{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:07:14Z","timestamp":1791234434411,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.micpath.2012.11.006","type":"journal-article","created":{"date-parts":[[2012,11,17]],"date-time":"2012-11-17T04:45:53Z","timestamp":1353127553000},"page":"40-46","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Identification of an atypical zinc metalloproteinase, ZmpC, from an epidemic conjunctivitis-causing strain of Streptococcus pneumoniae"],"prefix":"10.1016","volume":"56","author":[{"given":"Balaraj B.","family":"Menon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharathi","family":"Govindarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2012.11.006_bib1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1128\/MMBR.59.4.591-603.1995","article-title":"Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccines","volume":"59","author":"AlonsoDeVelasco","year":"1995","journal-title":"Microbiological Reviews"},{"key":"10.1016\/j.micpath.2012.11.006_bib2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrmicro1871","article-title":"The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease","volume":"6","author":"Kadioglu","year":"2008","journal-title":"Nature Reviews Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1469-0691.2010.03183.x","article-title":"Streptococcus pneumoniae: virulence factors and variation","volume":"16","author":"Mitchell","year":"2010","journal-title":"Clinical Microbiology and Infection"},{"key":"10.1016\/j.micpath.2012.11.006_bib4","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJMoa022521","article-title":"An outbreak of conjunctivitis due to atypical Streptococcus pneumoniae","volume":"348","author":"Martin","year":"2003","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.micpath.2012.11.006_bib5","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1128\/JCM.37.12.4039-4041.1999","article-title":"Genetic relatedness among nontypeable pneumococci implicated in sporadic cases of conjunctivitis","volume":"37","author":"Barker","year":"1999","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib6","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1128\/IAI.64.9.3772-3777.1996","article-title":"Uptake of Streptococcus pneumoniae by respiratory epithelial cells","volume":"64","author":"Talbot","year":"1996","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.micpath.2012.11.006_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.micpath.2007.08.016","article-title":"Adherence of nontypeable Streptococcus pneumoniae to human conjunctival epithelial cells","volume":"44","author":"Williamson","year":"2008","journal-title":"Microbial Pathogenesis"},{"key":"10.1016\/j.micpath.2012.11.006_bib8","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0092-8674(00)00071-4","article-title":"The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells","volume":"102","author":"Zhang","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.micpath.2012.11.006_bib9","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1365-2958.1997.mmi494.x","article-title":"Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae","volume":"25","author":"Rosenow","year":"1997","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib10","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1365-2958.2005.04984.x","article-title":"Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae","volume":"59","author":"King","year":"2006","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1099\/mic.0.28610-0","article-title":"Versatility of pneumococcal surface proteins","volume":"152","author":"Bergmann","year":"2006","journal-title":"Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib12","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1128\/IAI.73.5.2680-2689.2005","article-title":"PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation","volume":"73","author":"Pracht","year":"2005","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.micpath.2012.11.006_bib13","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1046\/j.1365-2958.2001.02448.x","article-title":"\u03b1-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surface","volume":"40","author":"Bergmann","year":"2001","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib14","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1073\/pnas.0511017103","article-title":"A\u00a0pneumococcal pilus influences virulence and host inflammatory responses","volume":"103","author":"Barocchi","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.micpath.2012.11.006_bib15","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1128\/JB.00384-08","article-title":"A\u00a0second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells","volume":"190","author":"Bagnoli","year":"2008","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.micpath.2012.11.006_bib16","doi-asserted-by":"crossref","first-page":"e1000026","DOI":"10.1371\/journal.ppat.1000026","article-title":"Pneumococcal Pili are composed of protofilaments exposing adhesive clusters of Rrg A","volume":"4","author":"Hilleringmann","year":"2008","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.micpath.2012.11.006_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/mi.2008.5","article-title":"Mucins in the mucosal barrier to infection","volume":"1","author":"Linden","year":"2008","journal-title":"Mucosal Immunology"},{"key":"10.1016\/j.micpath.2012.11.006_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0165-0378(99)00046-7","article-title":"MUC1\/episialin: a critical barrier in the female reproductive tract","volume":"45","author":"DeSouza","year":"2000","journal-title":"Journal of Reproductive Immunology"},{"key":"10.1016\/j.micpath.2012.11.006_bib19","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1053\/j.gastro.2007.07.003","article-title":"Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis","volume":"133","author":"McGuckin","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.micpath.2012.11.006_bib20","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1172\/JCI26705","article-title":"MUC1 cell surface mucin is a critical element of the mucosal barrier to infection","volume":"117","author":"McAuley","year":"2007","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.micpath.2012.11.006_bib21","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1167\/iovs.07-0430","article-title":"Functions of MUC16 in corneal epithelial cells","volume":"48","author":"Blalock","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.micpath.2012.11.006_bib22","doi-asserted-by":"crossref","first-page":"e32418","DOI":"10.1371\/journal.pone.0032418","article-title":"A\u00a0metalloproteinase secreted by Streptococcus pneumoniae removes membrane mucin MUC16 from the epithelial glycocalyx barrier","volume":"7","author":"Govindarajan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2012.11.006_bib23","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1167\/iovs.02-0851","article-title":"Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines","volume":"44","author":"Gipson","year":"2003","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.micpath.2012.11.006_bib24","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1167\/iovs.07-1081","article-title":"Release of membrane-associated mucins from ocular surface epithelia","volume":"49","author":"Blalock","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.micpath.2012.11.006_bib25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000217982","article-title":"Specificity and affinity of 26 monoclonal antibodies against the CA 125 antigen: first report from the ISOBM TD-1 workshop. international society for oncodevelopmental biology and medicine","volume":"17","author":"Nustad","year":"1996","journal-title":"Tumour Biology"},{"key":"10.1016\/j.micpath.2012.11.006_bib26","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1046\/j.1365-2958.2003.03596.x","article-title":"Pneumococcal zinc metalloproteinase ZmpC cleaves human matrix metalloproteinase 9 and is a virulence factor in experimental pneumonia","volume":"49","author":"Oggioni","year":"2003","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1074\/jbc.M608542200","article-title":"Streptococcus pneumoniae sheds syndecan-1 ectodomains through ZmpC, a metalloproteinase virulence factor","volume":"282","author":"Chen","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.micpath.2012.11.006_bib28","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1099\/mic.0.28417-0","article-title":"Zinc metalloproteinase genes in clinical isolates of Streptococcus pneumoniae: association of the full array with a clonal cluster comprising serotypes 8 and 11A","volume":"152","author":"Camilli","year":"2006","journal-title":"Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib29","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1128\/IAI.64.10.3957-3966.1996","article-title":"Characterization of the Streptococcus pneumoniae immunoglobulin A1 protease gene (iga) and its translation product","volume":"64","author":"Poulsen","year":"1996","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.micpath.2012.11.006_bib30","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1073\/pnas.0637469100","article-title":"Antibody-enhanced pneumococcal adherence requires IgA1 protease","volume":"100","author":"Weiser","year":"2003","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"10.1016\/j.micpath.2012.11.006_bib31","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1128\/IAI.71.9.4925-4935.2003","article-title":"ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract","volume":"71","author":"Blue","year":"2003","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.micpath.2012.11.006_bib32","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1097\/CCM.0b013e318169f0c3","article-title":"Establishment of a young mouse model and identification of an allelic variation of zmpB in complicated pneumonia caused by Streptococcus pneumoniae","volume":"36","author":"Hsieh","year":"2008","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.micpath.2012.11.006_bib33","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1046\/j.1365-2958.2001.02359.x","article-title":"The puzzle\u00a0of zmpB and extensive chain formation, autolysis defect and non-translocation of choline-binding proteins in Streptococcus pneumoniae","volume":"39","author":"Berg\u00e9","year":"2001","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2180-3-14","article-title":"The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice","volume":"3","author":"Chiavolini","year":"2003","journal-title":"BMC Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2180-11-25","article-title":"Complete genome sequence of a serotype 11A, ST62 Streptococcus pneumoniae invasive isolate","volume":"11","author":"Camilli","year":"2011","journal-title":"BMC Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0966-842X(00)01741-8","article-title":"Sortase: the surface protein anchoring transpeptidase and the LPXTG motif","volume":"8","author":"Novick","year":"2000","journal-title":"Trends in Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib37","doi-asserted-by":"crossref","first-page":"12424","DOI":"10.1073\/pnas.96.22.12424","article-title":"Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif","volume":"96","author":"Ton-That","year":"1999","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.micpath.2012.11.006_bib38","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1365-2958.2006.05256.x","article-title":"The atypical amino-terminal LPNTG-containing domain of the pneumococcal human IgA1-specific protease is required for proper enzyme localization and function","volume":"61","author":"Bender","year":"2006","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.micpath.2012.11.006_bib39","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1128\/IAI.65.11.4452-4459.1997","article-title":"Comparative analysis of immunoglobulin A1 protease activity among bacteria representing different genera, species, and strains","volume":"65","author":"Reinholdt","year":"1997","journal-title":"Infection and Immunity"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401012001982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401012001982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T02:37:35Z","timestamp":1594867055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401012001982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":39,"alternative-id":["S0882401012001982"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2012.11.006","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}