{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:16:09Z","timestamp":1786994169941,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":395,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.micinf.2020.04.007","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T16:57:27Z","timestamp":1588006647000},"page":"489-499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Xanthenedione (and intermediates involved in their synthesis) inhibit Zika virus migration to the central nervous system in murine neonatal models"],"prefix":"10.1016","volume":"22","author":[{"given":"\u00cdtalo Esposti","family":"Poly da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milene","family":"Lopes da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Sousa","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edjon Gon\u00e7alves","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cec\u00edlia","family":"Brangioni de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Silva de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Fl\u00e1via","family":"Costa da Silveira Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio","family":"Marques de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Canedo da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3bson Ricardo","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2275-5768","authenticated-orcid":false,"given":"S\u00e9rgio","family":"Oliveira de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2020.04.007_bib1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. I. Isolations and serological specificity","volume":"46","author":"Dick","year":"1952","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.micinf.2020.04.007_bib2","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"Zika virus outbreak on Yap Island, Federated States OF Micronesia","volume":"360","author":"Duffy","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.micinf.2020.04.007_bib3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1590\/0074-02760150192","article-title":"First report of autochthonous transmission of Zika virus in Brazil","volume":"110","author":"Zanluca","year":"2015","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.micinf.2020.04.007_bib4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0140-6736(16)00257-9","article-title":"Concern over Zika virus grips the world","volume":"387","author":"Samarasekera","year":"2016","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.micinf.2020.04.007_bib5","series-title":"SVS\/MS","first-page":"1","article-title":"Boletim epidemiol\u00f3gico vol. 48 - n\u00ba 44 - semana epidemiol\u00f3gica 49 de 2017","author":"SVS\/MS","year":"2017"},{"key":"10.1016\/j.micinf.2020.04.007_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/JVI.72.1.73-83.1998","article-title":"Phylogeny of the genus Flavivirus","volume":"72","author":"Kuno","year":"1998","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2020.04.007_bib7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.chom.2016.04.006","article-title":"From mosquitos to humans: genetic evolution of Zika virus","volume":"19","author":"Wang","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2020.04.007_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00705-006-0903-z","article-title":"Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses","volume":"152","author":"Kuno","year":"2007","journal-title":"Arch Virol"},{"key":"10.1016\/j.micinf.2020.04.007_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005048","article-title":"Full genome sequence and sfRNA interferon antagonist activity of Zika virus from recife, Brazil","volume":"10","author":"Donald","year":"2016","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.micinf.2020.04.007_bib10","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.chom.2016.04.013","article-title":"Structures of the Zika virus envelope protein and its complex with a Flavivirus broadly protective antibody","volume":"19","author":"Dai","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2020.04.007_bib11","series-title":"WHO statement on the first meeting of the International Health Regulations (2005) (IHR 2005) Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformations","author":"WHO","year":"2016"},{"key":"10.1016\/j.micinf.2020.04.007_bib12","doi-asserted-by":"crossref","first-page":"i1062","DOI":"10.1136\/bmj.i1062","article-title":"Zika virus: management of infection and risk","volume":"352","author":"Ahmad","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.micinf.2020.04.007_bib13","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2014.19.9.20720","article-title":"Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013","volume":"19","author":"Oehler","year":"2014","journal-title":"Euro Surveill : Bull Eur les Maladies Transmissibles Eur Commun Dis Bull"},{"key":"10.1016\/j.micinf.2020.04.007_bib14","first-page":"9","article-title":"Boletim Epidemiol\u00f3gico - monitoramento integrado de altera\u00e7\u00f5es no crescimento e desenvolvimento relacionadas \u00e0 infec\u00e7\u00e3o pelo v\u00edrus Zika e outras etiologias infecciosas, at\u00e9 a Semana Epidemiol\u00f3gica 20\/2017","author":"SVS\/MS","year":"2017"},{"key":"10.1016\/j.micinf.2020.04.007_bib15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/uog.15831","article-title":"Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound in obstetrics & gynecology","volume":"47","author":"Oliveira Melo","year":"2016","journal-title":"Off J Int Soc Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.micinf.2020.04.007_bib16","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in rio de Janeiro","volume":"375","author":"Brasil","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.micinf.2020.04.007_bib17","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3201\/eid2208.160496","article-title":"Time lags between exanthematous illness attributed to Zika virus, guillain-barre syndrome, and microcephaly, salvador, Brazil","volume":"22","author":"Paploski","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.micinf.2020.04.007_bib18","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0140-6736(16)00006-4","article-title":"Zika virus in Brazil and macular atrophy in a child with microcephaly","volume":"387","author":"Ventura","year":"2016","journal-title":"Lancet (London, England)"},{"issue":"3","key":"10.1016\/j.micinf.2020.04.007_bib19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/14787210.2018.1438265","article-title":"What we know and what we don\u2019t know about perinatal Zika virus infection: a systematic review","volume":"16","author":"Soriano-Arandes","year":"2018","journal-title":"Expert Rev Anti-infect Ther"},{"key":"10.1016\/j.micinf.2020.04.007_bib20","series-title":"The race to find antivirals for Zika virus","volume":"vol. 61","author":"Saiz","year":"2017"},{"issue":"1","key":"10.1016\/j.micinf.2020.04.007_bib21","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.arabjc.2017.09.001","article-title":"Synthesis and special characterization through X-ray analysis of 1,8-dioxooctahydroxanthenes","volume":"13","author":"da Silva","year":"2017","journal-title":"Arabian J Chem"},{"key":"10.1016\/j.micinf.2020.04.007_bib22","first-page":"1","article-title":"Naturally occurring xanthones: chemistry and biology","volume":"2013","author":"Negi","year":"2013","journal-title":"J\u00a0Appl Chem"},{"key":"10.1016\/j.micinf.2020.04.007_bib23","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.3382\/ps.2012-02468","article-title":"Antiviral activity and mode of action of extracts from neem seed kernel against duck plague virus in\u00a0vitro 1","volume":"91","author":"Xu","year":"2012","journal-title":"Poultry Sci"},{"issue":"65","key":"10.1016\/j.micinf.2020.04.007_bib24","first-page":"3564","article-title":"Whole animal perfusion fixation for rodents","author":"Gage","year":"2012","journal-title":"JoVE\u202f: JoVE"},{"key":"10.1016\/j.micinf.2020.04.007_bib25","doi-asserted-by":"crossref","first-page":"32713","DOI":"10.1038\/srep32713","article-title":"ZikaVR: an integrated Zika virus resource for genomics, proteomics, phylogenetic and therapeutic analysis","volume":"6","author":"Gupta","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.micinf.2020.04.007_bib26","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1523\/JNEUROSCI.3124-16.2017","article-title":"Zika virus targeting in the developing brain","volume":"37","author":"van den Pol","year":"2017","journal-title":"J\u00a0Neurosci : Off J Soc Neurosci"},{"key":"10.1016\/j.micinf.2020.04.007_bib27","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/S0140-6736(16)00651-6","article-title":"Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study","volume":"387","author":"Cauchemez","year":"2016","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.micinf.2020.04.007_bib28","series-title":"Guidance for industry: antiviral product development, conducting and submitting virology studies to the agency. U.S. Department of health and human services, Food and drug administration, center for drug evaluation and research","year":"2006"},{"key":"10.1016\/j.micinf.2020.04.007_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/v8120322","article-title":"Chloroquine, an endocytosis blocking agent, inhibits Zika virus infection in different cell models","volume":"8","author":"Delvecchio","year":"2016","journal-title":"Viruses"},{"key":"10.1016\/j.micinf.2020.04.007_bib30","first-page":"727","article-title":"Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors","volume":"72","author":"Xu","year":"2017","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.micinf.2020.04.007_bib31","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1002\/1873-3468.12443","article-title":"Substrate profiling of Zika virus NS2B-NS3 protease","volume":"590","author":"Gruba","year":"2016","journal-title":"FEBS Lett"},{"key":"10.1016\/j.micinf.2020.04.007_bib32","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/15548627.2016.1265192","article-title":"Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B","volume":"13","author":"Lennemann","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.micinf.2020.04.007_bib33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejmech.2018.02.037","article-title":"Zirconium catalyzed synthesis of 2-arylidene Indan-1,3-diones and evaluation of their inhibitory activity against NS2B-NS3 WNV protease","volume":"149","author":"Oliveira","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.micinf.2020.04.007_bib34","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature17994","article-title":"Structure of the thermally stable Zika virus","volume":"533","author":"Kostyuchenko","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2020.04.007_bib35","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1365-2672.2010.04663.x","article-title":"Isoelectric points of viruses","volume":"109","author":"Michen","year":"2010","journal-title":"J\u00a0Appl Microbiol"},{"key":"10.1016\/j.micinf.2020.04.007_bib36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/10643380091184174","article-title":"Removal of viruses by soil passage: Overview of modeling, processes, and parameters","volume":"30","author":"Schijven","year":"2000","journal-title":"Crit Rev Environ Sci Technol"},{"key":"10.1016\/j.micinf.2020.04.007_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1573409912999160315115502","article-title":"Editorial: computer-assisted approaches as decision support systems in the overall strategy of combating emerging diseases: some comments regarding drug design, vaccinomics, and genomic surveillance of the Zika virus","volume":"12","author":"Basak","year":"2016","journal-title":"Curr Comput Aided Drug Des"},{"key":"10.1016\/j.micinf.2020.04.007_bib38","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.celrep.2017.01.056","article-title":"Frequent Zika virus sexual transmission and prolonged viral RNA shedding in an immunodeficient mouse model","volume":"18","author":"Duggal","year":"2017","journal-title":"Cell Rep"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457920300745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457920300745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:37:44Z","timestamp":1761143864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457920300745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1286457920300745"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2020.04.007","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xanthenedione (and intermediates involved in their synthesis) inhibit Zika virus migration to the central nervous system in murine neonatal models","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2020.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}