{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:39:04Z","timestamp":1761179944206,"version":"build-2065373602"},"reference-count":70,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":4078,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"The Wellcome-DBT India Alliance and the Department of Biotechnology, Government of India"},{"name":"International Center for Genetic Engineering and Biotechnology, New Delhi"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.micinf.2012.07.019","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T17:15:43Z","timestamp":1344532543000},"page":"1220-1226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early secretory antigenic target-6 of Mycobacterium tuberculosis: enigmatic factor in pathogen\u2013host interactions"],"prefix":"10.1016","volume":"14","author":[{"given":"Ramesh","family":"Chandra Rai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ved Prakash","family":"Dwivedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samit","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durbaka Vijaya","family":"Raghava Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gobardhan","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2010","series-title":"Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases","author":"Mandell","key":"10.1016\/j.micinf.2012.07.019_bib1"},{"year":"2011","series-title":"Global Tuberculosis Control","author":"WHO","key":"10.1016\/j.micinf.2012.07.019_bib2"},{"key":"10.1016\/j.micinf.2012.07.019_bib3","first-page":"104","article-title":"Drug-resistant tuberculosis: etiology, management and prevention","volume":"2","author":"O'Brien","year":"1994","journal-title":"Semin. Respir. Infect."},{"key":"10.1016\/j.micinf.2012.07.019_bib4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1056\/NEJM199803053381008","article-title":"The evolving relation between humans and Mycobacterium tuberculosis","volume":"338","author":"Bloom","year":"1998","journal-title":"N. Engl. J. Med."},{"year":"2007","series-title":"Robbins Basic Pathology","author":"Kumar","key":"10.1016\/j.micinf.2012.07.019_bib5"},{"key":"10.1016\/j.micinf.2012.07.019_bib6","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.mib.2005.12.014","article-title":"Interaction of pathogenic mycobacteria with the host immune system","volume":"9","author":"Houben","year":"2006","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.micinf.2012.07.019_bib7","doi-asserted-by":"crossref","first-page":"e1000204","DOI":"10.1371\/journal.ppat.1000204","article-title":"Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence","volume":"4","author":"Peyron","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micinf.2012.07.019_bib8","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.meegid.2011.08.010","article-title":"Old and new selective pressures on Mycobacterium tuberculosis","volume":"12","author":"Brites","year":"2012","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.micinf.2012.07.019_bib9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1164\/ajrccm.157.3.9708002","article-title":"The host immune response to tuberculosis","volume":"157","author":"Schluger","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.micinf.2012.07.019_bib10","doi-asserted-by":"crossref","first-page":"e1002378","DOI":"10.1371\/journal.ppat.1002378","article-title":"Early secreted antigen ESAT6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner","volume":"7","author":"Chatterjee","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micinf.2012.07.019_bib11","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.4049\/jimmunol.0803579","article-title":"ESAT6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells","volume":"182","author":"Wang","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4049\/jimmunol.171.1.175","article-title":"Inhibition of IFN-gamma-induced class II transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasion","volume":"171","author":"Pai","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib13","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1128\/iai.63.5.1710-1717.1995","article-title":"Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis","volume":"63","author":"Sorensen","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.07.019_bib14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nm859","article-title":"Recombinant BCG exporting ESAT6 confers enhanced protection against tuberculosis","volume":"9","author":"Pym","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.micinf.2012.07.019_bib15","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.shpsc.2005.09.003","article-title":"The 'experimental stable' of the BCG vaccine: safety, efficacy, proof, and standards, 1921\u20131933","volume":"36","author":"Bonah","year":"2005","journal-title":"Stud. Hist. Philos. Biol. Biomed. Sci."},{"key":"10.1016\/j.micinf.2012.07.019_bib16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(86)90367-3","article-title":"Protective efficacy of BCG against leprosy in Northern Malawi","volume":"2","author":"Fine","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2012.07.019_bib17","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrmicro1211","article-title":"The success and failure of BCG \u2013 implications for a novel tuberculosis vaccine","volume":"3","author":"Andersen","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micinf.2012.07.019_bib18","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/jac\/dkr173","article-title":"Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs","volume":"66","author":"Almeida Da Silva","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micinf.2012.07.019_bib19","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1126\/science.284.5419.1520","article-title":"Comparative genomics of BCG vaccines by whole-genome DNA microarray","volume":"284","author":"Behr","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.micinf.2012.07.019_bib20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.tim.2004.09.007","article-title":"ESAT6 proteins: protective antigens and virulence factors?","volume":"12","author":"Brodin","year":"2004","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micinf.2012.07.019_bib21","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.tube.2008.05.002","article-title":"Role of M. tuberculosis RD-1 region encoded secretory proteins in protective response and virulence","volume":"88","author":"Ganguly","year":"2008","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.micinf.2012.07.019_bib22","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1128\/jb.178.5.1274-1282.1996","article-title":"Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis","volume":"178","author":"Mahairas","year":"1996","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micinf.2012.07.019_bib23","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1471-4906(01)01865-8","article-title":"TB vaccines: progress and problems","volume":"22","author":"Andersen","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/31159","article-title":"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence","volume":"393","author":"Cole","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2012.07.019_bib25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/iai.64.1.16-22.1996","article-title":"Evidence for occurrence of the ESAT6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG","volume":"64","author":"Harboe","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.07.019_bib26","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1099\/00221287-144-11-3195","article-title":"A Mycobacterium tuberculosis operon encoding ESAT6 and a novel low-molecular-mass culture filtrate protein (CFP10)","volume":"144","author":"Berthet","year":"1998","journal-title":"Microbiology"},{"key":"10.1016\/j.micinf.2012.07.019_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1086\/345862","article-title":"Deletion of RD1 from Mycobacterium tuberculosis mimics bacille Calmette\u2013Guerin attenuation","volume":"187","author":"Lewis","year":"2003","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2012.07.019_bib28","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1126\/science.1179663","article-title":"Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium","volume":"327","author":"Volkman","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.micinf.2012.07.019_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1084\/jem.181.1.257","article-title":"Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited","volume":"181","author":"Clemens","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2012.07.019_bib30","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.cell.2007.05.059","article-title":"M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells","volume":"129","author":"van der Wel","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2012.07.019_bib31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1046\/j.1365-2958.2003.03844.x","article-title":"Individual RD1-region genes are required for export of ESAT6\/CFP10 and for virulence of Mycobacterium tuberculosis","volume":"51","author":"Guinn","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micinf.2012.07.019_bib32","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<3949::AID-IMMU3949>3.0.CO;2-4","article-title":"Differential T cell responses to Mycobacterium tuberculosis ESAT6 in tuberculosis patients and healthy donors","volume":"28","author":"Ulrichs","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib33","doi-asserted-by":"crossref","first-page":"21598","DOI":"10.1074\/jbc.M201625200","volume":"277","author":"Renshaw","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2012.07.019_bib34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/sj.icb.7100117","article-title":"Mycobacterium tuberculosis secretory proteins CFP10, ESAT6 and the CFP10:ESAT6 complex inhibit lipopolysaccharide-induced NF-kappaB transactivation by downregulation of reactive oxidative species (ROS) production","volume":"86","author":"Ganguly","year":"2008","journal-title":"Immunol. Cell. Biol."},{"key":"10.1016\/j.micinf.2012.07.019_bib35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2172-8-24","article-title":"Mycobacterium tuberculosis 6-kDa early secreted antigenic target (ESAT6) protein downregulates lipopolysaccharide induced c-myc expression by modulating the extracellular signal regulated kinases 1\/2","volume":"8","author":"Ganguly","year":"2007","journal-title":"BMC Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib36","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.4049\/jimmunol.157.8.3527","article-title":"Key epitopes on the ESAT6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis","volume":"157","author":"Brandt","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1128\/IAI.74.1.88-98.2006","article-title":"Dissection of ESAT6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence","volume":"74","author":"Brodin","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.07.019_bib38","doi-asserted-by":"crossref","first-page":"13001","DOI":"10.1073\/pnas.2235593100","article-title":"Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system","volume":"100","author":"Stanley","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.micinf.2012.07.019_bib39","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.4049\/jimmunol.174.6.3570","article-title":"Influence of ESAT6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system","volume":"174","author":"Majlessi","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/286079a0","article-title":"Ammonia inhibits phagosome\u2013lysosome fusion in macrophages","volume":"286","author":"Gordon","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2012.07.019_bib41","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1126\/science.285.5428.732","article-title":"Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors","volume":"285","author":"Brightbill","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.micinf.2012.07.019_bib42","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1084\/jem.20051782","article-title":"TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis","volume":"202","author":"Bafica","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2012.07.019_bib43","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/icb.2011.54","article-title":"ESAT6 differentially inhibits IFN-gamma-inducible class II transactivator isoforms in both a TLR2-dependent and -independent manner","volume":"90","author":"Kumar","year":"2012","journal-title":"Immunol. Cell. Biol."},{"key":"10.1016\/j.micinf.2012.07.019_bib44","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ni1468","article-title":"Direct extracellular interaction between the early secreted antigen ESAT6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages","volume":"8","author":"Pathak","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib45","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tube.2005.08.021","article-title":"Innate immunity to mycobacterial infection in mice: critical role for toll-like receptors","volume":"85","author":"Ryffel","year":"2005","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.micinf.2012.07.019_bib46","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1084\/jem.20080353","article-title":"Delayed protection by ESAT6-specific effector CD4+ T cells after airborne M. tuberculosis infection","volume":"205","author":"Gallegos","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2012.07.019_bib47","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.coi.2005.06.006","article-title":"Host innate and Th1 responses and the bacterial factors that control Mycobacterium tuberculosis infection","volume":"17","author":"Salgame","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib48","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.it.2004.06.005","article-title":"IL-4 in tuberculosis: implications for vaccine design","volume":"25","author":"Rook","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib49","first-page":"27","article-title":"Increased IL-4 production in response to virulent Mycobacterium tuberculosis in tuberculosis patients with advanced disease","volume":"18","author":"Ordway","year":"2005","journal-title":"Acta Med. Port."},{"key":"10.1016\/j.micinf.2012.07.019_bib50","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1084\/jem.178.6.2243","article-title":"Disseminated tuberculosis in interferon gamma gene-disrupted mice","volume":"178","author":"Cooper","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2012.07.019_bib51","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","article-title":"An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection","volume":"178","author":"Flynn","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2012.07.019_bib52","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1365-2567.2001.01305.x","article-title":"Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation","volume":"104","author":"Leal","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.micinf.2012.07.019_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxh186","article-title":"Toll-like receptors in innate immunity","volume":"17","author":"Takeda","year":"2005","journal-title":"Int. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib54","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.4049\/jimmunol.179.5.3187","article-title":"Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in\u00a0vivo","volume":"179","author":"Kincaid","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib55","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/08916930701776605","article-title":"The inflammatory Th 17 subset in immunity against self and non-self antigens","volume":"41","author":"Jin","year":"2008","journal-title":"Autoimmunity"},{"key":"10.1016\/j.micinf.2012.07.019_bib56","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1084\/jem.20100265","article-title":"Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis","volume":"207","author":"Cruz","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2012.07.019_bib57","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1016\/j.vaccine.2005.12.066","article-title":"Priming but not boosting with plasmid DNA encoding mycolyl\u2013transferase Ag85A from Mycobacterium tuberculosis increases the survival time of Mycobacterium bovis BCG vaccinated mice against low dose intravenous challenge with M. tuberculosis H37Rv","volume":"24","author":"Romano","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.micinf.2012.07.019_bib58","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge","volume":"8","author":"Khader","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib59","doi-asserted-by":"crossref","first-page":"8684","DOI":"10.4049\/jimmunol.177.12.8684","article-title":"Interleukin-23 restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responses","volume":"177","author":"Wozniak","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib60","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/ncb1613","article-title":"MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation","volume":"9","author":"Fontana","year":"2007","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.micinf.2012.07.019_bib61","first-page":"861","article-title":"The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-\u03b3","volume":"12","author":"Feng","year":"2011","journal-title":"\u039dat. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib62","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","article-title":"Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses","volume":"142","author":"Lu","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2012.07.019_bib63","doi-asserted-by":"crossref","first-page":"34590","DOI":"10.1074\/jbc.M109.056317","article-title":"MiR-146a is critical for endotoxin-induced tolerance: implication in innate immunity","volume":"284","author":"Nahid","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2012.07.019_bib64","doi-asserted-by":"crossref","DOI":"10.1111\/j.1462-5822.2012.01827.x","article-title":"Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis","author":"Kumar","year":"2012","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.micinf.2012.07.019_bib65","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1128\/iai.65.11.4843-4849.1997","article-title":"Lethal tuberculosis in interleukin-6-deficient mutant mice","volume":"65","author":"Ladel","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.07.019_bib66","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2012.07.019_bib67","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-beta induces development of the T(H)17 lineage","volume":"441","author":"Mangan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2012.07.019_bib68","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4049\/jimmunol.154.1.465","article-title":"Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions","volume":"154","author":"Toossi","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.07.019_bib69","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1084\/jem.20082286","article-title":"Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation","volume":"206","author":"Das","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2012.07.019_bib70","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/abbs\/gmr045","article-title":"A novel recombinant Mycobacterium bovis bacillus Calmette\u2013Guerin strain expressing human granulocyte macrophage colony-stimulating factor and Mycobacterium tuberculosis early secretory antigenic target 6 complex augments Th1 immunity","volume":"43","author":"Yang","year":"2011","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457912001967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457912001967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:31:12Z","timestamp":1761143472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457912001967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":70,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S1286457912001967"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2012.07.019","relation":{},"ISSN":["1286-4579"],"issn-type":[{"type":"print","value":"1286-4579"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early secretory antigenic target-6 of Mycobacterium tuberculosis: enigmatic factor in pathogen\u2013host interactions","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2012.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Institut Pasteur. Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}