{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:55:36Z","timestamp":1790873736554,"version":"4.1.0"},"reference-count":101,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.micinf.2016.05.008","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T17:30:51Z","timestamp":1465320651000},"page":"577-594","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Centenary of the death of Elie Metchnikoff: a visionary and an outstanding team leader"],"prefix":"10.1016","volume":"18","author":[{"given":"Jean-Marc","family":"Cavaillon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Legout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2016.05.008_bib1","series-title":"Metchnikoff and the origins of immunology: from metaphor to theory","author":"Tauber","year":"1991"},{"key":"10.1016\/j.micinf.2016.05.008_bib2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0008-8749(92)90089-8","article-title":"The birth of immunology: III. The fate of the phagocytosis theory","volume":"139","author":"Tauber","year":"1992","journal-title":"Cell Immunol"},{"key":"10.1016\/j.micinf.2016.05.008_bib3","first-page":"187","article-title":"The idea of immunity: Metchnikoff's metaphysics and science","volume":"23","author":"Chernyak","year":"1990","journal-title":"J\u00a0Hist Biol"},{"key":"10.1016\/j.micinf.2016.05.008_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0008-8749(89)90043-9","article-title":"The birth of immunology. II. Metchnikoff and his critics","volume":"121","author":"Tauber","year":"1989","journal-title":"Cell Immunol"},{"key":"10.1016\/j.micinf.2016.05.008_bib5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1757-4749-5-5","article-title":"Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part I - autointoxication revisited","volume":"5","author":"Bested","year":"2013","journal-title":"Gut Pathog"},{"key":"10.1016\/j.micinf.2016.05.008_bib6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1189\/jlb.0211094","article-title":"The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff","volume":"90","author":"Cavaillon","year":"2011","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.micinf.2016.05.008_bib7","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1002\/eji.200838855","article-title":"Elie Metchnikoff: father of natural immunity","volume":"38","author":"Gordon","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.micinf.2016.05.008_bib8","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/ni0708-705","article-title":"Immunology's foundation: the 100-year anniversary of the Nobel prize to Paul Ehrlich and Elie Metchnikoff","volume":"9","author":"Kaufmann","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2016.05.008_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ni0103-3","article-title":"Darwinism and immunology: from Metchnikoff to burnet","volume":"4","author":"Silverstein","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2016.05.008_bib10","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nrm1244","article-title":"Metchnikoff and the phagocytosis theory","volume":"4","author":"Tauber","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.micinf.2016.05.008_bib11","series-title":"Elias Metschnikow, Leben und Werk","author":"Zeiss","year":"1932"},{"key":"10.1016\/j.micinf.2016.05.008_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF01206205","article-title":"The genius of E. E. Metchnikoff : discoveries over the centuries","volume":"16","author":"Petrov","year":"1996","journal-title":"Biosci Rep"},{"key":"10.1016\/j.micinf.2016.05.008_bib13","series-title":"Immunity. How Elie Metchnikoff changed the course of modern medicine","author":"Vikhanski","year":"2016"},{"key":"10.1016\/j.micinf.2016.05.008_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1086\/649557","article-title":"Resilience to bacterial infection: difference between species could be due to proteins in serum","volume":"201","author":"Warren","year":"2010","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2016.05.008_bib15","first-page":"842","article-title":"Contribution \u00e0 l'\u00e9tude de l'auto-purificationmicrobienne du vagin. Exp\u00e9riences sur les animaux","volume":"13","author":"Cahanesco","year":"1901","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib16","series-title":"La vie d'\u00c9lie Metchnikoff","author":"Metchnikoff","year":"1920"},{"key":"10.1016\/j.micinf.2016.05.008_bib17","first-page":"578","volume":"vol. XXIII","author":"Brandreth","year":"1910"},{"key":"10.1016\/j.micinf.2016.05.008_bib18","first-page":"358","article-title":"Jubil\u00e9 du Professeur Elie Metchnikoff - lettre de M. E. Roux","volume":"29","author":"Roux","year":"1915","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib19","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.micinf.2003.10.003","article-title":"Richard Pfeiffer and Alexandre Besredka: creators of the concept of endotoxin and anti-endotoxin","volume":"5","author":"Rietschel","year":"2003","journal-title":"Microbes Infect"},{"key":"10.1016\/j.micinf.2016.05.008_bib20","series-title":"Histoire d'une id\u00e9e. L'oeuvre de Metchnikoff","author":"Besredka","year":"1921"},{"key":"10.1016\/j.micinf.2016.05.008_bib21","series-title":"Introduction","author":"Tauber","year":"2000"},{"key":"10.1016\/j.micinf.2016.05.008_bib22","series-title":"Essais optimistes","author":"Metchnikoff","year":"1907"},{"key":"10.1016\/j.micinf.2016.05.008_bib23","first-page":"631","article-title":"Note sur l'influence des microbes dans le d\u00e9veloppement des t\u00eatards","volume":"1901","author":"Metchnikoff","year":"1901","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib24","first-page":"785","article-title":"Recherches sur l'\u00e9pid\u00e9miologie de la tuberculose dans les steppes des Kamoulks","volume":"25","author":"Metchnikoff","year":"1911","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib25","series-title":"Etudes sur la nature humaine : essai de philosophie optimiste","author":"Metchnikoff","year":"1904"},{"key":"10.1016\/j.micinf.2016.05.008_bib26","first-page":"206","article-title":"Ueber die ver\u00e4nderungen, welche die blutk\u00f6rperchen in der milz erleiden","volume":"6","author":"Ecker","year":"1847","journal-title":"Z\u00a0Ration Med"},{"key":"10.1016\/j.micinf.2016.05.008_bib27","series-title":"Ueber Bewegungserscheinungen der zellen","author":"Lieberk\u00fchn","year":"1870"},{"key":"10.1016\/j.micinf.2016.05.008_bib28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1189\/jlb.0712361","article-title":"Sir Marc Armand Ruffer and Giulio Bizzozero: the first reports on efferocytosis","volume":"93","author":"Cavaillon","year":"2013","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.micinf.2016.05.008_bib29","first-page":"132","article-title":"Studi sulla struttura delle ghiandole linfatiche","volume":"13","author":"Bizzozero","year":"1873","journal-title":"Giornale della R Accad Med Torino"},{"key":"10.1016\/j.micinf.2016.05.008_bib30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF01915921","article-title":"Das putride Gift, die Bakterien, die putride Infektion oder Intoxication und die Septik\u00e4mie","volume":"60","author":"Panum","year":"1874","journal-title":"Arch Path Anat Physiol Klin Med (Virchow's Archive)"},{"key":"10.1016\/j.micinf.2016.05.008_bib31","first-page":"145","article-title":"On the pathology of miner's lung","volume":"4","author":"Osler","year":"1875","journal-title":"Can Med Surg J"},{"key":"10.1016\/j.micinf.2016.05.008_bib32","first-page":"277","article-title":"Untersuchungen ueber Bakterien V. Die Aetiologie der Milzbrand-Krankheit, begruendent auf die Entwicklungsgeschichte des Bacillus Anthracis","volume":"2","author":"Koch","year":"1876","journal-title":"Beitr Z Biol D Pflanz"},{"key":"10.1016\/j.micinf.2016.05.008_bib33","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/BF01935236","article-title":"Beitr\u00e4ge zur systematischen Botanik der pflanzlichen Parasiten mit experimentellen Untersuchungen \u00fcber die durch sie bedingten Krankheiten","volume":"70","author":"Grawitz","year":"1877","journal-title":"Arch Pathol Anat Physiol Klin Med"},{"key":"10.1016\/j.micinf.2016.05.008_bib34","series-title":"Beitragen zur Biologie niederster Orgabismen. (Marburg)","author":"Roser","year":"1881"},{"key":"10.1016\/j.micinf.2016.05.008_bib35","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/bmj.1.1054.369","article-title":"Report upon micro-organisms in surgical diseases","author":"Ogston","year":"1881","journal-title":"Brit Med J"},{"key":"10.1016\/j.micinf.2016.05.008_bib36","series-title":"Untersuchungen uber die intracellul\u00e4re verdauung bei wirbellosen thieren","first-page":"5","author":"Metchnikoff","year":"1884"},{"issue":"18","key":"10.1016\/j.micinf.2016.05.008_bib37","first-page":"560","article-title":"Unterchungen \u00fcber die mesodermalen phagocyten einiger wirbeltiere","volume":"3","author":"Metchnikoff","year":"1883","journal-title":"Biol Cent"},{"key":"10.1016\/j.micinf.2016.05.008_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF02361555","article-title":"\u00dcber eine sprosspilzkrankheit der daphnien; Beitrag zur \u00fcber den kamp der phagocyten gengen krankheitserreger","volume":"96","author":"Metchnikoff","year":"1884","journal-title":"Arch Pathol Anat Physiol Klin Med"},{"key":"10.1016\/j.micinf.2016.05.008_bib39","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/BF02430437","article-title":"Ueber die beziehung der phagocyten zu milzbrandbacillen","volume":"97","author":"Metchnikoff","year":"1884","journal-title":"Arch Pathol Anat Physiol Klin Med"},{"key":"10.1016\/j.micinf.2016.05.008_bib40","first-page":"1","article-title":"The micro-environment of inflammation or Metchnikoff revisited","volume":"269","author":"Dubos","year":"1955","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2016.05.008_bib41","first-page":"706","article-title":"L'\u00e9tat actuel de la question de l'immunit\u00e9 (Rapport au congr\u00e8s international de Budapest)","volume":"8","author":"Metchnikoff","year":"1894","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib42","series-title":"Le\u00e7ons sur la pathologie compar\u00e9e de l'inflammation","author":"Metchnikoff","year":"1892"},{"key":"10.1016\/j.micinf.2016.05.008_bib43","first-page":"193","article-title":"Etudes sur l'immunit\u00e9","volume":"4","author":"Metchnikoff","year":"1890","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib44","first-page":"534","article-title":"La th\u00e9orie des phagocytes au congr\u00e8s hygi\u00e9nique de Londres","volume":"5","author":"Metchnikoff","year":"1891","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib45","first-page":"104","article-title":"Recherches sur la phagocytose","volume":"10","author":"Bordet","year":"1889","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib46","first-page":"673","article-title":"Du r\u00f4le des des leucocytes dans l'infection dipht\u00e9rique","volume":"8","author":"Gabritschewsky","year":"1894","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib47","first-page":"369","article-title":"Sur le m\u00e9canisme de l'immunit\u00e9 contre la septic\u00e9mie vibrionienne","volume":"10","author":"Mesnil","year":"1896","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib48","series-title":"Mode de destruction du vibrion chol\u00e9rique dans l'organisme","author":"Cantacuz\u00e8ne","year":"1894"},{"key":"10.1016\/j.micinf.2016.05.008_bib49","first-page":"273","article-title":"Nouvelles recherches sur le mode de destruction des vibrions dans l'organisme","volume":"12","author":"Cantacuz\u00e8ne","year":"1898","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib50","first-page":"209","article-title":"Etude de l'immunit\u00e9 dans l'infection typhique exp\u00e9rimentale","volume":"15","author":"Besredka","year":"1901","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib51","first-page":"928","article-title":"Contribution \u00e0 l'\u00e9tude de l'immunit\u00e9 des animaux vis \u00e0 vis du bacille du chancre mou","volume":"15","author":"Himmel","year":"1901","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib52","first-page":"663","article-title":"Le rouge neutre (neutralroth). Son r\u00f4le dans l'\u00e9tude de la phagocytose eb g\u00e9n\u00e9ral et celle de la blennorrhagie en particulier","volume":"16","author":"Himmel","year":"1902","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib53","first-page":"894","article-title":"Sur l'\u00e9tat de la cytase dans le plasma des animaux normaux et des organismes vaccin\u00e9s contre le vibrion chol\u00e9rique","volume":"15","author":"Levaditi","year":"1901","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib54","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.micinf.2016.05.008_bib55","first-page":"337","article-title":"Des ph\u00e9nom\u00e8nes de phagocytose dans les poumons","volume":"3","author":"Tchistovitch","year":"1889","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib56","first-page":"611","article-title":"Sur les opsonines et les antiphagines dans l'infection pneumococcique","volume":"22","author":"Tchistovitch","year":"1908","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib57","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1128\/iai.56.6.1538-1544.1988","article-title":"Demonstration of an outer membrane protein with antiphagocytic activity from Pasteurella multocida of avian origin","volume":"56","author":"Truscott","year":"1988","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2016.05.008_bib58","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/BF01928655","article-title":"Uber das verhalten der wandungen der blutgefasse bei der emigration weisser blutkorper","volume":"62","author":"Arnold","year":"1875","journal-title":"Virchows Arch A Pathol Anat Pathol"},{"key":"10.1016\/j.micinf.2016.05.008_bib59","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1084\/jem.20111622","article-title":"Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in\u00a0vivo","volume":"209","author":"Proebstl","year":"2012","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2016.05.008_bib60","first-page":"363","article-title":"Lokomotorische Richtungsbewegungen durchchemische Reize","volume":"1","author":"Pfeffer","year":"1884","journal-title":"Untersuchungen Bot Inst T\u00fcb"},{"key":"10.1016\/j.micinf.2016.05.008_bib61","first-page":"125","article-title":"Chemotactische werking van miltvuurbacillen op leucocyten van den kikvorsch","volume":"2","author":"Pekelharing","year":"1889","journal-title":"Handel het Nederl Nat. geneesk Congr Leiden"},{"key":"10.1016\/j.micinf.2016.05.008_bib62","first-page":"346","article-title":"Sur les propri\u00e9t\u00e9s chimiotactiques des leucocytes","volume":"4","author":"Gabritchevsky","year":"1890","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib63","article-title":"Recherches sur l'irritabilit\u00e9 des leucocytes","author":"Massart","year":"1890","journal-title":"J\u00a0de M\u00e9decine de Chir de Pharmacol"},{"key":"10.1016\/j.micinf.2016.05.008_bib64","first-page":"417","article-title":"Le Chimiotactisme des leucocytes et l\u2019infection microbienne","volume":"5","author":"Massart","year":"1891","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib65","first-page":"545","article-title":"Etudes experimentales des divers proc\u00e9d\u00e9s de d\u00e9fense de la cavit\u00e9 buccale contre l'invasion des bact\u00e9ries pathog\u00e8nes","volume":"10","author":"Hugenschmidt","year":"1896","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib66","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1016\/j.jprot.2012.05.018","article-title":"Detection and quantitation of forty eight cytokines, chemokines, growth factors and nine acute phase proteins in healthy human plasma, saliva and urine","volume":"75","author":"Khan","year":"2012","journal-title":"J\u00a0Proteomics"},{"key":"10.1016\/j.micinf.2016.05.008_bib67","first-page":"481","article-title":"On the phagocytes of the alimentary canal","volume":"30","author":"Ruffer","year":"1890","journal-title":"Quaterly J Microsc Sci"},{"key":"10.1016\/j.micinf.2016.05.008_bib68","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1136\/bmj.1.1629.591","article-title":"Remarks made at the discussion on phagocytosis and immunity at the Pathological Society of London","volume":"XX","author":"Ruffer","year":"1892","journal-title":"Brit Med J"},{"key":"10.1016\/j.micinf.2016.05.008_bib69","series-title":"Les phagocytes en chirurgie (preface)","author":"Metchnikoff","year":"1915"},{"key":"10.1016\/j.micinf.2016.05.008_bib70","first-page":"357","article-title":"An experimental investigation on the role of the blood fluids in connection with phagocytosis","volume":"72","author":"Wright","year":"1903","journal-title":"Proc R Soc (London)"},{"key":"10.1016\/j.micinf.2016.05.008_bib71","first-page":"175","article-title":"Sur le m\u00e9canisme de l'immunit\u00e9. La Cellule","volume":"11","author":"Denys","year":"1895","journal-title":"Recueil de Cytol d'Histologie g\u00e9n\u00e9rale"},{"key":"10.1016\/j.micinf.2016.05.008_bib72","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1055\/s-0029-1187750","article-title":"\u00dcber die antik\u00f6rper des Streptokokken und Pneumokokken immunserums","volume":"40","author":"Neufeld","year":"1904","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.micinf.2016.05.008_bib73","first-page":"149","article-title":"De l\u2019anti-endotoxine typhique et des anti-endotoxines, en g\u00e9n\u00e9ral","volume":"20","author":"Besredka","year":"1906","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib74","first-page":"529","article-title":"L'oeuvre de Paul Ehrlich","volume":"51","author":"Roux","year":"1914","journal-title":"Berl Klin Wochenschr"},{"key":"10.1016\/j.micinf.2016.05.008_bib75","first-page":"193","article-title":"Recherches sur la fi\u00e8vre typhoide exp\u00e9rimentale","volume":"25","author":"Metchnikoff","year":"1911","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib76","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nrd3439-c1","article-title":"Believe it or not: how much can we rely on published data on potential drug targets? Nature reviews","volume":"10","author":"Prinz","year":"2011","journal-title":"Drug Discov"},{"key":"10.1016\/j.micinf.2016.05.008_bib77","doi-asserted-by":"crossref","first-page":"e1002165","DOI":"10.1371\/journal.pbio.1002165","article-title":"The economics of reproducibility in preclinical research","volume":"13","author":"Freedman","year":"2015","journal-title":"PLoS Biol"},{"key":"10.1016\/j.micinf.2016.05.008_bib78","doi-asserted-by":"crossref","first-page":"e0147215","DOI":"10.1371\/journal.pone.0147215","article-title":"When quality beats quantity: decision theory, drug discovery, and the reproducibility crisis","volume":"11","author":"Scannell","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2016.05.008_bib79","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1017\/S0269889702000455","article-title":"Beyond species: Il'ya Ivanov and his experiments on cross-breeding humans and anthropoid apes","volume":"15","author":"Rossiianov","year":"2002","journal-title":"Sci context"},{"key":"10.1016\/j.micinf.2016.05.008_bib80","first-page":"865","article-title":"Etudes biologiques sur la vieillesse. I. Sur le blanchiment des cheveux et des poils","volume":"15","author":"Metchnikoff","year":"1901","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib81","first-page":"859","article-title":"Recherche sur le m\u00e9canisme de la destruction des cellules nerveuses","volume":"20","author":"Manou\u00e9lian","year":"1906","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib82","first-page":"912","article-title":"Etudes biologiques sur la vieillesse. II Recherche sur la vieillesse des perroquets","volume":"16","author":"Metchnikoff","year":"1902","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib83","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/ar.1092290311","article-title":"Effects of aging on the neuroglial cells and pericytes within area 17 of the rhesus monkey cerebral cortex","volume":"229","author":"Peters","year":"1991","journal-title":"Anatomical Rec"},{"key":"10.1016\/j.micinf.2016.05.008_bib84","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.stem.2010.08.014","article-title":"Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis","volume":"7","author":"Sierra","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.micinf.2016.05.008_bib85","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1750-1326-5-12","article-title":"Microglia in the aging brain: relevance to neurodegeneration","volume":"5","author":"Luo","year":"2010","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.micinf.2016.05.008_bib86","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.4049\/jimmunol.1003600","article-title":"Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death","volume":"186","author":"Neher","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2016.05.008_bib87","first-page":"937","article-title":"Pozerski, Distaso, Berthelot. Roussettes et microbes","volume":"23","author":"Metchnikoff","year":"1909","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib88","first-page":"345","article-title":"Etude de la flore bact\u00e9rienne du gros intestin du cheval","volume":"25","author":"Chouk\u00e9vitch","year":"1911","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib89","first-page":"807","article-title":"Action des l'intesting gr\u00eale sur les microbes","volume":"24","author":"Wollman","year":"1910","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib90","first-page":"217","article-title":"Sur la flore microbienne termophile du canal intestinal de l'homme","volume":"17","author":"Tsiklinsky","year":"1903","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib91","first-page":"929","article-title":"Etudes sur la flore intestinale. Ann Inst","volume":"22","author":"Metchnikoff","year":"1908","journal-title":"Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib92","first-page":"755","article-title":"Poisons intestinaux et scl\u00e9roses. Ann Inst","volume":"24","author":"Metchnikoff","year":"1910","journal-title":"Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1353\/bhm.1998.0056","article-title":"Cultural divergence: Elie Metchnikoff's Bacillus bulgaricus therapy and his underlying concept of health","volume":"72","author":"Podolsky","year":"1998","journal-title":"Bull Hist Med"},{"key":"10.1016\/j.micinf.2016.05.008_bib94","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2016.05.008_bib95","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1074\/jbc.M114.618249","article-title":"Transmission of atherosclerosis susceptibility with gut microbial transplantation","volume":"290","author":"Gregory","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.micinf.2016.05.008_bib96","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","article-title":"Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk","volume":"165","author":"Zhu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2016.05.008_bib97","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1126\/science.1254766","article-title":"Small molecules from human microbiota","volume":"349","author":"Donia","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.micinf.2016.05.008_bib98","first-page":"77","article-title":"Quelques remarques sur le lait aigre","volume":"10","author":"Metchnikoff","year":"1907","journal-title":"Revue g\u00e9n\u00e9rale de chimie pure appliqu\u00e9e"},{"key":"10.1016\/j.micinf.2016.05.008_bib99","first-page":"825","article-title":"Sur quelques essais de d\u00e9sintoxication intestinale","volume":"26","author":"Metchnikoff","year":"1912","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.micinf.2016.05.008_bib100","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/ajcn\/74.6.833","article-title":"Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019","volume":"74","author":"Gill","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.micinf.2016.05.008_bib101","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457916300697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457916300697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T17:53:13Z","timestamp":1701193993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457916300697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":101,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1286457916300697"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2016.05.008","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Centenary of the death of Elie Metchnikoff: a visionary and an outstanding team leader","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2016.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}