukin-1 receptor antagonist gene polymorphism and susceptibility to human brucellosis","volume":"68","author":"Hajilooi","year":"2006","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.micinf.2010.10.015_bib72","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1744-313X.2006.00626.x","article-title":"Th-1 cytokines gene polymorphism in human brucellosis","volume":"33","author":"Davoudi","year":"2006","journal-title":"Int. J. Immunogenet."},{"key":"10.1016\/j.micinf.2010.10.015_bib73","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1469-0691.2006.01575.x","article-title":"Transforming growth factor-beta1 polymorphisms in patients with brucellosis: an association between codon 10 and 25 polymorphisms and brucellosis","volume":"13","author":"Rafiei","year":"2007","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.micinf.2010.10.015_bib74","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cyto.2007.04.008","article-title":"IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis","volume":"38","author":"Budak","year":"2007","journal-title":"Cytokine"},{"key":"10.1016\/j.micinf.2010.10.015_bib75","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cyto.2007.05.003","article-title":"Association of interferon-gamma and interleukin-4 gene polymorphisms with susceptibility to brucellosis in Iranian patients","volume":"38","author":"Rasouli","year":"2007","journal-title":"Cytokine"},{"key":"10.1016\/j.micinf.2010.10.015_bib76","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1399-0039.2007.00823.x","article-title":"Polymorphism of the transmembrane region of the MICA gene and human brucellosis","volume":"69","author":"Bravo","year":"2007","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.micinf.2010.10.015_bib77","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.meegid.2007.02.005","article-title":"The Ser128Arg polymorphism for E-selectin gene and brucellosis","volume":"7","author":"Rafiei","year":"2007","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.micinf.2010.10.015_bib78","doi-asserted-by":"crossref","first-page":"196","DOI":"10.7883\/yoken.JJID.2007.196","article-title":"Fc gamma receptor IIa polymorphism in patients with brucellosis","volume":"60","author":"Hashemi","year":"2007","journal-title":"Jpn. J. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.10.015_bib79","first-page":"131","article-title":"Interleukin-10 gene polymorphisms and susceptibility to brucellosis in Iranian patients","volume":"5","author":"Rasouli","year":"2008","journal-title":"Iran J. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib80","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cyto.2008.07.008","article-title":"TGF-beta1 and IL-6 gene polymorphism in Spanish brucellosis patients","volume":"44","author":"Bravo","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.micinf.2010.10.015_bib81","first-page":"173","article-title":"TNF-alpha, TGF-beta, IL-10, IL-6 and IFN-gamma gene polymorphisms as risk factors for brucellosis","volume":"32","author":"Karaoglan","year":"2009","journal-title":"New Microbiol."},{"key":"10.1016\/j.micinf.2010.10.015_bib82","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/00365540802641864","article-title":"PTPN22 C1858T polymorphism and human brucellosis","volume":"41","author":"Bravo","year":"2009","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.10.015_bib83","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.humimm.2010.05.004","article-title":"No association of TAP and LMP genetic polymorphism in human brucellosis and its complications","volume":"71","author":"Bravo","year":"2010","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.micinf.2010.10.015_bib84","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/infdis\/147.6.1123","article-title":"Conventional therapy and levamisole in the management of chronic brucellosis","volume":"147","author":"Raptopoulou-Gigi","year":"1983","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.10.015_bib85","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1620\/tjem.201.221","article-title":"The effect of levamisole combined with the classical treatment in chronic brucellosis","volume":"201","author":"Irmak","year":"2003","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.micinf.2010.10.015_bib86","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000084020","article-title":"The effect of the doxycycline-rifampicin and levamisole combination on lymphocyte subgroups and functions of phagocytic cells in patients with chronic brucellosis","volume":"51","author":"Dizer","year":"2005","journal-title":"Chemotherapy"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457910002741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457910002741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:26:26Z","timestamp":1761143186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457910002741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":86,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S1286457910002741"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2010.10.015","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-mediated immunity in human brucellosis","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2010.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Institut Pasteur. Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}