{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:25:03Z","timestamp":1790267103920,"version":"4.1.0"},"reference-count":113,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":4048,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.micinf.2012.09.002","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T12:01:36Z","timestamp":1348228896000},"page":"1451-1464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Hookworm virulence factors: making the most of the host"],"prefix":"10.1016","volume":"14","author":[{"given":"Maria V.","family":"Periago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Bethony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2012.09.002_bib1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00001432-200410000-00006","article-title":"Hookworm infection: new developments and prospects for control","volume":"17","author":"Bungiro","year":"2004","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.micinf.2012.09.002_bib2","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1016\/j.vaccine.2006.05.008","article-title":"The antipoverty vaccines","volume":"24","author":"Hotez","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.micinf.2012.09.002_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-3024.1993.tb00601.x","article-title":"Soluble (s)CD23 levels in a parasitized population from Papua New Guinea","volume":"15","author":"Pritchard","year":"1993","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-3024.1995.tb00968.x","article-title":"Immunity in humans to Necator americanus: IgE, parasite weight and fecundity","volume":"17","author":"Pritchard","year":"1995","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib5","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-3024.1995.tb01005.x","article-title":"The specificity of the human IgE response to Necator americanus","volume":"17","author":"Pritchard","year":"1995","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib6","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1365-3024.1992.tb00034.x","article-title":"Isotypic variation in antibody responses in a community in Papua New Guinea to larval and adult antigens during infection, and following reinfection, with the hookworm Necator americanus","volume":"14","author":"Pritchard","year":"1992","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.0141-9838.2004.00727.x","article-title":"The immunoepidemiology of human hookworm infection","volume":"26","author":"Quinnell","year":"2004","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-3024.1995.tb00897.x","article-title":"Immunoepidemiology of human necatoriasis: correlations between antibody responses and parasite burdens","volume":"17","author":"Quinnell","year":"1995","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib9","first-page":"527","article-title":"Epidemiology of human hookworm and Ascaris lumbricoides infestations in rural Gambia","volume":"72","author":"Palmer","year":"1995","journal-title":"East. Afr. Med. J."},{"key":"10.1016\/j.micinf.2012.09.002_bib10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-3024.2007.00950.x","article-title":"Stage-specific immune responses in human Necator americanus infection","volume":"29","author":"Geiger","year":"2007","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-2249.2004.02449.x","article-title":"Cellular responses and cytokine production in post-treatment hookworm patients from an endemic area in Brazil","volume":"136","author":"Geiger","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0035-9203(78)90303-6","article-title":"Antibody responses in self-infections with Necator americanus","volume":"72","author":"Ogilvie","year":"1978","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.09.002_bib13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4269\/ajtmh.1987.37.126","article-title":"The clinical and immunologic responses of normal human volunteers to low dose hookworm (Necator americanus) infection","volume":"37","author":"Maxwell","year":"1987","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.09.002_bib14","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1365-2249.2005.02945.x","article-title":"Immune responses following experimental human hookworm infection","volume":"142","author":"Wright","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib15","doi-asserted-by":"crossref","first-page":"914","DOI":"10.4269\/ajtmh.2006.75.914","article-title":"Dose-ranging study for trials of therapeutic infection with Necator americanus in humans","volume":"75","author":"Mortimer","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.09.002_bib16","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.micinf.2008.09.003","article-title":"Early stage-specific immune responses in primary experimental human hookworm infection","volume":"10","author":"Geiger","year":"2008","journal-title":"Microbe. Infect."},{"key":"10.1016\/j.micinf.2012.09.002_bib17","doi-asserted-by":"crossref","first-page":"911","DOI":"10.4269\/ajtmh.2009.09-0237","article-title":"Immunologic profiles of persons recruited for a randomized, placebo-controlled clinical trial of hookworm infection","volume":"81","author":"Blount","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.09.002_bib18","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4269\/ajtmh.2008.78.936","article-title":"Development of a model of hookworm infection exhibiting salient characteristics of human infection","volume":"78","author":"Griffiths","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.09.002_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-3024.2006.00821.x","article-title":"Comparative immunology of human and animal models of hookworm infection","volume":"28","author":"Fujiwara","year":"2006","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib20","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0140-6736(06)68653-4","article-title":"Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm","volume":"367","author":"Bethony","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2012.09.002_bib21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1473-3099(08)70098-7","article-title":"Epidemiological and clinical characteristics of hookworm-related cutaneous larva migrans","volume":"8","author":"Heukelbach","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.micinf.2012.09.002_bib22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.pt.2010.01.005","article-title":"Hookworms of dogs and cats as agents of cutaneous larva migrans","volume":"26","author":"Bowman","year":"2010","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.7326\/0003-4819-120-5-199403010-00003","article-title":"Human enteric infection with canine hookworms","volume":"120","author":"Croese","year":"1994","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.micinf.2012.09.002_bib24","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/0140-6736(90)91186-E","article-title":"Human eosinophilic enteritis caused by dog hookworm Ancylostoma caninum","volume":"335","author":"Prociv","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2012.09.002_bib25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5694\/j.1326-5377.2003.tb05066.x","article-title":"Experimental human infection with the dog hookworm, Ancylostoma caninum","volume":"178","author":"Landmann","year":"2003","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.micinf.2012.09.002_bib26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev.immunol.15.1.505","article-title":"Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models","volume":"15","author":"Finkelman","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.0105-2896.2004.00191.x","article-title":"Helminth parasites \u2013 masters of regulation","volume":"201","author":"Maizels","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.micinf.2012.09.002_bib28","doi-asserted-by":"crossref","first-page":"4970","DOI":"10.1128\/IAI.00687-06","article-title":"Innate immune responses to lung-stage helminth infection induce alternatively activated alveolar macrophages","volume":"74","author":"Reece","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.09.002_bib29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0014-4894(78)90078-4","article-title":"Necator americanus and Ancylostoma duodenale: life history parameters and epidemiological implications of two sympatric hookworms of humans","volume":"44","author":"Hoagland","year":"1978","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib30","doi-asserted-by":"crossref","first-page":"434","DOI":"10.7326\/0003-4819-120-5-199403010-00013","article-title":"Hookworms: pets to humans","volume":"120","author":"Schad","year":"1994","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.micinf.2012.09.002_bib31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0169-4758(93)90159-D","article-title":"Hookworm larval infectivity, arrest and amphiparatenesis: the Caenorhabditis elegans Daf-c paradigm","volume":"9","author":"Hotez","year":"1993","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.micinf.2012.09.002_bib32","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0959-437X(96)80092-X","article-title":"Hookworm: developmental biology of the infectious process","volume":"6","author":"Hawdon","year":"1996","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.micinf.2012.09.002_bib33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4269\/ajtmh.1988.39.369","article-title":"Light, long-lasting Necator infection in a volunteer","volume":"39","author":"Beaver","year":"1988","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.09.002_bib34","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4269\/ajtmh.1953.2.102","article-title":"Persistence of hookworm larvae in soil","volume":"2","author":"Beaver","year":"1953","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.09.002_bib35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0065-308X(04)58004-1","article-title":"Human hookworm infection in the 21st century","volume":"58","author":"Brooker","year":"2004","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib36","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/CMR.14.4.689-703.2001","article-title":"Immune responses in hookworm infections","volume":"14","author":"Loukas","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micinf.2012.09.002_bib37","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.trstmh.2006.05.012","article-title":"Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern Brazil","volume":"101","author":"Brooker","year":"2007","journal-title":"Trans. Royal Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.09.002_bib38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.nutr.22.120501.134539","article-title":"Nutritional impact of intestinal helminthiasis during the human life cycle","volume":"22","author":"Crompton","year":"2002","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.micinf.2012.09.002_bib39","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-3156.2008.02022.x","article-title":"Age patterns in undernutrition and helminth infection in a rural area of Brazil: associations with ascariasis and hookworm","volume":"13","author":"Jardim-Botelho","year":"2008","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.micinf.2012.09.002_bib40","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/j.1365-3156.2008.02103.x","article-title":"Hookworm, Ascaris lumbricoides infection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren","volume":"13","author":"Jardim-Botelho","year":"2008","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.micinf.2012.09.002_bib41","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1128\/IAI.00419-08","article-title":"Binding of excreted and\/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil","volume":"76","author":"Teixeira-Carvalho","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.09.002_bib42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1128\/IAI.74.1.289-295.2006","article-title":"Dietary iron content mediates hookworm pathogenesis in\u00a0vivo","volume":"74","author":"Held","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.09.002_bib43","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/0091-6749(93)90119-Z","article-title":"Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum","volume":"92","author":"Lynch","year":"1993","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib44","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.vaccine.2009.12.016","article-title":"Type 2 immune-inducing helminth vaccination maintains protective efficacy in the setting of repeated parasite exposures","volume":"28","author":"Hubner","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.micinf.2012.09.002_bib45","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.4049\/jimmunol.173.4.2699","article-title":"A secreted protein from the human hookworm Necator americanus binds selectively to NK cells and induces IFN-gamma production","volume":"173","author":"Hsieh","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib46","doi-asserted-by":"crossref","first-page":"7380","DOI":"10.1128\/IAI.69.12.7380-7386.2001","article-title":"Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis, inhibits antigen processing and modulates antigen-specific immune response","volume":"69","author":"Dainichi","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.09.002_bib47","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/1521-4141(200007)30:7<1977::AID-IMMU1977>3.0.CO;2-3","article-title":"Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act\u00a0as adjuvants for Th2 responses","volume":"30","author":"Holland","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib48","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/eji.200636751","article-title":"Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection","volume":"37","author":"Finney","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib49","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/jcm.26.4.739-742.1988","article-title":"Role of specific immunoglobulin E to excretory\u2013secretory antigen in diagnosis and prognosis of hookworm infection","volume":"26","author":"Ganguly","year":"1988","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micinf.2012.09.002_bib50","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1017\/S0031182000067123","article-title":"Reinfection with hookworm after chemotherapy in Papua New Guinea","volume":"106","author":"Quinnell","year":"1993","journal-title":"Parasitology"},{"key":"10.1016\/j.micinf.2012.09.002_bib51","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.chom.2008.08.014","article-title":"Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection","volume":"4","author":"McCoy","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2012.09.002_bib52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0167-5699(99)01551-0","article-title":"Immunopathology of schistosomiasis: a cautionary tale of mice and men","volume":"21","author":"Fallon","year":"2000","journal-title":"Immunol. Today"},{"key":"10.1016\/j.micinf.2012.09.002_bib53","doi-asserted-by":"crossref","first-page":"844","DOI":"10.2307\/3276522","article-title":"Blood loss during hookworm infection determined by erythrocyte labeling with radioactive 51-chromium. I. Infection of dogs with normal and with X-irradiated Ancylostoma caninum","volume":"52","author":"Miller","year":"1966","journal-title":"J. Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib54","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0035-9203(68)90130-2","article-title":"Pathogenesis and immunity in hookworm infection","volume":"62","author":"Miller","year":"1968","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.09.002_bib55","first-page":"354","article-title":"Studies on the incidence of hookworm infection in East Africa","volume":"47","author":"Miller","year":"1970","journal-title":"East. Afr. Med. J."},{"key":"10.1016\/j.micinf.2012.09.002_bib56","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0065-308X(08)60161-X","article-title":"Vaccination against the canine hookworm diseases","volume":"9","author":"Miller","year":"1971","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib57","first-page":"706","article-title":"The diagnosis of hookworm disease","volume":"55","author":"Miller","year":"1974","journal-title":"Mod. Vet. Pract."},{"key":"10.1016\/j.micinf.2012.09.002_bib58","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0065-308X(08)60577-1","article-title":"Industrial development and field use of the canine hookworm vaccine","volume":"16","author":"Miller","year":"1978","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib59","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0065-308X(08)60552-7","article-title":"Hookworm infection in man","volume":"17","author":"Miller","year":"1979","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib60","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2307\/3276194","article-title":"Effect of X-irradiation upon the infective larvae of Ancylostoma caninum and the immunogenic effect in dogs of a single infection with 40 Kr-irradiated larvae","volume":"50","author":"Miller","year":"1964","journal-title":"J. Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib61","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3347\/kjp.2000.38.4.209","article-title":"Mucosal immunity against parasitic gastrointestinal nematodes","volume":"38","author":"Onah","year":"2000","journal-title":"Korean J. Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib62","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1055\/s-0038-1653811","article-title":"The anti-haemostatic strategies of the\u00a0human hookworm Necator americanus","volume":"73","author":"Pritchard","year":"1995","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.micinf.2012.09.002_bib63","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.iy.10.040192.002125","article-title":"Regulation of immunity to parasites by T cells and T cell-derived cytokines","volume":"10","author":"Sher","year":"1992","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib64","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.pt.2009.09.004","article-title":"The role of basophils in helminth infection","volume":"25","author":"Voehringer","year":"2009","journal-title":"Trends Parasitol."},{"issue":"Suppl. 2","key":"10.1016\/j.micinf.2012.09.002_bib65","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1590\/S0074-02761997000800004","article-title":"The pro-allergic influences of helminth parasites","volume":"92","author":"Pritchard","year":"1997","journal-title":"Mem. Instit. Oswaldo Cruz"},{"key":"10.1016\/j.micinf.2012.09.002_bib66","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-3024.1993.tb00571.x","article-title":"The detection of autoantibodies to IgE in plasma of individuals infected with hookworm (Necator americanus) and the demonstration of a predominant IgG1 anti-IgE autoantibody response","volume":"15","author":"Shakib","year":"1993","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib67","doi-asserted-by":"crossref","first-page":"860","DOI":"10.4269\/ajtmh.2007.77.860","article-title":"Basophil competence during hookworm (Necator americanus) infection","volume":"77","author":"Pritchard","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.09.002_bib68","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.jaci.2005.12.1341","article-title":"IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections","volume":"117","author":"Mitre","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib69","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1365-3024.2000.00265.x","article-title":"Protection in lambs vaccinated with Haemonchus contortus antigens is age related, and correlates with IgE rather than IgG1 antibody","volume":"22","author":"Kooyman","year":"2000","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib70","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1645\/0022-3395(2002)088[0684:EOVWRF]2.0.CO;2","article-title":"Effect of vaccinations with recombinant fusion proteins on Ancylostoma caninum habitat selection in the canine intestine","volume":"88","author":"Hotez","year":"2002","journal-title":"J. Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib71","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jaci.2012.04.027","article-title":"Generalized urticaria induced by the Na-ASP-2 hookworm vaccine \u2013 implications for the development of vaccines against helminths","volume":"130","author":"Diemert","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib72","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000237504","article-title":"Serum IgE level drives basophil and mast cell IgE receptor display","volume":"113","author":"MacGlashan","year":"1997","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib73","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1067\/mai.2000.108431","article-title":"The relationship between serum IgE and surface levels of FcepsilonR on human leukocytes in various diseases: correlation of expression with FcepsilonRI on basophils but not on monocytes or eosinophils","volume":"106","author":"Saini","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib74","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4269\/ajtmh.2003.69.87","article-title":"Lack of basophilia in human parasitic infections","volume":"69","author":"Mitre","year":"2003","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2012.09.002_bib75","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S1471-4922(00)01846-8","article-title":"Do basophils play a role in immunity against parasites?","volume":"17","author":"Falcone","year":"2001","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib76","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4049\/jimmunol.0901841","article-title":"Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells","volume":"184","author":"Ohnmacht","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib77","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2332\/allergolint.55.99","article-title":"Basophils: a potential liaison between innate and adaptive immunity","volume":"55","author":"Min","year":"2006","journal-title":"Allergol. Int."},{"key":"10.1016\/j.micinf.2012.09.002_bib78","first-page":"141","article-title":"Basophils, basophilia and helminth infections","volume":"90","author":"Mitre","year":"2006","journal-title":"Chem. Immunol. Allergy"},{"key":"10.1016\/j.micinf.2012.09.002_bib79","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nri2199","article-title":"Protective immune mechanisms in helminth infection","volume":"7","author":"Anthony","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib80","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.4049\/jimmunol.172.4.2439","article-title":"Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections","volume":"172","author":"Mitre","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib81","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jaci.2009.07.039","article-title":"Antigen-driven basophil activation is indicative of early Necator americanus infection in IgE-seronegative patients","volume":"124","author":"Falcone","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib82","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1365-3024.2012.01371.x","article-title":"Fusion of Na-ASP-2 with human immunoglobulin Fcgamma abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE","volume":"34","author":"Zhan","year":"2012","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib83","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1046\/j.1365-3024.2001.00394.x","article-title":"Divergent roles for macrophages in lymphatic filariasis","volume":"23","author":"Allen","year":"2001","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib84","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-3024.2006.00909.x","article-title":"Immune modulation by helminthic infections: worms and viral infections","volume":"28","author":"Kamal","year":"2006","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib85","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1002\/eji.200838956","article-title":"Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation","volume":"39","author":"Ince","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib86","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nri1183","article-title":"Immune regulation by helminth parasites: cellular and molecular mechanisms","volume":"3","author":"Maizels","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib87","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ni0901-816","article-title":"Regulatory T cells in the control of immune pathology","volume":"2","author":"Maloy","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib88","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1128\/IAI.00673-08","article-title":"Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis","volume":"76","author":"Bazzone","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.09.002_bib89","first-page":"381","article-title":"IgG4 responses to antigens of adult Necator americanus: potential for use in large-scale epidemiological studies","volume":"74","author":"Palmer","year":"1996","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.micinf.2012.09.002_bib90","doi-asserted-by":"crossref","first-page":"e399","DOI":"10.1371\/journal.pntd.0000399","article-title":"Necator americanus infection: a possible cause of altered dendritic cell differentiation and eosinophil profile in\u00a0chronically infected individuals","volume":"3","author":"Fujiwara","year":"2009","journal-title":"PLoS Neglect. Trop. Dis."},{"key":"10.1016\/j.micinf.2012.09.002_bib91","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1365-3024.1998.00151.x","article-title":"Profound suppression of cellular proliferation mediated by the secretions of nematodes","volume":"20","author":"Allen","year":"1998","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib92","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-3024.2000.00271.x","article-title":"The human hookworm pathogen Necator americanus induces apoptosis in T lymphocytes","volume":"22","author":"Chow","year":"2000","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib93","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1128\/IAI.00094-08","article-title":"Role for nitric oxide in hookworm-associated immune suppression","volume":"76","author":"Dondji","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.09.002_bib94","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijpara.2008.08.003","article-title":"Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites","volume":"39","author":"Patel","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib95","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1017\/S0022149X07867733","article-title":"The mucosal cellular response to infection with Ancylostoma ceylanicum","volume":"82","author":"Alkazmi","year":"2008","journal-title":"J. Helminthol."},{"key":"10.1016\/j.micinf.2012.09.002_bib96","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1017\/JOH2006372","article-title":"The effect of the hookworm Ancylostoma ceylanicum on the mucosal architecture of the small intestine in hamsters","volume":"80","author":"Alkazmi","year":"2006","journal-title":"J. Helminthol."},{"key":"10.1016\/j.micinf.2012.09.002_bib97","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1079\/JOH2003173","article-title":"The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype","volume":"77","author":"Ben-Smith","year":"2003","journal-title":"J. Helminthol."},{"key":"10.1016\/j.micinf.2012.09.002_bib98","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.4049\/jimmunol.0804299","article-title":"IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection","volume":"183","author":"Morimoto","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib99","doi-asserted-by":"crossref","first-page":"12423","DOI":"10.1073\/pnas.0806372105","article-title":"In\u00a0vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation","volume":"105","author":"van Panhuys","year":"2008","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"10.1016\/j.micinf.2012.09.002_bib100","doi-asserted-by":"crossref","first-page":"754","DOI":"10.4049\/jimmunol.180.2.754","article-title":"Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6","volume":"180","author":"King","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib101","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0167-5699(97)01102-X","article-title":"Th1-Th2: reliable paradigm or dangerous dogma?","volume":"18","author":"Allen","year":"1997","journal-title":"Immunol. Today"},{"key":"10.1016\/j.micinf.2012.09.002_bib102","doi-asserted-by":"crossref","first-page":"R711","DOI":"10.1016\/S0960-9822(98)70455-5","article-title":"Parasite immunology: pathways for expelling intestinal helminths","volume":"8","author":"Maizels","year":"1998","journal-title":"Curr. Biol. CB"},{"key":"10.1016\/j.micinf.2012.09.002_bib103","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1128\/IAI.73.1.385-394.2005","article-title":"Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells","volume":"73","author":"Nair","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.09.002_bib104","doi-asserted-by":"crossref","first-page":"e1000371","DOI":"10.1371\/journal.ppat.1000371","article-title":"Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis","volume":"5","author":"Pesce","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micinf.2012.09.002_bib105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1017\/S0022149X10000283","article-title":"The mucosal response of hamsters to a low-intensity superimposed secondary infection with the hookworm Ancylostoma ceylanicum","volume":"85","author":"Alkazmi","year":"2011","journal-title":"J. Helminthol."},{"key":"10.1016\/j.micinf.2012.09.002_bib106","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/gut.2005.079129","article-title":"A proof of concept study establishing Necator americanus in Crohn's patients and reservoir donors","volume":"55","author":"Croese","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.micinf.2012.09.002_bib107","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.pt.2006.09.010","article-title":"Intestinal allergy expels hookworms: seeing is believing","volume":"22","author":"Croese","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.micinf.2012.09.002_bib108","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1084\/jem.20091268","article-title":"Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection","volume":"206","author":"Herbert","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2012.09.002_bib109","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.4049\/jimmunol.0902879","article-title":"B cells have distinct roles in host protection against different nematode parasites","volume":"184","author":"Liu","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib110","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.4049\/jimmunol.169.12.6959","article-title":"Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in\u00a0vivo","volume":"169","author":"Liu","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2012.09.002_bib111","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00192.x","article-title":"Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites","volume":"201","author":"Finkelman","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.micinf.2012.09.002_bib112","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1128\/IAI.00192-08","article-title":"Hookworm-induced persistent changes to the immunological environment of the lung","volume":"76","author":"Reece","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2012.09.002_bib113","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.4049\/jimmunol.0803463","article-title":"Alternatively activated macrophages elicited by helminth infection can be reprogrammed to enable microbial killing","volume":"182","author":"Mylonas","year":"2009","journal-title":"J. Immunol."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457912002195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457912002195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:33:00Z","timestamp":1761143580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457912002195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":113,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1286457912002195"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2012.09.002","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hookworm virulence factors: making the most of the host","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2012.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Institut Pasteur. Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}