{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:20:58Z","timestamp":1778635258176,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.micpath.2006.05.001","type":"journal-article","created":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T14:30:22Z","timestamp":1153319422000},"page":"96-110","source":"Crossref","is-referenced-by-count":26,"title":["Murine macrophage transcriptional and functional responses to Bacillus anthracis edema toxin"],"prefix":"10.1016","volume":"41","author":[{"given":"Jason E.","family":"Comer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristi L.","family":"Galindo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Autumn M.","family":"Wenglikowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie L.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold R.","family":"Garner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny W.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok K.","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2006.05.001_bib1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1136\/jcp.56.3.182","article-title":"Bacillus anthracis","volume":"56","author":"Spencer","year":"2003","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.micpath.2006.05.001_bib2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1438-4221(00)80056-9","article-title":"Lethal factor of Bacillus anthracis cleaves the N-terminus of MAPKKs: analysis of the intracellular consequences in macrophages","volume":"290","author":"Pellizzari","year":"2000","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.micpath.2006.05.001_bib3","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1073\/pnas.79.10.3162","article-title":"Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells","volume":"79","author":"Leppla","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.micpath.2006.05.001_bib4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0014-5793(02)03609-8","article-title":"Anthrax toxin: a tripartite lethal combination","volume":"531","author":"Ascenzi","year":"2002","journal-title":"FEBS Lett"},{"key":"10.1016\/j.micpath.2006.05.001_bib5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0006-2952(02)01455-7","article-title":"Anthrax toxin receptor proteins","volume":"65","author":"Bradley","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.micpath.2006.05.001_bib6","doi-asserted-by":"crossref","first-page":"C1402","DOI":"10.1152\/ajpcell.00582.2004","article-title":"ATR\/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis\u2019 three sites of entry: implications for the pathogenesis of anthrax infection","volume":"288","author":"Bonuccelli","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.micpath.2006.05.001_bib7","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1128\/IAI.73.2.1069-1080.2005","article-title":"Murine macrophage transcriptional responses to Bacillus anthracis infection and intoxication","volume":"73","author":"Bergman","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2006.05.001_bib8","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1128\/IAI.73.3.1879-1885.2005","article-title":"GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis","volume":"73","author":"Comer","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2006.05.001_bib9","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1128\/IAI.70.9.4997-5007.2002","article-title":"Anthrax edema toxin requires influx of calcium for inducing cyclic AMP toxicity in target cells","volume":"70","author":"Kumar","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2006.05.001_bib10","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/415396a","article-title":"Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin","volume":"415","author":"Drum","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2006.05.001_bib11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1128\/IAI.47.1.306-310.1985","article-title":"Effects of anthrax toxin components on human neutrophils","volume":"47","author":"O\u2019Brien","year":"1985","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2006.05.001_bib12","doi-asserted-by":"crossref","first-page":"8275","DOI":"10.1128\/IAI.73.12.8275-8281.2005","article-title":"Direct inhibition of T-lymphocyte activation by anthrax toxins in vivo","volume":"73","author":"Comer","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2006.05.001_bib13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1084\/jem.20041557","article-title":"Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling","volume":"201","author":"Paccani","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.micpath.2006.05.001_bib14","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1128\/IAI.62.10.4432-4439.1994","article-title":"Anthrax edema toxin differentially regulates lipopolysaccharide-induced monocyte production of tumor necrosis factor alpha and interleukin-6 by increasing intracellular cyclic AMP","volume":"62","author":"Hoover","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2006.05.001_bib15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0014-5793(01)02973-8","article-title":"The main biological determinants of tumor line taxonomy elucidated by a principal component analysis of microarray data","volume":"507","author":"Crescenzi","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.micpath.2006.05.001_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","article-title":"Mammalian MAP kinase signalling cascades","volume":"410","author":"Chang","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2006.05.001_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.immunol.20.091301.131133","article-title":"MAP kinases in the immune response","volume":"20","author":"Dong","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.micpath.2006.05.001_bib18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/modpathol.3880337","article-title":"Quantitative pathology of inhalational anthrax I: quantitative microscopic findings","volume":"14","author":"Grinberg","year":"2001","journal-title":"Mod Pathol"},{"key":"10.1016\/j.micpath.2006.05.001_bib19","doi-asserted-by":"crossref","first-page":"11099","DOI":"10.1016\/S0021-9258(18)60433-8","article-title":"Internalization and processing of Bacillus anthracis lethal toxin by toxin-sensitive and -resistant cells","volume":"264","author":"Singh","year":"1989","journal-title":"J Biol Chem"},{"issue":"Pt3: 739-45","key":"10.1016\/j.micpath.2006.05.001_bib20","article-title":"Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor","volume":"352","author":"Vitale","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.micpath.2006.05.001_bib21","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cytogfr.2004.06.002","article-title":"A pleiotropic cytokine in the central nervous system","volume":"15","author":"Chen","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.micpath.2006.05.001_bib22","doi-asserted-by":"crossref","first-page":"E131","DOI":"10.1038\/ncb0502-e131","article-title":"AP-1 as a regulator of cell life and death","volume":"4","author":"Shaulian","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.micpath.2006.05.001_bib23","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1128\/MCB.17.7.3600","article-title":"CREB controls LAP\/C\/EBP beta transcription","volume":"17","author":"Niehof","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.micpath.2006.05.001_bib24","doi-asserted-by":"crossref","first-page":"9016","DOI":"10.1074\/jbc.M009284200","article-title":"Interleukin-6-induced tethering of STAT3 to the LAP\/C\/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3","volume":"276","author":"Niehof","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.micpath.2006.05.001_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0303-7207(00)00198-2","volume":"162","author":"Roesler","year":"2000","journal-title":"What is a cAMP response unit? Mol Cell Endocrinol"},{"key":"10.1016\/j.micpath.2006.05.001_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/15216540500097111","article-title":"From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance","volume":"57","author":"Karin","year":"2005","journal-title":"IUBMB Life"},{"key":"10.1016\/j.micpath.2006.05.001_bib27","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1242\/jcs.02459","article-title":"Molecular stop signs: regulation of cell-cycle arrest by C\/EBP transcription factors","volume":"118","author":"Johnson","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.micpath.2006.05.001_bib28","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product","volume":"162","author":"Hoshino","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.micpath.2006.05.001_bib29","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1073\/pnas.96.8.4518","article-title":"A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment","volume":"96","author":"Myokai","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micpath.2006.05.001_bib30","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1242\/jcs.114.6.1061","article-title":"Phagocytosis and the actin cytoskeleton","volume":"114","author":"May","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.micpath.2006.05.001_bib31","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1016\/j.cub.2004.12.017","article-title":"Engulfment: ingestion and migration with Rac, Rho and TRIO","volume":"15","author":"Henson","year":"2005","journal-title":"Curr Biol"},{"key":"10.1016\/j.micpath.2006.05.001_bib32","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1016\/j.cub.2004.12.029","article-title":"Phagocytosis of apoptotic cells is regulated by a UNC-73\/TRIO-MIG-2\/RhoG signaling module and armadillo repeats of CED-12\/ELMO","volume":"14","author":"deBakker","year":"2004","journal-title":"Curr Biol"},{"key":"10.1016\/j.micpath.2006.05.001_bib33","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0968-0004(02)02182-5","article-title":"Transglutaminase 2: an enigmatic enzyme with diverse functions","volume":"27","author":"Fesus","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.micpath.2006.05.001_bib34","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.biolcel.2004.03.003","article-title":"Ghalpha\/tissue transglutaminase 2: an emerging G protein in signal transduction","volume":"96","author":"Mhaouty-Kodja","year":"2004","journal-title":"Biol Cell"},{"key":"10.1016\/j.micpath.2006.05.001_bib35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0167-4889(97)00024-4","article-title":"tTGase\/G alpha h protein expression inhibits adenylate cyclase activity in Balb-C 3T3 fibroblasts membranes","volume":"1357","author":"Gentile","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.micpath.2006.05.001_bib36","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/j.1462-5822.2005.00545.x","article-title":"Anthrax toxin receptor 2 mediates Bacillus anthracis killing of macrophages following spore challenge","volume":"7","author":"Banks","year":"2005","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.micpath.2006.05.001_bib37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0006-291X(02)00227-9","article-title":"Lethal toxin of Bacillus anthracis causes apoptosis of macrophages","volume":"293","author":"Popov","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.micpath.2006.05.001_bib38","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.4049\/jimmunol.174.8.4934","article-title":"Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells","volume":"174","author":"Tournier","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.micpath.2006.05.001_bib39","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0002-9440(10)61218-7","article-title":"Bacillus anthracis Edema Toxin causes extensive tissue lesions and rapid lethality in mice","volume":"167","author":"Firoved","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.micpath.2006.05.001_bib40","doi-asserted-by":"crossref","first-page":"40198","DOI":"10.1074\/jbc.M305788200","article-title":"Identification of Aeromonas hydrophila cytotoxic enterotoxin-induced genes in macrophages using microarrays","volume":"278","author":"Galindo","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.micpath.2006.05.001_bib41","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1128\/IAI.72.9.5439-5445.2004","article-title":"Microarray analysis of Aeromonas hydrophila cytotoxic enterotoxin-treated murine primary macrophages","volume":"72","author":"Galindo","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2006.05.001_bib42","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) Method)","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.micpath.2006.05.001_bib43","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/mpat.2001.0490","article-title":"Early cell signaling by the cytotoxic enterotoxin of Aeromonas hydrophila in macrophages","volume":"32","author":"Ribardo","year":"2002","journal-title":"Microb Pathog"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401006000751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401006000751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T04:27:30Z","timestamp":1683520050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401006000751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":43,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0882401006000751"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2006.05.001","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}