{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:52:06Z","timestamp":1791298326595,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":3379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31370892"],"award-info":[{"award-number":["31370892"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31300712"],"award-info":[{"award-number":["31300712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31170868"],"award-info":[{"award-number":["31170868"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Basic Research Programs","award":["2015CB554302"],"award-info":[{"award-number":["2015CB554302"]}]},{"name":"National Major Projects for Science and Technology","award":["2012ZX10002007-003"],"award-info":[{"award-number":["2012ZX10002007-003"]}]},{"name":"National Major Projects for Science and Technology","award":["2014ZX0801011B-001"],"award-info":[{"award-number":["2014ZX0801011B-001"]}]},{"name":"Shanghai Key Laboratory of Molecular Medical Mycology","award":["10dz2220100"],"award-info":[{"award-number":["10dz2220100"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.micinf.2014.08.013","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T05:25:13Z","timestamp":1409635513000},"page":"845-854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome"],"prefix":"10.1016","volume":"16","author":[{"given":"Caiqin","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingkuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzong","family":"Fa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2014.08.013_bib1","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI42949","article-title":"Cryptococci at the brain gate: break and enter or use a Trojan horse?","volume":"120","author":"Casadevall","year":"2010","journal-title":"J Clin Investigation"},{"key":"10.1016\/j.micinf.2014.08.013_bib2","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.4049\/jimmunol.129.4.1675","article-title":"The capsule of cryptococcus neoformans passively inhibits phagocytosis of the yeast by macrophages","volume":"129","author":"Kozel","year":"1982","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.013_bib3","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1128\/iai.63.7.2604-2611.1995","article-title":"Ingestion of acapsular cryptococcus neoformans occurs via mannose and beta-glucan receptors, resulting in cytokine production and increased phagocytosis of the encapsulated form","volume":"63","author":"Cross","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2014.08.013_bib4","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2014.08.013_bib5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1128\/iai.16.1.99-106.1977","article-title":"Non-encapsulated variant of cryptococcus neoformans. II. Surface receptors for cryptococcal polysaccharide and their role in inhibition of phagocytosis by polysaccharide","volume":"16","author":"Kozel","year":"1977","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2014.08.013_bib6","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.4049\/jimmunol.166.7.4620","article-title":"Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to cryptococcus neoformans polysaccharide capsule","volume":"166","author":"Shoham","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.013_bib7","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.4049\/jimmunol.176.5.3053","article-title":"Cryptococcus neoformans glycoantigens are captured by multiple lectin receptors and presented by dendritic cells","volume":"176","author":"Mansour","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.013_bib8","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ni.2231","article-title":"Sensing and reacting to microbes through the inflammasomes","volume":"13","author":"Franchi","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2014.08.013_bib9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature07965","article-title":"Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence","volume":"459","author":"Gross","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2014.08.013_bib10","doi-asserted-by":"crossref","first-page":"e10008","DOI":"10.1371\/journal.pone.0010008","article-title":"Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase","volume":"5","author":"Said-Sadier","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2014.08.013_bib11","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/cr.2013.49","article-title":"Biofilm from a clinical strain of cryptococcus neoformans activates the NLRP3 inflammasome","volume":"23","author":"Lei","year":"2013","journal-title":"Cell Res"},{"key":"10.1016\/j.micinf.2014.08.013_bib12","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1128\/aem.41.5.1225-1229.1981","article-title":"Particle size of airborn cryptococcus neoformans in a tower","volume":"41","author":"Ruiz","year":"1981","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.micinf.2014.08.013_bib13","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1128\/IAI.01184-07","article-title":"The presence of capsule in cryptococcus neoformans influences the gene expression profile in dendritic cells during interaction with the fungus","volume":"76","author":"Lupo","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2014.08.013_bib14","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1128\/iai.63.8.2919-2923.1995","article-title":"Downregulation by cryptococcal polysaccharide of tumor necrosis factor alpha and interleukin-1 beta secretion from human monocytes","volume":"63","author":"Vecchiarelli","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2014.08.013_bib15","doi-asserted-by":"crossref","first-page":"e26232","DOI":"10.1371\/journal.pone.0026232","article-title":"Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with cryptococcus neoformans","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2014.08.013_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0165-5728(00)00319-2","article-title":"Establishment of protective immunity against cerebral cryptococcosis by means of an avirulent, non melanogenic Cryptococcus neoformans strain","volume":"109","author":"Barluzzi","year":"2000","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.micinf.2014.08.013_bib17","doi-asserted-by":"crossref","first-page":"7977","DOI":"10.1128\/AEM.01953-12","article-title":"EDTA inhibits biofilm formation, extracellular vesicular secretion, and shedding of the capsular polysaccharide glucuronoxylomannan by cryptococcus neoformans","volume":"78","author":"Robertson","year":"2012","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.micinf.2014.08.013_bib18","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1128\/AEM.02846-08","article-title":"Antibody-mediated immobilization of cryptococcus neoformans promotes biofilm formation","volume":"75","author":"Robertson","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.micinf.2014.08.013_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2014.08.013_bib20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/cr.2013.6","article-title":"Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock","volume":"23","author":"Mao","year":"2013","journal-title":"Cell Res"},{"key":"10.1016\/j.micinf.2014.08.013_bib21","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ni.1864","article-title":"The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses","volume":"11","author":"Rathinam","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2014.08.013_bib22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature10558","article-title":"Non-canonical inflammasome activation targets caspase-11","volume":"479","author":"Kayagaki","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2014.08.013_bib23","doi-asserted-by":"crossref","first-page":"e38326","DOI":"10.1371\/journal.pone.0038326","article-title":"Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of cryptococcus neoformans","volume":"7","author":"Fang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2014.08.013_bib24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1128\/iai.59.1.59-64.1991","article-title":"Facilitated isolation, purification, and analysis of glucuronoxylomannan of cryptococcus neoformans","volume":"59","author":"Cherniak","year":"1991","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2014.08.013_bib25","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1128\/EC.00398-06","article-title":"Parallel beta-helix proteins required for accurate capsule polysaccharide synthesis and virulence in the yeast cryptococcus neoformans","volume":"6","author":"Liu","year":"2007","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.micinf.2014.08.013_bib26","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1046\/j.1365-2958.2003.03780.x","article-title":"Cell wall alpha-1,3-glucan is required to anchor the cryptococcus neoformans capsule","volume":"50","author":"Reese","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micinf.2014.08.013_bib27","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1128\/IAI.01097-13","article-title":"Pathogenic fungus Microsporum canis activates the NLRP3 inflammasome","volume":"82","author":"Mao","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2014.08.013_bib28","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/sj.cdd.4402195","article-title":"Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration","volume":"14","author":"Petrilli","year":"2007","journal-title":"Cell death Differ"},{"key":"10.1016\/j.micinf.2014.08.013_bib29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0076-6879(08)01413-4","article-title":"Assembly, purification, and assay of the activity of the ASC pyroptosome","volume":"442","author":"Fernandes-Alnemri","year":"2008","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.micinf.2014.08.013_bib30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.200903124","article-title":"Glyburide inhibits the Cryopyrin\/Nalp3 inflammasome","volume":"187","author":"Lamkanfi","year":"2009","journal-title":"J Cell Biol"},{"key":"10.1016\/j.micinf.2014.08.013_bib31","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s13238-013-2127-9","article-title":"Human pathogenic fungus trichophyton schoenleinii activates the NLRP3 inflammasome","volume":"4","author":"Li","year":"2013","journal-title":"Protein Cell"},{"key":"10.1016\/j.micinf.2014.08.013_bib32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4049\/jimmunol.1100613","article-title":"Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome","volume":"187","author":"Bauernfeind","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.013_bib33","doi-asserted-by":"crossref","first-page":"e77955","DOI":"10.1371\/journal.pone.0077955","article-title":"Mycoplasma hyorhinis activates the NLRP3 inflammasome and promotes migration and invasion of gastric cancer cells","volume":"8","author":"Xu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2014.08.013_bib34","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","article-title":"K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter","volume":"38","author":"Munoz-Planillo","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2014.08.013_bib35","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1128\/IAI.70.11.5972-5981.2002","article-title":"Primary dendritic cells phagocytose cryptococcus neoformans via mannose receptors and Fc gamma receptor II for presentation to T lymphocytes","volume":"70","author":"Syme","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2014.08.013_bib36","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/aid.1.1986.2.211","article-title":"Poorly encapsulated Cryptococcus neoformans from patients with AIDS. I: preliminary observations","volume":"2","author":"Bottone","year":"1986","journal-title":"AIDS Res"},{"key":"10.1016\/j.micinf.2014.08.013_bib37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1574-695X.2011.00871.x","article-title":"Catch me if you can: phagocytosis and killing avoidance by cryptococcus neoformans","volume":"64","author":"Garcia-Rodas","year":"2012","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.micinf.2014.08.013_bib38","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1128\/EC.00039-10","article-title":"Cryptococcal interactions with the host immune system","volume":"9","author":"Voelz","year":"2010","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.micinf.2014.08.013_bib39","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1111\/j.1462-5822.2008.01152.x","article-title":"Antibody action after phagocytosis promotes cryptococcus neoformans and Cryptococcus gattii macrophage exocytosis with biofilm-like microcolony formation","volume":"10","author":"Alvarez","year":"2008","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.micinf.2014.08.013_bib40","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1073\/pnas.052702799","article-title":"Replication of cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm","volume":"99","author":"Tucker","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2014.08.013_bib41","doi-asserted-by":"crossref","first-page":"e1002555","DOI":"10.1371\/journal.ppat.1002555","article-title":"Fungal-induced cell cycle impairment, chromosome instability and apoptosis via differential activation of NF-kappaB","volume":"8","author":"Ben-Abdallah","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2014.08.013_bib42","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/intimm\/dxn112","article-title":"Cryptococcus neoformans glucuronoxylomannan induces macrophage apoptosis mediated by nitric oxide in a caspase-independent pathway","volume":"20","author":"Chiapello","year":"2008","journal-title":"Int Immunol"},{"key":"10.1016\/j.micinf.2014.08.013_bib43","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.4049\/jimmunol.174.6.3461","article-title":"Cryptococcus neoformans capsular glucuronoxylomannan induces expression of fas ligand in macrophages","volume":"174","author":"Monari","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2014.08.013_bib44","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/cmi.12067","article-title":"Cryptococcus interactions with macrophages: evasion and manipulation of the phagosome by a fungal pathogen","volume":"15","author":"Johnston","year":"2013","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.micinf.2014.08.013_bib45","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","article-title":"Recognition of microorganisms and activation of the immune response","volume":"449","author":"Medzhitov","year":"2007","journal-title":"Nature"},{"issue":"Suppl. 1","key":"10.1016\/j.micinf.2014.08.013_bib46","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/00002371-200203001-00003","article-title":"Interleukin-18 and host defense against infectious pathogens","volume":"25","author":"Kawakami","year":"2002","journal-title":"J Immunother"},{"key":"10.1016\/j.micinf.2014.08.013_bib47","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/ni.2369","article-title":"C-type lectin receptors orchestrate antifungal immunity","volume":"13","author":"Hardison","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2014.08.013_bib48","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.chom.2009.05.002","article-title":"An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans","volume":"5","author":"Hise","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2014.08.013_bib49","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12281-010-0034-6","article-title":"T-cell subsets and antifungal host defenses","volume":"4","author":"van de Veerdonk","year":"2010","journal-title":"Curr Fungal Infect Rep"},{"key":"10.1016\/j.micinf.2014.08.013_bib50","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1128\/IAI.00297-09","article-title":"Cytokine signaling regulates the outcome of intracellular macrophage parasitism by cryptococcus neoformans","volume":"77","author":"Voelz","year":"2009","journal-title":"Infect Immun"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457914001282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457914001282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:34:05Z","timestamp":1761143645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457914001282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1286457914001282"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2014.08.013","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2014.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Institut Pasteur. Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}