{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:47:57Z","timestamp":1792288077216,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":568,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["07\/58843-2"],"award-info":[{"award-number":["07\/58843-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["07\/59448-0"],"award-info":[{"award-number":["07\/59448-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["09\/17787-8"],"award-info":[{"award-number":["09\/17787-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["09\/53544-2"],"award-info":[{"award-number":["09\/53544-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["09\/54010-1"],"award-info":[{"award-number":["09\/54010-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["10\/19216-5"],"award-info":[{"award-number":["10\/19216-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["10\/18629-4"],"award-info":[{"award-number":["10\/18629-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["10\/13199-1"],"award-info":[{"award-number":["10\/13199-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["472419\/2009-9"],"award-info":[{"award-number":["472419\/2009-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["150723\/2010-5"],"award-info":[{"award-number":["150723\/2010-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI076248"],"award-info":[{"award-number":["AI076248"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.micinf.2011.08.010","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T08:31:36Z","timestamp":1314865896000},"page":"59-68","source":"Crossref","is-referenced-by-count":9,"title":["Early dystrophin disruption in the pathogenesis of experimental chronic Chagas cardiomyopathy"],"prefix":"10.1016","volume":"14","author":[{"given":"Cibele M.","family":"Prado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara R.N.","family":"Celes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lygia M.","family":"Malvestio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica C.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o S.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Jelicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert B.","family":"Tanowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos A.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2011.08.010_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0065-308X(08)60472-8","article-title":"Chagas' disease and Chagas' syndromes: the pathology of American trypanosomiasis","volume":"6","author":"K\u00f6berle","year":"1968","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.micinf.2011.08.010_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0002-8703(90)90191-Y","article-title":"Microvascular changes as a cause of chronic cardiomyopathy in Chagas' disease","volume":"120","author":"Rossi","year":"1990","journal-title":"Am. Heart J."},{"key":"10.1016\/j.micinf.2011.08.010_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000176822","article-title":"The challenge of chagasic cardiomyopathy. The pathologic roles of autonomic abnormalities, autoimmune mechanisms and microvascular changes, and therapeutic implications","volume":"86","author":"Rossi","year":"1995","journal-title":"Cardiology"},{"key":"10.1016\/j.micinf.2011.08.010_bib4","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.pcad.2009.02.001","article-title":"Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease)","volume":"51","author":"Tanowitz","year":"2009","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.micinf.2011.08.010_bib5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0008-6363(03)00361-4","article-title":"Pathophysiology of the heart in Chagas' disease: current status and new developments","volume":"60","author":"Higuchi","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.micinf.2011.08.010_bib6","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.2741\/948","article-title":"Chagas' heart disease: clinical-pathological correlation","volume":"8","author":"Rossi","year":"2003","journal-title":"Front. Biosci."},{"key":"10.1016\/j.micinf.2011.08.010_bib7","doi-asserted-by":"crossref","first-page":"e674","DOI":"10.1371\/journal.pntd.0000674","article-title":"Coronary microvascular disease in chronic Chagas cardiomyopathy including an overview on history, pathology, and other proposed pathogenic mechanisms","volume":"4","author":"Rossi","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.micinf.2011.08.010_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1600-0854.2006.00519.x","article-title":"Processing and assembly of the dystrophin glycoprotein complex","volume":"8","author":"Allikian","year":"2007","journal-title":"Traffic"},{"key":"10.1016\/j.micinf.2011.08.010_bib9","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(02)07815-7","article-title":"The muscular dystrophies","volume":"359","author":"Emery","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2011.08.010_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1096\/fj.03-0453com","article-title":"Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibers","volume":"18","author":"Kumar","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.micinf.2011.08.010_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbapap.2005.01.001","article-title":"A novel scheme of dystrophin disruption for the progression of advanced heart failure","volume":"1751","author":"Kawada","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.micinf.2011.08.010_bib12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/6543","article-title":"Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy","volume":"5","author":"Badorff","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.micinf.2011.08.010_bib13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/labinvest.2010.3","article-title":"Disruption of sarcolemmal dystrophin and beta-dystroglycan may be a potential mechanism for myocardial dysfunction in severe sepsis","volume":"90","author":"Celes","year":"2010","journal-title":"Lab. Invest."},{"key":"10.1016\/j.micinf.2011.08.010_bib14","first-page":"209","article-title":"Experimental Trypanosoma cruzi cardiomyopathy in BALB\/c mice. The potential role of intravascular platelet aggregation in its genesis","volume":"114","author":"Rossi","year":"1984","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.micinf.2011.08.010_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4269\/ajtmh.1999.61.207","article-title":"Application of cardiac gated magnetic resonance imaging in murine Chagas' disease","volume":"61","author":"Jelicks","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2011.08.010_bib16","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1128\/IAI.73.4.2496-2503.2005","article-title":"Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease","volume":"73","author":"Tanowitz","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2011.08.010_bib17","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","article-title":"Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms","volume":"2","author":"Schiller","year":"1989","journal-title":"J. Am. Soc. Echocardiogr"},{"key":"10.1016\/j.micinf.2011.08.010_bib18","first-page":"236","article-title":"Die Chagaskrankleit \u2013 ihre Pathogenese und ihre Bedeutung als Volksseuche","volume":"10","author":"K\u00f6berle","year":"1959","journal-title":"Tropenmed. Parasitol."},{"key":"10.1016\/j.micinf.2011.08.010_bib19","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0002-9440(10)63222-1","article-title":"Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice","volume":"164","author":"Arantes","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.micinf.2011.08.010_bib20","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2307\/3277711","article-title":"Comparison of infectivity of strains of Trypanosoma cruzi (Chagas, 1909)","volume":"56","author":"Bice","year":"1970","journal-title":"J. Parasitol."},{"key":"10.1016\/j.micinf.2011.08.010_bib21","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2307\/3279787","article-title":"Tissue tropism of different Trypanosoma cruzi strains","volume":"64","author":"Melo","year":"1978","journal-title":"J. Parasitol."},{"key":"10.1016\/j.micinf.2011.08.010_bib22","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0960-8966(01)00198-5","article-title":"Do immune cells promote the pathology of dystrophin-deficient myopathies?","volume":"11","author":"Spencer","year":"2001","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.micinf.2011.08.010_bib23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2377-10-33","article-title":"Myocardial inflammation in Duchenne Muscular Dystrophy as a precipitating factor for heart failure: a prospective study","volume":"10","author":"Mavrogeni","year":"2010","journal-title":"BMC Neurol."},{"key":"10.1016\/j.micinf.2011.08.010_bib24","doi-asserted-by":"crossref","first-page":"900","DOI":"10.4269\/ajtmh.2009.09-0338","article-title":"Micro-positron emission tomography in the evaluation of Trypanosoma cruzi-induced heart disease: comparison with other modalities","volume":"81","author":"Prado","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2011.08.010_bib25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1196\/annals.1302.017","article-title":"Linking gene expression to function: metabolic flexibility in the normal and diseased heart","volume":"1015","author":"Taegtmeyer","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.micinf.2011.08.010_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1161\/01.CIR.69.1.33","article-title":"Alterations in regional myocardial metabolism, perfusion, and wall motion in Duchenne muscular dystrophy studied by radionuclide imaging","volume":"69","author":"Perloff","year":"1984","journal-title":"Circulation"},{"key":"10.1016\/j.micinf.2011.08.010_bib27","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s12149-007-0067-2","article-title":"Quantitative FDG-uptake by positron emission tomography in progressive hypertrophy of rat hearts in\u00a0vivo","volume":"21","author":"Handa","year":"2007","journal-title":"Ann. Nucl. Med."},{"key":"10.1016\/j.micinf.2011.08.010_bib28","first-page":"1516","article-title":"Monitoring left ventricular dilation in mice with PET","volume":"46","author":"Stegger","year":"2005","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.micinf.2011.08.010_bib29","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1253\/circj.CJ-08-0046","article-title":"Multifocal, persistent cardiac uptake of [18-f]-fluoro-deoxy-glucose detected by positron emission tomography in patients with acute myocardial infarction","volume":"72","author":"Godino","year":"2008","journal-title":"Circ. J."},{"key":"10.1016\/j.micinf.2011.08.010_bib30","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.yjmcc.2008.09.125","article-title":"Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study","volume":"45","author":"Zhang","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.micinf.2011.08.010_bib31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.yjmcc.2007.05.015","article-title":"Metabolic and signaling alterations in dystrophin-deficient hearts precede overt cardiomyopathy","volume":"43","author":"Khairallah","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.micinf.2011.08.010_bib32","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.yjmcc.2005.02.019","article-title":"Ischemia depletes dystrophin and inhibits protein synthesis in the canine heart: mechanisms of myocardial ischemic injury","volume":"38","author":"Rodr\u00edguez","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.micinf.2011.08.010_bib33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2613.2008.00604.x","article-title":"Isoproterenol induces primary loss of dystrophin in rat hearts: correlation with myocardial injury","volume":"89","author":"Campos","year":"2008","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.micinf.2011.08.010_bib34","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1006\/jmcc.2001.1380","article-title":"Ischemic loss of sarcolemmal dystrophin and spectrin: correlation with myocardial injury","volume":"33","author":"Amstrong","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.micinf.2011.08.010_bib35","first-page":"155","article-title":"Experimental Trypanosoma cruzi cardiomyopathy in BALB\/c mice: histochemical evidence of hypoxic changes in the myocardium","volume":"66","author":"Rossi","year":"1985","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.micinf.2011.08.010_bib36","doi-asserted-by":"crossref","first-page":"246","DOI":"10.4269\/ajtmh.1985.34.246","article-title":"Abnormalities of the coronary microcirculation in acute murine Chagas' disease","volume":"34","author":"Factor","year":"1985","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2011.08.010_bib37","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2307\/3284127","article-title":"Compromised microcirculation in acute murine Trypanosoma cruzi infection","volume":"82","author":"Tanowitz","year":"1996","journal-title":"J. Parasitol."},{"key":"10.1016\/j.micinf.2011.08.010_bib38","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s00436-004-1080-1","article-title":"Effects of early and late verapamil administration on the development of cardiomyopathy in experimental chronic Trypanosoma cruzi (Brazil strain) infection","volume":"92","author":"De Souza","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micinf.2011.08.010_bib39","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0002-8703(95)90122-1","article-title":"Coronary vascular reactivity is abnormal in patients with Chagas' heart disease","volume":"129","author":"Torres","year":"1995","journal-title":"Am. Heart J."},{"key":"10.1016\/j.micinf.2011.08.010_bib40","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.expneurol.2010.07.021","article-title":"Calpain inhibition attenuates intracellular changes in muscle cells in response to extracellular inflammatory stimulation","volume":"225","author":"Nozaki","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.micinf.2011.08.010_bib41","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1471-4922(02)02283-3","article-title":"Chemokines, inflammation and Trypanosoma cruzi infection","volume":"18","author":"Teixeira","year":"2002","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.micinf.2011.08.010_bib42","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1096\/fj.02-0542com","article-title":"Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy","volume":"17","author":"Kumar","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.micinf.2011.08.010_bib43","doi-asserted-by":"crossref","first-page":"R345","DOI":"10.1152\/ajpregu.00454.2004","article-title":"Inflammatory processes in muscle injury and repair","volume":"288","author":"Tidball","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.micinf.2011.08.010_bib44","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF01869151","article-title":"Degradation of skeletal muscle plasma membrane proteins by calpain","volume":"110","author":"Zaidi","year":"1989","journal-title":"J. Membr. Biol."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457911002231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457911002231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T19:25:54Z","timestamp":1560540354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457911002231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1286457911002231"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2011.08.010","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}