{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:36:38Z","timestamp":1770910598443,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.micpath.2007.10.002","type":"journal-article","created":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T12:35:58Z","timestamp":1194525358000},"page":"279-285","source":"Crossref","is-referenced-by-count":36,"title":["Apolipoprotein E4 enhances attachment of Chlamydophila (Chlamydia) pneumoniae elementary bodies to host cells"],"prefix":"10.1016","volume":"44","author":[{"given":"Herv\u00e9 C.","family":"G\u00e9rard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Fomicheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A.","family":"Whittum-Hudson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan P.","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2007.10.002_bib1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.me.43.020192.001533","article-title":"Chlamydia pneumoniae, strain TWAR pneumonia","volume":"43","author":"Grayston","year":"1992","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.micpath.2007.10.002_bib2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1099\/0022-1317-51-8-623","article-title":"Chlamydia pneumoniae pathogenesis","volume":"51","author":"Campbell","year":"2002","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.micpath.2007.10.002_bib3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1081-1206(10)62666-X","article-title":"Chlamydia pneumoniae, asthma, and COPD: what is the evidence?","volume":"83","author":"Hahn","year":"1999","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.micpath.2007.10.002_bib4","first-page":"73","article-title":"Chlamydia pneumoniae infection and its role in asthma and chronic obstructive pulmonary disease","volume":"12","author":"Clementsen","year":"2002","journal-title":"J Investigat Allergol Clin Immunol"},{"key":"10.1016\/j.micpath.2007.10.002_bib5","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1002\/1529-0131(199909)42:9<1889::AID-ANR13>3.0.CO;2-W","article-title":"Chlamydia pneumoniae is present in synovial tissue of arthritis patients with lower prevalence than that of C. trachomatis","volume":"42","author":"Schumacher","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.micpath.2007.10.002_bib6","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/1529-0131(200007)43:7<1543::AID-ANR19>3.0.CO;2-8","article-title":"Detection of Chlamydia pneumoniae in giant cell vasculitis and correlation with the topographical arrangement of tissue-infiltrating dendritic cells","volume":"43","author":"Wagner","year":"2000","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.micpath.2007.10.002_bib7","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1086\/428739","article-title":"Chlamydia pneumoniae and atherosclerosis","volume":"40","author":"Grayston","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.micpath.2007.10.002_bib8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1462-5822.2003.00352.x","article-title":"Chlamydia pneumoniae and atherosclerosis","volume":"6","author":"Belland","year":"2004","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.micpath.2007.10.002_bib9","first-page":"57","article-title":"Pathogenetic mechanisms and epidemiology of Chlamydia pneumoniae","volume":"14","author":"Leinonen","year":"1993","journal-title":"Eur Heart J"},{"key":"10.1016\/j.micpath.2007.10.002_bib10","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1021\/bi00727a022","article-title":"Heterogeneity of human plasma very low density lipoproteins. Separation of species differing in protein components","volume":"12","author":"Shore","year":"1973","journal-title":"Biochemistry"},{"key":"10.1016\/j.micpath.2007.10.002_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00041433-199906000-00003","article-title":"Apolipoprotein E: from atherosclerosis to Alzheimers disease and beyond","volume":"10","author":"Mahley","year":"1999","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.micpath.2007.10.002_bib12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0022-2275(20)38690-9","article-title":"Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apoE1 and apoE5 isoforms","volume":"28","author":"Ordovas","year":"1987","journal-title":"J Lipid Res"},{"issue":"Suppl 1","key":"10.1016\/j.micpath.2007.10.002_bib13","first-page":"S63","article-title":"Apolipoproteins and atherosclerosis. Apolipoprotein E and Apolipoprotein(a) as candidate genes of premature development of atherosclerosis","volume":"49","author":"Horejsi","year":"2000","journal-title":"Physiol Res"},{"key":"10.1016\/j.micpath.2007.10.002_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.genom.1.1.507","article-title":"Apolipoprotein E: far more than a lipid transport protein","volume":"1","author":"Mahley","year":"2000","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.micpath.2007.10.002_bib15","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1749-6632.1998.tb10653.x","article-title":"Apolipoprotein E and Alzheimers disease: the tip of the susceptibility iceberg","volume":"855","author":"Roses","year":"1998","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.micpath.2007.10.002_bib16","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.micpath.2007.10.002_bib17","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1093\/rheumatology\/38.5.411","article-title":"Chlamydia pneumoniae as a triggering agent in reactive arthritis","volume":"38","author":"Hannu","year":"1999","journal-title":"Rheumatology"},{"key":"10.1016\/j.micpath.2007.10.002_bib18","series-title":"Chlamydia pneumoniae infection and diseases","first-page":"227","article-title":"Chlamydia pneumoniae and inflammatory arthritis","author":"Whittum-Hudson","year":"2004"},{"key":"10.1016\/j.micpath.2007.10.002_bib19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/mpat.1998.0242","article-title":"Frequency of apolipoprotein E (APOE) allele types in patients with Chlamydia-associated arthritis and other arthritides","volume":"26","author":"G\u00e9rard","year":"1999","journal-title":"Microb Pathogen"},{"key":"10.1016\/j.micpath.2007.10.002_bib20","series-title":"Chlamydia-intracellular biology, pathogenesis, and immunity","first-page":"29","article-title":"Developmental biology","author":"Hatch","year":"1999"},{"key":"10.1016\/j.micpath.2007.10.002_bib21","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-2275(20)43176-1","article-title":"Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI","volume":"31","author":"Hixson","year":"1990","journal-title":"J Lipid Res"},{"key":"10.1016\/j.micpath.2007.10.002_bib22","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/00000441-200610000-00003","article-title":"Chlamydophila (Chlamydia) pneumoniae infection of human astrocytes and microglia in culture displays an active, rather than a persistent, phenotype","volume":"332","author":"Dreses-Werringloer","year":"2006","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.micpath.2007.10.002_bib23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.micpath.2005.05.002","article-title":"The load of Chlamydia pneumoniae in the Alzheimer's brain varies with APOE genotype","volume":"39","author":"G\u00e9rard","year":"2005","journal-title":"Microb Pathogen"},{"key":"10.1016\/j.micpath.2007.10.002_bib24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1212\/WNL.50.2.571","article-title":"Multiple sclerosis associated with C. pneumoniae infection of the CNS","volume":"50","author":"Sriram","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.micpath.2007.10.002_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s004300050071","article-title":"Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain","volume":"187","author":"Balin","year":"1998","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.micpath.2007.10.002_bib26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1574-695X.2006.00154.x","article-title":"Chlamydophila (Chlamydia) pneumoniae in the Alzheimer's brain","volume":"48","author":"G\u00e9rard","year":"2006","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.micpath.2007.10.002_bib27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s00415-006-0298-5","article-title":"Evaluation of CSF-Chlamydia pneumoniae, CSF-tau, and CSF-Abeta42 in Alzheimer's disease and vascular dementia","volume":"254","author":"Paradowski","year":"2007","journal-title":"J Neurol"},{"issue":"Suppl 3","key":"10.1016\/j.micpath.2007.10.002_bib28","doi-asserted-by":"crossref","first-page":"S432","DOI":"10.1086\/315615","article-title":"Detection of C. pneumoniae in arterial tissues","volume":"181","author":"Kuo","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.micpath.2007.10.002_bib29","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1086\/514241","article-title":"Induction of macrophage foam cell formation by C. pneumoniae","volume":"177","author":"Kalayoglu","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.micpath.2007.10.002_bib30","series-title":"Human chlamydial infections","first-page":"153","article-title":"C. pneumoniae utilizes apoE and the LDL receptor family for host cell attachment","author":"G\u00e9rard","year":"2006"},{"key":"10.1016\/j.micpath.2007.10.002_bib31","series-title":"Human chlamydial infections","first-page":"157","article-title":"Do chlamydiae use apolipoprotein E and the LDL receptor family to infect epithelial cells?","author":"Mahony","year":"2006"},{"key":"10.1016\/j.micpath.2007.10.002_bib32","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1128\/IAI.69.9.5423-5429.2001","article-title":"Chlamydia pneumoniae expresses genes required for DNA replication but not cytokinesis during persistent infection of HEp-2 cells","volume":"69","author":"Byrne","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2007.10.002_bib33","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1046\/j.1365-2958.2001.02550.x","article-title":"Expression of Chlamydia trachomatis genes required for DNA synthesis and cell division in active vs. persistent infection","volume":"41","author":"G\u00e9rard","year":"2001","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micpath.2007.10.002_bib34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11060-005-7305-z","article-title":"Retinamide-induced apoptosis in gliobastomas is associated with down-regulation of Bcl-xL and Bcl-2 proteins","volume":"74","author":"Lytle","year":"2005","journal-title":"Neurooncol"},{"key":"10.1016\/j.micpath.2007.10.002_bib35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1286-4579(01)01504-0","article-title":"Chlamydia trachomatis genes whose products are related to energy metabolism are expressed differentially in active vs. persistent infection","volume":"4","author":"G\u00e9rard","year":"2002","journal-title":"Microb Infect"},{"key":"10.1016\/j.micpath.2007.10.002_bib36","series-title":"Molecular cloning: a laboratory manual","author":"Sambrook","year":"2001"},{"key":"10.1016\/j.micpath.2007.10.002_bib37","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1128\/IAI.72.11.6699-6701.2004","article-title":"Cleavage of the N-linked oligosaccharide from the surface of Chlamydia species affects attachment and infectivity of the organisms in epithelial and endothelial cells","volume":"72","author":"Kuo","year":"2004","journal-title":"Infect Immun"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401007001398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401007001398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T05:07:25Z","timestamp":1630040845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401007001398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0882401007001398"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2007.10.002","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}