{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:40:25Z","timestamp":1778744425901,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":1156,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307780\/2017-1"],"award-info":[{"award-number":["307780\/2017-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":[":305114\/2017-4"],"award-info":[{"award-number":[":305114\/2017-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018041","name":"American Society of Biomechanics","doi-asserted-by":"publisher","award":["2017\/18936-3"],"award-info":[{"award-number":["2017\/18936-3"]}],"id":[{"id":"10.13039\/100018041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.micinf.2020.07.005","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T01:40:48Z","timestamp":1595814048000},"page":"550-557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Contribution of Complement System pathways to the killing of Leptospira spp."],"prefix":"10.1016","volume":"22","author":[{"given":"Priscilla Yuri Okochi","family":"Alves da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Moura","family":"Midon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Bryan","family":"Heinemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewton","family":"de Moraes Vasconcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Silva","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Isaac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2020.07.005_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global morbidity and mortality of leptospirosis: a systematic review","volume":"9","author":"Costa","year":"2015","journal-title":"PloS Negl Trop Dis"},{"key":"10.1016\/j.micinf.2020.07.005_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007270","article-title":"Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics","volume":"13","author":"Vincent","year":"2019","journal-title":"PloS Negl Trop Dis"},{"key":"10.1016\/j.micinf.2020.07.005_bib3","series-title":"Leptospira and Leptospirosis","first-page":"65","article-title":"Leptospirosis in humans","author":"Haake","year":"2015"},{"key":"10.1016\/j.micinf.2020.07.005_bib4","first-page":"209","article-title":"Ueber einer eigenh\u00fcemliche, mit Milztumor, Icterus und Nephritis einhergehende, acute Infectionskrankheit","volume":"39","author":"Weil","year":"1886","journal-title":"Deutsch Arch Klin Med"},{"key":"10.1016\/j.micinf.2020.07.005_bib5","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2214\/ajr.152.5.955","article-title":"Leptospirosis of the lung: radiographic findings in 58 patients","volume":"152","author":"Im","year":"1989","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.micinf.2020.07.005_bib6","first-page":"377","article-title":"Identification of Leptospira in lung tissue by bronchoscopy and bronchial biopsy","volume":"8","author":"Carvalho","year":"1999","journal-title":"Pulm\u0101o RJ"},{"key":"10.1016\/j.micinf.2020.07.005_bib7","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/icb.1964.54","article-title":"Phagocytosis and its significance in leptospiral infection","volume":"42","author":"Faine","year":"1964","journal-title":"Aust J Exp Biol Med Sci"},{"key":"10.1016\/j.micinf.2020.07.005_bib8","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM200104053441406","article-title":"Complement \u2013 first of two parts","volume":"334","author":"Walport","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.micinf.2020.07.005_bib9","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3389\/fimmu.2019.00794","article-title":"The long pentraxin PTX3 as a humoral innate immunity functional player and biomarker of infections and sepsis","volume":"10","author":"Porte","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2020.07.005_bib10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1749-6632.1983.tb18116.x","article-title":"Initiation of the alternative complement pathway due to spontaneous hydrolysis of the thioester of C3","volume":"421","author":"Pangburn","year":"1983","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.micinf.2020.07.005_bib11","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3389\/fmicb.2017.00868","article-title":"Evasion mechanisms used by pathogens to escape the lectin complement pathway","volume":"8","author":"Rosbjerg","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.micinf.2020.07.005_bib12","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2020.07.005_bib13","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/ni.3858","article-title":"Novel mechanisms and functions of complement","volume":"17","author":"Hajishengallis","year":"2017","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2020.07.005_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molimm.2006.06.011","article-title":"Bacterial complement evasion","volume":"44","author":"Rooijakkers","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.micinf.2020.07.005_bib15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/nrmicro1824","article-title":"Complement evasion by human pathogens","volume":"6","author":"Lambris","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.micinf.2020.07.005_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2009.07.005","article-title":"Complement and immune defense: from innate immunity to human diseases","volume":"126","author":"Zipfel","year":"2009","journal-title":"Immun Lett"},{"key":"10.1016\/j.micinf.2020.07.005_bib17","first-page":"215","article-title":"Complement immune evasion by spirochetes","volume":"415","author":"Barbosa","year":"2018","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.micinf.2020.07.005_bib18","first-page":"261","article-title":"Activation of complement by leptospires and its bactericidal activity","volume":"254","author":"Cinco","year":"1983","journal-title":"Zentrabl Bakteriol Mikrobiol Hyg A"},{"key":"10.1016\/j.micinf.2020.07.005_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.micpath.2005.07.003","article-title":"Regulation of complement activation at the C3-level by serum resistant leptospires","volume":"39","author":"Meri","year":"2005","journal-title":"Microb Pathog"},{"key":"10.1016\/j.micinf.2020.07.005_bib20","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1128\/IAI.01310-08","article-title":"Immune evasion of Leptospira species by acquisition of human complement regulator C4BP","volume":"77","author":"Barbosa","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2020.07.005_bib21","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1128\/IAI.74.5.2659-2666.2006","article-title":"LfhA, a novel factor H-binding protein of Leptospira interrogans","volume":"74","author":"Verma","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2020.07.005_bib22","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/infdis\/jir875","article-title":"Leptospiral immunoglobulin-like proteins interact with human complement regulators factor H, FHL-1, FHR-1 and C4BP","volume":"205","author":"Castiblanco-Valencia","year":"2012","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2020.07.005_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2019.03.001","article-title":"Culture-attenuated pathogenic Leptospira lose the ability to survive to complement-mediated-killing due to lower expression of factor H binding proteins","author":"Moreno-Torres","year":"2019","journal-title":"Microbes Infect"},{"key":"10.1016\/j.micinf.2020.07.005_bib24","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1128\/IAI.00353-09","article-title":"Plasminogen acquisition and activation at the surface of Leptospira species lead to fibronectin degradation","volume":"77","author":"Vieira","year":"2009","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.micinf.2020.07.005_bib25","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.imbio.2016.01.001","article-title":"Plasmin cleaves fibrinogen and the human complement proteins C3b and C5 in the presence of Leptospira interrogans proteins: a\u00a0new role of LigA and LigB in invasion and complement immune evasion","volume":"221","author":"Castiblanco-Valencia","year":"2016","journal-title":"Immunobiology"},{"key":"10.1016\/j.micinf.2020.07.005_bib26","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/infdis\/jit569","article-title":"Immune evasion by pathogenic Leptospira strains: the secretion of proteases that directly cleave complement proteins","volume":"209","author":"Fraga","year":"2014","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2020.07.005_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2017.00958","article-title":"Pathogenic Leptospira secreted proteases target the membrane attack complex: a potential role for thermolysin in complement inhibition","volume":"8","author":"Amamura","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.micinf.2020.07.005_bib28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.imbio.2017.10.027","article-title":"Binding of human complement C1 sterase inhibitor to Leptospira spp","volume":"223","author":"Breda","year":"2018","journal-title":"Immunobiology"},{"key":"10.1016\/j.micinf.2020.07.005_bib29","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1128\/jb.91.4.1403-1409.1966","article-title":"Antileptospiral activity of the serum. I. Normal and immune serum","volume":"91","author":"Johnson","year":"1966","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.micinf.2020.07.005_bib30","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1128\/IAI.00279-10","article-title":"Functional characterization of LcpA, a surface-exposed protein of Leptospira spp. that binds the human complement regulator C4BP","volume":"78","author":"Barbosa","year":"2010","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.micinf.2020.07.005_bib31","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1128\/IAI.02844-14","article-title":"Pathogenic Leptospira species acquire factor H and vitronectin via the surface protein LcpA","volume":"83","author":"da Silva","year":"2015","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2020.07.005_bib32","first-page":"167","article-title":"Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma","volume":"2","author":"Wittenborn","year":"2010","journal-title":"J\u00a0Innate Immun"},{"key":"10.1016\/j.micinf.2020.07.005_bib33","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.imbio.2015.06.001","article-title":"Studies of the binding of ficolin-2 and ficolin-3 from the complement lectin pathway to Leptospira biflexa, Pasteurella pneumotropica and Diarrheagenic Escherichia coli","volume":"220","author":"Sahag\u00fan-Ruiz","year":"2015","journal-title":"Immunobiology"},{"key":"10.1016\/j.micinf.2020.07.005_bib34","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645792030143X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645792030143X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:37:55Z","timestamp":1761143875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S128645792030143X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S128645792030143X"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2020.07.005","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Contribution of Complement System pathways to the killing of Leptospira spp.","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2020.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Masson SAS on behalf of Institut Pasteur.","name":"copyright","label":"Copyright"}]}}