{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:53:56Z","timestamp":1792644836220,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":852,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.micinf.2021.104839","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:25:24Z","timestamp":1621556724000},"page":"104839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Correlation of adhesion molecules and non-typeable haemophilus influenzae growth in a mice coinfected model of acute inflammation"],"prefix":"10.1016","volume":"23","author":[{"given":"Xiao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunceng","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2021.104839_bib1","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0140-6736(17)33293-2","article-title":"Estimates of global seasonal influenza-associated respiratory mortality: a modelling study","volume":"391","author":"Iuliano","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2021.104839_bib2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1001\/jama.2012.194139","article-title":"Bacterial coinfection in influenza: a grand rounds review","volume":"309","author":"Chertow","year":"2013","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.micinf.2021.104839_bib3","first-page":"55","article-title":"Influenza infection and COPD","volume":"2","author":"Mallia","year":"2007","journal-title":"Int J Chronic Obstr Pulm Dis"},{"key":"10.1016\/j.micinf.2021.104839_bib4","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1086\/591708","article-title":"Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness","volume":"198","author":"Morens","year":"2008","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2021.104839_bib5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/IPC.0b013e3182948d4d","article-title":"Characterization of hospitalized community-onset Staphylococcus aureus lower respiratory tract infections among generally healthy persons 50 years of age or younger","volume":"21","author":"Tosh","year":"2013","journal-title":"Infect Dis Clin Pract (Baltim Md)"},{"key":"10.1016\/j.micinf.2021.104839_bib6","doi-asserted-by":"crossref","first-page":"800","DOI":"10.2353\/ajpath.2010.090596","article-title":"A\u00a0mouse model of lethal synergism between influenza virus and Haemophilus influenzae","volume":"176","author":"Lee","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.micinf.2021.104839_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejcdt.2015.07.001","article-title":"Radiological findings in patients with H1N1 influenza pneumonia","volume":"65","author":"Abdelsalam","year":"2016","journal-title":"Egypt J Chest Dis"},{"key":"10.1016\/j.micinf.2021.104839_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2001-1326-1-10","article-title":"Haemophilus influenzae and the lung (Haemophilus and the lung)","volume":"1","author":"King","year":"2012","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.micinf.2021.104839_bib9","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.3389\/fimmu.2018.02530","article-title":"The interplay between immune response and bacterial infection in COPD: focus upon non-typeable Haemophilus influenzae","volume":"9","author":"Su","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2021.104839_bib10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00001432-200304000-00009","article-title":"Respiratory infections caused by non-typeable Haemophilus influenzae","volume":"16","author":"Murphy","year":"2003","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.micinf.2021.104839_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003057","article-title":"Viral and bacterial interactions in the upper respiratory tract","volume":"9","author":"Bosch","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2021.104839_bib12","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1128\/IAI.74.2.830-838.2006","article-title":"Nontypeable Haemophilus influenzae adheres to intercellular adhesion molecule 1 (ICAM-1) on respiratory epithelial cells and upregulates ICAM-1 expression","volume":"74","author":"Avadhanula","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2021.104839_bib13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.anl.2018.11.003","article-title":"Role of phosphorylcholine in Streptococcus pneumoniae and nontypeable Haemophilus influenzae adherence to epithelial cells","volume":"46","author":"Iuchi","year":"2019","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.micinf.2021.104839_bib14","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/lary.20498","article-title":"Rhinovirus enhances various bacterial adhesions to nasal epithelial cells simultaneously","volume":"119","author":"Wang","year":"2009","journal-title":"Laryngoscope"},{"key":"10.1016\/j.micinf.2021.104839_bib15","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1128\/JVI.80.4.1629-1636.2006","article-title":"Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner","volume":"80","author":"Avadhanula","year":"2006","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2021.104839_bib16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.antiviral.2011.09.001","article-title":"In\u00a0vitro and in\u00a0vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections","volume":"92","author":"Kumaki","year":"2011","journal-title":"Antivir Res"},{"key":"10.1016\/j.micinf.2021.104839_bib17","first-page":"2322","article-title":"Establishment of Nontypeable Haemophilus influenzae airway infection murine model","volume":"56","author":"Kimura","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.micinf.2021.104839_bib18","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.3201\/eid1408.071313","article-title":"Deaths from bacterial pneumonia during 1918\u201319 influenza pandemic","volume":"14","author":"Brundage","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.micinf.2021.104839_bib19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1084\/jem.54.3.373","article-title":"Swine influenza: III. Filtration experiments and etiology","volume":"54","author":"Shope","year":"1931","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2021.104839_bib20","article-title":"Modified lipooligosaccharide structure protects nontypeable Haemophilus influenzae from IgM-mediated complement killing in experimental otitis media","volume":"3","author":"Jeroen","year":"2012","journal-title":"mBio"},{"key":"10.1016\/j.micinf.2021.104839_bib21","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1099\/jmm.0.000827","article-title":"Intranasal coinfection model allows for assessment of protein vaccines against nontypeable Haemophilus influenzae in mice","volume":"67","author":"Vacca Michel","year":"2018","journal-title":"J\u00a0Med Microbiol"},{"key":"10.1016\/j.micinf.2021.104839_bib22","doi-asserted-by":"crossref","first-page":"15413","DOI":"10.1073\/pnas.1311217110","article-title":"Genome-wide fitness profiling reveals adaptations required by Haemophilus in coinfection with influenza A virus in the murine lung","volume":"110","author":"Wong","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2021.104839_bib23","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1128\/IAI.01691-06","article-title":"Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media","volume":"75","author":"Hong","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2021.104839_bib24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1128\/IAI.02390-14","article-title":"Peroxiredoxin-glutaredoxin and catalase promote resistance of nontypeable Haemophilus influenzae 86-028NP to oxidants and survival within neutrophil extracellular traps","volume":"83","author":"Juneau","year":"2015","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2021.104839_bib25","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00614-2020","article-title":"Chronic infection by nontypeable Haemophilus influenzae fuels airway inflammation","volume":"7","author":"Saliu","year":"2021","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.micinf.2021.104839_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1471-2180-7-56","article-title":"Virulence phenotypes of low-passage clinical isolates of nontypeable Haemophilus influenzae assessed using the chinchilla laniger model of otitis media","volume":"7","author":"Buchinsky","year":"2007","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.micinf.2021.104839_bib27","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1699-0463.1998.tb00232.x","article-title":"Intra- and interstrain differences of virulence among nontypeable Haemophilus influenzae strains","volume":"106","author":"Melhus","year":"1998","journal-title":"APMIS"},{"key":"10.1016\/j.micinf.2021.104839_bib28","first-page":"1","article-title":"The studies of elimination of nontypeable Haemophilus influenzae strains using the animal model of infection","volume":"65","author":"Augustynowicz","year":"2013","journal-title":"Med Dosw Mikrobiol"},{"issue":"1","key":"10.1016\/j.micinf.2021.104839_bib29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12917-018-1469-1","article-title":"Comparison of the virulence of three H3N2 canine influenza virus isolates from Korea and China in mouse and Guinea pig models","volume":"14","author":"Xie","year":"2018","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.micinf.2021.104839_bib30","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fimmu.2018.00126","article-title":"Mouse models of influenza infection with circulating strains to test seasonal vaccine efficacy","volume":"9","author":"Groves","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2021.104839_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042343","article-title":"Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly pathogenic avian influenza H5N1 virus infections in ferrets","volume":"7","author":"van den Brand","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.micinf.2021.104839_bib32","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1128\/iai.41.2.618-623.1983","article-title":"Lethal synergism induced in mice by influenza type A virus and type Ia group B streptococci","volume":"41","author":"Jones","year":"1983","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.micinf.2021.104839_bib33","doi-asserted-by":"crossref","first-page":"ftaa017","DOI":"10.1093\/femspd\/ftaa017","article-title":"Exacerbation of disease by intranasal liquid administration following influenza virus infection in mice","volume":"78","author":"Lyu","year":"2020","journal-title":"Pathog Dis"},{"key":"10.1016\/j.micinf.2021.104839_bib34","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1086\/341462","article-title":"Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor","volume":"186","author":"McCullers","year":"2002","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2021.104839_bib35","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/s41564-019-0447-0","article-title":"Direct interactions with influenza promote bacterial adherence during respiratory infections","volume":"4","author":"Rowe","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.micinf.2021.104839_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1359-6101(98)00024-0","article-title":"Cytokine regulation of cellular adhesion molecule expression in inflammation","volume":"10","author":"Meager","year":"1999","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.micinf.2021.104839_bib37","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1099\/mic.0.000434","article-title":"Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease","volume":"163","author":"Kc","year":"2017","journal-title":"Microbiology (Read)"},{"key":"10.1016\/j.micinf.2021.104839_bib38","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1073\/pnas.1414422112","article-title":"Influenza viral neuraminidase primes bacterial coinfection through TGF-beta-mediated expression of host cell receptors","volume":"112","author":"Li","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2021.104839_bib39","doi-asserted-by":"crossref","first-page":"L194","DOI":"10.1152\/ajplung.00050.2005","article-title":"Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia","volume":"290","author":"KFvd","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.micinf.2021.104839_bib40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12906-017-1585-7","article-title":"The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function","volume":"17","author":"Ding","year":"2017","journal-title":"BMC Compl Alternative Med"},{"key":"10.1016\/j.micinf.2021.104839_bib41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/14787210.2018.1438263","article-title":"The adhesins of non-typeable Haemophilus influenzae","volume":"16","author":"Osman","year":"2018","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.micinf.2021.104839_bib42","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1002\/1873-3468.12351","article-title":"Host-pathogen interactions of nontypeable Haemophilus influenzae: from commensal to pathogen","volume":"590","author":"Luke Duell","year":"2016","journal-title":"FEBS Lett"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457921000617?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457921000617?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:39:25Z","timestamp":1761143965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457921000617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1286457921000617"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2021.104839","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correlation of adhesion molecules and non-typeable haemophilus influenzae growth in a mice coinfected model of acute inflammation","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2021.104839","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"104839"}}