{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:46:25Z","timestamp":1790959585135,"version":"4.1.0"},"reference-count":148,"publisher":"Elsevier BV","issue":"9-10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":1918,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research (CIHR) Foundation Grant","doi-asserted-by":"publisher","award":["FDN-143273"],"award-info":[{"award-number":["FDN-143273"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de recherche du Qu\u00e9bec\u2013Sant\u00e9 (FRQS)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Institute of McGill University Health Centre"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.micinf.2018.03.005","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T12:01:46Z","timestamp":1524052906000},"page":"560-569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Dissecting host cell death programs in the pathogenesis of influenza"],"prefix":"10.1016","volume":"20","author":[{"given":"Jeffrey","family":"Downey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Pernet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Coulombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maziar","family":"Divangahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2018.03.005_bib1","series-title":"Handbook of geographical and historical pathology","author":"Hirsh","year":"1883"},{"key":"10.1016\/j.micinf.2018.03.005_bib2","series-title":"Influenza (seasonal) fact sheet","author":"WHO","year":"2016"},{"key":"10.1016\/j.micinf.2018.03.005_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3201\/eid1209.05-0979","article-title":"1918 influenza: the mother of all pandemics","volume":"12","author":"Taubenberger","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens5040066","article-title":"Reviewing the history of pandemic influenza: understanding patterns of emergence and transmission","volume":"5","author":"Saunders-Hastings","year":"2016","journal-title":"Pathogens"},{"key":"10.1016\/j.micinf.2018.03.005_bib5","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0140-6736(14)60111-2","article-title":"Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study","volume":"383","author":"Chen","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2018.03.005_bib6","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0140-6736(97)11212-0","article-title":"Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus","volume":"351","author":"Claas","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2018.03.005_bib7","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3201\/eid2105.142020","article-title":"Novel Eurasian highly pathogenic avian influenza A H5 viruses in wild birds, Washington, USA, 2014","volume":"21","author":"Ip","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib8","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/rmv.1857","article-title":"Intracontinental and intercontinental dissemination of Asian H5 highly pathogenic avian influenza virus (clade 2.3.4.4) in the winter of 2014\u20132015","volume":"25","author":"Saito","year":"2015","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0140-6736(13)61207-6","article-title":"Human infection with avian influenza A H7N9 virus: an assessment of clinical severity","volume":"382","author":"Yu","year":"2013","journal-title":"Lancet"},{"issue":"Suppl.\u00a04","key":"10.1016\/j.micinf.2018.03.005_bib10","doi-asserted-by":"crossref","first-page":"D59","DOI":"10.1016\/j.vaccine.2008.07.025","article-title":"Pathology of human influenza revisited","volume":"26","author":"Kuiken","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.micinf.2018.03.005_bib11","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev.pathmechdis.3.121806.154316","article-title":"The pathology of influenza virus infections","volume":"3","author":"Taubenberger","year":"2008","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.micinf.2018.03.005_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1473-3099(13)70286-X","article-title":"Pathogenesis of influenza-induced acute respiratory distress syndrome","volume":"14","author":"Short","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib13","series-title":"MERS-CoV global summary and risk assessment","author":"WHO","year":"2016"},{"key":"10.1016\/j.micinf.2018.03.005_bib14","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S2213-2600(14)70158-4","article-title":"Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study","volume":"2","author":"Chan","year":"2014","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.micinf.2018.03.005_bib15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1164\/rccm.201305-0954LE","article-title":"Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs","volume":"188","author":"Hocke","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.micinf.2018.03.005_bib16","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/infdis\/jiv380","article-title":"Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways","volume":"213","author":"Chu","year":"2016","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib17","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1093\/infdis\/jit504","article-title":"Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis","volume":"209","author":"Zhou","year":"2014","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib18","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S2213-2600(13)70138-3","article-title":"Tropism and innate host responses of a novel avian influenza A H7N9 virus: an analysis of ex-vivo and in-vitro cultures of the human respiratory tract","volume":"1","author":"Chan","year":"2013","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.micinf.2018.03.005_bib19","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.2353\/ajpath.2010.091087","article-title":"Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex\u00a0vivo and in\u00a0vitro cultures of human conjunctiva and respiratory tract","volume":"176","author":"Chan","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.micinf.2018.03.005_bib20","doi-asserted-by":"crossref","first-page":"e00601","DOI":"10.1128\/mBio.00601-13","article-title":"The novel human influenza A (H7N9) virus is naturally adapted to efficient growth in human lung tissue","volume":"4","author":"Knepper","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.micinf.2018.03.005_bib21","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/infdis\/jis455","article-title":"Influenza A viruses target type II pneumocytes in the human lung","volume":"206","author":"Weinheimer","year":"2012","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib22","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1086\/650544","article-title":"2009 pandemic H1N1 influenza virus replicates in human lung tissues","volume":"201","author":"Zhang","year":"2010","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib23","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2353\/ajpath.2010.100115","article-title":"2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States","volume":"177","author":"Shieh","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.micinf.2018.03.005_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.virol.2015.03.037","article-title":"Transcriptional response of human umbilical vein endothelial cell to H9N2 influenza virus infection","volume":"482","author":"Wang","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.micinf.2018.03.005_bib25","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.immuni.2014.02.013","article-title":"Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages","volume":"40","author":"Coulombe","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2018.03.005_bib26","doi-asserted-by":"crossref","first-page":"e29443","DOI":"10.1371\/journal.pone.0029443","article-title":"Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation","volume":"7","author":"Hoeve","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.micinf.2018.03.005_bib27","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1099\/vir.0.82423-0","article-title":"Differential onset of apoptosis in influenza A virus H5N1- and H1N1-infected human blood macrophages","volume":"88","author":"Mok","year":"2007","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri3600","article-title":"Alveolar macrophages: plasticity in a tissue-specific context","volume":"14","author":"Hussell","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib29","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.it.2015.03.005","article-title":"Alveolar macrophages and type I IFN in airway homeostasis and immunity","volume":"36","author":"Divangahi","year":"2015","journal-title":"Trends Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br J Cancer"},{"key":"10.1016\/j.micinf.2018.03.005_bib31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/cdd.2008.150","article-title":"Classification of cell death: recommendations of the nomenclature committee on cell death 2009","volume":"16","author":"Kroemer","year":"2009","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.micinf.2018.03.005_bib32","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3201\/eid1305.060572","article-title":"Apoptosis and pathogenesis of avian influenza A (H5N1) virus in humans","volume":"13","author":"Uiprasertkul","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib33","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.micinf.2018.03.005_bib34","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrm2970","article-title":"Molecular mechanisms of necroptosis: an ordered cellular explosion","volume":"11","author":"Vandenabeele","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.micinf.2018.03.005_bib35","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrmicro3231","article-title":"The co-pathogenesis of influenza viruses with bacteria in the lung","volume":"12","author":"McCullers","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.micinf.2018.03.005_bib36","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1021\/pr300239r","article-title":"Response of primary human airway epithelial cells to influenza infection: a quantitative proteomic study","volume":"11","author":"Kroeker","year":"2012","journal-title":"J\u00a0Proteome Res"},{"key":"10.1016\/j.micinf.2018.03.005_bib37","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1084\/jem.29.6.537","article-title":"Edema of the lungs as a cause of death","volume":"29","author":"Winternitz","year":"1919","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2018.03.005_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1089\/vim.2010.0118","article-title":"Responses of mouse airway epithelial cells and alveolar macrophages to virulent and avirulent strains of influenza A virus","volume":"24","author":"Tate","year":"2011","journal-title":"Viral Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mib.2013.10.007","article-title":"Macrophages clean up: efferocytosis and microbial control","volume":"17","author":"Martin","year":"2014","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.micinf.2018.03.005_bib40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/bse0380009","article-title":"Caspases and apoptosis","volume":"38","author":"Salvesen","year":"2002","journal-title":"Essays Biochem"},{"key":"10.1016\/j.micinf.2018.03.005_bib41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrc776","article-title":"Death and anti-death: tumour resistance to apoptosis","volume":"2","author":"Igney","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.micinf.2018.03.005_bib42","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S1357-2725(00)00048-0","article-title":"Regulation of death receptor-mediated apoptosis pathways","volume":"32","author":"Schmitz","year":"2000","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.micinf.2018.03.005_bib43","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-1-4614-6111-1_6","article-title":"Dying to live: how the death modality of the infected macrophage affects immunity to tuberculosis","volume":"783","author":"Divangahi","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.micinf.2018.03.005_bib44","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature13168","article-title":"Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread","volume":"509","author":"Czuczman","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2018.03.005_bib45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.virusres.2003.08.007","article-title":"Active and inactive influenza virus induction of tumor necrosis factor-alpha and nitric oxide in J774.1 murine macrophages: modulation by interferon-gamma and failure to induce apoptosis","volume":"97","author":"McKinney","year":"2003","journal-title":"Virus Res"},{"key":"10.1016\/j.micinf.2018.03.005_bib46","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1099\/0022-1317-76-11-2869","article-title":"In\u00a0vivo induction of apoptosis by influenza virus","volume":"76","author":"Mori","year":"1995","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib47","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1099\/0022-1317-74-11-2347","article-title":"Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells","volume":"74","author":"Takizawa","year":"1993","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib48","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.arcmed.2009.10.001","article-title":"Comparison of the pathology caused by H1N1, H5N1, and H3N2 influenza viruses","volume":"40","author":"Guarner","year":"2009","journal-title":"Arch Med Res"},{"key":"10.1016\/j.micinf.2018.03.005_bib49","doi-asserted-by":"crossref","first-page":"11294","DOI":"10.1128\/JVI.01192-08","article-title":"H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells","volume":"82","author":"Daidoji","year":"2008","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib50","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ni1303","article-title":"Innate immune recognition of viral infection","volume":"7","author":"Kawai","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib51","doi-asserted-by":"crossref","first-page":"1738237","DOI":"10.1155\/2016\/1738237","article-title":"Influenza A virus and influenza B virus can induce apoptosis via intrinsic or extrinsic pathways and also via NF-kappaB in a time and dose dependent manner","volume":"2016","author":"El-Sayed","year":"2016","journal-title":"Biochem Res Int"},{"key":"10.1016\/j.micinf.2018.03.005_bib52","doi-asserted-by":"crossref","first-page":"6888","DOI":"10.1093\/emboj\/17.23.6888","article-title":"Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling","volume":"17","author":"Balachandran","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.micinf.2018.03.005_bib53","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0092-8674(90)90374-N","article-title":"Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon","volume":"62","author":"Meurs","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2018.03.005_bib54","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1074-7613(00)00014-5","article-title":"Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection","volume":"13","author":"Balachandran","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2018.03.005_bib55","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1128\/JVI.02310-09","article-title":"Semliki forest virus-induced endoplasmic reticulum stress accelerates apoptotic death of mammalian cells","volume":"84","author":"Barry","year":"2010","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib56","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1099\/vir.0.18913-0","article-title":"Influenza A virus-induced apoptosis in bronchiolar epithelial (NCI-H292) cells limits pro-inflammatory cytokine release","volume":"84","author":"Brydon","year":"2003","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib57","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1084\/jem.20140488","article-title":"Long-term survival of influenza virus infected club cells drives immunopathology","volume":"211","author":"Heaton","year":"2014","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2018.03.005_bib58","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1128\/JVI.76.4.1617-1625.2002","article-title":"NS1 protein of influenza A virus down-regulates apoptosis","volume":"76","author":"Zhirnov","year":"2002","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib59","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1128\/JVI.02082-06","article-title":"Influenza A virus NS1 protein activates the PI3K\/Akt pathway to mediate antiapoptotic signaling responses","volume":"81","author":"Ehrhardt","year":"2007","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib60","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1128\/JVI.01712-07","article-title":"Avian influenza virus A\/HK\/483\/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells","volume":"82","author":"Lam","year":"2008","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib61","doi-asserted-by":"crossref","first-page":"e562","DOI":"10.1038\/cddis.2013.89","article-title":"Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein Clusterin","volume":"4","author":"Tripathi","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib62","doi-asserted-by":"crossref","first-page":"e2018","DOI":"10.1038\/cddis.2015.360","article-title":"Nucleoprotein of influenza A virus negatively impacts antiapoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication","volume":"6","author":"Mayank","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib63","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1128\/JVI.02017-12","article-title":"Influenza virus induces apoptosis via BAD-mediated mitochondrial dysregulation","volume":"87","author":"Tran","year":"2013","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib64","doi-asserted-by":"crossref","first-page":"16004","DOI":"10.1074\/jbc.M900146200","article-title":"Bcl-2 expression and p38MAPK activity in cells infected with influenza A virus: impact on virally induced apoptosis and viral replication","volume":"284","author":"Nencioni","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.micinf.2018.03.005_bib65","doi-asserted-by":"crossref","first-page":"8233","DOI":"10.1128\/JVI.02672-08","article-title":"Lack of Bax prevents influenza A virus-induced apoptosis and causes diminished viral replication","volume":"83","author":"McLean","year":"2009","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib66","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1093\/emboj\/cdg279","article-title":"Caspase 3 activation is essential for efficient influenza virus propagation","volume":"22","author":"Wurzer","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.micinf.2018.03.005_bib67","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.chom.2009.09.005","article-title":"Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes","volume":"6","author":"Gannage","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2018.03.005_bib68","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/cdd.2016.19","article-title":"Influenza A virus enhances its propagation through the modulation of Annexin-A1 dependent endosomal trafficking and apoptosis","volume":"23","author":"Arora","year":"2016","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.micinf.2018.03.005_bib69","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.virol.2014.08.007","article-title":"Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276","volume":"468\u2013470","author":"Othumpangat","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.micinf.2018.03.005_bib70","doi-asserted-by":"crossref","first-page":"30931","DOI":"10.1074\/jbc.M403258200","article-title":"NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas\/FasL is crucial for efficient influenza virus propagation","volume":"279","author":"Wurzer","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.micinf.2018.03.005_bib71","doi-asserted-by":"crossref","first-page":"e55321","DOI":"10.1371\/journal.pone.0055321","article-title":"Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza","volume":"8","author":"Fujikura","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2018.03.005_bib72","doi-asserted-by":"crossref","first-page":"20388","DOI":"10.1073\/pnas.0908698106","article-title":"Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome","volume":"106","author":"Iyer","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2018.03.005_bib73","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2018.03.005_bib74","first-page":"143","article-title":"Dengue virus infection induces passive release of high mobility group box 1 protein by epithelial cells","volume":"56","author":"Chen","year":"2008","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.micinf.2018.03.005_bib75","doi-asserted-by":"crossref","first-page":"9953","DOI":"10.1128\/JVI.01562-13","article-title":"Bilateral entry and release of Middle East respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells","volume":"87","author":"Tao","year":"2013","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib76","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1465-9921-6-114","article-title":"Rhinovirus infection induces cytotoxicity and delays wound healing in bronchial epithelial cells","volume":"6","author":"Bossios","year":"2005","journal-title":"Respir Res"},{"key":"10.1016\/j.micinf.2018.03.005_bib77","doi-asserted-by":"crossref","first-page":"9298","DOI":"10.1128\/JVI.76.18.9298-9306.2002","article-title":"Release of macrophage migration inhibitory factor and CXCL8\/interleukin-8 from lung epithelial cells rendered necrotic by influenza A virus infection","volume":"76","author":"Arndt","year":"2002","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib78","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2018.03.005_bib79","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cell.2017.03.020","article-title":"ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences","volume":"169","author":"Gong","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2018.03.005_bib80","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.immuni.2013.02.003","article-title":"Necroptosis: the release of damage-associated molecular patterns and its physiological relevance","volume":"38","author":"Kaczmarek","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2018.03.005_bib81","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","article-title":"Phosphorylation-driven assembly of the RIP1\u2013RIP3 complex regulates programmed necrosis and virus-induced inflammation","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2018.03.005_bib82","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.chom.2015.01.003","article-title":"Herpes simplex virus suppresses necroptosis in human cells","volume":"17","author":"Guo","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2018.03.005_bib83","doi-asserted-by":"crossref","first-page":"16966","DOI":"10.1074\/jbc.C800051200","article-title":"Cytomegalovirus m45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1","volume":"283","author":"Upton","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.micinf.2018.03.005_bib84","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.chom.2016.05.011","article-title":"RIPK3 activates parallel pathways of MLKL-driven necroptosis and FADD-mediated apoptosis to protect against influenza A virus","volume":"20","author":"Nogusa","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2018.03.005_bib85","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: host cell death and inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.micinf.2018.03.005_bib86","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aag2045","article-title":"ZBP1\/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways","volume":"1","author":"Kuriakose","year":"2016","journal-title":"Sci Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib87","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1084\/jem.20081667","article-title":"Inflammasome recognition of influenza virus is essential for adaptive immune responses","volume":"206","author":"Ichinohe","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2018.03.005_bib88","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1513\/pats.200601-006AW","article-title":"Remodeling in asthma and chronic obstructive pulmonary disease","volume":"3","author":"Postma","year":"2006","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.micinf.2018.03.005_bib89","doi-asserted-by":"crossref","first-page":"e47323","DOI":"10.1371\/journal.pone.0047323","article-title":"Influenza infects lung microvascular endothelium leading to microvascular leak: role of apoptosis and claudin-5","volume":"7","author":"Armstrong","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2018.03.005_bib90","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1128\/JVI.06348-11","article-title":"Human pulmonary microvascular endothelial cells support productive replication of highly pathogenic avian influenza viruses: possible involvement in the pathogenesis of human H5N1 virus infection","volume":"86","author":"Zeng","year":"2012","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib91","doi-asserted-by":"crossref","first-page":"7613","DOI":"10.1128\/JVI.00553-10","article-title":"Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection","volume":"84","author":"Cilloniz","year":"2010","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib92","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1086\/600035","article-title":"Human infection with highly pathogenic avian influenza A (H5N1) virus: review of clinical issues","volume":"49","author":"Uyeki","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib93","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0140-6736(07)61515-3","article-title":"H5N1 infection of the respiratory tract and beyond: a molecular pathology study","volume":"370","author":"Gu","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2018.03.005_bib94","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.coi.2011.07.016","article-title":"The pathogenesis of influenza virus infections: the contributions of virus and host factors","volume":"23","author":"Fukuyama","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib95","doi-asserted-by":"crossref","first-page":"e1000115","DOI":"10.1371\/journal.ppat.1000115","article-title":"H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice","volume":"4","author":"Perrone","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2018.03.005_bib96","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.1119392","article-title":"Characterization of the reconstructed 1918 Spanish influenza pandemic virus","volume":"310","author":"Tumpey","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.micinf.2018.03.005_bib97","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0140-6736(13)60903-4","article-title":"Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome","volume":"381","author":"Chen","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2018.03.005_bib98","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.4049\/jimmunol.1302992","article-title":"Lymphopenia associated with highly virulent H5N1 virus infection due to plasmacytoid dendritic cell-mediated apoptosis of T cells","volume":"192","author":"Boonnak","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib99","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1182\/blood.V93.7.2395","article-title":"Influenza A virus accelerates neutrophil apoptosis and markedly potentiates apoptotic effects of bacteria","volume":"93","author":"Colamussi","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2018.03.005_bib100","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.4049\/jimmunol.179.8.5220","article-title":"High susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-alpha and TLR ligands","volume":"179","author":"Thitithanyanont","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib101","doi-asserted-by":"crossref","first-page":"e1001304","DOI":"10.1371\/journal.ppat.1001304","article-title":"Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice","volume":"7","author":"Seo","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2018.03.005_bib102","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00005792-200303000-00003","article-title":"Severe autoimmune cytopenias in treatment-naive hepatitis C virus infection: clinical description of 35 cases","volume":"82","author":"Ramos-Casals","year":"2003","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.micinf.2018.03.005_bib103","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1016\/j.celrep.2016.11.031","article-title":"Chronic infection depletes hematopoietic stem cells through stress-induced terminal differentiation","volume":"17","author":"Matatall","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.micinf.2018.03.005_bib104","doi-asserted-by":"crossref","first-page":"e1002099","DOI":"10.1371\/journal.ppat.1002099","article-title":"Highly pathogenic avian influenza virus H5N1 infects alveolar macrophages without virus production or excessive TNF-alpha induction","volume":"7","author":"van Riel","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2018.03.005_bib105","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1128\/JVI.00291-10","article-title":"Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice","volume":"84","author":"Tate","year":"2010","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib106","doi-asserted-by":"crossref","first-page":"e1004053","DOI":"10.1371\/journal.ppat.1004053","article-title":"Alveolar macrophages are essential for protection from respiratory failure and associated morbidity following influenza virus infection","volume":"10","author":"Schneider","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2018.03.005_bib107","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/ni.1637","article-title":"A\u00a0critical function for CD200 in lung immune homeostasis and the severity of influenza infection","volume":"9","author":"Snelgrove","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib108","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/icb.2016.97","article-title":"The contributions of lung macrophage and monocyte heterogeneity to influenza pathogenesis","volume":"95","author":"Duan","year":"2017","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.micinf.2018.03.005_bib109","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.antiviral.2011.08.022","article-title":"GM-CSF modulates pulmonary resistance to influenza A infection","volume":"92","author":"Sever-Chroneos","year":"2011","journal-title":"Antiviral Res"},{"key":"10.1016\/j.micinf.2018.03.005_bib110","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.4049\/jimmunol.1300014","article-title":"Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections","volume":"191","author":"Ghoneim","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib111","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2013.04.004","article-title":"Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes","volume":"38","author":"Hashimoto","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2018.03.005_bib112","doi-asserted-by":"crossref","first-page":"17999","DOI":"10.1038\/srep17999","article-title":"Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation","volume":"5","author":"Chang","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.micinf.2018.03.005_bib113","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1099\/jgv.0.000240","article-title":"Susceptibility of bone marrow-derived macrophages to influenza virus infection is dependent on macrophage phenotype","volume":"96","author":"Campbell","year":"2015","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib114","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nm1201-1306","article-title":"A\u00a0novel influenza A virus mitochondrial protein that induces cell death","volume":"7","author":"Chen","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.micinf.2018.03.005_bib115","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1099\/vir.0.007518-0","article-title":"Differential regulation of antiviral and proinflammatory cytokines and suppression of Fas-mediated apoptosis by NS1 of H9N2 avian influenza virus in chicken macrophages","volume":"90","author":"Xing","year":"2009","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib116","doi-asserted-by":"crossref","first-page":"E2110","DOI":"10.1073\/pnas.1322118111","article-title":"NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein","volume":"111","author":"Jaworska","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2018.03.005_bib117","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.chom.2007.09.001","article-title":"Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia","volume":"2","author":"McAuley","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2018.03.005_bib118","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1128\/JVI.01987-10","article-title":"A\u00a0single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in\u00a0vivo","volume":"85","author":"Conenello","year":"2011","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib119","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1128\/JVI.78.12.6304-6312.2004","article-title":"PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes","volume":"78","author":"Chanturiya","year":"2004","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2018.03.005_bib120","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1371\/journal.ppat.0010004","article-title":"Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1","volume":"1","author":"Zamarin","year":"2005","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2018.03.005_bib121","unstructured":"William JJ, Lea B, Alaina M, Rebecca EO-D, Mark TK, Claudia J, et\u00a0al. Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury."},{"key":"10.1016\/j.micinf.2018.03.005_bib122","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1084\/jem.20140825","article-title":"Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes","volume":"212","author":"Goritzka","year":"2015","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2018.03.005_bib123","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00430-010-0173-y","article-title":"Comparison of pro-inflammatory cytokine expression and cellular signal transduction in human macrophages infected with different influenza A viruses","volume":"200","author":"Geiler","year":"2011","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib124","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1177\/1753425911410998","article-title":"Apoptosis induced by avian H5N1 virus in human monocyte-derived macrophages involves TRAIL-inducing caspase-10 activation","volume":"18","author":"Ekchariyawat","year":"2012","journal-title":"Innate Immun"},{"key":"10.1016\/j.micinf.2018.03.005_bib125","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201012-2036OC","article-title":"GM-CSF in the lung protects against lethal influenza infection","volume":"184","author":"Huang","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.micinf.2018.03.005_bib126","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.antiviral.2013.05.007","article-title":"Type I interferon limits influenza virus-induced acute lung injury by regulation of excessive inflammation in mice","volume":"99","author":"Arimori","year":"2013","journal-title":"Antiviral Res"},{"key":"10.1016\/j.micinf.2018.03.005_bib127","doi-asserted-by":"crossref","first-page":"e1001081","DOI":"10.1371\/journal.pcbi.1001081","article-title":"Effect of 1918 PB1-F2 expression on influenza A virus infection kinetics","volume":"7","author":"Smith","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.micinf.2018.03.005_bib128","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.chom.2013.12.003","article-title":"Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival","volume":"15","author":"Rodrigue-Gervais","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2018.03.005_bib129","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/ni.3015","article-title":"RNA viruses promote activation of the NLRP3 inflammasome through a RIP1\u2013RIP3\u2013DRP1 signaling pathway","volume":"15","author":"Wang","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib130","doi-asserted-by":"crossref","first-page":"e1006326","DOI":"10.1371\/journal.ppat.1006326","article-title":"RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection","volume":"13","author":"Downey","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2018.03.005_bib131","doi-asserted-by":"crossref","first-page":"E3206","DOI":"10.1073\/pnas.1407068111","article-title":"Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages","volume":"111","author":"McComb","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2018.03.005_bib132","doi-asserted-by":"crossref","first-page":"E3109","DOI":"10.1073\/pnas.1301218110","article-title":"Interferon-induced RIP1\/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases","volume":"110","author":"Thapa","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2018.03.005_bib133","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/ni.2397","article-title":"Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium","volume":"13","author":"Robinson","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib134","doi-asserted-by":"crossref","first-page":"31268","DOI":"10.1074\/jbc.M113.462341","article-title":"Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL","volume":"288","author":"Kaiser","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.micinf.2018.03.005_bib135","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nature06013","article-title":"DAI (DLM-1\/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response","volume":"448","author":"Takaoka","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2018.03.005_bib136","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.it.2010.11.004","article-title":"Inflammasomes as mediators of immunity against influenza virus","volume":"32","author":"Pang","year":"2011","journal-title":"Trends Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib137","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.4049\/jimmunol.177.3.1817","article-title":"Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules","volume":"177","author":"Herold","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib138","doi-asserted-by":"crossref","first-page":"e1003188","DOI":"10.1371\/journal.ppat.1003188","article-title":"Macrophage-expressed IFN-beta contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia","volume":"9","author":"Hogner","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2018.03.005_bib139","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.4049\/jimmunol.178.4.2448","article-title":"Evidence for phagocytosis of influenza virus-infected, apoptotic cells by neutrophils and macrophages in mice","volume":"178","author":"Hashimoto","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2018.03.005_bib140","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S1534-5807(03)00090-X","article-title":"Annexin I is an endogenous ligand that mediates apoptotic cell engulfment","volume":"4","author":"Arur","year":"2003","journal-title":"Dev Cell"},{"key":"10.1016\/j.micinf.2018.03.005_bib141","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/sj.bjp.0706730","article-title":"Impaired phagocytic mechanism in annexin 1 null macrophages","volume":"148","author":"Yona","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.micinf.2018.03.005_bib142","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/infdis\/jiw127","article-title":"Formyl peptide receptor 2 plays a deleterious role during influenza A virus infections","volume":"214","author":"Tcherniuk","year":"2016","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib143","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1086\/432008","article-title":"Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A\/Vietnam\/1203\/04 influenza virus in mice","volume":"192","author":"Yen","year":"2005","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2018.03.005_bib144","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.antiviral.2017.03.002","article-title":"Aerosol administration increases the efficacy of oseltamivir for the treatment of mice infected with influenza viruses","volume":"142","author":"Leyva-Grado","year":"2017","journal-title":"Antiviral Res"},{"key":"10.1016\/j.micinf.2018.03.005_bib145","first-page":"CD008965","article-title":"Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children","author":"Jefferson","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.micinf.2018.03.005_bib146","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(14)62449-1","article-title":"Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials","volume":"385","author":"Dobson","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2018.03.005_bib147","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.chest.2016.11.012","article-title":"Efficacy of clarithromycin\u2013naproxen\u2013oseltamivir combination in the treatment of patients hospitalized for influenza A (H3N2) infection: an open-label randomized, controlled, phase IIb\/III trial","volume":"151","author":"Hung","year":"2017","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.micinf.2018.03.005_bib148","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1172\/JCI77014","article-title":"Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection","volume":"125","author":"Tzelepis","year":"2015","journal-title":"J Clin Invest"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457918300935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457918300935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:38:41Z","timestamp":1761143921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457918300935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":148,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S1286457918300935"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2018.03.005","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissecting host cell death programs in the pathogenesis of influenza","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2018.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}