{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:56:42Z","timestamp":1791374202776,"version":"4.3.1"},"reference-count":82,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":502,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Austrian research Funds"},{"name":"\u2018Verein zur F\u00f6rderung von Forschung und Weiterbildung in Infektiologie und Immunologie, Innsbruck\u2019"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.micinf.2011.10.005","type":"journal-article","created":{"date-parts":[[2011,11,5]],"date-time":"2011-11-05T18:32:47Z","timestamp":1320517967000},"page":"238-246","source":"Crossref","is-referenced-by-count":141,"title":["The pleiotropic effects of erythropoietin in infection and inflammation"],"prefix":"10.1016","volume":"14","author":[{"given":"Manfred","family":"Nairz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sonnweber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Schroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Theurl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2011.10.005_bib1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/46809","article-title":"Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1","volume":"401","author":"De Maria","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2011.10.005_bib2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/349257a0","article-title":"Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1","volume":"349","author":"Pevny","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2011.10.005_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1182\/blood-2005-11-4458","article-title":"Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in\u00a0vivo","volume":"108","author":"Liu","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2011.10.005_bib4","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.00174.2010","article-title":"Hypoxic regulation of erythropoiesis and iron metabolism","volume":"299","author":"Haase","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"Suppl 3","key":"10.1016\/j.micinf.2011.10.005_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2362.2005.01525.x","article-title":"Regulation of erythropoietin production","volume":"35","author":"Eckardt","year":"2005","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.micinf.2011.10.005_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cell.2008.02.038","article-title":"Epidermal sensing of oxygen is essential for systemic hypoxic response","volume":"133","author":"Boutin","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2011.10.005_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1600-0609.2007.00818.x","article-title":"Erythropoietin after a century of research: younger than ever","volume":"78","author":"Jelkmann","year":"2007","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.micinf.2011.10.005_bib8","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1096\/fj.02-0168fje","article-title":"Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappaB","volume":"16","author":"La Ferla","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.micinf.2011.10.005_bib9","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMra041809","article-title":"Anemia of chronic disease","volume":"352","author":"Weiss","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.micinf.2011.10.005_bib10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/jir.1998.18.555","article-title":"Proinflammatory cytokines lowering erythropoietin production","volume":"18","author":"Jelkmann","year":"1998","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.micinf.2011.10.005_bib11","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/labinvest.2010.85","article-title":"Cellular and molecular mechanisms regulating the hepatic erythropoietin expression during acute-phase response: a role for IL-6","volume":"90","author":"Ramadori","year":"2010","journal-title":"Lab. Invest."},{"key":"10.1016\/j.micinf.2011.10.005_bib12","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.180.7.4697","article-title":"Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function","volume":"180","author":"Jantsch","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2011.10.005_bib13","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1172\/JCI23865","article-title":"HIF-1alpha expression regulates the bactericidal capacity of phagocytes","volume":"115","author":"Peyssonnaux","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.micinf.2011.10.005_bib14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06905","article-title":"NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha","volume":"453","author":"Rius","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2011.10.005_bib15","doi-asserted-by":"crossref","first-page":"21276","DOI":"10.1073\/pnas.0903978106","article-title":"Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model","volume":"106","author":"Bernhardt","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.micinf.2011.10.005_bib16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1053\/j.gastro.2007.10.012","article-title":"The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis","volume":"134","author":"Cummins","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.micinf.2011.10.005_bib17","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.molcel.2008.11.026","article-title":"Symmetric signaling by an asymmetric 1 erythropoietin: 2 erythropoietin receptor complex","volume":"33","author":"Zhang","year":"2009","journal-title":"Mol. Cell."},{"key":"10.1016\/j.micinf.2011.10.005_bib18","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1182\/blood.V87.11.4495.bloodjournal87114495","article-title":"Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis","volume":"87","author":"Tauchi","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2011.10.005_bib19","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1182\/blood-2009-10-248666","article-title":"Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells","volume":"115","author":"Sinclair","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2011.10.005_bib20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2796.2008.02024.x","article-title":"Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response","volume":"264","author":"Brines","year":"2008","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.micinf.2011.10.005_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.critrevonc.2008.03.006","article-title":"The erythropoietin receptor in normal and cancer tissues","volume":"67","author":"Jelkmann","year":"2008","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.micinf.2011.10.005_bib22","first-page":"3721","article-title":"Importance of erythropoetin receptor expression in tumour tissue for the clinical course of breast cancer","volume":"30","author":"Volgger","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.micinf.2011.10.005_bib23","doi-asserted-by":"crossref","first-page":"17359","DOI":"10.1074\/jbc.M201842200","article-title":"Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases","volume":"277","author":"Haq","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2011.10.005_bib24","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/sj.onc.1208205","article-title":"Chemosensitization by erythropoietin through inhibition of the NF-kappaB rescue pathway","volume":"24","author":"Carvalho","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.micinf.2011.10.005_bib25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.immuni.2011.01.002","article-title":"Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-kappaB-inducible immune pathways","volume":"34","author":"Nairz","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2011.10.005_bib26","first-page":"526","article-title":"Erythropoietin deficiency decreases vascular stability in mice","volume":"118","author":"Chen","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.micinf.2011.10.005_bib27","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/35088074","article-title":"Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades","volume":"412","author":"Digicaylioglu","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2011.10.005_bib28","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1182\/blood-2008-09-179572","article-title":"Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia","volume":"113","author":"Sulahian","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2011.10.005_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ydbio.2004.08.025","article-title":"The role of erythropoietin in regulating angiogenesis","volume":"276","author":"Kertesz","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.micinf.2011.10.005_bib30","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1084\/jem.20100665","article-title":"Erythropoietin protects against diabetes through direct effects on pancreatic beta cells","volume":"207","author":"Choi","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2011.10.005_bib31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1172\/JCI18200","article-title":"A novel protective effect of erythropoietin in the infarcted heart","volume":"112","author":"Parsa","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.micinf.2011.10.005_bib32","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/ki.1996.347","article-title":"Effect of chronic human recombinant erythropoietin therapy on antibody responses to immunization in chronic hemodialysis patients","volume":"50","author":"Birmingham","year":"1996","journal-title":"Kidney Int."},{"key":"10.1016\/j.micinf.2011.10.005_bib33","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/ana.20274","article-title":"Beneficial effect of erythropoietin on experimental allergic encephalomyelitis","volume":"56","author":"Li","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.micinf.2011.10.005_bib34","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1525-1594.1999.06177.x","article-title":"Recombinant human erythropoietin stimulates production of interleukin 2 by whole blood cell cultures of hemodialysis patients","volume":"23","author":"Bryl","year":"1999","journal-title":"Artif. Organs"},{"key":"10.1016\/j.micinf.2011.10.005_bib35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0006-8993(02)03239-0","article-title":"Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis","volume":"952","author":"Agnello","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.micinf.2011.10.005_bib36","doi-asserted-by":"crossref","first-page":"e1924","DOI":"10.1371\/journal.pone.0001924","article-title":"Erythropoietin: a potent inducer of peripheral immuno\/inflammatory modulation in autoimmune EAE","volume":"3","author":"Yuan","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2011.10.005_bib37","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1073\/pnas.081275298","article-title":"Erythropoietin induces tumor regression and antitumor immune responses in murine myeloma models","volume":"98","author":"Mittelman","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.micinf.2011.10.005_bib38","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/eji.200637025","article-title":"Erythropoietin enhances immune responses in mice","volume":"37","author":"Katz","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2011.10.005_bib39","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1159\/000065044","article-title":"Interaction between erythropoietin and peripheral polymorphonuclear leukocytes in continuous ambulatory dialysis patients","volume":"91","author":"Shurtz-Swirski","year":"2002","journal-title":"Nephron"},{"key":"10.1016\/j.micinf.2011.10.005_bib40","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.molimm.2008.10.004","article-title":"Non-erythroid activities of erythropoietin: functional effects on murine dendritic cells","volume":"46","author":"Lifshitz","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.micinf.2011.10.005_bib41","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/art.20875","article-title":"Erythropoietin reduces the degree of arthritis caused by type II collagen in the mouse","volume":"52","author":"Cuzzocrea","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.micinf.2011.10.005_bib42","doi-asserted-by":"crossref","first-page":"e13986","DOI":"10.1371\/journal.pone.0013986","article-title":"Erythropoietin improves the survival of fat tissue after its transplantation in nude mice","volume":"5","author":"Hamed","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2011.10.005_bib43","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1086\/500844","article-title":"Recombinant human erythropoietin prevents the death of mice during cerebral malaria","volume":"193","author":"Kaiser","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2011.10.005_bib44","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1086\/381458","article-title":"Modulation of the course and outcome of blood-stage malaria by erythropoietin-induced reticulocytosis","volume":"189","author":"Chang","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2011.10.005_bib45","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.4269\/ajtmh.2006.74.1020","article-title":"Beneficial effect of erythropoietin administration on murine infection with Trypanosoma congolense","volume":"74","author":"Suzuki","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2011.10.005_bib46","doi-asserted-by":"crossref","first-page":"e5170","DOI":"10.1371\/journal.pone.0005170","article-title":"Mechanisms controlling anaemia in Trypanosoma congolense infected mice","volume":"4","author":"Noyes","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2011.10.005_bib47","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0301-472X(98)00019-8","article-title":"Analysis of erythropoietin and erythropoietin receptor genes expression in cattle during acute infection with Trypanosoma congolense","volume":"27","author":"Suliman","year":"1999","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.micinf.2011.10.005_bib48","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1203\/PDR.0b013e318159af7a","article-title":"No neuroprotective effect of erythropoietin under clinical treatment conditions in a rabbit model of Escherichia coli meningitis","volume":"62","author":"Spreer","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.micinf.2011.10.005_bib49","doi-asserted-by":"crossref","first-page":"6198","DOI":"10.4049\/jimmunol.1001198","article-title":"Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly","volume":"185","author":"Jackson","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2011.10.005_bib50","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/TA.0b013e31817f2c6e","article-title":"Improved survival of critically ill trauma patients treated with recombinant human erythropoietin","volume":"65","author":"Napolitano","year":"2008","journal-title":"J. Trauma"},{"key":"10.1016\/j.micinf.2011.10.005_bib51","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1056\/NEJMoa071533","article-title":"Efficacy and safety of epoetin alfa in critically ill patients","volume":"357","author":"Corwin","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.micinf.2011.10.005_bib52","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000105493","article-title":"Erythropoietin attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain","volume":"92","author":"Kumral","year":"2007","journal-title":"Neonatology"},{"key":"10.1016\/j.micinf.2011.10.005_bib53","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/ndt\/gfm216","article-title":"Erythropoietin ameliorates renal dysfunction during endotoxaemia","volume":"22","author":"Mitra","year":"2007","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.micinf.2011.10.005_bib54","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2215\/CJN.00380111","article-title":"Endogenous erythropoietin and the association with inflammation and mortality in diabetic chronic kidney disease","volume":"6","author":"Wagner","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.micinf.2011.10.005_bib55","doi-asserted-by":"crossref","first-page":"14907","DOI":"10.1073\/pnas.0406491101","article-title":"Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor","volume":"101","author":"Brines","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.micinf.2011.10.005_bib56","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1056\/NEJMoa074037","article-title":"A peptide-based erythropoietin-receptor agonist for pure red-cell aplasia","volume":"361","author":"Macdougall","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.micinf.2011.10.005_bib57","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.273.5274.458","article-title":"Small peptides as potent mimetics of the protein hormone erythropoietin","volume":"273","author":"Wrighton","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.micinf.2011.10.005_bib58","doi-asserted-by":"crossref","first-page":"10925","DOI":"10.1073\/pnas.0805594105","article-title":"Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin","volume":"105","author":"Brines","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.micinf.2011.10.005_bib59","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1574-695X.2011.00801.x","article-title":"The erythropoietin analogue ARA290 modulates the innate immune response and reduces Escherichia coli invasion into urothelial cells","volume":"62","author":"Polgarova","year":"2011","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.micinf.2011.10.005_bib60","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2119\/molmed.2009.00051","article-title":"Nonerythropoietic tissue protective compounds are highly effective facilitators of wound healing","volume":"15","author":"Erbayraktar","year":"2009","journal-title":"Mol. Med."},{"key":"10.1016\/j.micinf.2011.10.005_bib61","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1056\/NEJMoa1005109","article-title":"Erythropoietic response and outcomes in kidney disease and type 2 diabetes","volume":"363","author":"Solomon","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.micinf.2011.10.005_bib62","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.immuni.2011.01.004","article-title":"Erythropoietin surprises: an immune saga","volume":"34","author":"Broxmeyer","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2011.10.005_bib63","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri1703","article-title":"NF-kappaB: linking inflammation and immunity to cancer development and progression","volume":"5","author":"Karin","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.micinf.2011.10.005_bib64","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.4049\/jimmunol.176.8.4923","article-title":"Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa","volume":"176","author":"Sadikot","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2011.10.005_bib65","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S1286-4579(01)01408-3","article-title":"Impact of transcription factors AP-1 and NF-kappaB on the outcome of experimental Staphylococcus aureus arthritis and sepsis","volume":"3","author":"Gjertsson","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2011.10.005_bib66","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0092-8674(95)90415-8","article-title":"Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses","volume":"80","author":"Sha","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2011.10.005_bib67","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1189\/jlb.1210683","article-title":"Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1{alpha} (HIF1A) and result in differential HIF1A-dependent gene expression","volume":"90","author":"Jantsch","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.micinf.2011.10.005_bib68","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.20040624","article-title":"Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity","volume":"201","author":"Walmsley","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2011.10.005_bib69","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4161\/cc.7.1.5145","article-title":"Role of the hypoxia inducible factors HIF in iron metabolism","volume":"7","author":"Peyssonnaux","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.micinf.2011.10.005_bib70","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1182\/blood.V89.2.680","article-title":"Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells","volume":"89","author":"Weiss","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2011.10.005_bib71","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.4049\/jimmunol.162.10.6171","article-title":"Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression","volume":"162","author":"Dlaska","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2011.10.005_bib72","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1189\/jlb.0802420","article-title":"Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells","volume":"74","author":"Oexle","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.micinf.2011.10.005_bib73","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1182\/blood.V91.7.2565","article-title":"Response of monocyte iron regulatory protein activity to inflammation: abnormal behavior in genetic hemochromatosis","volume":"91","author":"Recalcati","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2011.10.005_bib74","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1111\/j.1462-5822.2010.01529.x","article-title":"The struggle for iron - a metal at the host-pathogen interface","volume":"12","author":"Nairz","year":"2010","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.micinf.2011.10.005_bib75","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood-2003-03-0672","article-title":"Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation","volume":"102","author":"Ganz","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2011.10.005_bib76","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","article-title":"Two to tango: regulation of mammalian iron metabolism","volume":"142","author":"Hentze","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2011.10.005_bib77","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1182\/blood-2007-05-090019","article-title":"Autocrine formation of hepcidin induces iron retention in human monocytes","volume":"111","author":"Theurl","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2011.10.005_bib78","doi-asserted-by":"crossref","first-page":"6707","DOI":"10.1182\/blood-2008-09-178095","article-title":"Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin","volume":"113","author":"Robach","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2011.10.005_bib79","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1084\/jem.180.3.969","article-title":"Iron regulates nitric oxide synthase activity by controlling nuclear transcription","volume":"180","author":"Weiss","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2011.10.005_bib80","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1172\/JCI42011","article-title":"Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice","volume":"120","author":"De Domenico","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.micinf.2011.10.005_bib81","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1182\/blood-2011-02-337212","article-title":"Low hepcidin accounts for the proinflammatory status associated with iron deficiency","volume":"118","author":"Pagani","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2011.10.005_bib82","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nm.2368","article-title":"Host-mediated regulation of superinfection in malaria","volume":"17","author":"Portugal","year":"2011","journal-title":"Nat. Med."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457911002589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457911002589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T19:24:46Z","timestamp":1686425086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457911002589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":82,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S1286457911002589"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2011.10.005","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}