{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:26:28Z","timestamp":1790630788580,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.micinf.2022.105021","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T08:50:08Z","timestamp":1657270208000},"page":"105021","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tim-3 expression is induced by mycobacterial antigens and identifies tissue-resident subsets of MAIT cells from patients with tuberculosis"],"prefix":"10.1016","volume":"25","author":[{"given":"Jing","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingfen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7036-4286","authenticated-orcid":false,"given":"Xiaoxing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2022.105021_bib1","series-title":"Global tuberculosis report 2021","year":"2021"},{"issue":"3","key":"10.1016\/j.micinf.2022.105021_bib2","doi-asserted-by":"crossref","DOI":"10.1172\/JCI136222","article-title":"The knowns and unknowns of latent Mycobacterium tuberculosis infection","volume":"131","author":"Boom","year":"2021","journal-title":"J\u00a0Clin Investig"},{"issue":"7","key":"10.1016\/j.micinf.2022.105021_bib3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/imcb.12275","article-title":"The generation of T-cell memory to protect against tuberculosis","volume":"97","author":"Counoupas","year":"2019","journal-title":"Immunol Cell Biol"},{"issue":"3","key":"10.1016\/j.micinf.2022.105021_bib4","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1016\/S1473-3099(18)30157-9","article-title":"Tuberculosis susceptibility and protection in children","volume":"19","author":"Basu Roy","year":"2019","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"10.1016\/j.micinf.2022.105021_bib5","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1084\/jem.189.12.1907","article-title":"An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha\/beta T cell subpopulation in mammals","volume":"189","author":"Tilloy","year":"1999","journal-title":"J\u00a0Exp Med"},{"issue":"11","key":"10.1016\/j.micinf.2022.105021_bib6","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1084\/jem.20130958","article-title":"Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells","volume":"210","author":"Reantragoon","year":"2013","journal-title":"J\u00a0Exp Med"},{"issue":"8","key":"10.1016\/j.micinf.2022.105021_bib7","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1084\/jem.20140507","article-title":"MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage","volume":"211","author":"Gold","year":"2014","journal-title":"J\u00a0Exp Med"},{"issue":"9","key":"10.1016\/j.micinf.2022.105021_bib8","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41590-019-0444-8","article-title":"The biology and functional importance of MAIT cells","volume":"20","author":"Godfrey","year":"2019","journal-title":"Nat Immunol"},{"issue":"7426","key":"10.1016\/j.micinf.2022.105021_bib9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nature11605","article-title":"MR1 presents microbial vitamin B metabolites to MAIT cells","volume":"491","author":"Kjer-Nielsen","year":"2012","journal-title":"Nature"},{"issue":"25","key":"10.1016\/j.micinf.2022.105021_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aao2556","article-title":"MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage","volume":"3","author":"Harriff","year":"2018","journal-title":"Sci Immunol"},{"issue":"8","key":"10.1016\/j.micinf.2022.105021_bib11","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/ni.1890","article-title":"Antimicrobial activity of mucosal-associated invariant T cells","volume":"11","author":"Le Bourhis","year":"2010","journal-title":"Nat Immunol"},{"issue":"6","key":"10.1016\/j.micinf.2022.105021_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000407","article-title":"Human mucosal associated invariant T cells detect bacterially infected cells","volume":"8","author":"Gold","year":"2010","journal-title":"PLoS Biol"},{"issue":"4","key":"10.1016\/j.micinf.2022.105021_bib13","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.immuni.2020.09.009","article-title":"MAIT cell development and functions: the microbial connection","volume":"53","author":"Legoux","year":"2020","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.micinf.2022.105021_bib14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1164\/rccm.201401-0106OC","article-title":"Mucosal-associated invariant T-cell function is modulated by programmed death-1 signaling in patients with active tuberculosis","volume":"190","author":"Jiang","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"10.1016\/j.micinf.2022.105021_bib15","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.4049\/jimmunol.1900674","article-title":"MR1-Independent activation of human mucosal-associated invariant T cells by mycobacteria","volume":"203","author":"Suliman","year":"2019","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"10.1016\/j.micinf.2022.105021_bib16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/imr.12948","article-title":"The role of donor-unrestricted T-cells, innate lymphoid cells, and NK cells in anti-mycobacterial immunity","volume":"301","author":"Ruibal","year":"2021","journal-title":"Immunol Rev"},{"key":"10.1016\/j.micinf.2022.105021_bib17","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fimmu.2019.00206","article-title":"Mucosal-associated invariant T cell levels are reduced in the peripheral blood and lungs of children with active pulmonary tuberculosis","volume":"10","author":"Malka-Ruimy","year":"2019","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.micinf.2022.105021_bib18","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/infdis\/jiaa173","article-title":"Peripheral blood mucosal-associated invariant T cells in tuberculosis patients and healthy Mycobacterium tuberculosis-exposed controls","volume":"222","author":"Suliman","year":"2020","journal-title":"J\u00a0Infect Dis"},{"issue":"3","key":"10.1016\/j.micinf.2022.105021_bib19","first-page":"338","article-title":"Mucosal-associated invariant T cells from patients with tuberculosis exhibit impaired immune response","volume":"72","author":"Jiang","year":"2016","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.micinf.2022.105021_bib20","article-title":"Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling","volume":"6","author":"Jiang","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.micinf.2022.105021_bib21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tube.2015.03.004","article-title":"Mucosal-associated invariant T cells are numerically and functionally deficient in patients with mycobacterial infection and reflect disease activity","volume":"95","author":"Kwon","year":"2015","journal-title":"Tuberculosis"},{"key":"10.1016\/j.micinf.2022.105021_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.648216","article-title":"Functional and activation profiles of mucosal-associated invariant T cells in patients with tuberculosis and HIV in a high endemic setting","volume":"12","author":"Balfour","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2022.105021_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.631410","article-title":"MR1-restricted MAIT cells from the human lung mucosal surface have distinct phenotypic, functional, and transcriptomic features that are preserved in HIV infection","volume":"12","author":"Khuzwayo","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2022.105021_bib24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s42003-019-0442-2","article-title":"TRAV1-2(+) CD8(+) T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis","volume":"2","author":"Wong","year":"2019","journal-title":"Commun Biol"},{"issue":"6","key":"10.1016\/j.micinf.2022.105021_bib25","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211314","article-title":"CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate","volume":"219","author":"Chen","year":"2022","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.micinf.2022.105021_bib26","first-page":"1","article-title":"Tissue resident memory T cells in the respiratory tract","author":"Zheng","year":"2021","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.micinf.2022.105021_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.710375","article-title":"The roles of tissue-resident memory T cells in lung diseases","volume":"12","author":"Yuan","year":"2021","journal-title":"Front Immunol"},{"issue":"9","key":"10.1016\/j.micinf.2022.105021_bib28","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.4049\/jimmunol.1901326","article-title":"Cutting edge: characterization of human tissue-resident memory T cells at different infection sites in patients with tuberculosis","volume":"204","author":"Yang","year":"2020","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2022.105021_bib29","article-title":"Tissue-resident memory-like CD8(+) T cells exhibit heterogeneous characteristics in tuberculous pleural effusion","volume":"2021","author":"Yu","year":"2021","journal-title":"J\u00a0Immunol Res"},{"issue":"10","key":"10.1016\/j.micinf.2022.105021_bib30","doi-asserted-by":"crossref","DOI":"10.1172\/JCI142014","article-title":"Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung","volume":"131","author":"Ogongo","year":"2021","journal-title":"J\u00a0Clin Investig"},{"issue":"5","key":"10.1016\/j.micinf.2022.105021_bib31","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/imcb.12021","article-title":"Human blood MAIT cell subsets defined using MR1 tetramers","volume":"96","author":"Gherardin","year":"2018","journal-title":"Immunol Cell Biol"},{"issue":"11","key":"10.1016\/j.micinf.2022.105021_bib32","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/ni.3565","article-title":"A\u00a0three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage","volume":"17","author":"Koay","year":"2016","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.micinf.2022.105021_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1084\/jem.20181483","article-title":"A\u00a0common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets","volume":"216","author":"Salou","year":"2019","journal-title":"J\u00a0Exp Med"},{"issue":"7","key":"10.1016\/j.micinf.2022.105021_bib34","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1084\/jem.20142110","article-title":"Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers","volume":"212","author":"Rahimpour","year":"2015","journal-title":"J\u00a0Exp Med"},{"issue":"3","key":"10.1016\/j.micinf.2022.105021_bib35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41577-019-0224-6","article-title":"TIM3 comes of age as an inhibitory receptor","volume":"20","author":"Wolf","year":"2020","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"10.1016\/j.micinf.2022.105021_bib36","first-page":"292","article-title":"Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis","volume":"62","author":"Wang","year":"2011","journal-title":"J\u00a0Infect"},{"issue":"11","key":"10.1016\/j.micinf.2022.105021_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002984","article-title":"Tim-3-expressing CD4+ and CD8+ T cells in human tuberculosis (TB) exhibit polarized effector memory phenotypes and stronger anti-TB effector functions","volume":"8","author":"Qiu","year":"2012","journal-title":"PLoS Pathog"},{"issue":"3","key":"10.1016\/j.micinf.2022.105021_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005490","article-title":"TIM3 mediates T cell exhaustion during Mycobacterium tuberculosis infection","volume":"12","author":"Jayaraman","year":"2016","journal-title":"PLoS Pathog"},{"issue":"15","key":"10.1016\/j.micinf.2022.105021_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22158068","article-title":"CD39 regulation and functions in T cells","volume":"22","author":"Timperi","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.micinf.2022.105021_bib40","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1182\/blood-2006-12-064527","article-title":"Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression","volume":"110","author":"Borsellino","year":"2007","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.micinf.2022.105021_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005177","article-title":"CD39 expression identifies terminally exhausted CD8+ T cells","volume":"11","author":"Gupta","year":"2015","journal-title":"PLoS Pathog"},{"issue":"8","key":"10.1016\/j.micinf.2022.105021_bib42","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41591-019-0522-3","article-title":"Clonal replacement of tumor-specific T cells following PD-1 blockade","volume":"25","author":"Yost","year":"2019","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.micinf.2022.105021_bib43","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1038\/s41467-018-05072-0","article-title":"Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors","volume":"9","author":"Duhen","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.micinf.2022.105021_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.840610","article-title":"T\u00a0cell metabolism in infection","volume":"13","author":"Wik","year":"2022","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.micinf.2022.105021_bib45","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1038\/nm.3704","article-title":"De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells","volume":"20","author":"Berod","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.micinf.2022.105021_bib46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fimmu.2019.00115","article-title":"Differential regulation of human Treg and Th17 cells by fatty acid synthesis and glycolysis","volume":"10","author":"Cluxton","year":"2019","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.micinf.2022.105021_bib47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41385-020-0332-4","article-title":"MAIT cell-directed therapy of Mycobacterium tuberculosis infection","volume":"14","author":"Sakai","year":"2021","journal-title":"Mucosal Immunol"},{"issue":"1","key":"10.1016\/j.micinf.2022.105021_bib48","article-title":"Artificially induced MAIT cells inhibit M. bovis BCG but not M.\u00a0tuberculosis during in\u00a0vivo pulmonary infection","volume":"10","author":"Yu","year":"2020","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.micinf.2022.105021_bib49","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41385-021-00425-3","article-title":"Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates","volume":"14","author":"Sakai","year":"2021","journal-title":"Mucosal Immunol"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457922000910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457922000910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:41:48Z","timestamp":1761144108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457922000910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":49,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S1286457922000910"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2022.105021","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tim-3 expression is induced by mycobacterial antigens and identifies tissue-resident subsets of MAIT cells from patients with tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2022.105021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"105021"}}