{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:47:36Z","timestamp":1771656456107,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":2132,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AI093692"],"award-info":[{"award-number":["R01AI093692"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UL1TR00165"],"award-info":[{"award-number":["UL1TR00165"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.micinf.2017.12.001","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T13:03:55Z","timestamp":1514293435000},"page":"176-184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["T cell phenotypes in women with Chlamydia trachomatis infection and influence of treatment on phenotype distributions"],"prefix":"10.1016","volume":"20","author":[{"given":"Brian M.O.","family":"Ogendi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2120-6625","authenticated-orcid":false,"given":"Rakesh K.","family":"Bakshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanupriya","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa","family":"Kapil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LaDraka T.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffanie","family":"Sabbaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christen G.","family":"Press","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Geisler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2017.12.001_bib1","doi-asserted-by":"crossref","first-page":"e0143304","DOI":"10.1371\/journal.pone.0143304","article-title":"Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting","volume":"10","author":"Newman","year":"2015","journal-title":"PLoS One"},{"issue":"Suppl.\u00a02","key":"10.1016\/j.micinf.2017.12.001_bib2","doi-asserted-by":"crossref","first-page":"S380","DOI":"10.1086\/513844","article-title":"Chlamydia trachomatis infections: progress and problems","volume":"179","author":"Stamm","year":"1999","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2017.12.001_bib3","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2015","volume":"64","author":"Workowski","year":"2015","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.micinf.2017.12.001_bib4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1086\/428287","article-title":"The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: a 5-year follow-up study","volume":"191","author":"Molano","year":"2005","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2017.12.001_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1258\/095646202762226092","article-title":"The natural course of asymptomatic Chlamydia trachomatis infections: 45% clearance and no development of clinical PID after one-year follow-up","volume":"13","author":"Morre","year":"2002","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.micinf.2017.12.001_bib6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/OLQ.0b013e3181a2a933","article-title":"Repeat infection with chlamydia and gonorrhea among females: a systematic review of the literature","volume":"36","author":"Hosenfeld","year":"2009","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.micinf.2017.12.001_bib7","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1128\/IAI.66.9.4030-4035.1998","article-title":"Route of infection that induces a high intensity of gamma interferon-secreting T cells in the genital tract produces optimal protection against Chlamydia trachomatis infection in mice","volume":"66","author":"Igietseme","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2017.12.001_bib8","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1128\/iai.63.5.1784-1789.1995","article-title":"Local Th1-like responses are induced by intravaginal infection of mice with the mouse pneumonitis biovar of Chlamydia trachomatis","volume":"63","author":"Cain","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2017.12.001_bib9","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1128\/IAI.70.6.2741-2751.2002","article-title":"Immunity to murine chlamydial genital infection","volume":"70","author":"Morrison","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2017.12.001_bib10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/mi.2010.58","article-title":"CXCR3 and CCR5 are both required for T cell-mediated protection against C.\u00a0trachomatis infection in the murine genital mucosa","volume":"4","author":"Olive","year":"2010","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.micinf.2017.12.001_bib11","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.4049\/jimmunol.1402675","article-title":"Protective immunity against Chlamydia trachomatis can engage both CD4+ and CD8+ T cells and bridge the respiratory and genital mucosae","volume":"194","author":"Nogueira","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2017.12.001_bib12","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1128\/iai.65.12.5198-5208.1997","article-title":"Identification of homing receptors that mediate the recruitment of CD4 T cells to the genital tract following intravaginal infection with Chlamydia trachomatis","volume":"65","author":"Kelly","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2017.12.001_bib13","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1128\/IAI.70.2.844-850.2002","article-title":"Chemokine and chemokine receptor dynamics during genital chlamydial infection","volume":"70","author":"Belay","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2017.12.001_bib14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1086\/432070","article-title":"Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon-gamma","volume":"192","author":"Cohen","year":"2005","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2017.12.001_bib15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1600-0897.2008.00639.x","article-title":"A\u00a0distinct cellular profile is seen in the human endocervix during Chlamydia trachomatis infection","volume":"60","author":"Ficarra","year":"2008","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.micinf.2017.12.001_bib16","doi-asserted-by":"crossref","first-page":"e58565","DOI":"10.1371\/journal.pone.0058565","article-title":"Human female genital tract infection by the obligate intracellular bacterium Chlamydia trachomatis elicits robust type 2 immunity","volume":"8","author":"Vicetti Miguel","year":"2013","journal-title":"PLos One"},{"key":"10.1016\/j.micinf.2017.12.001_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jri.2014.01.002","article-title":"Frequency of Chlamydia trachomatis-specific T cell interferon-gamma and interleukin-17 responses in CD4-enriched peripheral blood mononuclear cells of sexually active adolescent females","volume":"103","author":"Barral","year":"2014","journal-title":"J\u00a0Reprod Immunol"},{"issue":"4","key":"10.1016\/j.micinf.2017.12.001_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/CVI.00010-17","article-title":"The predominant CD4+ Th1 cytokine elicited to Chlamydia trachomatis infection in women is tumor necrosis factor-alpha and not interferon gamma","volume":"24","author":"Jordan","year":"2017","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.micinf.2017.12.001_bib19","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1093\/infdis\/jis621","article-title":"Immunoglobulin-specific responses to Chlamydia elementary bodies in individuals with and at risk for genital chlamydial infection","volume":"206","author":"Geisler","year":"2012","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2017.12.001_bib20","doi-asserted-by":"crossref","first-page":"8304","DOI":"10.1128\/JVI.00539-15","article-title":"Frequency, private specificity, and cross-reactivity of preexisting (Hepatitis C\u00a0virus)\u00a0(HCV)-specific CD8+ T cells in HCV-seronegative individuals: implications for vaccine responses","volume":"89","author":"Zhang","year":"2015","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2017.12.001_bib21","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.1086\/652399","article-title":"Protective immunity to chlamydial genital infection: evidence from animal studies","volume":"201","author":"Rank","year":"2010","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2017.12.001_bib22","first-page":"78","article-title":"Chlamydial lipoproteins stimulate toll-like receptors 1\/2 mediated inflammatory responses through MyD88-dependent pathway","volume":"8","author":"Wang","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.micinf.2017.12.001_bib23","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3782::AID-IMMU3782>3.0.CO;2-B","article-title":"IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infection","volume":"29","author":"Wang","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.micinf.2017.12.001_bib24","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.4049\/jimmunol.162.2.1010","article-title":"IL-10 gene knockout mice show enhanced Th1-like protective immunity and absent granuloma formation following Chlamydia trachomatis lung infection","volume":"162","author":"Yang","year":"1999","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2017.12.001_bib25","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.4049\/jimmunol.156.11.4338","article-title":"Genetically determined differences in IL-10 and IFN-gamma responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection","volume":"156","author":"Yang","year":"1996","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2017.12.001_bib26","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1128\/IAI.01328-06","article-title":"Th1 and Th2 cells help CD8 T-cell responses","volume":"75","author":"Ekkens","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2017.12.001_bib27","doi-asserted-by":"crossref","first-page":"e63933","DOI":"10.1371\/journal.pone.0063933","article-title":"Synergy between CD8 T cells and Th1 or Th2 polarised CD4 T cells for adoptive immunotherapy of brain tumours","volume":"8","author":"Hoepner","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2017.12.001_bib28","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/eji.201343995","article-title":"CCR4 and CXCR3 play different roles in the migration of T cells to inflammation in skin, arthritic joints, and lymph nodes","volume":"44","author":"Al-Banna","year":"2014","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.micinf.2017.12.001_bib29","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.4049\/jimmunol.0901216","article-title":"Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver","volume":"184","author":"Oo","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2017.12.001_bib30","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1002\/art.30521","article-title":"Coexpression of chemokine receptors CCR5, CXCR3, and CCR4 and ligands for P- and E-selectin on T lymphocytes of patients with juvenile idiopathic arthritis","volume":"63","author":"Issekutz","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.micinf.2017.12.001_bib31","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1172\/JCI1422","article-title":"The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions","volume":"101","author":"Qin","year":"1998","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.micinf.2017.12.001_bib32","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/infdis\/jiu670","article-title":"The epidemiology of Chlamydia trachomatis organism load during genital infection: a systematic review","volume":"211","author":"Vodstrcil","year":"2015","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2017.12.001_bib33","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/aji.12252","article-title":"Regulation of mucosal immunity in the female reproductive tract: the role of sex hormones in immune protection against sexually transmitted pathogens","volume":"72","author":"Wira","year":"2014","journal-title":"Am J Reprod Immunol"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645791730223X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645791730223X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:35:12Z","timestamp":1761143712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S128645791730223X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S128645791730223X"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2017.12.001","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T cell phenotypes in women with Chlamydia trachomatis infection and influence of treatment on phenotype distributions","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2017.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}