{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:39:36Z","timestamp":1791095976254,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":3562,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.micinf.2013.12.006","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T18:10:55Z","timestamp":1390414255000},"page":"328-336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Targeted extracellular signal-regulated kinase activation mediated by\u00a0Leishmania amazonensis requires MP1 scaffold"],"prefix":"10.1016","volume":"16","author":[{"given":"Paola M.","family":"Boggiatto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Pullikuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Bellaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Catling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2013.12.006_bib1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrm2748","article-title":"Endocytosis and signalling: intertwining molecular networks","volume":"10","author":"Sorkin","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.micinf.2013.12.006_bib2","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1002\/j.1460-2075.1994.tb06747.x","article-title":"Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma","volume":"13","author":"Di Guglielmo","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.micinf.2013.12.006_bib3","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1074\/jbc.273.2.685","article-title":"Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase","volume":"273","author":"Daaka","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.micinf.2013.12.006_bib4","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nrm883","article-title":"Signal transduction and endocytosis: close encounters of many kinds","volume":"3","author":"Sorkin","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.micinf.2013.12.006_bib5","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1091\/mbc.e07-02-0098","article-title":"Late endosomal traffic of the epidermal growth factor receptor ensures spatial and temporal fidelity of mitogen-activated protein kinase signaling","volume":"18","author":"Taub","year":"2007","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.micinf.2013.12.006_bib6","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.febslet.2005.02.002","article-title":"When kinases meet mathematics: the systems biology of MAPK signalling","volume":"579","author":"Kolch","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.micinf.2013.12.006_bib7","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1175668","article-title":"Cell signaling in space and time: where proteins come together and when they're apart","volume":"326","author":"Scott","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.micinf.2013.12.006_bib8","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1038\/sj.onc.1210411","article-title":"Scaffold proteins of MAP-kinase modules","volume":"26","author":"Dhanasekaran","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.micinf.2013.12.006_bib9","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.281.5383.1668","article-title":"MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade","volume":"281","author":"Schaeffer","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.micinf.2013.12.006_bib10","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.1073\/pnas.0305894101","article-title":"Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists","volume":"101","author":"Vomastek","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2013.12.006_bib11","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.2353\/ajpath.2009.080905","article-title":"Altered dendritic cell phenotype in response to Leishmania amazonensis amastigote infection is mediated by MAP kinase, ERK","volume":"174","author":"Boggiatto","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.micinf.2013.12.006_bib12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0960-9822(99)80164-X","article-title":"Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta","volume":"9","author":"Giroux","year":"1999","journal-title":"Curr Biol"},{"key":"10.1016\/j.micinf.2013.12.006_bib13","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1128\/MCB.25.12.5119-5133.2005","article-title":"The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals","volume":"25","author":"Pullikuth","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.micinf.2013.12.006_bib14","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1128\/IAI.70.4.2151-2158.2002","article-title":"Early enhanced Th1 response after Leishmania amazonensis infection of C57BL\/6 interleukin-10-deficient mice does not lead to resolution of infection","volume":"70","author":"Jones","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2013.12.006_bib15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.chom.2011.04.014","article-title":"Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200","volume":"9","author":"Cortez","year":"2011","journal-title":"Cell Host Microb"},{"key":"10.1016\/j.micinf.2013.12.006_bib16","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1128\/IAI.70.8.4571-4580.2002","article-title":"Opsonization modulates Rac-1 activation during cell entry by Leishmania amazonensis","volume":"70","author":"Morehead","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2013.12.006_bib17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1462-5822.2000.00071.x","article-title":"Surface-targeted lysosomal membrane glycoprotein-1 (Lamp-1) enhances lysosome exocytosis and cell invasion by Trypanosoma cruzi","volume":"2","author":"Kima","year":"2000","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.micinf.2013.12.006_bib18","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1128\/IAI.74.2.1305-1312.2006","article-title":"Biogenesis of Leishmania major-harboring vacuoles in murine dendritic cells","volume":"74","author":"Korner","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2013.12.006_bib19","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S1534-5807(02)00364-7","article-title":"Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction","volume":"3","author":"Teis","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.micinf.2013.12.006_bib20","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1038\/sj.onc.1210422","article-title":"Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer","volume":"26","author":"Roberts","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.micinf.2013.12.006_bib21","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1128\/IAI.74.3.1547-1554.2006","article-title":"Antigen-responsive CD4+ T cells from C3H mice chronically infected with Leishmania amazonensis are impaired in the transition to an effector phenotype","volume":"74","author":"Ramer","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2013.12.006_bib22","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.4049\/jimmunol.164.11.5858","article-title":"IL-12p70 production by Leishmania major-harboring human dendritic cells is a CD40\/CD40 ligand-dependent process","volume":"164","author":"Marovich","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2013.12.006_bib23","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S1369-5274(99)80077-0","article-title":"Inhibition of host cell signal transduction by Leishmania: observations relevant to the selective impairment of IL-12 responses","volume":"2","author":"McDowell","year":"1999","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.micinf.2013.12.006_bib24","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.ijpara.2007.04.007","article-title":"The amastigote forms of Leishmania are experts at exploiting host cell processes to establish infection and persist","volume":"37","author":"Kima","year":"2007","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.micinf.2013.12.006_bib25","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.4049\/jimmunol.178.2.1077","article-title":"Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages","volume":"178","author":"Yang","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2013.12.006_bib26","first-page":"2698","article-title":"The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection","volume":"125","author":"Taub","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1016\/j.micinf.2013.12.006_bib27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/CMR.18.2.293-305.2005","article-title":"Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view","volume":"18","author":"Olivier","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.micinf.2013.12.006_bib28","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Sancak","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2013.12.006_bib29","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4161\/auto.19653","article-title":"MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB","volume":"8","author":"Martina","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.micinf.2013.12.006_bib30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.micinf.2008.11.006","article-title":"Induction of autophagy correlates with increased parasite load of Leishmania amazonensis in BALB\/c but not C57BL\/6 macrophages","volume":"11","author":"Pinheiro","year":"2009","journal-title":"Microbes Infect"},{"key":"10.1016\/j.micinf.2013.12.006_bib31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.4269\/ajtmh.2007.76.669","article-title":"Macrophage killing of Leishmania amazonensis amastigotes requires both nitric oxide and superoxide","volume":"76","author":"Mukbel","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.micinf.2013.12.006_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture methods for generating large quantities of highly pure dendritic cells from mouse bone marrow.","volume":"223","author":"Lutz","year":"1999","journal-title":"J Immunol Methods"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457914000021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457914000021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:34:28Z","timestamp":1761143668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457914000021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1286457914000021"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2013.12.006","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted extracellular signal-regulated kinase activation mediated by\u00a0Leishmania amazonensis requires MP1 scaffold","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2013.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Institut Pasteur. Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}