{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:25:58Z","timestamp":1784280358387,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":4109,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.micinf.2012.07.003","type":"journal-article","created":{"date-parts":[[2012,7,14]],"date-time":"2012-07-14T05:03:06Z","timestamp":1342242186000},"page":"1111-1117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Immune responsiveness during disease progression from acute rheumatic fever to chronic rheumatic heart disease"],"prefix":"10.1016","volume":"14","author":[{"given":"Devinder","family":"Toor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpreet","family":"Vohra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2012.07.003_bib1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(05)70267-X","article-title":"The global burden of group A streptococcal disease","volume":"5","author":"Carapetis","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.micinf.2012.07.003_bib2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1128\/CMR.13.3.470","article-title":"Pathogenesis of group A streptococcus infections","volume":"13","author":"Cunningham","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micinf.2012.07.003_bib3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/00006454-199704000-00012","article-title":"Immunologic and clinical correlation in rheumatic fever and rheumatic heart disease","volume":"16","author":"Veasy","year":"1997","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.micinf.2012.07.003_bib4","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1086\/656214","article-title":"Priming the immune system for heart disease: a perspective on group A streptococci","volume":"202","author":"Ellis","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2012.07.003_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/intimm\/dxn004","article-title":"Comprehensive analysis of antibody responses to streptococcal and tissue antigens in patients with acute rheumatic fever","volume":"20","author":"Martins","year":"2008","journal-title":"Int. Immunol."},{"key":"10.1016\/j.micinf.2012.07.003_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0090-1229(89)90174-8","article-title":"Identification of mononuclear cells and T cells in rheumatic valvulitis","volume":"52","author":"Kemeny","year":"1989","journal-title":"Clin. Immunol. Immunopathol"},{"key":"10.1016\/j.micinf.2012.07.003_bib7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF00915249","article-title":"Serial studies on the cellular immune response to streptococcal antigens in acute and convalescent rheumatic fever patients in Trinidad","volume":"6","author":"Read","year":"1986","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.micinf.2012.07.003_bib8","first-page":"139","article-title":"Clinical and epidemiological features of rheumatic fever and rheumatic heart disease in Taiwan and the Far East","volume":"35","author":"Lue","year":"1983","journal-title":"Indian Heart J."},{"key":"10.1016\/j.micinf.2012.07.003_bib9","first-page":"854","article-title":"T cells and T cell subsets in rheumatic heart disease","volume":"76","author":"Ganguly","year":"1982","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.micinf.2012.07.003_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/clc.4960120106","article-title":"Lymphocyte subsets in acute rheumatic fever and acute rheumatic heart disease","volume":"2","author":"Bhatia","year":"1989","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.micinf.2012.07.003_bib11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/jaut.2000.0487","article-title":"Heart-directed autoimmunity: the case of rheumatic fever","volume":"16","author":"Guilherme","year":"2001","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.micinf.2012.07.003_bib12","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/infdis\/167.4.979","article-title":"Increase in activated T cells and reduction in supressor\/cytotoxic T cells in acute rheumatic fever and acute rheumatic heart disease: a longitudinal study","volume":"167","author":"Morris","year":"1993","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2012.07.003_bib13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/clin.1995.1140","article-title":"Lymphocyte subsets and plasma IL-1\u03b1, IL-2 and TNF-\u03b1 concentrations in acute rheumatic fever and chronic rheumatic heart disease","volume":"77","author":"Narin","year":"1995","journal-title":"Clin. Immunol. Immunopathol"},{"key":"10.1016\/j.micinf.2012.07.003_bib14","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.4049\/jimmunol.175.8.5448","article-title":"T cell mimicry and epitope specificity of cross-reactive T cell clones from rheumatic heart disease","volume":"175","author":"Ellis","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.07.003_bib15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1086\/318076","article-title":"Pathogenic mechanisms in rheumatic carditis: focus on valvular endothelium","volume":"183","author":"Roberts","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2012.07.003_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1365-2249.1993.tb05920.x","article-title":"Enhancement of IL-1, IL-2 production and IL-2 receptor generation in patients with acute rheumatic fever and rheumatic heart disease; a prospective study","volume":"91","author":"Morris","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.micinf.2012.07.003_bib17","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.4049\/jimmunol.176.9.5662","article-title":"Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease","volume":"176","author":"Fa\u00e9","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.07.003_bib18","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/adc.67.11.1373","article-title":"IL-2 in relation to T-cell subpopulations in rheumatic heart disease","volume":"67","author":"Zedan","year":"1992","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.micinf.2012.07.003_bib19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0090-1229(90)90073-Y","article-title":"T lymphocyte subsets, suppressor and contrasuppressor cell functions, and production of IL-2 in the peripheral blood of rheumatic fever patients and their apparently healthy siblings","volume":"55","author":"Alarcon-Riquelme","year":"1990","journal-title":"Clin. Immunol. Immunopathol"},{"key":"10.1016\/j.micinf.2012.07.003_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1196\/annals.1361.054","article-title":"How S. pyogenes - primed peripheral T cells trigger heart valve lesions","volume":"1051","author":"Guilherme","year":"2005","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.micinf.2012.07.003_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S146239940501015X","article-title":"Molecular pathogenesis of rheumatic fever and rheumatic heart disease","volume":"7","author":"Guilherme","year":"2005","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.micinf.2012.07.003_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1251\/bpo31","article-title":"High-yield method for isolation and culture of endothelial cells from rat coronary blood vessels suitable for analysis of intracellular calcium and nitric oxide biosynthetic pathways","volume":"4","author":"Nistri","year":"2002","journal-title":"Biol. Proced. Online"},{"key":"10.1016\/j.micinf.2012.07.003_bib23","first-page":"65","article-title":"Rheumatic fever: a model for the pathological consequences of microbial-host mimicry","volume":"4","author":"Zabriskie","year":"1986","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.micinf.2012.07.003_bib24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1084\/jem.185.3.373","article-title":"Multiple pathways for the initiation of T Helper 2 (Th2) responses","volume":"185","author":"Coffman","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2012.07.003_bib25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1084\/jem.185.3.461","article-title":"IL-6 directs the differentiation of IL-4 producing CD4+ T cells","volume":"185","author":"Rincon","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2012.07.003_bib26","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1182\/blood-2009-07-230631","article-title":"IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production","volume":"115","author":"Maeda","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2012.07.003_bib27","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0167-5699(90)90173-7","article-title":"Biological and clinical aspects of interleukin 6","volume":"11","author":"Hirano","year":"1990","journal-title":"Immunol. Today"},{"key":"10.1016\/j.micinf.2012.07.003_bib28","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0952-7915(98)80087-3","article-title":"Regulation of autoimmunity by proinflammatory cytokines","volume":"10","author":"Cope","year":"1998","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.micinf.2012.07.003_bib29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.immunol.14.1.397","article-title":"Role of cytokines in rheumatoid arthiritis","volume":"14","author":"Feldmann","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.micinf.2012.07.003_bib30","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0167-5699(99)01573-X","article-title":"Tumor necrosis factor: a master regulator of leukocyte movement","volume":"21","author":"Sedgwick","year":"2000","journal-title":"Immunol. Today"},{"key":"10.1016\/j.micinf.2012.07.003_bib31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0167-5699(97)81662-3","article-title":"Cytokine regulation of endothelial cell function: from molecular level to the bedside","volume":"18","author":"Mantovani","year":"1997","journal-title":"Immunol. Today"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457912001803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457912001803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:31:30Z","timestamp":1761143490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457912001803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S1286457912001803"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2012.07.003","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune responsiveness during disease progression from acute rheumatic fever to chronic rheumatic heart disease","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2012.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Institut Pasteur. Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}