{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:05:35Z","timestamp":1777100735185,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100021778","name":"ANPCyT","doi-asserted-by":"publisher","award":["PICT 2021 I A 00264"],"award-info":[{"award-number":["PICT 2021 I A 00264"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021778","name":"ANPCyT","doi-asserted-by":"publisher","award":["PICT 2021 GRF TI 00741"],"award-info":[{"award-number":["PICT 2021 GRF TI 00741"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003033","name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.micinf.2024.105375","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T07:05:49Z","timestamp":1717657549000},"page":"105375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bordetella pertussis outer membrane vesicles impair neutrophil bactericidal activity"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-0572","authenticated-orcid":false,"given":"Jimena","family":"Alvarez Hayes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Blanc\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6412-1774","authenticated-orcid":false,"given":"Juan Pablo","family":"Gorgojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Baroli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela del Carmen","family":"Carrica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-428X","authenticated-orcid":false,"given":"Maria Eugenia","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2024.105375_bib1","first-page":"3007","article-title":"Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing","volume":"92","author":"Hampton","year":"1998","journal-title":"Blood, The Journal of the American Society of Hematology"},{"key":"10.1016\/j.micinf.2024.105375_bib2","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1182\/blood.V89.10.3503","article-title":"Granules of the human neutrophilic polymorphonuclear leukocyte","volume":"89","author":"Borregaard","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2024.105375_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0952-7915(99)80005-3","article-title":"Antimicrobial peptides in mammalian and insect host defence","volume":"11","author":"Lehrer","year":"1999","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.micinf.2024.105375_bib4","first-page":"432","article-title":"Neutrophils and bacterial immune evasion","volume":"10","author":"Kobayashi","year":"2018","journal-title":"J\u00a0Innate Immun"},{"key":"10.1016\/j.micinf.2024.105375_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008625","article-title":"Whoop! There it is: the surprising resurgence of pertussis","volume":"16","author":"Fullen","year":"2020","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2024.105375_bib6","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.micpath.2008.01.002","article-title":"Cholesterol-rich domains are involved in Bordetella pertussis phagocytosis and intracellular survival in neutrophils","volume":"44","author":"Lamberti","year":"2008","journal-title":"Microb Pathog"},{"key":"10.1016\/j.micinf.2024.105375_bib7","doi-asserted-by":"crossref","first-page":"6545","DOI":"10.4049\/jimmunol.167.11.6545","article-title":"Fc receptor-mediated immunity against Bordetella pertussis","volume":"167","author":"Rodriguez","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2024.105375_bib8","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1128\/IAI.02487-14","article-title":"Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin","volume":"82","author":"Eby","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2024.105375_bib9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.tim.2005.09.005","article-title":"Type II secretion: a protein secretion system for all seasons","volume":"13","author":"Cianciotto","year":"2005","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.micinf.2024.105375_bib10","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1128\/MMBR.68.4.692-744.2004","article-title":"Type V protein secretion pathway: the autotransporter story","volume":"68","author":"Henderson","year":"2004","journal-title":"Microbiol Mol Biol Rev : MMBR (Microbiol Mol Biol Rev)"},{"key":"10.1016\/j.micinf.2024.105375_bib11","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.micinf.2010.05.008","article-title":"Outer membrane vesicles function as offensive weapons in host-parasite interactions","volume":"12","author":"Amano","year":"2010","journal-title":"Microb Infect"},{"key":"10.1016\/j.micinf.2024.105375_bib12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/tra.12488","article-title":"The outer membrane vesicles: secretion system type zero","volume":"18","author":"Guerrero-Mandujano","year":"2017","journal-title":"Traffic"},{"key":"10.1016\/j.micinf.2024.105375_bib13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/mmi.12288","article-title":"In\u00a0vitro resistance mechanisms of Neisseria meningitidis against neutrophil extracellular traps","volume":"89","author":"Lappann","year":"2013","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micinf.2024.105375_bib14","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fmicb.2018.00262","article-title":"Staphylococcus aureus membrane-derived vesicles promote bacterial virulence and confer protective immunity in murine infection models","volume":"9","author":"Askarian","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.micinf.2024.105375_bib15","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1128\/IAI.00637-06","article-title":"Cytotoxic necrotizing factor type 1 delivered by outer membrane vesicles of uropathogenic Escherichia coli attenuates polymorphonuclear leukocyte antimicrobial activity and chemotaxis","volume":"74","author":"Davis","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2024.105375_bib16","article-title":"Coating and corruption of human neutrophils by bacterial outer membrane vesicles","volume":"10","author":"du","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.micinf.2024.105375_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftac031","article-title":"Bordetella pertussis outer membrane vesicles as virulence factor vehicles that influence bacterial interaction with macrophages","volume":"80","author":"Blanc\u00e1","year":"2022","journal-title":"Pathogens and disease"},{"key":"10.1016\/j.micinf.2024.105375_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftv081","article-title":"Review of the neutrophil response to Bordetella pertussis infection","volume":"73","author":"Eby","year":"2015","journal-title":"Pathogens and disease"},{"key":"10.1016\/j.micinf.2024.105375_bib19","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.4049\/jimmunol.139.8.2749","article-title":"Inhibition of monocyte oxidative responses by Bordetella pertussis adenylate cyclase toxin","volume":"139","author":"Pearson","year":"1987","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2024.105375_bib20","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1128\/IAI.68.3.1735-1739.2000","article-title":"Bordetella pertussis virulence factors affect phagocytosis by human neutrophils","volume":"68","author":"Weingart","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2024.105375_bib21","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1128\/IAI.73.11.7317-7323.2005","article-title":"Influence of CR3 (CD11b\/CD18) expression on phagocytosis of Bordetella pertussis by human neutrophils","volume":"73","author":"Mobberley-Schuman","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2024.105375_bib22","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1086\/514090","article-title":"Bordetella pertussis infection of human monocytes inhibits antigen-dependent CD4 T cell proliferation","volume":"176","author":"Boschwitz","year":"1997","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2024.105375_bib23","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1128\/IAI.01150-08","article-title":"Role of neutrophils in response to Bordetella pertussis infection in mice","volume":"77","author":"Andreasen","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2024.105375_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/(SICI)1097-4652(200004)183:1<91::AID-JCP11>3.0.CO;2-S","article-title":"Adaptive responses of human monocytes infected by bordetella pertussis: the role of adenylate cyclase hemolysin","volume":"183","author":"Njamkepo","year":"2000","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.micinf.2024.105375_bib25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.mib.2005.12.011","article-title":"Bordetella adenylate cyclase toxin: a swift saboteur of host defense","volume":"9","author":"Vojtova","year":"2006","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.micinf.2024.105375_bib26","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.4049\/jimmunol.1402941","article-title":"Bordetella pertussis adenylate cyclase toxin blocks induction of bactericidal nitric oxide in macrophages through cAMP-dependent activation of the SHP-1 phosphatase","volume":"194","author":"Cerny","year":"2015","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"key":"10.1016\/j.micinf.2024.105375_bib27","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1086\/319266","article-title":"Targeting to Fcgamma receptors, but not CR3 (CD11b\/CD18), increases clearance of Bordetella pertussis","volume":"183","author":"Hellwig","year":"2001","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micinf.2024.105375_bib28","doi-asserted-by":"crossref","first-page":"8731","DOI":"10.1016\/j.vaccine.2011.07.143","article-title":"Identification of a new protective antigen of Bordetella pertussis","volume":"29","author":"Alvarez Hayes","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.micinf.2024.105375_bib29","first-page":"2","article-title":"Recommendations guiding physicians in biomedical research involving human subjects","volume":"35","year":"1997","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.micinf.2024.105375_bib30","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1128\/IAI.00662-12","article-title":"Bordetella parapertussis survives the innate interaction with human neutrophils by impairing bactericidal trafficking inside the cell through a lipid raft-dependent mechanism mediated by the lipopolysaccharide O antigen","volume":"80","author":"Gorgojo","year":"2012","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2024.105375_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169936","article-title":"Bordetella parapertussis circumvents neutrophil extracellular bactericidal mechanisms","volume":"12","author":"Gorgojo","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2024.105375_bib32","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1128\/iai.58.8.2516-2522.1990","article-title":"A\u00a0new assay for invasion of HeLa 229 cells by Bordetella pertussis: effects of inhibitors, phenotypic modulation, and genetic alterations","volume":"58","author":"Lee","year":"1990","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2024.105375_bib33","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01743-19","article-title":"Bordetella adenylate cyclase toxin inhibits monocyte-to-macrophage transition and dedifferentiates human alveolar macrophages into monocyte-like cells","volume":"10","author":"Ahmad","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.micinf.2024.105375_bib34","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/0092-8674(90)90701-F","article-title":"Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b\/CD18) binds filamentous hemagglutinin of Bordetella pertussis","volume":"61","author":"Relman","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2024.105375_bib35","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0968-0004(89)90106-0","article-title":"Invasive adenylate cyclase toxin of Bordetella pertussis","volume":"14","author":"Hanski","year":"1989","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.micinf.2024.105375_bib36","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.febslet.2012.01.032","article-title":"Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles","volume":"586","author":"Donato","year":"2012","journal-title":"FEBS Lett"},{"key":"10.1016\/j.micinf.2024.105375_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftw073","article-title":"Bordetella pertussis modulates human macrophage defense gene expression","volume":"74","author":"Valdez","year":"2016","journal-title":"Pathogens and disease"},{"key":"10.1016\/j.micinf.2024.105375_bib38","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev.immunol.20.103001.114744","article-title":"Phagocytosis of microbes: complexity in action","volume":"20","author":"Underhill","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.micinf.2024.105375_bib39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1462-5822.2003.00259.x","article-title":"Interaction of Actinobacillus actinomycetemcomitans outer membrane vesicles with HL60 cells does not require leukotoxin","volume":"5","author":"Demuth","year":"2003","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.micinf.2024.105375_bib40","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1128\/iai.61.4.1460-1467.1993","article-title":"Specific and nonspecific responses of murine B cells to membrane blebs of Borrelia burgdorferi","volume":"61","author":"Whitmire","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2024.105375_bib41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1189\/jlb.0810457","article-title":"Phagosome dynamics during phagocytosis by neutrophils","volume":"90","author":"Nordenfelt","year":"2011","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.micinf.2024.105375_bib42","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2165\/00003495-200666060-00001","article-title":"Shift in the epidemiology of pertussis infection: an indication for pertussis vaccine boosters for adults?","volume":"66","author":"Yeh","year":"2006","journal-title":"Drugs"},{"key":"10.1016\/j.micinf.2024.105375_bib43","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1017\/S0950268813000071","article-title":"Pertussis resurgence: waning immunity and pathogen adaptation - two sides of the same coin","volume":"142","author":"Mooi","year":"2014","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.micinf.2024.105375_bib44","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1111\/j.1365-2958.2004.04227.x","article-title":"Newly secreted adenylate cyclase toxin is responsible for intoxication of target cells by Bordetella pertussis","volume":"53","author":"Gray","year":"2004","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micinf.2024.105375_bib45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.molcel.2016.03.018","article-title":"Calcium-driven folding of RTX domain \u03b2-rolls ratchets translocation of RTX proteins through type I secretion ducts","volume":"62","author":"Bumba","year":"2016","journal-title":"Mol Cell"},{"key":"10.1016\/j.micinf.2024.105375_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000901","article-title":"Bordetella adenylate cyclase toxin mobilizes its beta2 integrin receptor into lipid rafts to accomplish translocation across target cell membrane in two steps","volume":"6","author":"Bumba","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2024.105375_bib47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/10409239609110575","article-title":"Homeostatic control of plasma calcium concentration","volume":"31","author":"Hurwitz","year":"1996","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.micinf.2024.105375_bib48","first-page":"832","article-title":"Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation","volume":"18","author":"Kovacs","year":"1997","journal-title":"Endocr Rev"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457924001114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457924001114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T20:59:00Z","timestamp":1762030740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457924001114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1286457924001114"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2024.105375","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bordetella pertussis outer membrane vesicles impair neutrophil bactericidal activity","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2024.105375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"105375"}}