{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:14:55Z","timestamp":1791234895535,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":4170,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.micinf.2012.05.005","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T13:50:55Z","timestamp":1337781055000},"page":"863-873","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Adenosine signaling in normal and sickle erythrocytes and beyond"],"prefix":"10.1016","volume":"14","author":[{"given":"Yujin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2012.05.005_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399406010659","article-title":"Pathophysiology and therapy for haemoglobinopathies. Part I: sickle cell disease","volume":"8","author":"Madigan","year":"2006","journal-title":"Exp. Rev. Mol. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399406010805","article-title":"Pathophysiology and therapy for haemoglobinopathies. Part II: thalassaemias","volume":"8","author":"Urbinati","year":"2006","journal-title":"Exp. Rev. Mol. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib3","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","article-title":"Sickle-cell disease","volume":"376","author":"Rees","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2012.05.005_bib4","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1182\/blood-2006-08-039438","article-title":"Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability","volume":"109","author":"Hsu","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2012.05.005_bib5","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1056\/NEJMra0804411","article-title":"Pulmonary complications of sickle cell disease","volume":"359","author":"Gladwin","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib6","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/jcp.22195","article-title":"Sickle cell anemia and vascular dysfunction: the nitric oxide connection","volume":"224","author":"Akinsheye","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.micinf.2012.05.005_bib7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1001\/archinte.1910.00050330050003","article-title":"Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia","volume":"6","author":"Herrick","year":"1910","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.110.2865.543","article-title":"Sickle cell anemia a molecular disease","volume":"110","author":"Pauling","year":"1949","journal-title":"Science"},{"key":"10.1016\/j.micinf.2012.05.005_bib9","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/178792a0","article-title":"A specific chemical difference between the globins of normal human and sickle-cell anaemia haemoglobin","volume":"178","author":"Ingram","year":"1956","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2012.05.005_bib10","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0140-6736(81)90584-5","article-title":"Antenatal diagnosis of sickle cell anaemia by direct analysis of the sickle mutation","volume":"2","author":"Chang","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2012.05.005_bib11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1182\/blood.V77.2.214.214","article-title":"Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology","volume":"77","author":"Hebbel","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2012.05.005_bib12","first-page":"1375","article-title":"Advances in sickle cell disease","volume":"192","author":"de Montalembert","year":"2008","journal-title":"Bull. Acad. Nat. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib13","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1365-2141.2005.05701.x","article-title":"Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality","volume":"130","author":"Kato","year":"2005","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.micinf.2012.05.005_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/08880010601185892","article-title":"Pulmonary hypertension in sickle cell disease: relevance to children","volume":"24","author":"Kato","year":"2007","journal-title":"Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.micinf.2012.05.005_bib15","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1182\/blood-2007-04-084921","article-title":"A network model to predict the risk of death in sickle cell disease","volume":"110","author":"Sebastiani","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2012.05.005_bib16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1586\/ehm.11.66","article-title":"Prevalence, risk factors and mortality of pulmonary hypertension defined by right heart catheterization in patients with sickle cell disease","volume":"4","author":"Gladwin","year":"2011","journal-title":"Expert Review Hematology"},{"key":"10.1016\/j.micinf.2012.05.005_bib17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1182\/asheducation-2007.1.97","article-title":"Current issues in sickle cell pain and its management, hematology\/the education program of the American Society of Hematology","author":"Ballas","year":"2007","journal-title":"Am. Soc. Hematol."},{"key":"10.1016\/j.micinf.2012.05.005_bib18","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMra0910283","article-title":"Hypoxia and inflammation","volume":"364","author":"Eltzschig","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrgastro.2010.39","article-title":"Hypoxia: an alarm signal during intestinal inflammation","volume":"7","author":"Colgan","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.micinf.2012.05.005_bib20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0031-6997(24)01511-4","article-title":"International union of pharmacology. XXV. Nomenclature and classification of adenosine receptors","volume":"53","author":"Fredholm","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.micinf.2012.05.005_bib21","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/sj.cdd.4402132","article-title":"Adenosine, an endogenous distress signal, modulates tissue damage and repair","volume":"14","author":"Fredholm","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.micinf.2012.05.005_bib22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1096\/fj.04-3371fje","article-title":"Purinoceptors are involved in the induction of an osmolyte permeability in malaria-infected and oxidized human erythrocytes","volume":"20","author":"Tanneur","year":"2006","journal-title":"Faseb J."},{"key":"10.1016\/j.micinf.2012.05.005_bib23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11302-010-9202-y","article-title":"Purinergic signalling is involved in the malaria parasite Plasmodium falciparum invasion to red blood cells","volume":"6","author":"Levano-Garcia","year":"2010","journal-title":"Purinergic Signalling"},{"key":"10.1016\/j.micinf.2012.05.005_bib24","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00424-008-0572-8","article-title":"The Plasmodium falciparum-induced anion channel of human erythrocytes is an ATP-release pathway","volume":"457","author":"Akkaya","year":"2009","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.micinf.2012.05.005_bib25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s11302-005-5302-5","article-title":"Physiological roles for ecto-5\u2032-nucleotidase (CD73)","volume":"2","author":"Colgan","year":"2006","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.micinf.2012.05.005_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nm1685","article-title":"The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak","volume":"14","author":"Tager","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nm.2280","article-title":"Detrimental effects of adenosine signaling in sickle cell disease","volume":"17","author":"Zhang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/10739680490278402","article-title":"The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy","volume":"11","author":"Hebbel","year":"2004","journal-title":"Microcirculation"},{"key":"10.1016\/j.micinf.2012.05.005_bib29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00062752-199704020-00003","article-title":"Transgenic and gene knock-out mouse models of sickle cell anemia and the thalassemias","volume":"4","author":"Paszty","year":"1997","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.micinf.2012.05.005_bib30","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1126\/science.278.5339.876","article-title":"Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease","volume":"278","author":"Paszty","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.micinf.2012.05.005_bib31","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1182\/blood.V76.5.1028.1028","article-title":"2,3-Diphosphoglycerate and intracellular pH as interdependent determinants of the physiologic solubility of deoxyhemoglobin S","volume":"76","author":"Poillon","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2012.05.005_bib32","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1182\/blood.V85.11.3289.bloodjournal85113289","article-title":"Antisickling effects of 2,3-diphosphoglycerate depletion","volume":"85","author":"Poillon","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2012.05.005_bib33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0003-9861(86)90006-8","article-title":"The effect of 2,3-diphosphoglycerate on the solubility of deoxyhemoglobin S","volume":"249","author":"Poillon","year":"1986","journal-title":"Arch. biochemistry Biophysics"},{"key":"10.1016\/j.micinf.2012.05.005_bib34","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ncpneph1008","article-title":"Sickle cell disease and the kidney","volume":"5","author":"Scheinman","year":"2009","journal-title":"Nat. Clin. Pract."},{"key":"10.1016\/j.micinf.2012.05.005_bib35","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1182\/blood-2007-10-117044","article-title":"A2B adenosine receptor dampens hypoxia-induced vascular leak","volume":"111","author":"Eckle","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2012.05.005_bib36","first-page":"3301","article-title":"A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice","volume":"118","author":"Eckle","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.micinf.2012.05.005_bib37","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ncpuro0277","article-title":"Therapy insight: priapism associated with hematologic dyscrasias","volume":"2","author":"Burnett","year":"2005","journal-title":"Nat. Clin. Pract. Urol."},{"key":"10.1016\/j.micinf.2012.05.005_bib38","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/j.1743-6109.2008.00770.x","article-title":"Sickle cell disease status and outcomes of African\u2013American men presenting with priapism","volume":"5","author":"Bennett","year":"2008","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib39","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1182\/blood-2005-04-1594","article-title":"Hemolysis-associated priapism in sickle cell disease","volume":"106","author":"Nolan","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2012.05.005_bib40","doi-asserted-by":"crossref","first-page":"36737","DOI":"10.1074\/jbc.M506493200","article-title":"The essential role of MEKK3 signaling in angiotensin II-induced calcineurin\/nuclear factor of activated T-cells activation","volume":"280","author":"Abbasi","year":"2005","journal-title":"J.Biol. Chem."},{"issue":"Suppl. 6","key":"10.1016\/j.micinf.2012.05.005_bib41","first-page":"52","article-title":"Adenosine and adenosine triphosphate","volume":"60","author":"Yonezawa","year":"2002","journal-title":"Nippon Rinsho"},{"key":"10.1016\/j.micinf.2012.05.005_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-2999(01)01167-0","article-title":"Role of adenosine and P2 receptors in the penile tumescence in anesthetized dogs","volume":"425","author":"Noto","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.micinf.2012.05.005_bib43","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1046\/j.1365-2605.2000.00232.x","article-title":"Functional adenosine receptors in human corpora cavernosa","volume":"23","author":"Filippi","year":"2000","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.micinf.2012.05.005_bib44","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0022-5347(01)61828-7","article-title":"Stimulation of P2y purinoceptors induces, via nitric oxide production, endothelium-dependent relaxation of human isolated corpus cavernosum","volume":"161","author":"Shalev","year":"1999","journal-title":"J. Urol."},{"key":"10.1016\/j.micinf.2012.05.005_bib45","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/0306-3623(95)00114-X","article-title":"Effects of adenosine analogues on apomorphine-induced penile erection in rats","volume":"26","author":"Sharifzadeh","year":"1995","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.micinf.2012.05.005_bib46","first-page":"191","article-title":"Adenosine: a new agent in the diagnosis of impotence","volume":"6","author":"Kilic","year":"1994","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.micinf.2012.05.005_bib47","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1182\/blood-2005-11-4500","article-title":"Pathology of \"Berkeley\" sickle-cell mice includes gallstones and priapism","volume":"107","author":"Hsu","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2012.05.005_bib48","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1172\/JCI33467","article-title":"Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling","volume":"118","author":"Mi","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"Suppl. 3","key":"10.1016\/j.micinf.2012.05.005_bib49","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1743-6109.2008.01187.x","article-title":"Adenosine signaling, priapism and novel therapies","volume":"6","author":"Dai","year":"2009","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib50","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1111\/j.1743-6109.2009.01555.x","article-title":"Role of adenosine signaling in penile erection and erectile disorders","volume":"7","author":"Phatarpekar","year":"2010","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib51","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ucl.2007.08.006","article-title":"Priapism: current principles and practice","volume":"34","author":"Burnett","year":"2007","journal-title":"Urol. Clin. North Am."},{"key":"10.1016\/j.micinf.2012.05.005_bib52","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1111\/j.1743-6109.2009.01552.x","article-title":"Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapism","volume":"7","author":"Wen","year":"2010","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib53","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1096\/fj.11-181057","article-title":"A2B adenosine receptor contributes to penile erection via PI3K\/AKT signaling cascade-mediated eNOS activation","volume":"25","author":"Wen","year":"2011","journal-title":"Faseb J."},{"key":"10.1016\/j.micinf.2012.05.005_bib54","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2010-06-290643","article-title":"Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease","author":"Wallace","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2012.05.005_bib55","doi-asserted-by":"crossref","first-page":"S228","DOI":"10.1016\/S0090-1229(95)90306-2","article-title":"PEG-ADA replacement therapy for adenosine deaminase deficiency: an update after 8.5 years","volume":"76","author":"Hershfield","year":"1995","journal-title":"Clin. Immunol. Immunopathol"},{"key":"10.1016\/j.micinf.2012.05.005_bib56","doi-asserted-by":"crossref","first-page":"32114","DOI":"10.1074\/jbc.M005153200","article-title":"The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities","volume":"275","author":"Blackburn","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2012.05.005_bib57","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0035-9203(54)90101-7","article-title":"The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria","volume":"48","author":"Allison","year":"1954","journal-title":"Trans. R. Soc.Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.05.005_bib58","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.amjmed.2008.12.020","article-title":"Complications associated with sickle cell trait: a brief narrative review","volume":"122","author":"Tsaras","year":"2009","journal-title":"Am. J. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib59","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1182\/asheducation-2010.1.418","article-title":"Sickle-cell trait: novel clinical significance, hematology\/the education program of the American society of hematology","author":"Key","year":"2010","journal-title":"Am. Soc. Hematol."},{"key":"10.1016\/j.micinf.2012.05.005_bib60","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/bmj.1.4857.290","article-title":"Protection afforded by sickle-cell trait against subtertian malarial infection","volume":"1","author":"Allison","year":"1954","journal-title":"Br. Med. J."},{"key":"10.1016\/j.micinf.2012.05.005_bib61","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1749-6632.1961.tb31102.x","article-title":"Genetic factors in resistance to malaria","volume":"91","author":"Allison","year":"1961","journal-title":"Ann. New York Acad. Sci."},{"key":"10.1016\/j.micinf.2012.05.005_bib62","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(02)08273-9","article-title":"Protective effects of the sickle cell gene against malaria morbidity and mortality","volume":"359","author":"Aidoo","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2012.05.005_bib63","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.coi.2009.04.001","article-title":"Genetic control of resistance to human malaria","volume":"21","author":"Allison","year":"2009","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.micinf.2012.05.005_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2010.07.008","article-title":"Mechanisms of genetically-based resistance to malaria","volume":"467","author":"Lopez","year":"2010","journal-title":"Gene"},{"key":"10.1016\/j.micinf.2012.05.005_bib65","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.micinf.2012.05.006","article-title":"Abnormal PfEMP1\/knob display on Plasmodium falciparum-infected erythrocytes containing hemoglobin variants: fresh insights into malaria pathogenesis and protection","volume":"14","author":"Fairhurst","year":"2012","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2012.05.005_bib66","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1086\/605843","article-title":"Adenosine triphosphate depletion of erythrocytes simulates the phenotype associated with pyruvate kinase deficiency and confers protection against Plasmodium falciparum in\u00a0vitro","volume":"200","author":"Ayi","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2012.05.005_bib67","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm1586","article-title":"Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria","volume":"13","author":"Pamplona","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.micinf.2012.05.005_bib68","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1073\/pnas.85.1.237","article-title":"Accelerated autoxidation and heme loss due to instability of sickle hemoglobin","volume":"85","author":"Hebbel","year":"1988","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"10.1016\/j.micinf.2012.05.005_bib69","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1182\/blood-2004-06-2066","article-title":"Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism","volume":"104","author":"Eltzschig","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2012.05.005_bib70","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1056\/NEJMcibr1105118","article-title":"Lessons from sickle cell disease in the treatment and control of malaria","volume":"364","author":"Rosenthal","year":"2011","journal-title":"N. Engl. J. Med."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457912001232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457912001232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:30:44Z","timestamp":1761143444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457912001232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1286457912001232"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2012.05.005","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adenosine signaling in normal and sickle erythrocytes and beyond","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2012.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Institut Pasteur. Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}