{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:03:26Z","timestamp":1791140606896,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"9-10","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":791,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.micinf.2021.104867","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T17:48:27Z","timestamp":1626889707000},"page":"104867","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["USP13-mediated IRAK4 deubiquitination disrupts the pathological symptoms of lipopolysaccharides-induced sepsis"],"prefix":"10.1016","volume":"23","author":[{"given":"Zhigao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2021.104867_bib1","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM consensus conference committee. American college of chest physicians\/society of critical Care medicine","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.micinf.2021.104867_bib2","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.amjmed.2007.01.035","volume":"120","author":"O'Brien","year":"2007","journal-title":"Sepsis. Am J Med"},{"issue":"Suppl 1","key":"10.1016\/j.micinf.2021.104867_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/SHK.0b013e318181af2a","article-title":"TLR signaling pathway in patients with sepsis","volume":"30","author":"Salomao","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.micinf.2021.104867_bib4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.micinf.2021.104867_bib5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.micinf.2021.104867_bib6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2017.17687","article-title":"Enhancing recovery from sepsis: a review","volume":"319","author":"Prescott","year":"2018","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.micinf.2021.104867_bib7","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/CCM.0b013e3181968f3a","article-title":"Effects of aging on the immunopathologic response to sepsis","volume":"37","author":"Turnbull","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.micinf.2021.104867_bib8","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3389\/fphar.2018.01080","article-title":"Inhibition of ubiquitin-specific proteases as a novel anticancer therapeutic strategy","volume":"9","author":"Yuan","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.micinf.2021.104867_bib9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pharmthera.2014.11.002","article-title":"Deubiquitinase inhibition as a cancer therapeutic strategy","volume":"147","author":"D'Arcy","year":"2015","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.micinf.2021.104867_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cell.2011.08.037","article-title":"Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13","volume":"147","author":"Liu","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2021.104867_bib11","doi-asserted-by":"crossref","first-page":"9119","DOI":"10.1073\/pnas.1100028108","article-title":"Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control","volume":"108","author":"Chen","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micinf.2021.104867_bib12","doi-asserted-by":"crossref","first-page":"15534","DOI":"10.1038\/ncomms15534","article-title":"USP13 negatively regulates antiviral responses by deubiquitinating STING","volume":"8","author":"Sun","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.micinf.2021.104867_bib13","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.4049\/jimmunol.1300225","article-title":"Ubiquitin-specific protease 13 regulates IFN signaling by stabilizing STAT1","volume":"191","author":"Yeh","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2021.104867_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015263","article-title":"A\u00a0method for generation of bone marrow-derived macrophages from cryopreserved mouse bone marrow cells","volume":"5","author":"Marim","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.micinf.2021.104867_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1471-2105-7-85","article-title":"Statistical analysis of real-time PCR data","volume":"7","author":"Yuan","year":"2006","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.micinf.2021.104867_bib16","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.molmet.2017.03.016","article-title":"Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders","volume":"6","author":"Chen","year":"2017","journal-title":"Mol Metab"},{"key":"10.1016\/j.micinf.2021.104867_bib17","article-title":"Lung section staining and microscopy","volume":"7","author":"Zhou","year":"2017","journal-title":"Bio Protoc"},{"key":"10.1016\/j.micinf.2021.104867_bib18","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.4049\/jimmunol.175.4.2357","article-title":"Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry","volume":"175","author":"Krutzik","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2021.104867_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145342","article-title":"Novel markers to delineate murine M1 and M2 macrophages","volume":"10","author":"Jablonski","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.micinf.2021.104867_bib20","doi-asserted-by":"crossref","first-page":"6561","DOI":"10.4049\/jimmunol.174.11.6561","article-title":"Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells","volume":"174","author":"Raes","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2021.104867_bib21","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1038\/s41467-019-12657-w","article-title":"The TLR7\/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer","volume":"10","author":"Michaelis","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.micinf.2021.104867_bib22","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2174\/1566524023362159","article-title":"Toll-like receptor 9, CpG DNA and innate immunity","volume":"2","author":"Ashkar","year":"2002","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.micinf.2021.104867_bib23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/JLB.2A1117-449R","article-title":"IRAK4 activity controls immune responses to intracellular bacteria Listeria monocytogenes and Mycobacterium smegmatis","volume":"104","author":"Pattabiraman","year":"2018","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.micinf.2021.104867_bib24","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1074\/jbc.M609039200","article-title":"Interleukin-1 (IL-1)-induced TAK1-dependent versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification","volume":"282","author":"Yao","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.micinf.2021.104867_bib25","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1084\/jem.20061825","article-title":"A\u00a0critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity","volume":"204","author":"Kim","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2021.104867_bib26","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/eji.200838161","article-title":"IRAK4 in TLR\/IL-1R signaling: possible clinical applications","volume":"38","author":"Li","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.micinf.2021.104867_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2567.2005.02275.x","article-title":"Herpes simplex virus 1 infection induces the expression of proinflammatory cytokines, interferons and TLR7 in human corneal epithelial cells","volume":"117","author":"Li","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.micinf.2021.104867_bib28","doi-asserted-by":"crossref","first-page":"15579","DOI":"10.1038\/s41598-018-34011-8","article-title":"Melatonin suppresses TLR9-triggered proinflammatory cytokine production in macrophages by inhibiting ERK1\/2 and AKT activation","volume":"8","author":"Xu","year":"2018","journal-title":"Sci Rep"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457921000897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457921000897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:39:09Z","timestamp":1761143949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457921000897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":28,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S1286457921000897"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2021.104867","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"USP13-mediated IRAK4 deubiquitination disrupts the pathological symptoms of lipopolysaccharides-induced sepsis","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2021.104867","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"104867"}}