{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:37:55Z","timestamp":1791434275719,"version":"4.3.3"},"reference-count":51,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 0118"],"award-info":[{"award-number":["PIP 0118"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021778","name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PICT 2019-2611"],"award-info":[{"award-number":["PICT 2019-2611"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.micinf.2024.105378","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T17:02:37Z","timestamp":1718384557000},"page":"105378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["C1q modulation of antibody-dependent enhancement of dengue virus infection in human myeloid cell lines is dependent on cell type and antibody specificity"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9370-1073","authenticated-orcid":false,"given":"Alana B.","family":"Byrne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-8672","authenticated-orcid":false,"given":"Florencia A.","family":"Bonnin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo L.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando P.","family":"Polack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-474X","authenticated-orcid":false,"given":"Laura B.","family":"Talarico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2024.105378_bib1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2024.105378_bib2","doi-asserted-by":"crossref","first-page":"e975","DOI":"10.1371\/journal.pntd.0000975","article-title":"Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand","volume":"5","author":"Endy","year":"2011","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.micinf.2024.105378_bib3","series-title":"Dengue: Guidelines for diagnosis, treatment, prevention and control","year":"2009"},{"key":"10.1016\/j.micinf.2024.105378_bib4","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00705-013-1645-3","article-title":"Secondary infection as a risk factor for dengue hemorrhagic fever\/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection","volume":"158","author":"Guzman","year":"2013","journal-title":"Arch Virol"},{"key":"10.1016\/j.micinf.2024.105378_bib5","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans","volume":"358","author":"Katzelnick","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.micinf.2024.105378_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(20)30601-0","article-title":"Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis","author":"Sangkaew","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.micinf.2024.105378_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00528-19","article-title":"Antibody-dependent dengue virus entry modulates cell intrinsic responses for enhanced infection","volume":"4","author":"Chan","year":"2019","journal-title":"mSphere"},{"key":"10.1016\/j.micinf.2024.105378_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/bs.pmbts.2014.10.005","article-title":"A\u00a0game of numbers: the stoichiometry of antibody-mediated neutralization of flavivirus infection","volume":"129","author":"Pierson","year":"2015","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1016\/j.micinf.2024.105378_bib9","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00003-12","article-title":"Role of complement in dengue virus infection: protection or pathogenesis?","volume":"3","author":"Shresta","year":"2012","journal-title":"mBio"},{"key":"10.1016\/j.micinf.2024.105378_bib10","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri3014","article-title":"Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms","volume":"11","author":"Rothman","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.micinf.2024.105378_bib11","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1086\/517587","article-title":"Dengue virus evolution and virulence models","volume":"44","author":"Rico-Hesse","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.micinf.2024.105378_bib12","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1128\/JVI.01257-06","article-title":"Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis","volume":"80","author":"Clyde","year":"2006","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2024.105378_bib13","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.coviro.2017.06.009","article-title":"Flavivirus structural heterogeneity: implications for cell entry","volume":"24","author":"Rey","year":"2017","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.micinf.2024.105378_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004386","article-title":"Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune sera","volume":"10","author":"de Alwis","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2024.105378_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.572681","article-title":"Antibody-dependent enhancement: a challenge for developing a safe dengue vaccine","volume":"10","author":"Shukla","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.micinf.2024.105378_bib16","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1586\/14760584.2016.1121814","article-title":"Paradoxical role of antibodies in dengue virus infections: considerations for prophylactic vaccine development","volume":"15","author":"Acosta","year":"2016","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.micinf.2024.105378_bib17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fimmu.2015.00262","article-title":"Complement system Part I - molecular mechanisms of activation and regulation","volume":"6","author":"Merle","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2024.105378_bib18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1128\/JVI.00992-07","article-title":"Infection-enhancing and -neutralizing activities of mouse monoclonal antibodies against dengue type 2 and 4 viruses are controlled by complement levels","volume":"82","author":"Yamanaka","year":"2008","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2024.105378_bib19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chom.2007.09.015","article-title":"Complement protein C1q inhibits antibody-dependent enhancement of flavivirus infection in an IgG subclass-specific manner","volume":"2","author":"Mehlhop","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2024.105378_bib20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.chom.2009.09.003","article-title":"Complement protein C1q reduces the stoichiometric threshold for antibody-mediated neutralization of West Nile virus","volume":"6","author":"Mehlhop","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micinf.2024.105378_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.virol.2009.08.019","article-title":"Complement modulates pathogenesis and antibody-dependent neutralization of West Nile virus infection through a C5-independent mechanism","volume":"393","author":"Mehlhop","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.micinf.2024.105378_bib22","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ijid.2020.12.039","article-title":"Role of the complement system in antibody-dependent enhancement of flavivirus infections","volume":"103","author":"Byrne","year":"2021","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.micinf.2024.105378_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101762","article-title":"Dissecting virus entry: replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of beta-galactosidase","volume":"9","author":"Burkard","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2024.105378_bib24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.virol.2007.01.043","article-title":"Interference in dengue virus adsorption and uncoating by carrageenans","volume":"363","author":"Talarico","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.micinf.2024.105378_bib25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.virusres.2013.03.005","article-title":"Requirement of cholesterol in the viral envelope for dengue virus infection","volume":"174","author":"Carro","year":"2013","journal-title":"Virus Res"},{"key":"10.1016\/j.micinf.2024.105378_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006685","article-title":"Blockade of dengue virus entry into myeloid cells by endocytic inhibitors in the presence or absence of antibodies","volume":"12","author":"Carro","year":"2018","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.micinf.2024.105378_bib27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.antiviral.2013.08.013","article-title":"Antibody-dependent enhancement of dengue virus infection is inhibited by SA-17, a doxorubicin derivative","volume":"100","author":"Ayala-Nunez","year":"2013","journal-title":"Antivir Res"},{"key":"10.1016\/j.micinf.2024.105378_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000790","article-title":"Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification","volume":"6","author":"Balsitis","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2024.105378_bib29","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1128\/JVI.02484-07","article-title":"Role of dendritic cells in antibody-dependent enhancement of dengue virus infection","volume":"82","author":"Boonnak","year":"2008","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2024.105378_bib30","article-title":"Utility of a dengue-derived monoclonal antibody to enhance zika infection in\u00a0vitro","volume":"8","author":"Charles","year":"2016","journal-title":"PLoS Curr"},{"key":"10.1016\/j.micinf.2024.105378_bib31","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ni.3515","article-title":"Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus","volume":"17","author":"Dejnirattisai","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2024.105378_bib32","doi-asserted-by":"crossref","first-page":"7814","DOI":"10.1128\/JVI.74.17.7814-7823.2000","article-title":"Infection of human cells by dengue virus is modulated by different cell types and viral strains","volume":"74","author":"Diamond","year":"2000","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.micinf.2024.105378_bib33","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1083\/jcb.123.5.1107","article-title":"Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation","volume":"123","author":"Wang","year":"1993","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.micinf.2024.105378_bib34","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.devcel.2006.04.002","article-title":"Dynasore, a cell-permeable inhibitor of dynamin","volume":"10","author":"Macia","year":"2006","journal-title":"Dev Cell"},{"issue":"Pt 2","key":"10.1016\/j.micinf.2024.105378_bib35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/bj3350433","article-title":"Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane","volume":"335","author":"Ilangumaran","year":"1998","journal-title":"Biochem J"},{"key":"10.1016\/j.micinf.2024.105378_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/srep28768","article-title":"How antibodies alter the cell entry pathway of dengue virus particles in macrophages","volume":"6","author":"Ayala-Nunez","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.micinf.2024.105378_bib37","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4161\/mabs.28808","article-title":"Highly parallel characterization of IgG Fc binding interactions","volume":"6","author":"Boesch","year":"2014","journal-title":"MAbs"},{"key":"10.1016\/j.micinf.2024.105378_bib38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.molimm.2020.08.015","article-title":"Cross-reactivity of mouse IgG subclasses to human Fc gamma receptors: antibody deglycosylation only eliminates IgG2b binding","volume":"127","author":"Temming","year":"2020","journal-title":"Mol Immunol"},{"key":"10.1016\/j.micinf.2024.105378_bib39","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.1248943","article-title":"Complement is activated by IgG hexamers assembled at the cell surface","volume":"343","author":"Diebolder","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.micinf.2024.105378_bib40","article-title":"The ligands for human IgG and their effector functions","volume":"8","author":"de Taeye","year":"2019","journal-title":"Antibodies (Basel)"},{"key":"10.1016\/j.micinf.2024.105378_bib41","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3389\/fimmu.2018.00958","article-title":"Potential of murine IgG1 and human IgG4 to inhibit the classical complement and fcgamma receptor activation pathways","volume":"9","author":"Lilienthal","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2024.105378_bib42","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.4049\/jimmunol.1200501","article-title":"Impact of immune complex size and glycosylation on IgG binding to human FcgammaRs","volume":"190","author":"Lux","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micinf.2024.105378_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060989","article-title":"Effects of microparticle size and Fc density on macrophage phagocytosis","volume":"8","author":"Pacheco","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.micinf.2024.105378_bib44","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3389\/fimmu.2019.00223","article-title":"Multiple variables at the leukocyte cell surface impact Fc gamma receptor-dependent mechanisms","volume":"10","author":"Patel","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2024.105378_bib45","article-title":"The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design","author":"Rey","year":"2017","journal-title":"EMBO Rep"},{"key":"10.1016\/j.micinf.2024.105378_bib46","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.imbio.2008.11.008","article-title":"Role of antibodies in controlling dengue virus infection","volume":"214","author":"van der Schaar","year":"2009","journal-title":"Immunobiology"},{"key":"10.1016\/j.micinf.2024.105378_bib47","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature02165","article-title":"Structure of the dengue virus envelope protein after membrane fusion","volume":"427","author":"Modis","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2024.105378_bib48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.virusres.2013.11.007","article-title":"C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells","volume":"179","author":"Douradinha","year":"2014","journal-title":"Virus Res"},{"key":"10.1016\/j.micinf.2024.105378_bib49","article-title":"Antibody-dependent enhancement of dengue virus infection inhibits RLR-mediated Type-I IFN-independent signalling through upregulation of cellular autophagy","volume":"6","author":"Huang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.micinf.2024.105378_bib50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fcimb.2017.00157","article-title":"Anti-idiotypic antibodies specific to prM monoantibody prevent antibody dependent enhancement of dengue virus infection","volume":"7","author":"Wang","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.micinf.2024.105378_bib51","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.molimm.2017.05.025","article-title":"C1q: a fresh look upon an old molecule","volume":"89","author":"Thielens","year":"2017","journal-title":"Mol Immunol"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645792400114X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645792400114X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T20:59:19Z","timestamp":1762030759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S128645792400114X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S128645792400114X"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2024.105378","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"C1q modulation of antibody-dependent enhancement of dengue virus infection in human myeloid cell lines is dependent on cell type and antibody specificity","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2024.105378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"105378"}}