{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:22:10Z","timestamp":1784784130979,"version":"3.55.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.micpath.2004.06.009","type":"journal-article","created":{"date-parts":[[2004,9,21]],"date-time":"2004-09-21T18:24:36Z","timestamp":1095791076000},"page":"177-184","source":"Crossref","is-referenced-by-count":67,"title":["Stat 4 but not Stat 6 mediated immune mechanisms are essential in protection against plague"],"prefix":"10.1016","volume":"37","author":[{"given":"Stephen. J.","family":"Elvin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Diane","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.micpath.2004.06.009_bib1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"Yersinia pestis\u2014etiologic agent of plague","volume":"10","author":"Perry","year":"1997","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"10.1016\/j.micpath.2004.06.009_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3201\/eid0701.010106","article-title":"Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis","volume":"7","author":"Guiyole","year":"2001","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"10.1016\/j.micpath.2004.06.009_bib3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1365-2958.2002.03159.x","article-title":"High frquency conjugative transfer of antibiotic resistance genes to Yersinia pestis in the flea mid-gut","volume":"46","author":"Hinnebusch","year":"2002","journal-title":"Mol Microbiol"},{"issue":"3","key":"10.1016\/j.micpath.2004.06.009_bib4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/oxfordjournals.bmb.a011715","article-title":"Plague","volume":"54","author":"Titball","year":"1998","journal-title":"Br Med Bull"},{"key":"10.1016\/j.micpath.2004.06.009_bib5","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1093\/infdis\/129.Supplement_1.S19","article-title":"Plague immunisation II. Relation of adverse clinical reactions to multiple immunisations with killed vaccine","volume":"129","author":"Marshall","year":"1974","journal-title":"J Infect Dis"},{"key":"10.1016\/j.micpath.2004.06.009_bib6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1001\/jama.202.4.365","article-title":"Pneumonic plague in an untreated plague vaccined individual","volume":"202","author":"Cohen","year":"1967","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.micpath.2004.06.009_bib7","first-page":"653","article-title":"Effectiveness of live or killed plague vaccines in man","volume":"42","author":"Meyer","year":"1970","journal-title":"Bull World Health Org"},{"key":"10.1016\/j.micpath.2004.06.009_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4049\/jimmunol.68.2.131","article-title":"Studies on immunisation against plague","volume":"68","author":"Baker","year":"1952","journal-title":"J Immunol"},{"key":"10.1016\/j.micpath.2004.06.009_bib9","first-page":"59","article-title":"Virulence of Pasturella pestis and immunity to plague","volume":"37","author":"Burrows","year":"1963","journal-title":"Ergebnisse der Mikrobiologie"},{"issue":"3","key":"10.1016\/j.micpath.2004.06.009_bib10","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1128\/IAI.70.3.1453-1460.2002","article-title":"Role of fraction 1 antigen of Yersinia pestis in inhibition of phagocytosis","volume":"70","author":"Du","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2004.06.009_bib11","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/1791246a0","article-title":"Virulence of Pasturella pestis","volume":"179","author":"Burrows","year":"1957","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.micpath.2004.06.009_bib12","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1128\/IAI.64.11.4580-4585.1996","article-title":"Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis","volume":"64","author":"Anderson","year":"1996","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.micpath.2004.06.009_bib13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.4269\/ajtmh.1990.43.389","article-title":"Recombinant Capsular Antigen (Fraction-1) from Yersinia pestis induces a protective antibody-response in BALB\/C mice","volume":"43","author":"Simpson","year":"1990","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"10.1016\/j.micpath.2004.06.009_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1128\/IAI.63.2.563-568.1995","article-title":"Immunization with Live Recombinant Salmonella Typhimurium aroA producing F1 antigen protects against plague","volume":"63","author":"Oyston","year":"1995","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.micpath.2004.06.009_bib15","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1128\/IAI.31.2.839-841.1981","article-title":"Plasmids in Yersinia Pestis","volume":"31","author":"Ferber","year":"1981","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.micpath.2004.06.009_bib16","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1128\/jb.173.5.1607-1616.1991","article-title":"Analysis of the V-Antigen Lcrgvh-Yopbd Operon of Yersinia Pseudotuberculosis\u2014evidence for a regulatory role of Lcrh and Lcrv","volume":"173","author":"Bergman","year":"1991","journal-title":"J Bacteriol"},{"issue":"1","key":"10.1016\/j.micpath.2004.06.009_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1128\/IAI.61.1.23-31.1993","article-title":"Association between virulence of Yersinia pestis and suppression of gamma interferon and tumour necrosis factor alpha","volume":"61","author":"Nakajima","year":"1993","journal-title":"Infect Immun"},{"issue":"8","key":"10.1016\/j.micpath.2004.06.009_bib18","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1128\/IAI.63.8.3021-3029.1995","article-title":"Suppression of Cytokines in Mice by Protein a-V antigen fusion peptide and restoration of synthesis by active immunization","volume":"63","author":"Nakajima","year":"1995","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.micpath.2004.06.009_bib19","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1128\/IAI.65.4.1196-1203.1997","article-title":"Resistance to lipopolysaccharide mediated by the Yersinia pestis V antigen-polyhistidine fusion peptide: amplification of interleukin-10","volume":"65","author":"Nedialkov","year":"1997","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.micpath.2004.06.009_bib20","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.4049\/jimmunol.168.3.1315","article-title":"Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice","volume":"168","author":"Sing","year":"2002","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.micpath.2004.06.009_bib21","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1128\/JB.180.5.1207-1214.1998","article-title":"The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD","volume":"180","author":"Sarker","year":"1998","journal-title":"J Bacteriol"},{"issue":"8","key":"10.1016\/j.micpath.2004.06.009_bib22","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1128\/IAI.63.8.2854-2858.1995","article-title":"Active immunization with recombinant V-antigen from Yersinia Pestis protects mice against plague","volume":"63","author":"Leary","year":"1995","journal-title":"Infect Immun"},{"issue":"10","key":"10.1016\/j.micpath.2004.06.009_bib23","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0264-410X(96)00303-9","article-title":"A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunized animals against pneumonic plague","volume":"15","author":"Williamson","year":"1997","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.micpath.2004.06.009_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2249.1999.00859.x","article-title":"An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse model","volume":"116","author":"Williamson","year":"1999","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"10.1016\/j.micpath.2004.06.009_bib25","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1084\/jem.176.4.1091","article-title":"The Presence of Interleukin-4 during in vitro priming determines the lymphokine-producing potential of Cd4+T-cells from T-cell receptor transgenic mice","volume":"176","author":"Seder","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/j.micpath.2004.06.009_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"Th1-Cell and Th2-Cell\u2014different patterns of lymphokine secretion lead to different functional-properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu Rev Immunol"},{"issue":"3","key":"10.1016\/j.micpath.2004.06.009_bib27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0167-5699(96)80606-2","article-title":"The expanding universe of T-cell subsets: Th1, Th2 and more","volume":"17","author":"Mosmann","year":"1996","journal-title":"Immunol Today"},{"issue":"3\/4","key":"10.1016\/j.micpath.2004.06.009_bib28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1574-695X.1995.tb00196.x","article-title":"A new improved subunit vaccine for plague\u2014the basis of protection","volume":"12","author":"Williamson","year":"1995","journal-title":"Fems Immunol Med Microbiol"},{"issue":"4804","key":"10.1016\/j.micpath.2004.06.009_bib29","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.3107127","article-title":"Interferon-Gamma and B-cell stimulatory factor-I reciprocally regulate Ig isotype production","volume":"236","author":"Snapper","year":"1987","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.micpath.2004.06.009_bib30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/mpat.2000.0385","article-title":"The F1 and V subunit vaccine protects against plague in the absence of IL-4 driven immune responses","volume":"29","author":"Elvin","year":"2000","journal-title":"Microb Pathog"},{"issue":"3","key":"10.1016\/j.micpath.2004.06.009_bib31","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0167-5699(96)80600-1","article-title":"IL-4 and IL-13 receptors: are they one and the same?","volume":"17","author":"Callard","year":"1996","journal-title":"Immunol Today"},{"key":"10.1016\/j.micpath.2004.06.009_bib32","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1146\/annurev.immunol.17.1.701","article-title":"The IL-4 receptor: signaling mechanisms and biologic functions","volume":"17","author":"Nelms","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.micpath.2004.06.009_bib33","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/380630a0","article-title":"Lack of IL-4-induced Th2 response and IgE switching in mice with disrupted Stat6 gene","volume":"380","author":"Shimoda","year":"1996","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.micpath.2004.06.009_bib34","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1074-7613(00)80477-X","article-title":"IL-13, IL-4R alpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis","volume":"8","author":"Urban","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.micpath.2004.06.009_bib35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1074-7613(00)80156-9","article-title":"Stat6-Independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment","volume":"12","author":"Ouyang","year":"2000","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.micpath.2004.06.009_bib36","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80240-8","article-title":"The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells","volume":"89","author":"Zheng","year":"1997","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.micpath.2004.06.009_bib37","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1074-7613(00)80073-4","article-title":"The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines","volume":"10","author":"Kim","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.micpath.2004.06.009_bib38","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.immunol.15.1.707","article-title":"Transcription factors of the NFAT family: regulation and function","volume":"15","author":"Rao","year":"1997","journal-title":"Annu Rev Immunol"},{"issue":"2-3","key":"10.1016\/j.micpath.2004.06.009_bib39","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0264-410X(00)00108-0","article-title":"Protection conferred by a fully recombinant sub-unit vaccine against Yersinia pestis in male and female mice of four inbred strains","volume":"19","author":"Jones","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2004.06.009_bib40","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.4049\/jimmunol.161.5.2223","article-title":"Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes","volume":"161","author":"Dubois","year":"1998","journal-title":"J Immunol"},{"issue":"6587","key":"10.1016\/j.micpath.2004.06.009_bib41","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/382171a0","article-title":"Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells","volume":"382","author":"Thierfelder","year":"1996","journal-title":"Nature"},{"issue":"6587","key":"10.1016\/j.micpath.2004.06.009_bib42","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/382174a0","article-title":"Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice","volume":"382","author":"Kaplan","year":"1996","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.micpath.2004.06.009_bib43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0167-5699(85)90080-5","article-title":"Immune Interferon\u2014a Pleiotropic Lymphokine with multiple effects","volume":"6","author":"Trinchieri","year":"1985","journal-title":"Immunol Today"},{"issue":"6","key":"10.1016\/j.micpath.2004.06.009_bib44","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1128\/IAI.62.6.2590-2599.1994","article-title":"Immune-responses to Yersinia enterocolitica in susceptible BALB\/C and resistant C57BL\/6 mice\u2014an essential role for Gamma-interferon","volume":"62","author":"Autenrieth","year":"1994","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.micpath.2004.06.009_bib45","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1128\/IAI.66.5.2213-2220.1998","article-title":"Ambiguous role of interleukin-12 in Yersinia enterocolitica infection in susceptible and resistant mouse strains","volume":"66","author":"Bohn","year":"1998","journal-title":"Infect Immun"},{"issue":"16","key":"10.1016\/j.micpath.2004.06.009_bib46","doi-asserted-by":"crossref","first-page":"8778","DOI":"10.1073\/pnas.97.16.8778","article-title":"Molecular and cell biology aspects of plague","volume":"97","author":"Cornelis","year":"2000","journal-title":"Proc Natl Acad Sci"},{"issue":"8","key":"10.1016\/j.micpath.2004.06.009_bib47","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1084\/jem.20020908","article-title":"Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression","volume":"196","author":"Sing","year":"2002","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.micpath.2004.06.009_bib48","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1574-695X.1998.tb01168.x","article-title":"Macromolecular organisation of recombinant Yersinia pestis F1 antigen and the effect of structure on immunogenicity","volume":"21","author":"Miller","year":"1998","journal-title":"Fems Immunol Med Microbiol"},{"issue":"11","key":"10.1016\/j.micpath.2004.06.009_bib49","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1128\/IAI.65.11.4476-4482.1997","article-title":"Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunization","volume":"65","author":"Hill","year":"1997","journal-title":"Infect Immun"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401004000828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401004000828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T10:18:08Z","timestamp":1682763488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401004000828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0882401004000828"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2004.06.009","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}