{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:24:43Z","timestamp":1792787083351,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR056959"],"award-info":[{"award-number":["R01 AR056959"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AR052282"],"award-info":[{"award-number":["T32 AR052282"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 AI072365"],"award-info":[{"award-number":["K08 AI072365"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Children's Hospital of Pittsburgh Research Advisory Committee (AN)","id":[{"id":"https:\/\/ror.org\/03763ep67","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.micpath.2014.04.005","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T00:31:32Z","timestamp":1398299492000},"page":"70-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Follistatin-like protein 1 is a critical mediator of experimental Lyme arthritis and the humoral response to Borrelia burgdorferi infection"],"prefix":"10.1016","volume":"73","author":[{"given":"Brian T.","family":"Campfield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi L.","family":"Nolder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Marinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bushnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caressa","family":"Spychala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Nowalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2014.04.005_bib1","first-page":"1","article-title":"Surveillance for Lyme disease\u2013United States, 1992-2006","volume":"57","author":"Bacon","year":"2008","journal-title":"MMWR Surveill Summ"},{"key":"10.1016\/j.micpath.2014.04.005_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/art.1780200102","article-title":"Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities","volume":"20","author":"Steere","year":"1977","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.micpath.2014.04.005_bib3","first-page":"497","article-title":"Prominent expression of mRNA for proinflammatory cytokines in synovium in patients with juvenile rheumatoid arthritis or chronic Lyme arthritis","volume":"27","author":"Harjacek","year":"2000","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.micpath.2014.04.005_bib4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","article-title":"Cytokines in the pathogenesis of rheumatoid arthritis","volume":"7","author":"McInnes","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.micpath.2014.04.005_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yexmp.2008.03.004","article-title":"Gene expression profiling provides insights into the pathways involved in inflammatory arthritis development: murine model of Lyme disease","volume":"85","author":"Miller","year":"2008","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.micpath.2014.04.005_bib6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4049\/jimmunol.182.1.234","article-title":"Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma","volume":"182","author":"Clutter","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micpath.2014.04.005_bib7","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1002\/art.27485","article-title":"Follistatin-like protein 1 is a mesenchyme-derived inflammatory protein and may represent a biomarker for systemic-onset juvenile rheumatoid arthritis","volume":"62","author":"Wilson","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.micpath.2014.04.005_bib8","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.4049\/jimmunol.177.7.4758","article-title":"Follistatin-like protein-1 is a novel proinflammatory molecule","volume":"177","author":"Miyamae","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micpath.2014.04.005_bib9","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/art.33422","article-title":"FSTL1 promotes arthritis in mice by enhancing inflammatory cytokine\/chemokine expression","volume":"64","author":"Chaly","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.micpath.2014.04.005_bib10","doi-asserted-by":"crossref","first-page":"7930","DOI":"10.4049\/jimmunol.177.11.7930","article-title":"Gene expression profiling reveals unique pathways associated with differential severity of lyme arthritis","volume":"177","author":"Crandall","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micpath.2014.04.005_bib11","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1128\/CVI.00251-12","article-title":"The DBA\/1 strain is a novel mouse model for experimental Borrelia burgdorferi infection","volume":"19","author":"Campfield","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.micpath.2014.04.005_bib12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.micpath.2014.04.005_bib13","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1128\/IAI.00189-06","article-title":"Serologic proteome analysis of Borrelia burgdorferi membrane-associated proteins","volume":"74","author":"Nowalk","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2014.04.005_bib14","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micpath.2014.04.005_bib15","doi-asserted-by":"crossref","first-page":"7058","DOI":"10.1073\/pnas.1007293108","article-title":"Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development","volume":"108","author":"Geng","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micpath.2014.04.005_bib16","doi-asserted-by":"crossref","first-page":"e22616","DOI":"10.1371\/journal.pone.0022616","article-title":"The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis","volume":"6","author":"Sylva","year":"2011","journal-title":"PloS One"},{"issue":"Suppl.\u00a033","key":"10.1016\/j.micpath.2014.04.005_bib17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1438-4221(02)80027-3","article-title":"Immune evasion of Borrelia burgdorferi: insufficient killing of the pathogens by complement and antibody","volume":"291","author":"Kraiczy","year":"2002","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.micpath.2014.04.005_bib18","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S1369-5274(00)00202-2","article-title":"Host-pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes","volume":"4","author":"Wooten","year":"2001","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.micpath.2014.04.005_bib19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/cr.2011.43","article-title":"Reduction of follistatin-like 1 in primary afferent neurons contributes to neuropathic pain hypersensitivity","volume":"21","author":"Li","year":"2011","journal-title":"Cell Res"},{"key":"10.1016\/j.micpath.2014.04.005_bib20","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.neuron.2011.01.022","article-title":"Follistatin-like 1 suppresses sensory afferent transmission by activating Na+,K+-ATPase","volume":"69","author":"Li","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.micpath.2014.04.005_bib21","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1161\/CIRCULATIONAHA.112.115089","article-title":"Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models","volume":"126","author":"Ogura","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.micpath.2014.04.005_bib22","doi-asserted-by":"crossref","first-page":"E899","DOI":"10.1073\/pnas.1108559108","article-title":"Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload","volume":"108","author":"Shimano","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micpath.2014.04.005_bib23","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jpeds.2012.01.011","article-title":"Plasma follistatin-like protein 1 is elevated in Kawasaki disease and may predict coronary artery aneurysm formation","volume":"161","author":"Gorelik","year":"2012","journal-title":"J\u00a0Pediatrics"},{"key":"10.1016\/j.micpath.2014.04.005_bib24","doi-asserted-by":"crossref","first-page":"R193","DOI":"10.1186\/ar3522","article-title":"Follistatin-like protein 1: a serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis","volume":"13","author":"Wang","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.micpath.2014.04.005_bib25","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1073\/pnas.0909501107","article-title":"Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium","volume":"107","author":"Umezu","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.micpath.2014.04.005_bib26","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1161\/CIRCULATIONAHA.108.767673","article-title":"Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart","volume":"117","author":"Oshima","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.micpath.2014.04.005_bib27","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.1128\/IAI.67.10.5142-5150.1999","article-title":"Dual role of interleukin-10 in murine Lyme disease: regulation of arthritis severity and host defense","volume":"67","author":"Brown","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.micpath.2014.04.005_bib28","doi-asserted-by":"crossref","first-page":"e7191","DOI":"10.1371\/journal.pone.0007191","article-title":"Synergistic antibacterial and anti-inflammatory activity of temporin A and modified temporin B in\u00a0vivo","volume":"4","author":"Capparelli","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2014.04.005_bib29","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1128\/CVI.00291-12","article-title":"Identification of synthetic host defense Peptide mimics that exert dual antimicrobial and anti-inflammatory activities","volume":"19","author":"Som","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.micpath.2014.04.005_bib30","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2741\/s294","article-title":"Deciphering the role of Toll-like receptors in humoral responses to Borreliae","volume":"4","author":"Dickinson","year":"2012","journal-title":"Front Biosci Sch Ed"},{"key":"10.1016\/j.micpath.2014.04.005_bib31","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4049\/jimmunol.168.1.348","article-title":"Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi","volume":"168","author":"Wooten","year":"2002","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.micpath.2014.04.005_bib32","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0165-2478(93)90056-8","article-title":"Distinct patterns of protective antibodies are generated against Borrelia burgdorferi in mice experimentally inoculated with high and low doses of antigen","volume":"36","author":"Schaible","year":"1993","journal-title":"Immunol Lett"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401014000564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401014000564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T04:59:44Z","timestamp":1597726784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401014000564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":32,"alternative-id":["S0882401014000564"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2014.04.005","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Follistatin-like protein 1 is a critical mediator of experimental Lyme arthritis and the humoral response to Borrelia burgdorferi infection","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2014.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}