{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:39:40Z","timestamp":1792507180092,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.micpath.2007.12.001","type":"journal-article","created":{"date-parts":[[2007,12,28]],"date-time":"2007-12-28T15:51:39Z","timestamp":1198857099000},"page":"467-472","source":"Crossref","is-referenced-by-count":52,"title":["Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage"],"prefix":"10.1016","volume":"44","author":[{"given":"Shu-Ru","family":"Kuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Willingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Bour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissa A.","family":"Andreas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Kyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carney","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Duesbery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Leppla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur E.","family":"Frankel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2007.12.001_bib1","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1056\/NEJMoa012948","article-title":"Index case of fatal inhalational anthrax due to bioterrorism in the United States","volume":"345","author":"Bush","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.micpath.2007.12.001_bib2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/jama.287.7.863","article-title":"Fatal inhalational anthrax in a 94-year-old Connecticut woman","volume":"287","author":"Barakat","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.micpath.2007.12.001_bib3","doi-asserted-by":"crossref","first-page":"13509","DOI":"10.1073\/pnas.0509870103","article-title":"Polyvalent inhibitors of anthrax toxin that target host receptors","volume":"103","author":"Basha","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.micpath.2007.12.001_bib4","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1172\/JCI17991","article-title":"Bacillus anthracis lethal toxin induces TNF\u03b1-independent hypoxia-mediated toxicity in mice","volume":"112","author":"Moayeri","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.micpath.2007.12.001_bib5","doi-asserted-by":"crossref","first-page":"7006","DOI":"10.1128\/IAI.73.10.7006-7010.2005","article-title":"Pathophysiological manifestations in mice exposed to anthrax lethal toxin","volume":"73","author":"Culley","year":"2005","journal-title":"Infect Immunol"},{"key":"10.1016\/j.micpath.2007.12.001_bib6","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1128\/IAI.73.7.4238-4244.2005","article-title":"Endocrine perturbation increases susceptibility of mice to anthrax lethal toxin","volume":"73","author":"Moayeri","year":"2005","journal-title":"Infect Immunol"},{"key":"10.1016\/j.micpath.2007.12.001_bib7","doi-asserted-by":"crossref","first-page":"R699","DOI":"10.1152\/ajpregu.00593.2003","article-title":"Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats","volume":"286","author":"Cui","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.micpath.2007.12.001_bib8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1086\/427189","article-title":"Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis","volume":"191","author":"Cui","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.micpath.2007.12.001_bib9","doi-asserted-by":"crossref","unstructured":"Nye SH, Wittenburg AL, Evans DL, O\u2019Connor JA, Roman RJ, Jacob HJ. Rat survival to anthrax lethal toxin is likely controlled by a single gene. Pharmacogenomics J 2007 [epub].","DOI":"10.1038\/sj.tpj.6500448"},{"key":"10.1016\/j.micpath.2007.12.001_bib10","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1371\/journal.ppat.0020111","article-title":"Anthrax toxin receptor 2-dependent lethal toxin killing in vivo","volume":"2","author":"Scobie","year":"2006","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.micpath.2007.12.001_bib11","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1097\/01.CCM.0000266535.95770.A2","article-title":"Fluid support worsens outcome and negates the benefit of protective antigen-directed monoclonal antibody in a lethal toxin-infused rat Bacillus anthracis shock model","volume":"35","author":"Sherer","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.micpath.2007.12.001_bib12","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0002-9440(10)61218-7","article-title":"Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice","volume":"167","author":"Fioed","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.micpath.2007.12.001_bib13","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.2741\/2416","article-title":"Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction","volume":"12","author":"Watson","year":"2007","journal-title":"Front Biosci"},{"issue":"5","key":"10.1016\/j.micpath.2007.12.001_bib14","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1371\/journal.pone.0000466","article-title":"Anthrax toxins induce shock in rats by depressed cardiac ventricular function","volume":"2","author":"Watson","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.micpath.2007.12.001_bib15","doi-asserted-by":"crossref","unstructured":"Cheng CP, Masutani S, Cheng HJ, Cross M, Zhang CX, Zhou P, et al. Progressive left ventricle, myocyte dysfunction and heart failure in the lethality of anthrax toxin in conscious dogs. Circulation 2007; (supplement II) 116(16): II\u2013758.","DOI":"10.1161\/circ.116.suppl_16.II_758-a"},{"key":"10.1016\/j.micpath.2007.12.001_bib16","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1086\/510856","article-title":"Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model","volume":"195","author":"Cui","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.micpath.2007.12.001_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.biochem.75.103004.142728","article-title":"Anthrax toxin: receptor binding, internalization, pore formation and translocation","volume":"76","author":"Young","year":"2007","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.micpath.2007.12.001_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2004.11.004","article-title":"STRESS signaling pathways that modulate cardiac myocyte apoptosis","volume":"38","author":"Baines","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.micpath.2007.12.001_bib19","doi-asserted-by":"crossref","first-page":"H2973","DOI":"10.1152\/ajpheart.00419.2006","article-title":"Differential effects of phosphodiesterase PDE-3\/PDE-4-specific inhibitors on vasoconstriction and cAMP-dependent vasorelaxation following balloon angioplasty","volume":"292","author":"Zhao","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.micpath.2007.12.001_bib20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1053\/j.seminoncol.2005.08.002","article-title":"Toxin conjugate therapy of cancer","volume":"32","author":"Wong","year":"2005","journal-title":"Sem Oncol"},{"key":"10.1016\/j.micpath.2007.12.001_bib21","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0950-3536(87)80020-3","article-title":"The contracted plasma volume syndromes (relative polycythaemias) and their haemorheological significance","volume":"1","author":"Isbister","year":"1987","journal-title":"Baillieres Clin Haematol"},{"key":"10.1016\/j.micpath.2007.12.001_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0021-9975(88)90093-X","article-title":"A comparison of two dye-binding methods for the determination of dog, rat and human plasma albumins","volume":"98","author":"Evans","year":"1988","journal-title":"J Comp Pathol"},{"key":"10.1016\/j.micpath.2007.12.001_bib23","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1128\/IAI.72.1.430-439.2004","article-title":"Anthrax lethal toxin induces human endothelial cell apoptosis","volume":"72","author":"Kirby","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2007.12.001_bib24","doi-asserted-by":"crossref","first-page":"20858","DOI":"10.1074\/jbc.M310643200","article-title":"The pro-apoptotic protein Bim is a convergence point for cAMP\/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells","volume":"279","author":"Zhang","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.micpath.2007.12.001_bib25","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1164\/rccm.200609-1370OC","article-title":"Cell-based angiopoietin-1 gene therapy for acute lung injury","volume":"175","author":"McCarter","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.micpath.2007.12.001_bib26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11936-006-0028-4","article-title":"Therapeutic strategies for cardiogenic shock, 2006","volume":"8","author":"Ellis","year":"2006","journal-title":"Curr Treat Options Cardiovasc Med"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401007001775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401007001775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T11:02:05Z","timestamp":1630407725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401007001775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0882401007001775"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2007.12.001","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}