{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:19:14Z","timestamp":1777904354931,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["5222034"],"award-info":[{"award-number":["5222034"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.micinf.2025.105499","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T11:26:52Z","timestamp":1741087612000},"page":"105499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRIM32 positively regulates c-di-GMP-Induced type I interferon signaling pathway in Listeria monocytogenes infection"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-3947","authenticated-orcid":false,"given":"Yaya","family":"Pian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"OuYang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2025.105499_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11112617","article-title":"Combining whole genome sequencing data from human and non-human sources: tackling Listeria monocytogenes outbreaks","volume":"11","author":"Friesema","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.micinf.2025.105499_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11102568","article-title":"Natural antimicrobials: a reservoir to contrast Listeria monocytogenes","volume":"11","author":"Ricci","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.micinf.2025.105499_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-micro-110422-112841","article-title":"Raising a bacterium to the rank of a model system: the Listeria paradigm","volume":"77","author":"Cossart","year":"2023","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.micinf.2025.105499_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens11121491","article-title":"Listeria monocytogenes\u2014how this pathogen uses its virulence mechanisms to infect the hosts","volume":"11","author":"Osek","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.micinf.2025.105499_bib5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-065X.2010.00993.x","article-title":"Cell biology and immunology of Listeria monocytogenes infections: novel insights","volume":"240","author":"Stavru","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.micinf.2025.105499_bib6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/mmi.14472","article-title":"Structure and function of Listeria teichoic acids and their implications","volume":"113","author":"Sumrall","year":"2020","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micinf.2025.105499_bib7","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1074\/jbc.RA117.001614","article-title":"Discovery of genes required for lipoteichoic acid glycosylation predicts two distinct mechanisms for wall teichoic acid glycosylation","volume":"293","author":"Rismondo","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1016\/j.micinf.2025.105499_bib8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41586-024-07614-7","article-title":"Molecular definition of the endogenous Toll-like receptor signalling pathways","volume":"631","author":"Fisch","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2025.105499_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008622","article-title":"TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes","volume":"16","author":"Nguyen","year":"2020","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2025.105499_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/s13099-023-00558-9","article-title":"TRIM32 reduced the recruitment of innate immune cells and the killing capacity of Listeria monocytogenes by inhibiting secretion of chemokines","volume":"15","author":"OuYang","year":"2023","journal-title":"Gut Pathog"},{"key":"10.1016\/j.micinf.2025.105499_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijmm.2021.151515","article-title":"LincRNA-Cox2 regulates IL6\/JAK3\/STAT3 and NF-\u03baB P65 pathway activation in Listeria monocytogenes-infected RAW264.7 cells","volume":"311","author":"Zhu","year":"2021","journal-title":"International Journal of Medical Microbiology"},{"key":"10.1016\/j.micinf.2025.105499_bib12","article-title":"CLEC5A is a critical receptor in innate immunity against Listeria infection","volume":"8","author":"Chen","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.micinf.2025.105499_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2024.100829","article-title":"Immunopeptidomics mapping of Listeria monocytogenes T cell epitopes in mice","volume":"23","author":"Gul","year":"2024","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.micinf.2025.105499_bib14","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-004022","article-title":"CD4(+) T-cell epitope-based heterologous prime-boost vaccination potentiates anti-tumor immunity and PD-1\/PD-L1 immunotherapy","volume":"10","author":"Xiao","year":"2022","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.micinf.2025.105499_bib15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.31083\/j.fbl2905176","article-title":"Designing a multiepitope vaccine against the foodborne pathogenic bacteria Listeria monocytogenes using subtractive immunoinformatics approaches","volume":"29","author":"Aziz","year":"2024","journal-title":"Front Biosci"},{"key":"10.1016\/j.micinf.2025.105499_bib16","doi-asserted-by":"crossref","DOI":"10.1172\/JCI168465","article-title":"Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection","volume":"133","author":"McIntosh","year":"2023","journal-title":"J Clin Investig"},{"key":"10.1016\/j.micinf.2025.105499_bib17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.biocel.2016.07.023","article-title":"TRIM32 ubiquitin E3 ligase, one enzyme for several pathologies: from muscular dystrophy to tumours","volume":"79","author":"Lazzari","year":"2016","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.micinf.2025.105499_bib18","doi-asserted-by":"crossref","first-page":"28646","DOI":"10.1074\/jbc.M112.362608","article-title":"TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA\/STING protein for K63-linked ubiquitination","volume":"287","author":"Zhang","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.micinf.2025.105499_bib19","article-title":"The age of cyclic dinucleotide vaccine adjuvants","volume":"8","author":"Gogoi","year":"2020","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.micinf.2025.105499_bib20","article-title":"TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3\/4-mediated innate immune responses","volume":"13","author":"Philpott","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2025.105499_bib21","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.4049\/jimmunol.181.3.2028","article-title":"Lipoproteins of Listeria monocytogenes are critical for virulence and TLR2-mediated immune activation","volume":"181","author":"Machata","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2025.105499_bib22","article-title":"Pattern recognition receptors in innate immunity to obligate intracellular bacteria","volume":"1","author":"Fisher","year":"2021","journal-title":"Zoon"},{"key":"10.1016\/j.micinf.2025.105499_bib23","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191422","article-title":"HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection","volume":"217","author":"Bodda","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.micinf.2025.105499_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2014.00050","article-title":"The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons","volume":"4","author":"Dussurget","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.micinf.2025.105499_bib25","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1111\/j.1462-5822.2011.01619.x","article-title":"The bacterial second messenger c-di-GMP: mechanisms of signalling","volume":"13","author":"Mills","year":"2011","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.micinf.2025.105499_bib26","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.4049\/jimmunol.178.4.2171","article-title":"Bacterial c-di-GMP is an immunostimulatory molecule","volume":"178","author":"Karaolis","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2025.105499_bib27","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1128\/IAI.01762-06","article-title":"Cyclic di-GMP stimulates protective innate immunity in bacterial pneumonia","volume":"75","author":"Karaolis","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2025.105499_bib28","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1128\/AAC.49.3.1029-1038.2005","article-title":"c-di-GMP (3'-5'-cyclic diguanylic acid) inhibits Staphylococcus aureus cell-cell interactions and biofilm formation","volume":"49","author":"Karaolis","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.micinf.2025.105499_bib29","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1084\/jem.20082874","article-title":"A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP","volume":"206","author":"McWhirter","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.micinf.2025.105499_bib30","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/ni.2460","article-title":"The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response","volume":"13","author":"Parvatiyar","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.micinf.2025.105499_bib31","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1128\/jb.96.2.352-357.1968","article-title":"Listeria monocytogenes L forms. I. Induction maintenance, and biological characteristics","volume":"96","author":"Edman","year":"1968","journal-title":"J Bacteriol"},{"key":"10.1016\/j.micinf.2025.105499_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00957-19","article-title":"TRIM32 drives pathogenesis in streptococcal toxic shock-like syndrome and Streptococcus suis meningitis by regulating innate immune responses","volume":"88","author":"OuYang","year":"2020","journal-title":"Infect Immun"},{"key":"10.1016\/j.micinf.2025.105499_bib33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/MMBR.05015-11","article-title":"Into the eye of the cytokine storm","volume":"76","author":"Jennifer","year":"2012","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.micinf.2025.105499_bib34","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3389\/fimmu.2020.01446","article-title":"The COVID-19 cytokine storm; what we know so far","volume":"11","author":"Ragab","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.micinf.2025.105499_bib35","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1084\/jem.20040976","article-title":"Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes","volume":"200","author":"Auerbuch","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.micinf.2025.105499_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003861","article-title":"STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes","volume":"10","author":"Archer","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2025.105499_bib37","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.4049\/jimmunol.1100088","article-title":"MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP","volume":"187","author":"Jin","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2025.105499_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004301","article-title":"Cyclic di-GMP-dependent signaling pathways in the pathogenic Firmicute Listeria monocytogenes","volume":"10","author":"Chen","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.micinf.2025.105499_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fsi.2016.11.036","article-title":"Fish TRIM32 functions as a critical antiviral molecule against iridovirus and nodavirus","volume":"60","author":"Yu","year":"2017","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.micinf.2025.105499_bib40","first-page":"394","article-title":"EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer","volume":"1","author":"Gong","year":"2020","journal-title":"Nat Can (Ott)"},{"key":"10.1016\/j.micinf.2025.105499_bib41","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.4049\/jimmunol.1700699","article-title":"NEMO-IKK\u03b2 are essential for IRF3 and NF-\u03baB activation in the cGAS-STING pathway","volume":"199","author":"Fang","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.micinf.2025.105499_bib42","doi-asserted-by":"crossref","first-page":"25729","DOI":"10.1074\/jbc.M111.241893","article-title":"TRIM32 protein sensitizes cells to tumor necrosis factor (TNF\u03b1)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of apoptosis (XIAP)","volume":"286","author":"Ryu","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.micinf.2025.105499_bib43","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fcimb.2014.00050","article-title":"The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons","volume":"4","author":"Dussurget","year":"2014","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457925000310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457925000310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:22:32Z","timestamp":1777638152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457925000310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1286457925000310"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2025.105499","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRIM32 positively regulates c-di-GMP-Induced type I interferon signaling pathway in Listeria monocytogenes infection","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2025.105499","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"105499"}}