{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:41:05Z","timestamp":1776980465744,"version":"3.51.4"},"reference-count":70,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":3318,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CAPES\/PNPD"},{"name":"INCT-Vacinas"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.micinf.2014.08.010","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T16:46:44Z","timestamp":1409158004000},"page":"979-984","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Brucella abortus DNA is a major bacterial agonist to activate the host innate immune system"],"prefix":"10.1016","volume":"16","author":[{"given":"Priscila Carneiro","family":"Campos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco T\u00falio Ribeiro","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam Maria Silva","family":"Costa Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Martins","family":"Marim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Costa","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2014.08.010_bib1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.smim.2009.05.006","article-title":"The innate immune response to DNA","volume":"21","author":"Vilaysane","year":"2009","journal-title":"Semin Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)80412-2","article-title":"Innate immunity: the virtues of a nonclonal system of recognition","volume":"91","author":"Medzhitov","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2014.08.010_bib3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.clim.2013.01.003","article-title":"Nucleic acid driven sterile inflammation","volume":"147","author":"Ablasser","year":"2013","journal-title":"Clin Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S1074-7613(01)00144-3","article-title":"Toll meets bacterial CpG-DNA","volume":"14","author":"Wagner","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2014.08.010_bib5","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.cell.2009.06.015","article-title":"RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway","volume":"138","author":"Chiu","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2014.08.010_bib6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ni1282","article-title":"A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA","volume":"7","author":"Ishii","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib7","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2014.08.010_bib8","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature12305","article-title":"Structural mechanism of cytosolic DNA sensing by cGAS","volume":"498","author":"Civril","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2014.08.010_bib9","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature07725","article-title":"AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC","volume":"458","author":"Hornung","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2014.08.010_bib10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.chom.2012.03.007","article-title":"Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages","volume":"11","author":"Manzanillo","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2014.08.010_bib11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ni.1864","article-title":"The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses","volume":"11","author":"Rathinam","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.immuni.2005.12.003","article-title":"Recognition of cytosolic DNA activates an IRF3-dependent innate immune response","volume":"24","author":"Stetson","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2014.08.010_bib13","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.4049\/jimmunol.173.12.7416","article-title":"IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism","volume":"173","author":"Stockinger","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib14","doi-asserted-by":"crossref","first-page":"9771","DOI":"10.1073\/pnas.1003738107","article-title":"Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis","volume":"107","author":"Jones","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2014.08.010_bib15","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.4049\/jimmunol.175.6.3964","article-title":"Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9","volume":"175","author":"Huang","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib16","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.4049\/jimmunol.1202817","article-title":"Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection","volume":"190","author":"Gomes","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.vetimm.2011.05.036","article-title":"Update on the role of innate immune receptors during Brucella abortus infection","volume":"148","author":"Oliveira","year":"2012","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.micinf.2014.08.010_bib18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0378-1135(02)00223-7","article-title":"The innate immune response against Brucella in humans","volume":"90","author":"Dornand","year":"2002","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.micinf.2014.08.010_bib19","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/eji.1830250922","article-title":"CD8+ type 1 CD44hi CD45 RBlo T lymphocytes control intracellular Brucella abortus infection as demonstrated in major histocompatibility complex class I- and class II-deficient mice","volume":"25","author":"Oliveira","year":"1995","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib20","doi-asserted-by":"crossref","first-page":"e23135","DOI":"10.1371\/journal.pone.0023135","article-title":"MyD88 and STING signaling pathways are required for IRF3-mediated IFN-beta induction in response to Brucella abortus infection","volume":"6","author":"de Almeida","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2014.08.010_bib21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib22","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1126\/science.1220363","article-title":"TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification","volume":"337","author":"Oldenburg","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.micinf.2014.08.010_bib23","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1051\/medsci\/2012281023","article-title":"Toll-like receptor 8: the awkward TLR","volume":"28","author":"Alexopoulou","year":"2012","journal-title":"Med Sci (Paris)"},{"key":"10.1016\/j.micinf.2014.08.010_bib24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1600-065X.2008.00729.x","article-title":"Regulatory molecules required for nucleotide-sensing toll-like receptors","volume":"227","author":"Saitoh","year":"2009","journal-title":"Immunol Rev"},{"key":"10.1016\/j.micinf.2014.08.010_bib25","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1600-0854.2009.00899.x","article-title":"How location governs toll-like receptor signaling","volume":"10","author":"Chaturvedi","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.micinf.2014.08.010_bib26","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.4049\/jimmunol.0900399","article-title":"Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes","volume":"183","author":"Yasuda","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.coi.2010.12.015","article-title":"Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses","volume":"23","author":"Barber","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib28","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S1074-7613(00)80402-1","article-title":"MyD88: an adapter that recruits IRAK to the IL-1 receptor complex","volume":"7","author":"Wesche","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2014.08.010_bib29","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.it.2012.05.002","article-title":"Dissecting negative regulation of toll-like receptor signaling","volume":"33","author":"Kondo","year":"2012","journal-title":"Trends Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib30","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1128\/IAI.73.8.5137-5143.2005","article-title":"MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus","volume":"73","author":"Weiss","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2014.08.010_bib31","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4049\/jimmunol.180.2.1080","article-title":"Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection","volume":"180","author":"Macedo","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib32","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1128\/IAI.05289-11","article-title":"Interleukin-1 receptor-associated kinase 4 is essential for initial host control of Brucella abortus infection","volume":"79","author":"Oliveira","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2014.08.010_bib33","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1128\/IAI.01356-12","article-title":"Toll-like receptor 6 plays an important role in host innate resistance to Brucella abortus infection in mice","volume":"81","author":"de Almeida","year":"2013","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2014.08.010_bib34","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.micpath.2009.09.005","article-title":"Brucella abortus induces Irgm3 and Irga6 expression via type-I IFN by a MyD88-dependent pathway, without the requirement of TLR2, TLR4, TLR5 and TLR9","volume":"47","author":"Lapaque","year":"2009","journal-title":"Microb Pathog"},{"key":"10.1016\/j.micinf.2014.08.010_bib35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature06664","article-title":"The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response","volume":"452","author":"Muruve","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2014.08.010_bib36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nri2690","article-title":"Intracellular DNA recognition","volume":"10","author":"Hornung","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1600-065X.2011.01051.x","article-title":"Cytoplasmic DNA innate immune pathways","volume":"243","author":"Barber","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.micinf.2014.08.010_bib38","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ni.1702","article-title":"An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome","volume":"10","author":"Burckstummer","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib39","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4049\/jimmunol.1100523","article-title":"Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III","volume":"188","author":"Wenzel","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib40","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ni.1859","article-title":"The AIM2 inflammasome is critical for innate immunity to Francisella tularensis","volume":"11","author":"Fernandes-Alnemri","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1462-5822.2011.01700.x","article-title":"Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells","volume":"14","author":"Belhocine","year":"2012","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.micinf.2014.08.010_bib42","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s10875-010-9419-0","article-title":"Sensing cytoplasmic danger signals by the inflammasome","volume":"30","author":"Alnemri","year":"2010","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib43","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10875-010-9425-2","article-title":"Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes","volume":"30","author":"Wu","year":"2010","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib44","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/eji.201040425","article-title":"Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome","volume":"40","author":"Kim","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib45","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/intimm\/dxs062","article-title":"Critical role of AIM2 in Mycobacterium tuberculosis infection","volume":"24","author":"Saiga","year":"2012","journal-title":"Int Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib46","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1093\/infdis\/jit347","article-title":"The AIM2 inflammasome is involved in macrophage activation during infection with virulent Mycobacterium bovis strain","volume":"208","author":"Yang","year":"2013","journal-title":"J Infect Dis"},{"key":"10.1016\/j.micinf.2014.08.010_bib47","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.4049\/jimmunol.1203326","article-title":"ASC controls IFN-gamma levels in an IL-18-dependent manner in caspase-1-deficient mice infected with Francisella novicida","volume":"191","author":"Pierini","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib48","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2014.08.010_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2013.03.024","article-title":"How do cells sense foreign DNA? a new outlook on the function of STING","volume":"50","author":"Wallach","year":"2013","journal-title":"Mol Cell"},{"key":"10.1016\/j.micinf.2014.08.010_bib50","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.it.2013.10.010","article-title":"STING-dependent cytosolic DNA sensing pathways","volume":"35","author":"Barber","year":"2014","journal-title":"Trends Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib51","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.molcel.2012.05.029","article-title":"Cyclic di-GMP sensing via the innate immune signaling protein STING","volume":"46","author":"Yin","year":"2012","journal-title":"Mol Cell"},{"key":"10.1016\/j.micinf.2014.08.010_bib52","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nature10429","article-title":"STING is a direct innate immune sensor of cyclic di-GMP","volume":"478","author":"Burdette","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2014.08.010_bib53","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.micinf.2014.08.010_bib54","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.molcel.2013.01.039","article-title":"STING recognition of cytoplasmic DNA instigates cellular defense","volume":"50","author":"Abe","year":"2013","journal-title":"Mol Cell"},{"key":"10.1016\/j.micinf.2014.08.010_bib55","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2014.08.010_bib56","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.molcel.2014.03.040","article-title":"The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling","volume":"54","author":"Cai","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.micinf.2014.08.010_bib57","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1128\/IAI.00999-10","article-title":"The N-ethyl-N-nitrosourea-induced goldenticket mouse mutant reveals an essential function of sting in the in\u00a0vivo interferon response to Listeria monocytogenes and cyclic dinucleotides","volume":"79","author":"Sauer","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2014.08.010_bib58","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00018-13","article-title":"STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection","volume":"4","author":"Barker","year":"2013","journal-title":"MBio"},{"key":"10.1016\/j.micinf.2014.08.010_bib59","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/embor.2009.258","article-title":"Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway","volume":"11","author":"Castanier","year":"2010","journal-title":"EMBO Rep"},{"key":"10.1016\/j.micinf.2014.08.010_bib60","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s13238-012-2063-0","article-title":"The essential adaptors of innate immune signaling","volume":"4","author":"Chen","year":"2013","journal-title":"Protein Cell"},{"key":"10.1016\/j.micinf.2014.08.010_bib61","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/ni.1779","article-title":"RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate","volume":"10","author":"Ablasser","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib62","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ni1243","article-title":"IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction","volume":"6","author":"Kawai","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib63","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/nature04193","article-title":"Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus","volume":"437","author":"Meylan","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2014.08.010_bib64","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cell.2005.08.012","article-title":"Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3","volume":"122","author":"Seth","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2014.08.010_bib65","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.molcel.2005.08.014","article-title":"VISA is an adapter protein required for virus-triggered IFN-beta signaling","volume":"19","author":"Xu","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.micinf.2014.08.010_bib66","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1084\/jem.20060792","article-title":"Essential role of IPS-1 in innate immune responses against RNA viruses","volume":"203","author":"Kumar","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.micinf.2014.08.010_bib67","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1128\/JVI.02623-08","article-title":"MAVS self-association mediates antiviral innate immune signaling","volume":"83","author":"Tang","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.micinf.2014.08.010_bib68","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1016\/j.febslet.2006.03.057","article-title":"Cytoplasmic Listeria monocytogenes stimulates IFN-beta synthesis without requiring the adapter protein MAVS","volume":"580","author":"Soulat","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.micinf.2014.08.010_bib69","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.4049\/jimmunol.0902947","article-title":"Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells","volume":"184","author":"Buss","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.010_bib70","doi-asserted-by":"crossref","first-page":"e62872","DOI":"10.1371\/journal.pone.0062872","article-title":"RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells","volume":"8","author":"Hagmann","year":"2013","journal-title":"PLoS One"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457914001178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457914001178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:34:58Z","timestamp":1761143698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457914001178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S1286457914001178"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2014.08.010","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brucella abortus DNA is a major bacterial agonist to activate the host innate immune system","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2014.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Institut Pasteur. Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}