{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:18:36Z","timestamp":1792167516665,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1016\/j.micpath.2005.07.003","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T11:12:06Z","timestamp":1126955526000},"page":"139-147","source":"Crossref","is-referenced-by-count":109,"title":["Regulation of complement activation at the C3-level by serum resistant leptospires"],"prefix":"10.1016","volume":"39","author":[{"given":"Taru","family":"Meri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Murgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Stefanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Meri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Cinco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2005.07.003_bib1","article-title":"Leptospira and leptospirosis. Melbourne, Australia","author":"Faine","year":"1999","journal-title":"MediSci"},{"key":"10.1016\/j.micpath.2005.07.003_bib2","series-title":"Nature Encyclopedia of Life Sciences December","article-title":"Leptospirosis.","author":"Sitripija","year":"1999"},{"key":"10.1016\/j.micpath.2005.07.003_bib3","first-page":"409","article-title":"Studies on the interaction between macrophages and leptospires","volume":"124","author":"Cinco","year":"1981","journal-title":"J Gen Microbiol"},{"key":"10.1016\/j.micpath.2005.07.003_bib4","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1128\/IAI.46.3.809-813.1984","article-title":"Role of specific antibody in interaction of leptospires with human monocytes and monocyte-derived macrophages","volume":"46","author":"Wang","year":"1984","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.07.003_bib5","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1128\/IAI.70.12.7172-7175.2002","article-title":"Leptospires are killed in vitro by both oxygen-dependent and -independent reactions","volume":"70","author":"Murgia","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.07.003_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/mpat.2002.0537","article-title":"Leptospira interrogans binds to the CR3 receptor on mammalian cells","volume":"33","author":"Cinco","year":"2002","journal-title":"Microb Pathog"},{"key":"10.1016\/j.micpath.2005.07.003_bib7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1128\/JB.93.2.513-519.1967","article-title":"Antileptospiral activity of serum. II. Leptospiral virulence factor","volume":"93","author":"Johnson","year":"1967","journal-title":"J Bacteriol"},{"key":"10.1016\/j.micpath.2005.07.003_bib8","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1128\/JB.91.4.1403-1409.1966","article-title":"Antileptospiral activity of serum. I. Normal and immune serum","volume":"91","author":"Johnson","year":"1966","journal-title":"J Bacteriol"},{"key":"10.1016\/j.micpath.2005.07.003_bib9","first-page":"261","article-title":"Activation of complement by leptospires and its bactericidal activity","volume":"254","author":"Cinco","year":"1983","journal-title":"Zentralbl Bakteriol Mikrobiol Hyg"},{"key":"10.1016\/j.micpath.2005.07.003_bib10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0161-5890(99)00049-8","article-title":"Evasion of pathogens by avoiding recognition or eradication by complement, in part via molecular mimicry","volume":"36","author":"W\u00fcrzner","year":"1999","journal-title":"Mol Immunol"},{"key":"10.1016\/j.micpath.2005.07.003_bib11","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S1286-4579(99)80081-1","article-title":"Complement-resistance mechanisms of bacteria","volume":"1","author":"Rautemaa","year":"1999","journal-title":"Microb Infect"},{"key":"10.1016\/j.micpath.2005.07.003_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev.mi.42.100188.001221","article-title":"Complement evasion by bacteria and parasites","volume":"42","author":"Joiner","year":"1988","journal-title":"Ann Rev Microbiol"},{"key":"10.1016\/j.micpath.2005.07.003_bib13","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.4049\/jimmunol.161.9.4894","article-title":"Role of the hypervariable region in streptococcal M proteins: binding of a human complement inhibitor","volume":"161","author":"Johnsson","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.micpath.2005.07.003_bib14","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.4049\/jimmunol.160.7.3349","article-title":"Identification of a domain in human factor H and factor H-like protein- 1 required for the interaction with streptococcal M proteins","volume":"160","author":"Kotarsky","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.micpath.2005.07.003_bib15","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1128\/IAI.67.9.4517-4524.1999","article-title":"Resistance to both complement activation and phagocytosis in type 3 pneumococci is mediated by the binding of complement regulatory protein factor H","volume":"67","author":"Neeleman","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.07.003_bib16","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0161-5890(99)00114-5","article-title":"The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis","volume":"36","author":"Ram","year":"1999","journal-title":"Mol Immunol"},{"key":"10.1016\/j.micpath.2005.07.003_bib17","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1084\/jem.188.4.671","article-title":"Binding of complement factor H to loop 5 of porin protein 1A: a molecular mechanism of serum resistance of nonsialylated Neisseria gonorrhoeae","volume":"188","author":"Ram","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.micpath.2005.07.003_bib18","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1128\/IAI.69.6.3685-3691.2001","article-title":"Complement evasion by Borrelia burgdorferi: serum-resistant strains promote C3b inactivation","volume":"69","author":"Alitalo","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.07.003_bib19","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.4049\/jimmunol.169.7.3847","article-title":"Complement inhibitor factor H binding to lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs","volume":"169","author":"Alitalo","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.micpath.2005.07.003_bib20","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1002\/1521-4141(200106)31:6<1674::AID-IMMU1674>3.0.CO;2-2","article-title":"Immune evasion of Borrelia burgdorferi by acquisition of human complement regulators FHL-1\/reconectin and Factor H","volume":"31","author":"Kraiczy","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.micpath.2005.07.003_bib21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1567-5769(00)00041-2","article-title":"Mechanism of complement resistance of pathogenic Borrelia burgdorferi isolates","volume":"1","author":"Kraiczy","year":"2001","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.micpath.2005.07.003_bib22","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.1128\/IAI.70.9.5185-5192.2002","article-title":"The yeast Candida albicans binds complement regulators factor H and FHL- 1","volume":"70","author":"Meri","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.07.003_bib23","series-title":"Leptospirosis in man and animals","author":"Alston","year":"1958"},{"key":"10.1016\/j.micpath.2005.07.003_bib24","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1128\/IAI.56.8.1831-1836.1988","article-title":"Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation","volume":"56","author":"Schwan","year":"1988","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.07.003_bib25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/mpat.2002.0537","article-title":"Leptospira interrogans binds to the CR3 receptor on mammalian cells","volume":"33","author":"Cinco","year":"2002","journal-title":"Microb Pathog"},{"key":"10.1016\/j.micpath.2005.07.003_bib26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-1-4684-8088-7_17","article-title":"Leptospires macrophage interactions","volume":"141","author":"Cinco","year":"1982","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.micpath.2005.07.003_bib27","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.4049\/jimmunol.155.12.5663","article-title":"Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1","volume":"155","author":"K\u00fchn","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.micpath.2005.07.003_bib28","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/eji.1830190936","article-title":"Human complement factor H: an additional gene product of 43 kDa isolated from human plasma shows cofactor activity for the cleavage of the third component of complement","volume":"19","author":"Misasi","year":"1989","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.micpath.2005.07.003_bib29","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1128\/IAI.71.5.2414-2421.2003","article-title":"LipL21 is a novel surface-exposed lipoprotein of pathogenic Leptospira species","volume":"71","author":"Cullen","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.07.003_bib30","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1128\/jb.175.13.4225-4234.1993","article-title":"Molecular cloning and sequence analysis of the gene encoding OmpL1, a transmembrane outer membrane protein of pathogenic Leptospira spp","volume":"175","author":"Haake","year":"1993","journal-title":"J Bacteriol"},{"key":"10.1016\/j.micpath.2005.07.003_bib31","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1128\/IAI.68.4.2276-2285.2000","article-title":"The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infection","volume":"68","author":"Haake","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.07.003_bib32","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1128\/IAI.66.4.1579-1587.1998","article-title":"Characterization of leptospiral outer membrane lipoprotein LipL36: downregulation associated with late-log-phase growth and mammalian infection","volume":"66","author":"Haake","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.07.003_bib33","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1128\/JB.186.7.2164-2172.2004","article-title":"Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis","volume":"186","author":"Nascimento","year":"2004","journal-title":"J Bacteriol"},{"key":"10.1016\/j.micpath.2005.07.003_bib34","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000463102","article-title":"Common binding region of complement factors B, H and CR1 on C3b revealed by monoclonal anti-C3d","volume":"6","author":"Koistinen","year":"1989","journal-title":"Complement Inflamm"},{"key":"10.1016\/j.micpath.2005.07.003_bib35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1042\/bj2830317","article-title":"Limited tryptic cleavage of complement factor H abrogates recognition of sialic acid-containing surfaces by the alternative pathway of complement","volume":"283","author":"Koistinen","year":"1992","journal-title":"Biochem J"},{"key":"10.1016\/j.micpath.2005.07.003_bib36","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1099\/00222615-6-4-487","article-title":"Growth temperatures, virulence, survival, and nutrition of leptospires","volume":"6","author":"Ellinghausen","year":"1973","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.micpath.2005.07.003_bib37","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/infdis\/157.4.697","article-title":"Analysis of C3 deposition and degradation on bacterial surfaces after opsonization","volume":"157","author":"Gordon","year":"1988","journal-title":"J Inf Dis"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401005000835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401005000835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:52:41Z","timestamp":1706575961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401005000835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S0882401005000835"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2005.07.003","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}