{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:53:25Z","timestamp":1790380405433,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","award":["R01AI047997"],"award-info":[{"award-number":["R01AI047997"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.micinf.2016.07.002","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T15:26:47Z","timestamp":1468855607000},"page":"669-674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF"],"prefix":"10.1016","volume":"18","author":[{"given":"Zhangsheng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2016.07.002_bib1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.molimm.2015.01.020","article-title":"Contribution of the complement Membrane Attack Complex to the bactericidal activity of human serum","volume":"65","author":"Berends","year":"2015","journal-title":"Mol Immunol"},{"key":"10.1016\/j.micinf.2016.07.002_bib2","doi-asserted-by":"crossref","first-page":"e50327","DOI":"10.1371\/journal.pone.0050327","article-title":"A\u00a0new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci","volume":"7","author":"Bode","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.micinf.2016.07.002_bib3","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1084\/jem.20070563","article-title":"MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection","volume":"204","author":"Brandl","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2016.07.002_bib4","doi-asserted-by":"crossref","first-page":"e1002842","DOI":"10.1371\/journal.ppat.1002842","article-title":"A\u00a0chlamydial protease in search of an authentic substrate","volume":"8","author":"Chen","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2016.07.002_bib5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.abb.2009.01.014","article-title":"Identifying catalytic residues in CPAF, a Chlamydia-secreted protease","volume":"485","author":"Chen","year":"2009","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.micinf.2016.07.002_bib6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.micpath.2010.05.008","article-title":"Autoprocessing and self-activation of the secreted protease CPAF in Chlamydia-infected cells","volume":"49","author":"Chen","year":"2010","journal-title":"Microb Pathog"},{"key":"10.1016\/j.micinf.2016.07.002_bib7","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1099\/mic.0.040527-0","article-title":"Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway","volume":"156","author":"Chen","year":"2010","journal-title":"Microbiology"},{"key":"10.1016\/j.micinf.2016.07.002_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1034\/j.1399-3011.2003.00053.x","article-title":"Susceptibility of human and murine Chlamydia trachomatis serovars to granulocyte- and epithelium-derived antimicrobial peptides","volume":"61","author":"Chong-Cerrillo","year":"2003","journal-title":"J\u00a0Pept Res"},{"key":"10.1016\/j.micinf.2016.07.002_bib9","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.micinf.2013.09.008","article-title":"A\u00a0path forward for the chlamydial virulence factor CPAF","volume":"15","author":"Conrad","year":"2013","journal-title":"Microbes Infect\/Institut Pasteur"},{"key":"10.1016\/j.micinf.2016.07.002_bib10","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/j.1365-2958.2004.04072.x","article-title":"Cleavage-dependent activation of a chlamydia-secreted protease","volume":"52","author":"Dong","year":"2004","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micinf.2016.07.002_bib11","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1128\/IAI.72.7.3869-3875.2004","article-title":"Intramolecular dimerization is required for the chlamydia-secreted protease CPAF to degrade host transcriptional factors","volume":"72","author":"Dong","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2016.07.002_bib12","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1093\/infdis\/jit640","article-title":"The complement C3a receptor is critical in defense against Chlamydia psittaci in mouse lung infection and required for antibody and optimal T cell response","volume":"209","author":"Dutow","year":"2014","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2016.07.002_bib13","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/cei.12464","article-title":"Regulation of the alternative pathway of complement modulates injury and immunity in a chronic model of dextran sulphate sodium-induced colitis","volume":"179","author":"Elvington","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.micinf.2016.07.002_bib14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1084\/jem.187.4.487","article-title":"Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation","volume":"187","author":"Fan","year":"1998","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2016.07.002_bib15","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1074\/jbc.M110.178350","article-title":"Antibacterial activity of the contact and complement systems is blocked by SIC, a protein secreted by Streptococcus pyogenes","volume":"286","author":"Frick","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.micinf.2016.07.002_bib16","first-page":"45","article-title":"Phagocytosis of target particles bearing C3b-IgG covalent complexes by human monocytes and polymorphonuclear leucocytes","volume":"62","author":"Fries","year":"1987","journal-title":"Immunology"},{"key":"10.1016\/j.micinf.2016.07.002_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF02697367","article-title":"Anaphylatoxins: their role in bacterial infection and inflammation","volume":"37","author":"Haas","year":"2007","journal-title":"Immunol Res"},{"key":"10.1016\/j.micinf.2016.07.002_bib18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.micinf.2014.02.008","article-title":"The chlamydial protease CPAF: important or not, important for what?","volume":"16","author":"Hacker","year":"2014","journal-title":"Microbes Infect\/Institut Pasteur"},{"key":"10.1016\/j.micinf.2016.07.002_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00481-13","article-title":"CspA from Borrelia burgdorferi inhibits the terminal complement pathway","volume":"4","author":"Hallstrom","year":"2013","journal-title":"MBio"},{"key":"10.1016\/j.micinf.2016.07.002_bib20","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1136\/gut.33.7.902","article-title":"Surface epithelium related activation of complement differs in Crohn's disease and ulcerative colitis","volume":"33","author":"Halstensen","year":"1992","journal-title":"Gut"},{"key":"10.1016\/j.micinf.2016.07.002_bib21","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1128\/IAI.01094-13","article-title":"Versatile roles of CspA orthologs in complement inactivation of serum-resistant Lyme disease spirochetes","volume":"82","author":"Hammerschmidt","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2016.07.002_bib22","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1128\/IAI.00746-15","article-title":"Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37","volume":"83","author":"Hou","year":"2015","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2016.07.002_bib23","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1128\/JB.02087-12","article-title":"Chlamydia trachomatis outer membrane complex protein B (OmcB) is processed by the protease CPAF","volume":"195","author":"Hou","year":"2013","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.micinf.2016.07.002_bib24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.chom.2008.10.005","article-title":"Structural basis for activation and inhibition of the secreted Chlamydia protease CPAF","volume":"4","author":"Huang","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2016.07.002_bib25","doi-asserted-by":"crossref","first-page":"e113333","DOI":"10.1371\/journal.pone.0113333","article-title":"MyD88 deficiency alters expression of antimicrobial factors in mouse salivary glands","volume":"9","author":"Into","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.micinf.2016.07.002_bib26","first-page":"369","article-title":"A\u00a0study of inactivation of Chlamydia trachomatis by normal human serum","volume":"59","author":"Johnson","year":"1983","journal-title":"Br J Vener Dis"},{"key":"10.1016\/j.micinf.2016.07.002_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femspd\/ftv007","article-title":"Induction and inhibition of CPAF activity during analysis of Chlamydia-infected cells","volume":"73","author":"Johnson","year":"2015","journal-title":"Pathog Dis"},{"key":"10.1016\/j.micinf.2016.07.002_bib28","doi-asserted-by":"crossref","first-page":"e64529","DOI":"10.1371\/journal.pone.0064529","article-title":"Identification of a novel nuclear localization signal sequence in Chlamydia trachomatis-secreted hypothetical protein CT311","volume":"8","author":"Lei","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.micinf.2016.07.002_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.micpath.2011.05.002","article-title":"Localization of Chlamydia trachomatis hypothetical protein CT311 in host cell cytoplasm","volume":"51","author":"Lei","year":"2011","journal-title":"Microb Pathog"},{"key":"10.1016\/j.micinf.2016.07.002_bib30","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1128\/IAI.01377-07","article-title":"The chlamydial plasmid-encoded protein pgp3 is secreted into the cytosol of Chlamydia-infected cells","volume":"76","author":"Li","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2016.07.002_bib31","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1128\/iai.60.6.2547-2550.1992","article-title":"Early complement components enhance neutralization of Chlamydia trachomatis infectivity by human sera","volume":"60","author":"Lin","year":"1992","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2016.07.002_bib32","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.1128\/IAI.02576-14","article-title":"Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice","volume":"82","author":"Liu","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2016.07.002_bib33","doi-asserted-by":"crossref","first-page":"e68764","DOI":"10.1371\/journal.pone.0068764","article-title":"Chlamydia trachomatis GlgA is secreted into host cell cytoplasm","volume":"8","author":"Lu","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.micinf.2016.07.002_bib34","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.4049\/jimmunol.161.8.4220","article-title":"Apoptosis of epithelial cells and macrophages due to infection with the obligate intracellular pathogen Chlamydia psittaci","volume":"161","author":"Ojcius","year":"1998","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2016.07.002_bib35","first-page":"244","article-title":"Susceptibility of different serovars of Chlamydia trachomatis to inactivation by normal human serum","volume":"61","author":"Osborn","year":"1985","journal-title":"Genitourin Med"},{"key":"10.1016\/j.micinf.2016.07.002_bib36","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1128\/IAI.00003-11","article-title":"A\u00a0Chlamydia trachomatis OmcB C-terminal fragment is released into host cell cytoplasm and is immunogenic in humans","volume":"79","author":"Qi","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2016.07.002_bib37","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1128\/JB.01301-10","article-title":"Chlamydia trachomatis secretion of an immunodominant hypothetical protein (CT795) into host cell cytoplasm","volume":"193","author":"Qi","year":"2011","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.micinf.2016.07.002_bib38","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1128\/IAI.00382-15","article-title":"Chlamydia muridarum infection of macrophages elicits bactericidal nitric oxide production via reactive oxygen species and cathepsin B","volume":"83","author":"Rajaram","year":"2015","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2016.07.002_bib39","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.fertnstert.2011.06.021","article-title":"Genome-wide identification of Chlamydia trachomatis antigens associated with tubal factor infertility","volume":"96","author":"Rodgers","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.micinf.2016.07.002_bib40","doi-asserted-by":"crossref","first-page":"7164","DOI":"10.1128\/IAI.72.12.7164-7171.2004","article-title":"Human antibody responses to a Chlamydia-secreted protease factor","volume":"72","author":"Sharma","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2016.07.002_bib41","first-page":"680","article-title":"Evidence of chlamydial infection in infertile women with fallopian tube obstruction","volume":"46","author":"Sharma","year":"2003","journal-title":"Indian J Pathol Microbiol"},{"issue":"3","key":"10.1016\/j.micinf.2016.07.002_bib42","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/2049-632X.12179","article-title":"Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches","volume":"71","author":"Snavely","year":"2014","journal-title":"Pathog Dis"},{"key":"10.1016\/j.micinf.2016.07.002_bib43","doi-asserted-by":"crossref","first-page":"9409","DOI":"10.1074\/jbc.M312008200","article-title":"Activation of Raf\/MEK\/ERK\/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids","volume":"279","author":"Su","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.micinf.2016.07.002_bib44","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/2049-632X.12213","article-title":"The Chlamydia protease CPAF: caution, precautions and function","volume":"72","author":"Tan","year":"2014","journal-title":"Pathog Dis"},{"key":"10.1016\/j.micinf.2016.07.002_bib45","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.micinf.2015.02.005","article-title":"Chlamydia-secreted protease CPAF degrades host antimicrobial peptides","volume":"17","author":"Tang","year":"2015","journal-title":"Microbes Infect\/Institut Pasteur"},{"key":"10.1016\/j.micinf.2016.07.002_bib46","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1128\/IAI.00275-15","article-title":"Characterization of CPAF critical residues and secretion during Chlamydia trachomatis infection","volume":"83","author":"Yang","year":"2015","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2016.07.002_bib47","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1084\/jem.193.8.935","article-title":"Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors","volume":"193","author":"Zhong","year":"2001","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2016.07.002_bib48","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1084\/jem.189.12.1931","article-title":"Chlamydia inhibits interferon gamma-inducible major histocompatibility complex class II expression by degradation of upstream stimulatory factor 1","volume":"189","author":"Zhong","year":"1999","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2016.07.002_bib49","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1084\/jem.191.9.1525","article-title":"Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon gamma-inducible major histocompatibility complex class I expression in chlamydia-infected cells","volume":"191","author":"Zhong","year":"2000","journal-title":"J\u00a0Exp Med"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457916300946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457916300946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T17:53:16Z","timestamp":1701193996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457916300946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S1286457916300946"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2016.07.002","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2016.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}