{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:40:56Z","timestamp":1766086856365},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases (NIAID)","doi-asserted-by":"crossref","award":["U01AI075563"],"award-info":[{"award-number":["U01AI075563"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Child Health and Human Development (NICHD)","award":["P01HD013021"],"award-info":[{"award-number":["P01HD013021"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.micpath.2013.04.008","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T21:31:29Z","timestamp":1366925489000},"page":"1-10","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Group B Streptococcus induces a caspase-dependent apoptosis in fetal rat lung interstitium"],"prefix":"10.1016","volume":"61-62","author":[{"given":"David E.","family":"Kling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Tsvang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam P.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Newburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2013.04.008_bib1","series-title":"Infectious diseases of the fetus and newborn","first-page":"419","article-title":"Group B Streptococcal infections","author":"Edwards","year":"2011"},{"key":"10.1016\/j.micpath.2013.04.008_bib2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/adc.88.5.375","article-title":"Group B streptococcal conjugate vaccines","volume":"88","author":"Baker","year":"2003","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.micpath.2013.04.008_bib3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1471-0528.1984.tb04759.x","article-title":"Intrauterine infections with group B beta-haemolytic streptococci","volume":"91","author":"Desa","year":"1984","journal-title":"Br J Obstet Gynaecol"},{"issue":"59","key":"10.1016\/j.micpath.2013.04.008_bib4","first-page":"1","article-title":"Prevention of perinatal group B streptococcal disease\u2013revised guidelines from CDC","volume":"2010","author":"Verani","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.micpath.2013.04.008_bib5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1586\/erv.11.61","article-title":"An update on vaccination against group B streptococcus","volume":"10","author":"Heath","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.micpath.2013.04.008_bib6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1128\/CMR.18.1.102-127.2005","article-title":"Surface proteins of Streptococcus agalactiae and related proteins in other bacterial pathogens","volume":"18","author":"Lindahl","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.micpath.2013.04.008_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2958.2004.04266.x","article-title":"Molecular pathogenesis of neonatal group B streptococcal infection: no longer in its infancy","volume":"54","author":"Doran","year":"2004","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micpath.2013.04.008_bib8","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1086\/340818","article-title":"Group B streptococcal beta-hemolysin induces mortality and liver injury in experimental sepsis","volume":"185","author":"Ring","year":"2002","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micpath.2013.04.008_bib9","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.4049\/jimmunol.165.7.3923","article-title":"Group B Streptococcus induces apoptosis in macrophages","volume":"165","author":"Fettucciari","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micpath.2013.04.008_bib10","doi-asserted-by":"crossref","first-page":"14491","DOI":"10.1073\/pnas.0406143101","article-title":"Sword and shield: linked group B streptococcal beta-hemolysin\/cytolysin and carotenoid pigment function to subvert host phagocyte defense","volume":"101","author":"Liu","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micpath.2013.04.008_bib11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.micpath.2008.05.003","article-title":"Group B streptococcus induces trophoblast death","volume":"45","author":"Kaplan","year":"2008","journal-title":"Microb Pathog"},{"key":"10.1016\/j.micpath.2013.04.008_bib12","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.4049\/jimmunol.175.4.2555","article-title":"Mechanisms of group B streptococcal-induced apoptosis of murine macrophages","volume":"175","author":"Ulett","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micpath.2013.04.008_bib13","doi-asserted-by":"crossref","first-page":"e29963","DOI":"10.1371\/journal.pone.0029963","article-title":"Group B streptococcus GAPDH is released upon cell lysis, associates with bacterial surface, and induces apoptosis in murine macrophages","volume":"7","author":"Oliveira","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2013.04.008_bib14","doi-asserted-by":"crossref","first-page":"e2446","DOI":"10.1371\/journal.pone.0002446","article-title":"Group B streptococcal beta-hemolysin\/cytolysin directly impairs cardiomyocyte viability and function","volume":"3","author":"Hensler","year":"2008","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2013.04.008_bib15","doi-asserted-by":"crossref","first-page":"6134","DOI":"10.4049\/jimmunol.179.9.6134","article-title":"TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia","volume":"179","author":"Lehnardt","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micpath.2013.04.008_bib16","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1203\/00006450-199905010-00003","article-title":"Group B streptococcal beta-hemolysin promotes injury of lung microvascular endothelial cells","volume":"45","author":"Gibson","year":"1999","journal-title":"Pediatr Res"},{"key":"10.1016\/j.micpath.2013.04.008_bib17","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1128\/IAI.64.9.3818-3826.1996","article-title":"Group B streptococcal beta-hemolysin expression is associated with injury of lung epithelial cells","volume":"64","author":"Nizet","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2013.04.008_bib18","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1086\/378202","article-title":"Beta-hemolysin-independent induction of apoptosis of macrophages infected with serotype III group B streptococcus","volume":"188","author":"Ulett","year":"2003","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micpath.2013.04.008_bib19","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1101\/gad.1126903","article-title":"Ways of dying: multiple pathways to apoptosis","volume":"17","author":"Adams","year":"2003","journal-title":"Genes Dev"},{"key":"10.1016\/j.micpath.2013.04.008_bib20","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/sj.cdd.4400527","article-title":"Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death","volume":"6","author":"Lorenzo","year":"1999","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.micpath.2013.04.008_bib21","first-page":"49","article-title":"Molecular mechanisms of brain damage in bacterial meningitis","volume":"14","author":"Braun","year":"1999","journal-title":"Adv Pediatr Infect Dis"},{"key":"10.1016\/j.micpath.2013.04.008_bib22","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/0002-9378(78)90865-7","article-title":"Experimental group B streptococcal infection in the rhesus monkey. I. Disease production in the neonate","volume":"132","author":"Larsen","year":"1978","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.micpath.2013.04.008_bib23","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/infdis\/164.2.320","article-title":"Pathophysiology and histopathology of group B streptococcal sepsis in Macaca nemestrina primates induced after intraamniotic inoculation: evidence for bacterial cellular invasion","volume":"164","author":"Rubens","year":"1991","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.micpath.2013.04.008_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.micpath.2008.10.009","article-title":"Lactic acid is a potential virulence factor for group B Streptococcus","volume":"46","author":"Kling","year":"2009","journal-title":"Microb Pathog"},{"key":"10.1016\/j.micpath.2013.04.008_bib25","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1365-2958.1993.tb01631.x","article-title":"Identification of cpsD, a gene essential for type III capsule expression in group B streptococci","volume":"8","author":"Rubens","year":"1993","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micpath.2013.04.008_bib26","doi-asserted-by":"crossref","first-page":"L370","DOI":"10.1152\/ajplung.00200.2001","article-title":"MEK-1\/2 inhibition reduces branching morphogenesis and causes mesenchymal cell apoptosis in fetal rat lungs","volume":"282","author":"Kling","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.micpath.2013.04.008_bib27","series-title":"Prism 4 statistics guide-statistical analyses for laboratory and clinical researchers","author":"Motulsky","year":"2003"},{"key":"10.1016\/j.micpath.2013.04.008_bib28","unstructured":"Rasband WS ImageJ. U. S. National Institutes of Health, Bethesda, Maryland, USA; 1997\u20132011."},{"key":"10.1016\/j.micpath.2013.04.008_bib29","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1128\/JB.01216-08","article-title":"The CiaR response regulator in group B Streptococcus promotes intracellular survival and resistance to innate immune defenses","volume":"191","author":"Quach","year":"2009","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.micpath.2013.04.008_bib30","doi-asserted-by":"crossref","first-page":"6149","DOI":"10.4049\/jimmunol.180.9.6149","article-title":"Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis","volume":"180","author":"Henneke","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micpath.2013.04.008_bib31","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1046\/j.1365-2958.2000.02099.x","article-title":"Identification of Streptococcus agalactiae virulence genes in the neonatal rat sepsis model using signature-tagged mutagenesis","volume":"37","author":"Jones","year":"2000","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micpath.2013.04.008_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/jsre.2002.6461","article-title":"Oxidation-reduction (redox) controls fetal hypoplastic lung growth","volume":"106","author":"Fisher","year":"2002","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.micpath.2013.04.008_bib33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0022-3468(99)90251-8","article-title":"Prenatal vitamin E treatment improves lung growth in fetal rats with congenital diaphragmatic hernia","volume":"34","author":"Islam","year":"1999","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.micpath.2013.04.008_bib34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/bdrb.20247","article-title":"Nitrofen induces apoptosis independently of retinaldehyde dehydrogenase (RALDH) inhibition","volume":"89","author":"Kling","year":"2010","journal-title":"Birth Defects Res B: Dev Reprod Toxicol"},{"key":"10.1016\/j.micpath.2013.04.008_bib35","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/01902140802271842","article-title":"Apoptosis of mesenchymal cells during the pseudoglandular stage of lung development affects branching morphogenesis","volume":"34","author":"Wongtrakool","year":"2008","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.micpath.2013.04.008_bib36","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/019021401753181836","article-title":"Programmed cell death in normal fetal rat lung development","volume":"27","author":"Stiles","year":"2001","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.micpath.2013.04.008_bib37","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1203\/00006450-199803000-00020","article-title":"Ontogeny of apoptosis during lung development","volume":"43","author":"Kresch","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1016\/j.micpath.2013.04.008_bib38","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/ar.1092320411","article-title":"Macrophage development: III. Transformation of pulmonary macrophages from precursors in fetal lungs and their later maturation in organ culture","volume":"232","author":"Sorokin","year":"1992","journal-title":"Anatomical Rec"},{"key":"10.1016\/j.micpath.2013.04.008_bib39","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1182\/blood.V81.6.1607.1607","article-title":"Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins","volume":"81","author":"Holness","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.micpath.2013.04.008_bib40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2217\/17460913.4.2.201","article-title":"Understanding the regulation of Group B Streptococcal virulence factors","volume":"4","author":"Rajagopal","year":"2009","journal-title":"Future Microbiol"},{"key":"10.1016\/j.micpath.2013.04.008_bib41","doi-asserted-by":"crossref","first-page":"613S","DOI":"10.1080\/07315724.2007.10719667","article-title":"Mechanisms and significance of cell volume regulation","volume":"26","author":"Lang","year":"2007","journal-title":"J\u00a0Am Coll Nutr"},{"key":"10.1016\/j.micpath.2013.04.008_bib42","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/0885066605278644","article-title":"Lactic acidosis: from sour milk to septic shock","volume":"20","author":"Fall","year":"2005","journal-title":"J\u00a0Intensive Care Med"},{"key":"10.1016\/j.micpath.2013.04.008_bib43","first-page":"144","article-title":"Purpura fulminans in three cases of early-onset neonatal group B streptococcal meningitis","volume":"11","author":"Lynn","year":"1991","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.micpath.2013.04.008_bib44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1824-7288-35-10","article-title":"Spot diagnosis: an ominous rash in a newborn","volume":"35","author":"Hon","year":"2009","journal-title":"Italian J Pediatrics"},{"key":"10.1016\/j.micpath.2013.04.008_bib45","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.ph.58.030196.000521","article-title":"Morphogenesis of the lung: control of embryonic and fetal branching","volume":"58","author":"Hilfer","year":"1996","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.micpath.2013.04.008_bib46","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1165\/rcmb.4764","article-title":"Insulin-like growth factor-I receptor-mediated vasculogenesis\/angiogenesis in human lung development","volume":"28","author":"Han","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.micpath.2013.04.008_bib47","doi-asserted-by":"crossref","first-page":"7542","DOI":"10.4049\/jimmunol.176.12.7542","article-title":"Group B Streptococcus induces macrophage apoptosis by calpain activation","volume":"176","author":"Fettucciari","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micpath.2013.04.008_bib48","doi-asserted-by":"crossref","first-page":"6655","DOI":"10.1016\/j.bmc.2012.09.017","article-title":"Clarifying the structure of granadaene: total synthesis of related analogue [2]-granadaene and confirmation of its absolute stereochemistry","volume":"20","author":"Paradas","year":"2012","journal-title":"Bioorg Med Chem"},{"issue":"426","key":"10.1016\/j.micpath.2013.04.008_bib49","first-page":"e1","article-title":"Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis","volume":"198","author":"Dulay","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.micpath.2013.04.008_bib50","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00281-002-0099-6","article-title":"Human parvovirus B19-induced cell cycle arrest and apoptosis","volume":"24","author":"Morita","year":"2002","journal-title":"Springer Semin Immunopathol"},{"key":"10.1016\/j.micpath.2013.04.008_bib51","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1056\/NEJMcpc079021","article-title":"Case records of the Massachusetts General Hospital. Case 27-2007. A 30-year-old pregnant woman with intrauterine fetal death","volume":"357","author":"Gibbs","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.micpath.2013.04.008_bib52","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3109\/00016347809155890","article-title":"Intrauterine death due to infection with group B Streptococci","volume":"57","author":"Bergqvist","year":"1978","journal-title":"Acta obstetricia et gynecologica Scandinavica"},{"key":"10.1016\/j.micpath.2013.04.008_bib53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0070-2153(07)00002-6","article-title":"The erythroblastic island","volume":"82","author":"Manwani","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.micpath.2013.04.008_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(07)00001-4","article-title":"Ontogeny of erythropoiesis in the mammalian embryo","volume":"82","author":"McGrath","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.micpath.2013.04.008_bib55","doi-asserted-by":"crossref","first-page":"L141","DOI":"10.1152\/ajplung.00148.2004","article-title":"Distal angiogenesis: a new concept for lung vascular morphogenesis","volume":"288","author":"Parera","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.micpath.2013.04.008_bib56","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1073\/pnas.0610666104","article-title":"Unrestrained erythroblast development in Nix-\/- mice reveals a mechanism for apoptotic modulation of erythropoiesis","volume":"104","author":"Diwan","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micpath.2013.04.008_bib57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(95)90234-1","article-title":"Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor","volume":"83","author":"Wu","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.micpath.2013.04.008_bib58","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/01.shk0000225856.32260.0d","article-title":"Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis","volume":"26","author":"Schreiber","year":"2006","journal-title":"Shock"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401013000545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401013000545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T13:56:07Z","timestamp":1715262967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401013000545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":58,"alternative-id":["S0882401013000545"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2013.04.008","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Group B Streptococcus induces a caspase-dependent apoptosis in fetal rat lung interstitium","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2013.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}