{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:06:13Z","timestamp":1788307573749,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":1187,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.micinf.2020.05.015","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T11:50:52Z","timestamp":1592394652000},"page":"423-431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Human mesenchymal stem cell based intracellular dormancy model of Mycobacterium tuberculosis"],"prefix":"10.1016","volume":"22","author":[{"given":"Vipul K.","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Bark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunmani","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvakumar","family":"Subbian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinnaswamy","family":"Jagannath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-2854","authenticated-orcid":false,"given":"Arshad","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2020.05.015_bib1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S1473-3099(16)00086-4","article-title":"World TB Day 2016-advancing global tuberculosis control efforts","volume":"16","author":"Zumla","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.micinf.2020.05.015_bib2","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1128\/AAC.06288-11","article-title":"Targeting persisters for tuberculosis control","volume":"56","author":"Zhang","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.micinf.2020.05.015_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040120","article-title":"Why is long-term therapy required to cure tuberculosis?","volume":"4","author":"Connolly","year":"2007","journal-title":"PLoS Med"},{"key":"10.1016\/j.micinf.2020.05.015_bib4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijid.2014.11.028","article-title":"Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them","volume":"32","author":"Evangelopoulos","year":"2015","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.micinf.2020.05.015_bib5","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1128\/AAC.02202-12","article-title":"Reduced drug uptake in phenotypically resistant nutrient-starved nonreplicating Mycobacterium tuberculosis","volume":"57","author":"Sarathy","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.micinf.2020.05.015_bib6","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1128\/AAC.01380-15","article-title":"Phenotypically adapted Mycobacterium tuberculosis populations from sputum are tolerant to first-line drugs","volume":"60","author":"Turapov","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.micinf.2020.05.015_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006077","article-title":"A\u00a0novel in\u00a0vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen","volume":"4","author":"Deb","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.micinf.2020.05.015_bib8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev.micro.55.1.139","article-title":"Nonreplicating persistence of mycobacterium tuberculosis","volume":"55","author":"Wayne","year":"2001","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.micinf.2020.05.015_bib9","first-page":"75","article-title":"Models of latent tuberculosis: their salient features, limitations, and development","volume":"3","author":"Jhamb","year":"2011","journal-title":"J\u00a0Lab Physicians"},{"key":"10.1016\/j.micinf.2020.05.015_bib10","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1590\/S1517-838246320140507","article-title":"Dormancy models for Mycobacterium tuberculosis a minireview","volume":"46","author":"Alnimr","year":"2015","journal-title":"Braz J Microbiol"},{"key":"10.1016\/j.micinf.2020.05.015_bib11","doi-asserted-by":"crossref","unstructured":"Gupta UD, Katoch VM. Animal models of tuberculosis. Tuberculosis (Edinb) n.d.;85:277\u2013293. doi:10.1016\/j.tube.2005.08.008.","DOI":"10.1016\/j.tube.2005.08.008"},{"key":"10.1016\/j.micinf.2020.05.015_bib12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ddmod.2005.05.019","article-title":"Modeling pathogen and host: in\u00a0vitro, in\u00a0vivo and in silico models of latent Mycobacterium tuberculosis infection","volume":"2","author":"Lin","year":"2005","journal-title":"Drug Discov Today Dis Model"},{"key":"10.1016\/j.micinf.2020.05.015_bib13","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/j.tube.2016.09.019","article-title":"Emerging role of mesenchymal stem cells during tuberculosis: the fifth element in cell mediated immunity","volume":"101","author":"Khan","year":"2016","journal-title":"Tuberculosis"},{"key":"10.1016\/j.micinf.2020.05.015_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15290-z","article-title":"Mesenchymal stem cells internalize Mycobacterium tuberculosis through scavenger receptors and restrict bacterial growth through autophagy","volume":"7","author":"Khan","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.micinf.2020.05.015_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004912","article-title":"CD271+ bone marrow mesenchymal stem cells may provide a niche for dormant Mycobacterium tuberculosis","volume":"5","author":"Das","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.micinf.2020.05.015_bib16","doi-asserted-by":"crossref","first-page":"21653","DOI":"10.1073\/pnas.1007967107","article-title":"Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells","volume":"107","author":"Raghuvanshi","year":"2010","journal-title":"Proc Natl Acad Sci Unit States Am"},{"key":"10.1016\/j.micinf.2020.05.015_bib17","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/j.ajpath.2014.08.024","article-title":"Bone marrow mesenchymal stem cells provide an antibiotic-protective niche for persistent viable Mycobacterium tuberculosis that survive antibiotic treatment","volume":"184","author":"Beamer","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.micinf.2020.05.015_bib18","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.ajpath.2015.03.028","article-title":"Preclinical and clinical evidence of Mycobacterium tuberculosis persistence in the hypoxic niche of bone marrow mesenchymal stem cells after therapy","volume":"185","author":"Garhyan","year":"2015","journal-title":"Am J Pathol"},{"key":"10.1016\/j.micinf.2020.05.015_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169119","article-title":"Human and mouse hematopoietic stem cells are a depot for dormant Mycobacterium tuberculosis","volume":"12","author":"Tornack","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.micinf.2020.05.015_bib20","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tube.2006.06.001","article-title":"Intracellular growth and drug susceptibility of Mycobacterium tuberculosis in macrophages","volume":"87","author":"Chanwong","year":"2007","journal-title":"Tuberculosis"},{"key":"10.1016\/j.micinf.2020.05.015_bib21","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1634\/stemcells.20-6-530","article-title":"Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality","volume":"20","author":"Sekiya","year":"2002","journal-title":"Stem Cell"},{"key":"10.1016\/j.micinf.2020.05.015_bib22","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1089\/scd.2010.0140","article-title":"Human bone marrow and adipose tissue mesenchymal stem cells: a user\u2019s guide","volume":"19","author":"Mosna","year":"2010","journal-title":"Stem Cell Dev"},{"key":"10.1016\/j.micinf.2020.05.015_bib23","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1093\/jac\/dkq374","article-title":"Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosis","volume":"65","author":"de Steenwinkel","year":"2010","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.micinf.2020.05.015_bib24","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1128\/JB.180.4.801-808.1998","article-title":"Mycobacterial stationary phase induced by low oxygen tension: cell wall thickening and localization of the 16-kilodalton alpha-crystallin homolog","volume":"180","author":"Cunningham","year":"1998","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.micinf.2020.05.015_bib25","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1128\/IAI.01196-13","article-title":"Reversible lipid accumulation and associated division arrest of Mycobacterium avium in lipoprotein-induced foamy macrophages may resemble key events during latency and reactivation of tuberculosis","volume":"82","author":"Caire-Br\u00e4ndli","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2020.05.015_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002093","article-title":"Mycobacterium tuberculosis uses host esTriacylglycerol to accumulate lipid droplets and acquires a dormancy-like phenotype in lipid-loaded macrophag","volume":"7","author":"Daniel","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2020.05.015_bib27","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1128\/AAC.00693-15","article-title":"Serum levels of antituberculosis drugs and their effect on tuberculosis treatment outcome","volume":"60","author":"Park","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.micinf.2020.05.015_bib28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s002849900095","article-title":"In\u00a0vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages","volume":"33","author":"Rastogi","year":"1996","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.micinf.2020.05.015_bib29","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.4049\/jimmunol.170.4.1939","article-title":"Constrained intracellular survival of Mycobacterium tuberculosis in human dendritic cells","volume":"170","author":"Tailleux","year":"2003","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2020.05.015_bib30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1128\/MMBR.00010-14","article-title":"Latent tuberculosis infection: myths, models, and molecular mechanisms","volume":"78","author":"Dutta","year":"2014","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.micinf.2020.05.015_bib31","article-title":"Quantity and quality of inhaled dose predicts immunopathology in tuberculosis","volume":"6","author":"Fennelly","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2020.05.015_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003190","article-title":"Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in\u00a0vivo","volume":"9","author":"Repasy","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2020.05.015_bib33","article-title":"Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages","volume":"6","author":"Lee","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.micinf.2020.05.015_bib34","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1099\/mic.0.023028-0","article-title":"Dormant forms of Mycobacterium smegmatis with distinct morphology","volume":"155","author":"Anuchin","year":"2009","journal-title":"Microbiology"},{"key":"10.1016\/j.micinf.2020.05.015_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087329","article-title":"Non-replicating Mycobacterium tuberculosis elicits a reduced infectivity profile with corresponding modifications to the cell wall and extracellular matrix","volume":"9","author":"Bacon","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.micinf.2020.05.015_bib36","doi-asserted-by":"crossref","first-page":"a021113","DOI":"10.1101\/cshperspect.a021113","article-title":"The mycobacterial cell wall\u2014peptidoglycan and arabinogalactan","volume":"5","author":"Alderwick","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.micinf.2020.05.015_bib37","article-title":"New approaches and therapeutic options for Mycobacterium tuberculosis in a dormant state","volume":"31","author":"Ca\u00f1o-Mu\u00f1iz","year":"2017","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.micinf.2020.05.015_bib38","first-page":"473","article-title":"Filterable forms of mycobacterium tuberculosis","volume":"69","author":"Werner","year":"1954","journal-title":"Am Rev Tubercul"},{"key":"10.1016\/j.micinf.2020.05.015_bib39","article-title":"Antibacterial activity of human mesenchymal stem cells mediated directly by constitutively secreted factors and indirectly by activation of innate immune effector cells","author":"Chow","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.micinf.2020.05.015_bib40","first-page":"1","article-title":"Antimicrobial properties of mesenchymal stem cells: therapeutic potential for cystic fibrosis infection, and treatment","volume":"2016","author":"Sutton","year":"2016","journal-title":"Stem Cell Int"},{"key":"10.1016\/j.micinf.2020.05.015_bib41","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1574-6976.2012.00331.x","article-title":"Mycobacterium tuberculosis: success through dormancy","volume":"36","author":"Gengenbacher","year":"2012","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.micinf.2020.05.015_bib42","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.tube.2006.12.001","article-title":"Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein","volume":"87","author":"Hartkoorn","year":"2007","journal-title":"Tuberculosis"},{"key":"10.1016\/j.micinf.2020.05.015_bib43","first-page":"81","article-title":"Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance: evolutionary considerations","volume":"374","author":"Szumowski","year":"2013","journal-title":"Curr Top Microbiol Immunol"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457920300939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457920300939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:38:15Z","timestamp":1761143895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457920300939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1286457920300939"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2020.05.015","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human mesenchymal stem cell based intracellular dormancy model of Mycobacterium tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2020.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}