{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:44:09Z","timestamp":1779324249193,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.micinf.2019.08.002","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T11:10:21Z","timestamp":1566040221000},"page":"40-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ripk3 licenced protection against microbial infection in the absence of Caspase1-11 inflammasome"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4669-5656","authenticated-orcid":false,"given":"Bojan","family":"Shutinoski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajen","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianna J.","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Schlossmacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subash","family":"Sad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2019.08.002_bib1","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1038\/cdd.2016.51","article-title":"K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in\u00a0vivo","volume":"23","author":"Shutinoski","year":"2016","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.micinf.2019.08.002_bib2","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1016\/S0140-6736(11)61752-2","article-title":"Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa","volume":"379","author":"Feasey","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2019.08.002_bib3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.micinf.2016.02.001","article-title":"New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence","volume":"18","author":"Nieto","year":"2016","journal-title":"Microb Infect"},{"key":"10.1016\/j.micinf.2019.08.002_bib4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1286-4579(00)00273-2","article-title":"Salmonella pathogenicity islands: big virulence in small packages","volume":"2","author":"Marcus","year":"2000","journal-title":"Microb Infect"},{"key":"10.1016\/j.micinf.2019.08.002_bib5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.chom.2017.07.009","article-title":"Salmonella SPI-2 type III secretion system effectors: molecular mechanisms and physiological consequences","volume":"22","author":"Jennings","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2019.08.002_bib6","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1111\/j.1462-5822.2011.01701.x","article-title":"Salmonella effectors: important players modulating host cell function during infection","volume":"13","author":"Agbor","year":"2011","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.micinf.2019.08.002_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2958.1996.tb02497.x","article-title":"Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cells","volume":"20","author":"Stein","year":"1996","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micinf.2019.08.002_bib8","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1126\/science.1230751","article-title":"Caspase-11 protects against bacteria that escape the vacuole","volume":"339","author":"Aachoui","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.micinf.2019.08.002_bib9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1006\/smim.1998.0143","article-title":"An innate sense of danger","volume":"10","author":"Matzinger","year":"1998","journal-title":"Semin Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/smim.2000.0230","article-title":"How does the immune system distinguish self from nonself?","volume":"12","author":"Medzhitov","year":"2000","journal-title":"Semin Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib11","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nri.2017.25","article-title":"Multi-receptor detection of individual bacterial products by the innate immune system","volume":"17","author":"Kieser","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib12","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1128\/IAI.70.3.1033-1041.2002","article-title":"Toll receptors: a central element in innate immune responses","volume":"70","author":"Vasselon","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2019.08.002_bib13","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/ni1411","article-title":"The TREM receptor family and signal integration","volume":"7","author":"Klesney-Tait","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib14","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/414916a","article-title":"Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage","volume":"414","author":"Ohta","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2019.08.002_bib15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-cellbio-101011-155745","article-title":"Inflammasomes and their roles in health and disease","volume":"28","author":"Lamkanfi","year":"2012","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.micinf.2019.08.002_bib17","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature10394","article-title":"Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity","volume":"477","author":"Kofoed","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2019.08.002_bib18","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ni1344","article-title":"Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf","volume":"7","author":"Miao","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ni1346","article-title":"Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in Salmonella-infected macrophages","volume":"7","author":"Franchi","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib20","doi-asserted-by":"crossref","first-page":"14408","DOI":"10.1073\/pnas.1306376110","article-title":"Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation","volume":"110","author":"Yang","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2019.08.002_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/imr.12293","article-title":"The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus","volume":"265","author":"Zhao","year":"2015","journal-title":"Immunol Rev"},{"key":"10.1016\/j.micinf.2019.08.002_bib22","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1128\/IAI.00417-06","article-title":"Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection","volume":"74","author":"Raupach","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2019.08.002_bib23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nrm.2016.149","article-title":"Necroptosis in development, inflammation and disease","volume":"18","author":"Weinlich","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.micinf.2019.08.002_bib24","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1038\/cti.2016.83","article-title":"Caspase-8: not so silently deadly","volume":"6","author":"Feltham","year":"2017","journal-title":"Clin Transl Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.immuni.2017.06.001","article-title":"MLKL, the protein that mediates necroptosis, also regulates endosomal trafficking and extracellular vesicle generation","volume":"47","author":"Yoon","year":"2017","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.micinf.2019.08.002_bib26","article-title":"Necroptosis: MLKL polymerization","volume":"4","author":"Johnston","year":"2018","journal-title":"J\u00a0Nat Sci"},{"key":"10.1016\/j.micinf.2019.08.002_bib27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.immuni.2012.01.012","article-title":"Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation","volume":"36","author":"Vince","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2019.08.002_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2012.09.015","article-title":"Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome","volume":"38","author":"Kang","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2019.08.002_bib29","doi-asserted-by":"crossref","first-page":"7515","DOI":"10.1038\/ncomms8515","article-title":"Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3","volume":"6","author":"Kang","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.micinf.2019.08.002_bib30","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.4049\/jimmunol.1402167","article-title":"A\u00a0RIPK3-caspase 8 complex mediates atypical pro-IL-1\u03b2 processing","volume":"194","author":"Moriwaki","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib31","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/ni.2397","article-title":"Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium","volume":"13","author":"Robinson","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib32","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1038\/cdd.2017.112","article-title":"Culling of APCs by inflammatory cell death pathways restricts TIM3 and PD-1 expression and promotes the survival of primed CD8 T cells","volume":"24","author":"Patel","year":"2017","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.micinf.2019.08.002_bib33","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.celrep.2014.06.028","article-title":"The neutrophil NLRC4 inflammasome selectively promotes IL-1\u03b2 maturation without pyroptosis during acute Salmonella challenge","volume":"8","author":"Chen","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.micinf.2019.08.002_bib34","doi-asserted-by":"crossref","first-page":"18055","DOI":"10.1073\/pnas.1109176108","article-title":"Inflammasome activation and IL-1\u03b2 target IL-1\u03b1 for secretion as opposed to surface expression","volume":"108","author":"Fettelschoss","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2019.08.002_bib35","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4161\/viru.21087","article-title":"Salmonella enterica serovars Typhimurium and Typhi as model organisms: revealing paradigm of host-pathogen interactions","volume":"3","author":"Garai","year":"2012","journal-title":"Virulence"},{"key":"10.1016\/j.micinf.2019.08.002_bib36","doi-asserted-by":"crossref","first-page":"775","DOI":"10.4161\/21505594.2014.960726","article-title":"What is a pathogen? Toward a process view of host-parasite interactions","volume":"5","author":"M\u00e9thot","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.micinf.2019.08.002_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/078538902317338580","article-title":"What is a pathogen?","volume":"34","author":"Casadevall","year":"2002","journal-title":"Ann Med"},{"key":"10.1016\/j.micinf.2019.08.002_bib38","first-page":"689","article-title":"Mode of transmission and histology of M.\u00a0leprae infection in nude mice","volume":"71","author":"McDermott-Lancaster","year":"1990","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.micinf.2019.08.002_bib39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib40","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3389\/fimmu.2014.00309","article-title":"Emerging concepts about NAIP\/NLRC4 inflammasomes","volume":"5","author":"Lage","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib41","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2019.08.002_bib42","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2019.08.002_bib43","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1126\/science.1194598","article-title":"Salmonella pathogenesis and processing of secreted effectors by caspase-3","volume":"330","author":"Srikanth","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.micinf.2019.08.002_bib44","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1038\/mi.2017.12","article-title":"Bcl-xL mediates RIPK3-dependent necrosis in M.\u00a0tuberculosis-infected macrophages","volume":"10","author":"Zhao","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib45","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.4049\/jimmunol.1301581","article-title":"Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1\u03b2 production","volume":"191","author":"Man","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2019.08.002_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006502","article-title":"Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5\/NLRC4\/ASC inflammasome","volume":"13","author":"Mascarenhas","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2019.08.002_bib47","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1073\/pnas.1403477111","article-title":"Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death","volume":"111","author":"Weng","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2019.08.002_bib48","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1074-7613(00)80609-3","article-title":"Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas\/Apo1, and DR3 and is lethal prenatally","volume":"9","author":"Varfolomeev","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2019.08.002_bib49","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature09857","article-title":"RIP3 mediates the embryonic lethality of caspase-8-deficient mice","volume":"471","author":"Kaiser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2019.08.002_bib50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature09852","article-title":"Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis","volume":"471","author":"Oberst","year":"2011","journal-title":"Nature"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457919300851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457919300851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:37:25Z","timestamp":1761143845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457919300851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S1286457919300851"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2019.08.002","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ripk3 licenced protection against microbial infection in the absence of Caspase1-11 inflammasome","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2019.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}