{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:18:38Z","timestamp":1777526318553,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,12]],"date-time":"2017-02-12T00:00:00Z","timestamp":1486857600000},"content-version":"vor","delay-in-days":377,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.micinf.2015.10.005","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T16:47:52Z","timestamp":1445878072000},"page":"137-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["TLR 9 involvement in early protection induced by immunization with rPb27 against Paracoccidioidomycosis"],"prefix":"10.1016","volume":"18","author":[{"given":"Elis Araujo","family":"Morais","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7418-8665","authenticated-orcid":false,"given":"Daniela Ferreira","family":"Chame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliza Mathias","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junnia Alvarenga","family":"de Carvalho Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cl\u00e1udia Chagas","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andiara Cardoso","family":"Peixoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edlian","family":"da Silva Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawidson Assis","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1715-3834","authenticated-orcid":false,"given":"Remo Castro","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo Miranda","family":"de Goes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2015.10.005_bib1","series-title":"Treaty of medical mycology","author":"Lacaz","year":"2002"},{"key":"10.1016\/j.micinf.2015.10.005_bib2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11046-014-9815-8","article-title":"Immunization with recombinant Pb27 protein reduces the levels of pulmonary fibrosis caused by the inflammatory response against Paracoccidioides brasiliensis","volume":"179","author":"Morais","year":"2014","journal-title":"Mycopathologia"},{"key":"10.1016\/j.micinf.2015.10.005_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ympev.2009.04.005","article-title":"Phylogenetic analysis reveals a high level of speciation in the Paracoccidioides genus","volume":"52","author":"Teixeira","year":"2009","journal-title":"Mol Phylogenet Evol"},{"key":"10.1016\/j.micinf.2015.10.005_bib4","first-page":"19","article-title":"Paracoccidioides lutzii sp. nov.: biological and clinical implications","volume":"52","author":"Teixeira","year":"2014","journal-title":"Med Mycol"},{"key":"10.1016\/j.micinf.2015.10.005_bib5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/mmy\/myv011","article-title":"Transcriptional profile of the human pathogenic fungus Paracoccidioides lutzii in response to sulfamethoxazole","volume":"53","author":"Zambuzzi-Carvalho","year":"2015","journal-title":"Med Mycol"},{"key":"10.1016\/j.micinf.2015.10.005_bib6","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1590\/S0037-86822010000400034","article-title":"Paracoccidioidomycosis: the dimension of the problem of a neglected disease","volume":"43","author":"Martinez","year":"2010","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.micinf.2015.10.005_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11046-007-9065-0","article-title":"An overview of the immunopathology of human paracoccidioidomycosis","volume":"165","author":"Benard","year":"2008","journal-title":"Mycopathologia"},{"key":"10.1016\/j.micinf.2015.10.005_bib8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11046-007-9048-1","article-title":"Innate immunity to Paracoccidioides brasiliensis infection","volume":"165","author":"Calich","year":"2008","journal-title":"Mycopathologia"},{"key":"10.1016\/j.micinf.2015.10.005_bib9","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Mogensen Pathogen recognition and inflammatory signaling in innate immune defenses","volume":"22","author":"Trine","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.micinf.2015.10.005_bib10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2015.10.005_bib11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fimmu.2013.00248","article-title":"Sweeten PAMPs: role of sugar complexed PAMPs in innate immunity and vaccine biology","volume":"4","author":"Mahla","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2015.10.005_bib12","first-page":"694","article-title":"TLR-2, TLR-4 and dectin-1 expression in human monocytes and neutrophils stimulated by Paracoccidioides brasiliensis","volume":"49","author":"Bonfim","year":"2009","journal-title":"Med Mycol"},{"key":"10.1016\/j.micinf.2015.10.005_bib13","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1098\/rstb.2011.0106","article-title":"Innate immunity and adjuvants","volume":"366","author":"Akira","year":"2011","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.micinf.2015.10.005_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-2478(02)00228-6","article-title":"Recognition of pathogen-associated molecular. Patterns by TLR family","volume":"85","author":"Akira","year":"2003","journal-title":"Immunol Lett"},{"key":"10.1016\/j.micinf.2015.10.005_bib15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ni1028","article-title":"TLR 9 signals after translocating from the ER to cpg DNA in the lysosome","volume":"5","author":"Latz","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2015.10.005_bib16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.immuni.2010.03.012","article-title":"Intracellular toll-like receptors","volume":"32","author":"Blasius","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2015.10.005_bib17","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.4049\/jimmunol.173.2.1179","article-title":"TLR 9 is localized in the endoplasmic reticulum prior to stimulation","volume":"173","author":"Leifer","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2015.10.005_bib18","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2015.10.005_bib19","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.3748\/wjg.v19.i26.4119","article-title":"Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: clinico-pathogenic aspects","volume":"19","author":"F\u0171ri","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.micinf.2015.10.005_bib20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1586\/erv.10.174","article-title":"CPG DNA as a vaccine adjuvant","volume":"10","author":"Bode","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.micinf.2015.10.005_bib21","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nrd2059","article-title":"Therapeutic potential of toll-like receptor 9 activation","volume":"5","author":"Krieg","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.micinf.2015.10.005_bib22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.0105-2896.2004.00148.x","article-title":"Use of CPG oligodeoxynucleotides as immune adjuvants","volume":"199","author":"Klinman","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.micinf.2015.10.005_bib23","first-page":"779","article-title":"Novel adjuvants & delivery vehicles for vaccines development: a road ahead","volume":"138","author":"Mohan","year":"2013","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.micinf.2015.10.005_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1513\/pats.200701-021AW","article-title":"Antiinfective applications of toll-like receptor 9 agonists","volume":"4","author":"Krieg","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.micinf.2015.10.005_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2004.02.022","article-title":"Strategies for enhancing the immunostimulatory effects of CPG oligodeoxynucleotides","volume":"97","author":"Mutwiri","year":"2004","journal-title":"J Control Release"},{"key":"10.1016\/j.micinf.2015.10.005_bib26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00436-003-1039-7","article-title":"The use of CPG as an adjuvant to Toxoplasma gondii vaccination","volume":"92","author":"Spencer","year":"2004","journal-title":"Parasitol Res"},{"key":"10.1016\/j.micinf.2015.10.005_bib27","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1016\/j.vaccine.2007.05.009","article-title":"The role of CPG-ODN in enhancement of immune response and protection in BALB\/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63) encapsulated in cationic liposome","volume":"25","author":"Jaafari","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.micinf.2015.10.005_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0264-410X(03)00541-3","article-title":"Use of purified Trypanosoma cruzi antigen and CPG oligodeoxynucleotides for immunoprotection against a lethal challenge with trypomastigotes","volume":"22","author":"Frank","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.micinf.2015.10.005_bib29","first-page":"913","article-title":"Immunization with rPb27 protects mice from the disruption of VEGF signaling in Paracoccidioides brasiliensis infection","volume":"7","author":"Morais","year":"2013","journal-title":"J Life Sci"},{"key":"10.1016\/j.micinf.2015.10.005_bib30","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1016\/j.vaccine.2008.07.097","article-title":"Protective immunity induced by rPb27 of Paracoccidioides brasiliensis","volume":"43","author":"Reis","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.micinf.2015.10.005_bib31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1189\/jlb.0610346","article-title":"Phosphoinositide 3-kinase \u03b3 plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice","volume":"89","author":"Russo","year":"2011","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.micinf.2015.10.005_bib32","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.4049\/jimmunol.1103053","article-title":"Early induction of CCL7 downstream of TLR 9 signaling promotes the development of robust immunity to cryptococcal infection","volume":"188","author":"Qiu","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2015.10.005_bib33","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1128\/IAI.01401-12","article-title":"Role of toll-like receptor 9 signaling in experimental Leishmania braziliensis infection","volume":"81","author":"Weinkopffa","year":"2013","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2015.10.005_bib34","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1128\/IAI.00079-12","article-title":"Timing of toll-like receptor 9 agonist administration in pneumococcal vaccination impacts both humoral and cellular immune responses as well as nasopharyngeal colonization in mice","volume":"80","author":"Jensen","year":"2012","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2015.10.005_bib35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4161\/hv.22950","article-title":"TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36\/AHG malaria vaccine in nonhuman primate models","volume":"9","author":"Tougan","year":"2013","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.micinf.2015.10.005_bib36","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1128\/CVI.00734-13","article-title":"Topical CPG adjuvantation of a protein-based vaccine induces protective immunity to Listeria monocytogenes","volume":"21","author":"Cheng","year":"2014","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.micinf.2015.10.005_bib37","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1269\/jrr.10098","article-title":"Radioprotection of bone marrow hematopoiesis by CPG oligodeoxynucleotides administered to miceafter total-body irradiation","volume":"52","author":"ZHANG\u2020","year":"2011","journal-title":"J Radiat Res"},{"key":"10.1016\/j.micinf.2015.10.005_bib38","first-page":"2879","article-title":"CPG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon y","volume":"93","author":"Klinman","year":"1996","journal-title":"Immunology"},{"key":"10.1016\/j.micinf.2015.10.005_bib39","doi-asserted-by":"crossref","first-page":"e2317","DOI":"10.1371\/journal.pntd.0002317","article-title":"TLR 9 activation dampens the early inflammatory response to Paracoccidioides brasiliensis","volume":"7","author":"Menino","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.micinf.2015.10.005_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/S1517-83822004000100009","article-title":"Natural antibodies in paracoccidioidomycosis","volume":"35","author":"Unterkircher","year":"2004","journal-title":"Braz J Microbiol"},{"key":"10.1016\/j.micinf.2015.10.005_bib41","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/glycob\/7.4.463","article-title":"A monoclonal antibody directed to terminal residue of B-galactofuranose of a glycolipid antigen isolated from Paracoccidioides brasiliensis: cross-reactivity with Leishmania major and Trypanosoma cruzi","volume":"7","author":"Suzuki","year":"1997","journal-title":"Glycobiology"},{"key":"10.1016\/j.micinf.2015.10.005_bib42","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.micinf.2007.08.001","article-title":"A surface 75-kDa protein with acid phosphatase activity recognized by monoclonal antibodies that inhibit Paracoccidioides brasiliensis growth","volume":"9","author":"Xander","year":"2007","journal-title":"Microbes Infect"},{"key":"10.1016\/j.micinf.2015.10.005_bib43","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.4049\/jimmunol.182.3.1386","article-title":"TLR9-dependent activation of dendritic cells by DNA from Leishmania major favors Th1 cell development and the resolution of lesions","volume":"182","author":"Fakher","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2015.10.005_bib44","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.4049\/jimmunol.178.4.2415","article-title":"TLR9 signaling in B cells determines class switch recombination to IgG2a","volume":"178","author":"Jegerlehner","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2015.10.005_bib45","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1084\/jem.177.5.1277","article-title":"Tumor necrosis factor alpha (TNF-alpha) induced cell adhesion to human endotelial cells is under dominant control of one TNF receptor type, TNF-R55","volume":"177","author":"Mackay","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.micinf.2015.10.005_bib46","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0092-8674(93)90464-2","article-title":"A novel domain within the 55 kd TNF receptor signals cell death","volume":"74","author":"Tartaglia","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2015.10.005_bib47","first-page":"1282","article-title":"Cells mediate increase of phagocytic activity but not of proinflammatory cytokine (interleukin-6 [IL-6], tumor necrosis factor alpha, and IL-12) production elicited in splenic macrophages by tilorone treatment of mice during acute systemic candidiasis","volume":"9","author":"Gaforio","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.micinf.2015.10.005_bib48","doi-asserted-by":"crossref","first-page":"e3317","DOI":"10.1371\/journal.pntd.0003317","article-title":"Therapeutic administration of recombinant paracoccin confers protection against Paracoccidioides brasiliensis infection: involvement of TLRs","volume":"8","author":"Alegre-Maller","year":"2014","journal-title":"PLoS Negl Trop Dis"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457915002282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457915002282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T20:11:04Z","timestamp":1567282264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457915002282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1286457915002282"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2015.10.005","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TLR 9 involvement in early protection induced by immunization with rPb27 against Paracoccidioidomycosis","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2015.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Institut Pasteur. Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}