{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:46:51Z","timestamp":1758815211022},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.micpath.2005.11.005","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T12:41:51Z","timestamp":1137760911000},"page":"110-115","source":"Crossref","is-referenced-by-count":13,"title":["Expression of OmpP2A and OmpP2B is not required for pustule formation by Haemophilus ducreyi in human volunteers"],"prefix":"10.1016","volume":"40","author":[{"given":"Diane","family":"Janowicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole R.","family":"Luke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate R.","family":"Fortney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry P.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony A.","family":"Campagnari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley M.","family":"Spinola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2005.11.005_bib1","first-page":"818","article-title":"Eradicating chancroid","volume":"79","author":"Steen","year":"2001","journal-title":"Bull WHO"},{"key":"10.1016\/j.micpath.2005.11.005_bib2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S1286-4579(02)01639-8","article-title":"Haemophilus ducreyi: clinical features, epidemiology, and prospects for disease control","volume":"4","author":"Bong","year":"2002","journal-title":"Microbes Infect"},{"key":"10.1016\/j.micpath.2005.11.005_bib3","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1093\/infdis\/169.5.1146","article-title":"Experimental human infection with Haemophilus ducreyi","volume":"169","author":"Spinola","year":"1994","journal-title":"J Infect Dis"},{"key":"10.1016\/j.micpath.2005.11.005_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00007435-200002000-00009","article-title":"Cumulative experience with Haemophilus ducreyi in the human model of experimental infection","volume":"27","author":"Al-Tawfiq","year":"2000","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.micpath.2005.11.005_bib5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00007435-200202000-00009","article-title":"Men are more susceptible to pustule formation than women in the experimental model of Haemophilus ducreyi infection","volume":"29","author":"Bong","year":"2002","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.micpath.2005.11.005_bib6","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1128\/IAI.71.11.6658-6663.2003","article-title":"Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infection","volume":"71","author":"Spinola","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib7","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1128\/IAI.70.4.1667-1676.2002","article-title":"Immunopathogenesis of Haemophilus ducreyi infection (chancroid)","volume":"70","author":"Spinola","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib8","doi-asserted-by":"crossref","first-page":"7178","DOI":"10.1128\/IAI.71.12.7178-7182.2003","article-title":"Haemophilus ducreyi requires an intact flp gene cluster for virulence in humans","volume":"71","author":"Spinola","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib9","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1128\/IAI.72.8.4528-4533.2004","article-title":"Expression of the LspA1 and LspA2 proteins by Haemophilus ducreyi is required for virulence in human volunteers","volume":"72","author":"Janowicz","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib10","doi-asserted-by":"crossref","unstructured":"Janowicz D, Leduc I, Fortney KR, Katz BP, Elkins C, Spinola SM. A DltA mutant of Haemophilus ducreyi is partially attenuated in its ability to cause pustules in human volunteers. Infect Immun, in Press.","DOI":"10.1128\/IAI.74.2.1394-1397.2006"},{"key":"10.1016\/j.micpath.2005.11.005_bib11","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1128\/IAI.72.11.6271-6278.2004","article-title":"Differential experssion of porins OmpP2A and OmpP2B of Haemophilus ducreyi","volume":"72","author":"Prather","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib12","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1128\/IAI.56.10.2673-2679.1988","article-title":"Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae","volume":"56","author":"Murphy","year":"1988","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib13","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1128\/jb.169.3.929-933.1987","article-title":"Role of porins in outer membrane permeability","volume":"169","author":"Hancock","year":"1987","journal-title":"J Bacteriol"},{"key":"10.1016\/j.micpath.2005.11.005_bib14","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1128\/AAC.33.11.1831","article-title":"Outer membrane barrier as a mechanism of antimicrobial resistance","volume":"33","author":"Nikaido","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.micpath.2005.11.005_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.49.1.1-32.1985","article-title":"Molecular basis of bacterial outer membrane permeability","volume":"49","author":"Nikaido","year":"1985","journal-title":"Microbiol Rev"},{"key":"10.1016\/j.micpath.2005.11.005_bib16","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1128\/IAI.68.11.6441-6448.2000","article-title":"Expression of peptidoglycan-associated lipoprotein is required for virulence in the human model of Haemophilus ducreyi infection","volume":"68","author":"Fortney","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/jac\/38.5.849","article-title":"Comparison of the E-test with agar dilution for antimicrobial susceptibility testing of Haemophilus ducreyi","volume":"38","author":"Lagergard","year":"1996","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.micpath.2005.11.005_bib18","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1086\/314489","article-title":"The immune response to Haemophilus ducreyi resembles a delayed-type hypersensitivity reaction throughout experimental infection of human subjects","volume":"178","author":"Palmer","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.micpath.2005.11.005_bib19","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/infdis\/173.2.394","article-title":"Haemophilus ducreyi elicits a cutaneous infiltrate of CD4 cells during experimental human infection","volume":"173","author":"Spinola","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1016\/j.micpath.2005.11.005_bib20","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1128\/IAI.69.2.773-778.2001","article-title":"Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains","volume":"69","author":"Neary","year":"2001","journal-title":"IAI"},{"key":"10.1016\/j.micpath.2005.11.005_bib21","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1128\/IAI.58.10.3312-3318.1990","article-title":"Characterization of a mutant of haemophilus influenzae type b lacking the P2 major outer membrane protein","volume":"58","author":"Cope","year":"1990","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib22","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1084\/jem.174.3.705","article-title":"Bacterial entry and intracellular processing of Neisseria gonorrhoeae in epithelial cells: immunomorphological evidence for alterations in the major outer membrane protein P.IB","volume":"174","author":"Weel","year":"1991","journal-title":"J Exp Med"},{"key":"10.1016\/j.micpath.2005.11.005_bib23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0966-842X(02)00037-9","article-title":"The role of porins in Neisserial pathogenesis and immunity","volume":"11","author":"Massari","year":"2003","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.micpath.2005.11.005_bib24","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1128\/IAI.70.8.4028-4034.2002","article-title":"Immunization with the recombinant PorB outer membrane protein induces a bactericidal immune response against Neisseria meningitidis","volume":"70","author":"Wright","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib25","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1046\/j.1365-2958.1999.01230.x","article-title":"Mutagenesis of the Neisseria gonorrhoeae porin reduces invasion in epithelial cells and enhances phagocyte responsiveness","volume":"31","author":"Bauer","year":"1999","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micpath.2005.11.005_bib26","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1128\/AAC.42.11.2799","article-title":"Gonococcal resistance to beta-lactams and tetracycline involves mutation in loop 3 of the porin encoded at the penB locus","volume":"42","author":"Gill","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.micpath.2005.11.005_bib27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1099\/13500872-145-3-673","article-title":"Porin expression in clinical isolates of Klebsiella pneumoniae","volume":"145","author":"Hernandez-Allez","year":"1999","journal-title":"Microbiology"},{"key":"10.1016\/j.micpath.2005.11.005_bib28","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1128\/jb.179.5.1764-1773.1997","article-title":"The major outer membrane protein of Haemophilus ducreyi consists of two OmpA homologs","volume":"179","author":"Klesney-Tait","year":"1997","journal-title":"J Bacteriol"},{"key":"10.1016\/j.micpath.2005.11.005_bib29","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0021-9258(17)35239-0","article-title":"Identification and characterization of porins in Pseudomonas aeruginosa","volume":"266","author":"Nikaido","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.micpath.2005.11.005_bib30","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1016\/S0021-9258(18)83347-6","article-title":"Identification of the porins in the outer membrane of Pseudomonas aeruginosa that form small diffusion pores","volume":"264","author":"Yoshihara","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.micpath.2005.11.005_bib31","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1016\/S0021-9258(18)45908-X","article-title":"Pore-forming activity of OmpA protein of Escherichia coli","volume":"267","author":"Sugawara","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.micpath.2005.11.005_bib32","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1128\/IAI.61.4.1346-1351.1993","article-title":"The major outer membrane protein of Haemophilus ducreyi is a member of the OmpA family of proteins","volume":"61","author":"Spinola","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib33","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1128\/IAI.68.5.2602-2607.2000","article-title":"Evaluation of an isogenic MOMP-deficient mutant in the human model of Haemophilus ducreyi infection","volume":"68","author":"Throm","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib34","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1128\/IAI.68.6.3352-3361.2000","article-title":"Construction and characterization of Haemophilus ducreyi lipooligosaccharide (LOS) mutants defective in expression of heptosyltransferase III and beta1, 4-glucosyltransferase: identification of LOS glycoforms containing lactosamine repeats","volume":"68","author":"Filiatrault","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2005.11.005_bib35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1574-6968.1998.tb13097.x","article-title":"Facile construction of mutations in Haemophilus ducreyi using lacz as a counter-selectable marker","volume":"164","author":"Bozue","year":"1998","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.micpath.2005.11.005_bib36","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1128\/jb.175.18.5899-5906.1993","article-title":"Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells","volume":"175","author":"Menard","year":"1993","journal-title":"J Bacteriol"},{"key":"10.1016\/j.micpath.2005.11.005_bib37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2958.1993.tb01696.x","article-title":"Generation of isogenic K54 capsule-deficient Escherichia coli strains through TnphoA-mediated gene disruption","volume":"9","author":"Russo","year":"1993","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micpath.2005.11.005_bib38","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1086\/314483","article-title":"Standardization of the experimental model of Haemophilus ducreyi infection in human subjects","volume":"178","author":"Al-Tawfiq","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.micpath.2005.11.005_bib39","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1086\/315309","article-title":"An isogenic hemoglobin receptor-deficient mutant of Haemophilus ducreyi is attenuated in the human model of experimental infection","volume":"181","author":"Al-Tawfiq","year":"2000","journal-title":"J Infect Dis"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401005001531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401005001531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T22:35:09Z","timestamp":1626993309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401005001531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0882401005001531"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2005.11.005","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}