{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T21:25:39Z","timestamp":1775942739094,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"8-9","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772248"],"award-info":[{"award-number":["81772248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["1808085QH255"],"award-info":[{"award-number":["1808085QH255"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.micinf.2019.04.003","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T15:03:13Z","timestamp":1555686193000},"page":"361-367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["VraSR has an important role in immune evasion of Staphylococcus aureus with low level vancomycin resistance"],"prefix":"10.1016","volume":"21","author":[{"given":"Caihong","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjiao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2019.04.003_bib1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowey","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.micinf.2019.04.003_bib2","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1093\/jac\/dkr278","article-title":"Is methicillin-resistant Staphylococcus aureus replacing methicillin-susceptible S.\u00a0aureus?","volume":"66","author":"Mostofsky","year":"2011","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.micinf.2019.04.003_bib3","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.3389\/fmicb.2016.01601","article-title":"Molecular events for promotion of vancomycin resistance in vancomycin intermediate Staphylococcus aureus","volume":"7","author":"Hu","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.micinf.2019.04.003_bib4","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.meegid.2013.03.047","article-title":"The evolution of vancomycin intermediate Staphylococcus aureus (VISA) and heterogenous-VISA","volume":"21","author":"Howden","year":"2014","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.micinf.2019.04.003_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2180-8-39","article-title":"Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia","volume":"8","author":"Howden","year":"2008","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.micinf.2019.04.003_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1128\/CMR.00042-09","article-title":"Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications","volume":"23","author":"Howden","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.micinf.2019.04.003_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.biochem.69.1.183","article-title":"Two-compnent signal tranduction","volume":"69","author":"Stock","year":"2000","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.micinf.2019.04.003_bib8","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1128\/JB.188.3.1120-1133.2006","article-title":"Overexpression of genes of the cell wall stimulon in clinical isolates of staphylococcus aureus exhibiting vancomycin-intermediate-S.\u00a0aureus-type resistance to vancomycin","volume":"188","author":"McAleese","year":"2006","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.micinf.2019.04.003_bib9","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1128\/AAC.49.8.3404-3413.2005","article-title":"DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus","volume":"49","author":"Cui","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.micinf.2019.04.003_bib10","doi-asserted-by":"crossref","first-page":"12354","DOI":"10.1074\/jbc.M710010200","article-title":"A\u00a0close-up view of the VraSR two-component system. A mediator of Staphylococcus aureus response to cell wall damage","volume":"283","author":"Belcheva","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.micinf.2019.04.003_bib11","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1006\/bbrc.2000.2277","article-title":"Identification of the up- and down-regulated genes in vancomycin-resistant Staphylococcus aureus strains Mu3 and Mu50 by cDNA differential hybridization method","volume":"269","author":"Kuroda","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.micinf.2019.04.003_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02740-16","article-title":"VraR binding to the promoter region of agr inhibits its function in VISA\/h-VISA","volume":"61","author":"Dai","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.micinf.2019.04.003_bib13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.plasmid.2005.05.005","article-title":"Allelic replacement in Staphylococcus aureus with inducible counter-selection[J]","volume":"55","author":"Bae","year":"2006","journal-title":"Plasmid"},{"key":"10.1016\/j.micinf.2019.04.003_bib14","first-page":"105","article-title":"Optimal conditions for the opsonophagocytosis test with Streptococcus pneumoniae serotypes 3, 6A, 7F and 19F and human granulocytes","volume":"94","author":"Silvennoinen-Kassinen","year":"1986","journal-title":"Acta Pathol Microbiol Immunol Scand C"},{"issue":"10","key":"10.1016\/j.micinf.2019.04.003_bib15","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1073\/pnas.092148299","article-title":"Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expression","volume":"99","author":"Kobayashi","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.micinf.2019.04.003_bib16","first-page":"43","article-title":"Phagocytosis of Staphylococcus aureus by human leukocytes: quantitation by a flow cytometric and a microbiological method","volume":"92","author":"Bass\u00f8e","year":"1984","journal-title":"Acta Pathol Microbiol Immunol Scand C"},{"key":"10.1016\/j.micinf.2019.04.003_bib17","first-page":"639","article-title":"Phagocytosis and killing of Staphylococcus aureus by human neutrophils","volume":"6","author":"Lu","year":"2014","journal-title":"J\u00a0Innate Immun"},{"key":"10.1016\/j.micinf.2019.04.003_bib18","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1099\/mic.0.057448-0","article-title":"The two-component system Ihk\/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism","volume":"158","author":"Han","year":"2012","journal-title":"Microbiology"},{"key":"10.1016\/j.micinf.2019.04.003_bib19","doi-asserted-by":"crossref","first-page":"7906","DOI":"10.1128\/AAC.00568-15","article-title":"Methicillin-resistant Staphylococcus aureus grown on vancomycin-supplemented screening agar displays enhanced biofilm formation","volume":"59","author":"Chang","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.micinf.2019.04.003_bib20","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1086\/596629","article-title":"Clinical features of heteroresistant vancomycin intermediate Staphylococcus aureus bacteremia versus those of methicillin-resistant S.\u00a0aureus bacteremia","volume":"199","author":"Maor","year":"2009","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2019.04.003_bib21","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1128\/IAI.00718-09","article-title":"Yersinia pestis two-component gene regulatory systems promote survival in human neutrophils","volume":"78","author":"O'Loughlin","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2019.04.003_bib22","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1086\/598967","article-title":"The SaeR\/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus","volume":"199","author":"Voyich","year":"2009","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2019.04.003_bib23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fcimb.2017.00204","article-title":"The SaeRS two-component system controls survival of Staphylococcus aureus in human blood through regulation of coagulase","volume":"7","author":"Guo","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"10.1016\/j.micinf.2019.04.003_bib24","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1080\/21505594.2018.1428519","article-title":"The VraSR regulatory system contributes to virulence in Streptococcus suis via resistance to innate immune defenses","volume":"9","author":"Chang","year":"2018","journal-title":"Virulence"},{"key":"10.1016\/j.micinf.2019.04.003_bib25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4049\/jimmunol.127.1.84","article-title":"Suppression of phagocytosis and chemotaxis by cell wall components of Staphylococcus aureus","volume":"127","author":"Musher","year":"1981","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2019.04.003_bib26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.chom.2009.12.008","article-title":"Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1\u03b2 secretion","volume":"7","author":"Shimada","year":"2010","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.micinf.2019.04.003_bib27","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1046\/j.1365-2958.2003.03599.x","article-title":"Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus","volume":"49","author":"Kuroda","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micinf.2019.04.003_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00281-011-0295-3","article-title":"Neutrophils in innate host defense against Staphylococcus aureus infections","volume":"34","author":"Rigby","year":"2012","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.micinf.2019.04.003_bib29","first-page":"353","article-title":"Methionine sulfoxide reductases protect against oxidative stress in Staphylococcus aureus encountering exogenous oxidants and human neutrophils","volume":"6","author":"Pang","year":"2014","journal-title":"J\u00a0Innate Immun"},{"key":"10.1016\/j.micinf.2019.04.003_bib30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1365-3164.2009.00825.x","article-title":"Colonization and infection of the human host by staphylococci: adhesion, survival and immune evasion","volume":"20","author":"Foster","year":"2009","journal-title":"Vet Dermatol"},{"key":"10.1016\/j.micinf.2019.04.003_bib31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0945-053X(99)00025-6","article-title":"Role of fibronectin-binding MSCRAMMs in bacterial adherence and entry into mammalian cells","volume":"18","author":"Joh","year":"1999","journal-title":"Matrix Biol"},{"key":"10.1016\/j.micinf.2019.04.003_bib32","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.3389\/fmicb.2017.02433","article-title":"Staphylococcal adhesion and host cell invasion: fibronectin-binding and other mechanisms","volume":"8","author":"Josse","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.micinf.2019.04.003_bib33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1574-6968.2006.00229.x","article-title":"Clumping factor A of Staphylococcus aureus inhibits phagocytosis by human polymorphonuclear leucocytes","volume":"258","author":"Higgins","year":"2006","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.micinf.2019.04.003_bib34","doi-asserted-by":"crossref","first-page":"6585","DOI":"10.4049\/jimmunol.1002794","article-title":"Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in\u00a0vivo","volume":"186","author":"Thurlow","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2019.04.003_bib35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: survival mechanisms of clinically relevant microorganisms","volume":"15","author":"Donlan","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.micinf.2019.04.003_bib36","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilms: a common cause of persistent infections","volume":"284","author":"Costerton","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.micinf.2019.04.003_bib37","first-page":"37","article-title":"Hiding in plain sight: interplay between Staphylococcal biofilms and host immunity","volume":"5","author":"Scherr","year":"2014","journal-title":"Front Microbiol"},{"key":"10.1016\/j.micinf.2019.04.003_bib38","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.3389\/fmicb.2015.01174","article-title":"Quorum-sensing regulation in staphylococci-an overview","volume":"6","author":"Le","year":"2015","journal-title":"Front Microbiol"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457919300504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457919300504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T22:08:36Z","timestamp":1694815716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457919300504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":38,"journal-issue":{"issue":"8-9","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S1286457919300504"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2019.04.003","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VraSR has an important role in immune evasion of Staphylococcus aureus with low level vancomycin resistance","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2019.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Masson SAS on behalf of Institut Pasteur.","name":"copyright","label":"Copyright"}]}}