{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:50:02Z","timestamp":1789627802079,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2013M540255"],"award-info":[{"award-number":["2013M540255"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Basic Science Research Program","award":["2015CB150306"],"award-info":[{"award-number":["2015CB150306"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.micpath.2015.05.009","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T15:06:19Z","timestamp":1433516779000},"page":"29-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Bovine TLR2 and TLR4 mediate Cryptosporidium parvum recognition in bovine intestinal epithelial cells"],"prefix":"10.1016","volume":"85","author":[{"given":"Zhengtao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhe","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengtao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2015.05.009_bib1","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.1128\/JCM.38.11.3984-3990.2000","article-title":"Molecular epidemiological analysis of Cryptosporidium spp. in the United Kingdom: results of genotyping Cryptosporidium spp. in 1,705 fecal samples from humans and 105 fecal samples from livestock animals","volume":"38","author":"McLauchlin","year":"2000","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.micpath.2015.05.009_bib2","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.ijpara.2013.07.005","article-title":"Cryptosporidiosis and Cryptosporidium species in animals and humans: a thirty colour rainbow?","volume":"43","author":"Slapeta","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.micpath.2015.05.009_bib3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2460\/javma.1999.214.03.391","article-title":"Duration of naturally acquired giardiosis and cryptosporidiosis in dairy calves and their association with diarrhea","volume":"214","author":"O'Handley","year":"1999","journal-title":"J.\u00a0Am. Veterinary Med. Assoc."},{"key":"10.1016\/j.micpath.2015.05.009_bib4","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1128\/JCM.02194-10","article-title":"Characteristics of Cryptosporidium transmission in preweaned dairy cattle in Henan, China","volume":"49","author":"Wang","year":"2011","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.micpath.2015.05.009_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0304-4017(00)00338-1","article-title":"Prevalence of Cryptosporidium parvum infection and pattern of oocyst shedding in calves in Japan","volume":"94","author":"Uga","year":"2000","journal-title":"Veterinary Parasitol."},{"key":"10.1016\/j.micpath.2015.05.009_bib6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.vetpar.2007.12.003","article-title":"Prevalence and risk factors for Cryptosporidium spp. infection in young calves","volume":"152","author":"Brook","year":"2008","journal-title":"Veterinary Parasitol."},{"key":"10.1016\/j.micpath.2015.05.009_bib7","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S1286-4579(02)01629-5","article-title":"Cryptosporidiosis: biology, pathogenesis and disease","volume":"4","author":"Tzipori","year":"2002","journal-title":"Microbes Infection\/Institut Pasteur"},{"key":"10.1016\/j.micpath.2015.05.009_bib8","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0020-7519(99)00076-4","article-title":"A\u00a0review of the importance of cryptosporidiosis in farm animals","volume":"29","author":"de Graaf","year":"1999","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.micpath.2015.05.009_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.micpath.2015.05.009_bib10","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micpath.2015.05.009_bib11","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1189\/jlb.0203082","article-title":"How we detect microbes and respond to them: the toll-like receptors and their transducers","volume":"74","author":"Beutler","year":"2003","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.micpath.2015.05.009_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2052.2005.01364.x","article-title":"Radiation hybrid mapping of all 10 characterized bovine toll-like receptors","volume":"37","author":"McGuire","year":"2006","journal-title":"Anim. Genet."},{"key":"10.1016\/j.micpath.2015.05.009_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1172\/JCI11837","article-title":"Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity","volume":"107","author":"Zhang","year":"2001","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.micpath.2015.05.009_bib14","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.1062374","article-title":"Duration of nuclear NF-kappaB action regulated by reversible acetylation","volume":"293","author":"Chen","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.micpath.2015.05.009_bib15","doi-asserted-by":"crossref","first-page":"7447","DOI":"10.4049\/jimmunol.175.11.7447","article-title":"Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB","volume":"175","author":"Chen","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.micpath.2015.05.009_bib16","doi-asserted-by":"crossref","first-page":"28929","DOI":"10.1074\/jbc.M702633200","article-title":"A\u00a0cellular micro-RNA, let-7i, regulates toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection","volume":"282","author":"Chen","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.micpath.2015.05.009_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.exppara.2006.09.018","article-title":"Cryptosporidium parvum: Identification of a new surface adhesion protein on sporozoite and oocyst by screening of a phage-display cDNA library","volume":"115","author":"Yao","year":"2007","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.micpath.2015.05.009_bib18","first-page":"475","article-title":"Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage","volume":"15","author":"Wu","year":"2014","journal-title":"J.\u00a0Veterinary Sci."},{"key":"10.1016\/j.micpath.2015.05.009_bib19","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0016-5085(00)70219-8","article-title":"Mechanisms of attachment and internalization of Cryptosporidium parvum to biliary and intestinal epithelial cells","volume":"118","author":"Chen","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.micpath.2015.05.009_bib20","doi-asserted-by":"crossref","first-page":"F589","DOI":"10.1152\/ajprenal.00628.2009","article-title":"Expression and function of CXCL12\/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis","volume":"298","author":"Arms","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.micpath.2015.05.009_bib21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.vetimm.2013.08.003","article-title":"Staphylococcus aureus and Escherichia coli elicit different innate immune responses from bovine mammary epithelial cells","volume":"155","author":"Fu","year":"2013","journal-title":"Veterinary Immunol. Immunopathol."},{"key":"10.1016\/j.micpath.2015.05.009_bib22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/431405a","article-title":"Cancer: an inflammatory link","volume":"431","author":"Balkwill","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2015.05.009_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cvfa.2008.10.013","article-title":"Pathophysiology of diarrhea in calves","volume":"25","author":"Foster","year":"2009","journal-title":"Veterinary Clin. N. Am. Food Animal Pract."},{"key":"10.1016\/j.micpath.2015.05.009_bib24","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1189\/jlb.0203082","article-title":"How we detect microbes and respond to them: the toll-like receptors and their transducers","volume":"74","author":"Beutler","year":"2003","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.micpath.2015.05.009_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00436-003-0831-8","article-title":"The role of Cryptosporidium parvum-derived phospholipase in intestinal epithelial cell invasion","volume":"90","author":"Pollok","year":"2003","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micpath.2015.05.009_bib26","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1471-4922(03)00122-3","article-title":"Mucin and toll-like receptors in host defense against intestinal parasites","volume":"19","author":"Moncada","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.micpath.2015.05.009_bib27","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.4049\/jimmunol.179.2.1129","article-title":"Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii","volume":"179","author":"Debierre-Grockiego","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.micpath.2015.05.009_bib28","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/intimm\/dxg108","article-title":"TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection","volume":"15","author":"Mun","year":"2003","journal-title":"Int. Immunol."},{"key":"10.1016\/j.micpath.2015.05.009_bib29","doi-asserted-by":"crossref","first-page":"7589","DOI":"10.4049\/jimmunol.176.12.7589","article-title":"TLR9 is required for the gut-associated lymphoid tissue response following oral infection of Toxoplasma gondii","volume":"176","author":"Minns","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.micpath.2015.05.009_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J.\u00a0Clin. Investigation"},{"key":"10.1016\/j.micpath.2015.05.009_bib31","doi-asserted-by":"crossref","first-page":"15148","DOI":"10.1074\/jbc.273.24.15148","article-title":"Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene","volume":"273","author":"Taylor","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.micpath.2015.05.009_bib32","doi-asserted-by":"crossref","first-page":"e1002702","DOI":"10.1371\/journal.ppat.1002702","article-title":"miR-27b targets KSRP to coordinate TLR4-mediated epithelial defense against Cryptosporidium parvum infection","volume":"8","author":"Zhou","year":"2012","journal-title":"PLoS Pathog."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240101500090X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240101500090X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T10:53:32Z","timestamp":1717930412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088240101500090X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":32,"alternative-id":["S088240101500090X"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2015.05.009","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bovine TLR2 and TLR4 mediate Cryptosporidium parvum recognition in bovine intestinal epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2015.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}