{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:02:38Z","timestamp":1790938958737,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.micpath.2011.02.010","type":"journal-article","created":{"date-parts":[[2011,3,5]],"date-time":"2011-03-05T14:12:00Z","timestamp":1299334320000},"page":"343-349","source":"Crossref","is-referenced-by-count":43,"title":["Exposure of Thomsen-Friedenreich antigen in Streptococcus pneumoniae infection is dependent on pneumococcal neuraminidase A"],"prefix":"10.1016","volume":"50","author":[{"given":"Mamie T.","family":"Coats","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trudy","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Paton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Briles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.micpath.2011.02.010_bib1","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1086\/516503","article-title":"Protective immunity against respiratory syncytial virus in early life after murine maternal or neonatal vaccination with the recombinant G fusion protein BBG2Na","volume":"176","author":"Brandt","year":"1997","journal-title":"J\u00a0Infect Dis"},{"issue":"6","key":"10.1016\/j.micpath.2011.02.010_bib2","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1053\/j.ajkd.2004.02.010","article-title":"Non-enteropathic hemolytic uremic syndrome: causes and short-term course","volume":"43","author":"Constantinescu","year":"2004","journal-title":"Am J Kidney Dis"},{"issue":"11","key":"10.1016\/j.micpath.2011.02.010_bib3","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1007\/s00467-007-0518-y","article-title":"Streptococcus pneumoniae-associated hemolytic uremic syndrome","volume":"23","author":"Copelovitch","year":"2008","journal-title":"Pediatr Nephrol"},{"issue":"5","key":"10.1016\/j.micpath.2011.02.010_bib4","first-page":"251","article-title":"Is pneumococcal hemolytic-uremic syndrome a new disease?","volume":"18","author":"Gray","year":"2001","journal-title":"Infections Med"},{"issue":"2","key":"10.1016\/j.micpath.2011.02.010_bib5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jpeds.2007.03.055","article-title":"Hemolytic uremic syndrome associated with invasive pneumococcal disease: the United kingdom experience","volume":"151","author":"Waters","year":"2007","journal-title":"J\u00a0Pediatr"},{"issue":"3","key":"10.1016\/j.micpath.2011.02.010_bib6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/sj.ki.5001581","article-title":"A\u00a0classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders","volume":"70","author":"Besbas","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.micpath.2011.02.010_bib7","first-page":"905","article-title":"H\u00e4molytich-ur\u00e4miche Syndrome: bilaterale Nierenrindennekrosen bei akuten erworbenen h\u00e4molytischen An\u00e4mien [Hemolytic-uremic syndrome: bilateral necrosis of the renal cortex in acute acquired hemolytic anemia]","volume":"85","author":"Gasser","year":"1955","journal-title":"Schweiz Med Wochenschr"},{"issue":"4 Pt 1","key":"10.1016\/j.micpath.2011.02.010_bib8","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1542\/peds.101.4.699","article-title":"Hemolytic uremic syndrome associated with invasive Streptococcus pneumoniae infection","volume":"101","author":"Cabrera","year":"1998","journal-title":"Pediatrics"},{"issue":"8046","key":"10.1016\/j.micpath.2011.02.010_bib9","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0140-6736(77)92915-4","article-title":"Thomsen-Friedenreich antigen in haemolytic-uraemic syndrome","volume":"2","author":"Klein","year":"1977","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.micpath.2011.02.010_bib10","first-page":"263","article-title":"The Thomsen-Friedenreich (TF) antigen: a critical review on the structural, biosynthetic and histochemical aspects of a pancarcinoma-associated antigen","volume":"12","author":"Hanisch","year":"1997","journal-title":"Histol Histopathol"},{"issue":"3","key":"10.1016\/j.micpath.2011.02.010_bib11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000469069","article-title":"Purification and properties of Streptococcus pneumoniae neuraminidase","volume":"41","author":"Scanlon","year":"1989","journal-title":"Enzyme"},{"key":"10.1016\/j.micpath.2011.02.010_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/j.1537-2995.2008.01871.x","article-title":"A\u00a0severe case of atypical hemolytic uremic syndrome associated with pneumococcal infection and T activation treated successfully with plasma exchange","author":"Hopkins","year":"2008","journal-title":"Transfusion"},{"issue":"6","key":"10.1016\/j.micpath.2011.02.010_bib13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/BF00522515","article-title":"Radioiodinated peanut lectin: a potential radiopharmaceutical for immunodetection of carcinoma expressing the T antigen","volume":"8","author":"Zabel","year":"1983","journal-title":"Eur J Nucl Med"},{"issue":"2 Pt 1","key":"10.1016\/j.micpath.2011.02.010_bib14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1542\/peds.110.2.371","article-title":"Invasive pneumococcal disease and hemolytic uremic syndrome","volume":"110","author":"Brandt","year":"2002","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.micpath.2011.02.010_bib15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00467-003-1382-z","article-title":"Pneumococcus-induced T-antigen activation in hemolytic uremic syndrome and anemia","volume":"19","author":"Cochran","year":"2004","journal-title":"Pediatr Nephrol"},{"issue":"2","key":"10.1016\/j.micpath.2011.02.010_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00852894","article-title":"Haemolytic uraemic syndrome and the Thomsen Friedenreich antigen","volume":"3","author":"McGraw","year":"1989","journal-title":"Pediatr Nephrol"},{"issue":"4","key":"10.1016\/j.micpath.2011.02.010_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/15513818309025872","article-title":"Hemolytic-uremic syndrome and T-cryptantigen exposure by neuraminidase-producing pneumococci: an emerging problem?","volume":"1","author":"Novak","year":"1983","journal-title":"Pediatr Pathol"},{"issue":"6","key":"10.1016\/j.micpath.2011.02.010_bib18","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1128\/IAI.01442-05","article-title":"Variation in the presence of neuraminidase genes among Streptococcus pneumoniae isolates with identical sequence types","volume":"74","author":"Pettigrew","year":"2006","journal-title":"Infect Immun"},{"issue":"15","key":"10.1016\/j.micpath.2011.02.010_bib19","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1128\/JB.187.15.5376-5386.2005","article-title":"NanA, a neuraminidase from Streptococcus pneumoniae, shows high levels of sequence diversity, at least in part through recombination with Streptococcus oralis","volume":"187","author":"King","year":"2005","journal-title":"J\u00a0Bacteriol"},{"issue":"1","key":"10.1016\/j.micpath.2011.02.010_bib20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0882-4010(88)90046-0","article-title":"Purification and immunological characterization of neuraminidase produced by Streptococcus pneumoniae","volume":"4","author":"Lock","year":"1988","journal-title":"Microb Pathog"},{"issue":"12","key":"10.1016\/j.micpath.2011.02.010_bib21","doi-asserted-by":"crossref","first-page":"7161","DOI":"10.1128\/IAI.70.12.7161-7164.2002","article-title":"Neuraminidase expressed by Streptococcus pneumoniae desialylates the lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae: a paradigm for interbacterial competition among pathogens of the human respiratory tract","volume":"70","author":"Shakhnovich","year":"2002","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.micpath.2011.02.010_bib22","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/00016480260000111","article-title":"Effect of neuraminidase on receptor-mediated adherence of Streptococcus pneumoniae to chinchilla tracheal epithelium","volume":"122","author":"Tong","year":"2002","journal-title":"Acta Otolaryngol"},{"issue":"2","key":"10.1016\/j.micpath.2011.02.010_bib23","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1128\/IAI.68.2.921-924.2000","article-title":"Evaluation of the virulence of a Streptococcus pneumoniae neuraminidase-deficient mutant in nasopharyngeal colonization and development of otitis media in the chinchilla model","volume":"68","author":"Tong","year":"2000","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.micpath.2011.02.010_bib24","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1084\/jem.20090386","article-title":"The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion","volume":"206","author":"Uchiyama","year":"2009","journal-title":"J\u00a0Exp Med"},{"issue":"6","key":"10.1016\/j.micpath.2011.02.010_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/mpat.2001.0473","article-title":"Comparison of structural changes of cell surface carbohydrates in the eustachian tube epithelium of chinchillas infected with a Streptococcus pneumoniae neuraminidase-deficient mutant or its isogenic parent strain","volume":"31","author":"Tong","year":"2001","journal-title":"Microb Pathog"},{"key":"10.1016\/j.micpath.2011.02.010_bib26","doi-asserted-by":"crossref","first-page":"14363","DOI":"10.1073\/pnas.2235844100","article-title":"Pneumococcal carriage results in ganglioside- mediated olfactory tissue infection","volume":"24","author":"Van Ginkel","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.micpath.2011.02.010_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/MMBR.65.2.187-207.2001","article-title":"Pneumococcal virulence factors: structure and function","volume":"65","author":"Jedrzejas","year":"2001","journal-title":"Microbiol Mol Biol Rev"},{"issue":"1","key":"10.1016\/j.micpath.2011.02.010_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1365-2958.2004.04252.x","article-title":"Phase variable desialylation of host proteins that bind to Streptococcus pneumoniae in vivo and protect the airway","volume":"54","author":"King","year":"2004","journal-title":"Mol Microbiol"},{"issue":"5","key":"10.1016\/j.micpath.2011.02.010_bib29","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1128\/IAI.71.5.2758-2765.2003","article-title":"Inactivation of the srtA gene affects localization of surface proteins and decreases adhesion of Streptococcus pneumoniae to human pharyngeal cells in vitro","volume":"71","author":"Kharat","year":"2003","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.micpath.2011.02.010_bib30","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1128\/IAI.62.9.3688-3695.1994","article-title":"A\u00a0neuraminidase from Streptococcus pneumoniae has the features of a surface protein","volume":"62","author":"Camara","year":"1994","journal-title":"Infect Immun"},{"issue":"5529","key":"10.1016\/j.micpath.2011.02.010_bib31","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1126\/science.1061217","article-title":"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae","volume":"293","author":"Tettelin","year":"2001","journal-title":"Science"},{"issue":"16","key":"10.1016\/j.micpath.2011.02.010_bib32","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1128\/jb.178.16.4854-4860.1996","article-title":"Cloning and characterization of nanB, a second Streptococcus pneumoniae neuraminidase gene, and purification of the NanB enzyme from recombinant Escherichia coli","volume":"178","author":"Berry","year":"1996","journal-title":"J\u00a0Bacteriol"},{"issue":"23\u201324","key":"10.1016\/j.micpath.2011.02.010_bib33","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1016\/j.febslet.2008.08.026","article-title":"Structural and functional studies of Streptococcus pneumoniae neuraminidase B: an intramolecular trans-sialidase","volume":"582","author":"Gut","year":"2008","journal-title":"FEBS Lett"},{"issue":"7","key":"10.1016\/j.micpath.2011.02.010_bib34","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1128\/IAI.01237-05","article-title":"Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis","volume":"74","author":"Manco","year":"2006","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.micpath.2011.02.010_bib35","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0882-4010(88)90007-1","article-title":"Comparative efficacy of pneumococcal neuraminidase and pneumolysin as immunogens protective against Streptococcus pneumoniae","volume":"5","author":"Lock","year":"1988","journal-title":"Microb Pathog"},{"issue":"6","key":"10.1016\/j.micpath.2011.02.010_bib36","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.resmic.2005.12.009","article-title":"Identification of amino acids essential for catalytic activity of pneumococcal neuraminidase A","volume":"157","author":"Yesilkaya","year":"2006","journal-title":"Res Microbiol"},{"issue":"3","key":"10.1016\/j.micpath.2011.02.010_bib37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1086\/376571","article-title":"Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae","volume":"188","author":"Briles","year":"2003","journal-title":"J\u00a0Infect Dis"},{"issue":"3","key":"10.1016\/j.micpath.2011.02.010_bib38","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1128\/JB.155.3.1372-1381.1983","article-title":"Streptococcus pneumoniae proteins released into medium upon inhibition of cell wall biosynthesis","volume":"155","author":"Hakenbeck","year":"1983","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.micpath.2011.02.010_bib39","author":"Queener","year":"1986","journal-title":"Beta-lactam Antibiot for Clin Use Informa Health Care"},{"issue":"1","key":"10.1016\/j.micpath.2011.02.010_bib40","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1128\/JCM.43.1.74-83.2005","article-title":"Molecular epidemiology of pneumococcal colonization in response to pneumococcal conjugate vaccination in children with recurrent acute otitis media","volume":"43","author":"Bogaert","year":"2005","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.micpath.2011.02.010_bib41","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1086\/319246","article-title":"Pneumococcal carriage and otitis media induce salivary antibodies to pneumococcal surface adhesin A, pneumolysin, and pneumococcal surface protein A in children","volume":"183","author":"Simell","year":"2001","journal-title":"J\u00a0Infect Dis"},{"issue":"1","key":"10.1016\/j.micpath.2011.02.010_bib42","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/IAI.60.1.111-116.1992","article-title":"Strong association between capsular type and virulence for mice among human isolates of Streptococcus pneumoniae","volume":"60","author":"Briles","year":"1992","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.micpath.2011.02.010_bib43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/mpat.1997.0142","article-title":"Establishment of a Streptococcus pneumoniae nasopharyngeal colonization model in adult mice","volume":"23","author":"Wu","year":"1997","journal-title":"Microb Pathog"},{"key":"10.1016\/j.micpath.2011.02.010_bib44","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1086\/514589","article-title":"Invasive pneumococcal disease in Dallas County, Texas: results from Population-based Surveillance in 1995","volume":"26","author":"Pastor","year":"1998","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.micpath.2011.02.010_bib45","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/1471-2180-8-173","article-title":"Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates","volume":"8","author":"Hall-Stoodley","year":"2008","journal-title":"BMC Microbiol"},{"issue":"1","key":"10.1016\/j.micpath.2011.02.010_bib46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/IAI.68.1.133-140.2000","article-title":"Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulence proteins","volume":"68","author":"Berry","year":"2000","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.micpath.2011.02.010_bib47","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1128\/IAI.70.5.2526-2534.2002","article-title":"Role of pneumococcal surface protein C in nasopharyngeal carriage and pneumonia and its ability to elicit protection against carriage of Streptococcus pneumoniae","volume":"70","author":"Balachandran","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2011.02.010_bib48","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1086\/317602","article-title":"Immunization of humans with rPspA elicits antibodies, which passively protect mice from fatal infection with Streptococcus pneumoniae bearing heterologous PspA","volume":"182","author":"Briles","year":"2000","journal-title":"J\u00a0Infect Dis"},{"issue":"2","key":"10.1016\/j.micpath.2011.02.010_bib49","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0378-1119(88)90046-7","article-title":"Cloning and expression of the pneumococcal neuraminidase gene in Escherichia coli","volume":"71","author":"Berry","year":"1988","journal-title":"Gene"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401011000441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401011000441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T02:38:16Z","timestamp":1592361496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401011000441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0882401011000441"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2011.02.010","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}