{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:59:26Z","timestamp":1767826766823,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004481","name":"University of Tehran","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004481","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002660","name":"Islamic Azad University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002660","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.micpath.2015.09.005","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T02:25:16Z","timestamp":1443234316000},"page":"87-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Multiple repeats of Helicobacter pylori CagA EPIYA-C phosphorylation sites predict risk of gastric ulcer in Iran"],"prefix":"10.1016","volume":"89","author":[{"given":"Sahar","family":"Honarmand-Jahromy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farideh","family":"Siavoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Malekzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taher Nejad","family":"Sattari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Latifi-Navid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2015.09.005_bib1","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1056\/NEJMra020542","article-title":"Helicobacter pylori infection","volume":"347","author":"Suerbaum","year":"2002","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.micpath.2015.09.005_bib2","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1128\/JCM.36.8.2258-2263.1998","article-title":"Variants of the 3\u2032 region of the cagA gene in Helicobacter pylori isolates from patients with different H. pylori-associated diseases","volume":"36","author":"Yamaoka","year":"1998","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.micpath.2015.09.005_bib3","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0016-5085(97)80006-6","article-title":"Helicobacter pylori factors associated with disease development","volume":"113","author":"Mobley","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.micpath.2015.09.005_bib4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJM199607253350404","article-title":"The risk of stomach cancer in patients with gastric or duodenal ulcer disease","volume":"335","author":"Hansson","year":"1996","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.micpath.2015.09.005_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev.pathol.1.110304.100125","article-title":"The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases","volume":"1","author":"Atherton","year":"2006","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.micpath.2015.09.005_bib6","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1073\/pnas.90.12.5791","article-title":"Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer","volume":"90","author":"Covacci","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micpath.2015.09.005_bib7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/gut.40.3.297","article-title":"Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection","volume":"40","author":"Parsonnet","year":"1997","journal-title":"Gut"},{"key":"10.1016\/j.micpath.2015.09.005_bib8","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1023\/A:1026636803101","article-title":"Relationship of Helicobacter pylori CagA status to gastric cell proliferation and apoptosis","volume":"44","author":"Rokkas","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.micpath.2015.09.005_bib9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/41483","article-title":"The complete genome sequence of the gastric pathogen Helicobacter pylori","volume":"388","author":"Tomb","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2015.09.005_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1099\/jmm.0.46824-0","article-title":"Helicobacter pylori cag pathogenicity island genes: clinical relevance for peptic ulcer disease development in Brazil","volume":"56","author":"Mattar","year":"2007","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.micpath.2015.09.005_bib11","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.micinf.2011.03.011","article-title":"Pathophysiological functions of the CagA oncoprotein during infection by Helicobacter pylori","volume":"13","author":"Murata-Kamiya","year":"2011","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micpath.2015.09.005_bib12","doi-asserted-by":"crossref","first-page":"6775","DOI":"10.1074\/jbc.C100754200","article-title":"Src is the kinase of the Helicobacter pylori CagA protein in\u00a0vitro and in\u00a0vivo","volume":"277","author":"Selbach","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.micpath.2015.09.005_bib13","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1046\/j.1365-2958.2002.02781.x","article-title":"c-Src\/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs","volume":"43","author":"Stein","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micpath.2015.09.005_bib14","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1074\/jbc.M208155200","article-title":"Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase","volume":"278","author":"Tsutsumi","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.micpath.2015.09.005_bib15","doi-asserted-by":"crossref","first-page":"14428","DOI":"10.1073\/pnas.222375399","article-title":"Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites","volume":"99","author":"Higashi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micpath.2015.09.005_bib16","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrc1433","article-title":"Oncogenic mechanisms of the Helicobacter pylori CagA protein","volume":"4","author":"Hatakeyama","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.micpath.2015.09.005_bib17","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1053\/j.gastro.2004.06.006","article-title":"Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori","volume":"127","author":"Argent","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.micpath.2015.09.005_bib18","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1086\/345374","article-title":"Correlation between variation of the 3\u2032 region of the cagA gene in Helicobacter pylori and disease outcome in Japan","volume":"186","author":"Azuma","year":"2002","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.micpath.2015.09.005_bib19","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1128\/AEM.68.3.1436-1439.2002","article-title":"Isolation and genotyping of Helicobacter pylori from untreated municipal wastewater","volume":"68","author":"Lu","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.micpath.2015.09.005_bib20","series-title":"Helicobacter pylori: Techniques for Clinical Diagnosis and Basic Research","first-page":"94","article-title":"PCR amplification of gene sequences from Helicobacter pylori strains","author":"Covacci","year":"1996"},{"key":"10.1016\/j.micpath.2015.09.005_bib21","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1128\/JCM.43.2.791-795.2005","article-title":"Simple method for determination of the number of Helicobacter pylori CagA variable-region EPIYA tyrosine phosphorylation motifs by PCR","volume":"43","author":"Argent","year":"2005","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.micpath.2015.09.005_bib22","doi-asserted-by":"crossref","first-page":"e9645","DOI":"10.1371\/journal.pone.0009645","article-title":"Ethnic and geographic differentiation of Helicobacter pylori within Iran","volume":"5","author":"Latifi-Navid","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2015.09.005_bib23","first-page":"835","article-title":"The association of vacA genotype and Helicobacter pylori-related disease in Latin American and African populations","volume":"15","author":"Sugimoto","year":"2009","journal-title":"Clin. Microbiol. Infect. Off. Publ. Eur. Soc. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.micpath.2015.09.005_bib24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1365-2036.2003.01396.x","article-title":"Risk factors for failure of Helicobacter pylori therapy\u2013results of an individual data analysis of 2751 patients","volume":"17","author":"Broutet","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.micpath.2015.09.005_bib25","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1053\/j.gastro.2005.12.038","article-title":"Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA","volume":"130","author":"Naito","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.micpath.2015.09.005_bib26","doi-asserted-by":"crossref","first-page":"32344","DOI":"10.1074\/jbc.M606172200","article-title":"Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells","volume":"281","author":"Ren","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.micpath.2015.09.005_bib27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1469-0691.2009.02811.x","article-title":"CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions","volume":"16","author":"Sicinschi","year":"2010","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.micpath.2015.09.005_bib28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1099\/jmm.0.014894-0","article-title":"DNA sequence analysis of cagA 3\u2032 motifs of Helicobacter pylori strains from patients with peptic ulcer diseases","volume":"59","author":"Salih","year":"2010","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.micpath.2015.09.005_bib29","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1007\/s10620-005-9030-z","article-title":"Analysis of the 3\u2032 variable region of the cagA gene of Helicobacter pylori isolated in Koreans","volume":"52","author":"Choi","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.micpath.2015.09.005_bib30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1574-695X.2010.00722.x","article-title":"Diversity of the cagA gene of Helicobacter pylori strains from patients with gastroduodenal diseases in the Philippines","volume":"60","author":"Cortes","year":"2010","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.micpath.2015.09.005_bib31","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1523-5378.2012.00954.x","article-title":"A\u00a0potential association between Helicobacter pylori CagA EPIYA and multimerization motifs with cytokeratin 18 cleavage rate during early apoptosis","volume":"17","author":"Saberi","year":"2012","journal-title":"Helicobacter"},{"key":"10.1016\/j.micpath.2015.09.005_bib32","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1440-1746.2009.05979.x","article-title":"Analysis of 3\u2032-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian population","volume":"25","author":"Shokrzadeh","year":"2010","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"key":"10.1016\/j.micpath.2015.09.005_bib33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.meegid.2013.03.048","article-title":"Determination of Helicobacter pylori CagA EPIYA types in Iranian isolates with different gastroduodenal disorders","volume":"17","author":"Vaziri","year":"2013","journal-title":"Infect. Genet. Evol."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.micpath.2015.09.005_bib34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1523-5378.2009.00702.x","article-title":"Pathogenesis of Helicobacter pylori infection","volume":"14","author":"Costa","year":"2009","journal-title":"Helicobacter"},{"key":"10.1016\/j.micpath.2015.09.005_bib35","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1099\/jmm.0.47465-0","article-title":"Functional association between the Helicobacter pylori virulence factors VacA and CagA","volume":"57","author":"Argent","year":"2008","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.micpath.2015.09.005_bib36","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/gut.45.6.804","article-title":"Relation between clinical presentation, Helicobacter pylori density, interleukin 1beta and 8 production, and cagA status","volume":"45","author":"Yamaoka","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.micpath.2015.09.005_bib37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/1319-3767.108474","article-title":"Study of the cytoxin-associated gene a (CagA gene) in Helicobacter pylori using gastric biopsies of Iraqi patients","volume":"19","author":"Kalaf","year":"2013","journal-title":"Saudi J. Gastroenterol. Off. J. Saudi Gastroenterol. Assoc."},{"key":"10.1016\/j.micpath.2015.09.005_bib38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/j.gastro.2008.03.041","article-title":"Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms","volume":"135","author":"Basso","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.micpath.2015.09.005_bib39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2180-11-121","article-title":"Helicobacter pylori with stronger intensity of CagA phosphorylation lead to an increased risk of gastric intestinal metaplasia and cancer","volume":"11","author":"Chuang","year":"2011","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.micpath.2015.09.005_bib40","doi-asserted-by":"crossref","first-page":"e7736","DOI":"10.1371\/journal.pone.0007736","article-title":"A\u00a0comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori","volume":"4","author":"Xia","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2015.09.005_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1471-2180-11-61","article-title":"Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer","volume":"11","author":"Batista","year":"2011","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.micpath.2015.09.005_bib42","first-page":"30","article-title":"Prevalence of EPIYA motifs in Helicobacter pylori strains isolated from patients with gastroduodenal disorders in northern Iran","volume":"1","author":"Ajami","year":"2013","journal-title":"Res. Mol. Med."},{"key":"10.1016\/j.micpath.2015.09.005_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.chom.2008.11.010","article-title":"Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation","volume":"5","author":"Suzuki","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micpath.2015.09.005_bib44","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1590\/S0004-28032011000300003","article-title":"High prevalence of duodenal ulcer in a tertiary care hospital in the city of Sao Paulo, SP, Brazil","volume":"48","author":"Marques","year":"2011","journal-title":"Arq. Gastroenterol."},{"key":"10.1016\/j.micpath.2015.09.005_bib45","doi-asserted-by":"crossref","first-page":"5404","DOI":"10.3748\/wjg.v18.i38.5404","article-title":"Different risk factors influence peptic ulcer disease development in a Brazilian population","volume":"18","author":"Suzuki","year":"2012","journal-title":"World J. Gastroenterol. WJG"},{"key":"10.1016\/j.micpath.2015.09.005_bib46","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1053\/hupa.2001.21136","article-title":"Helicobacter pylori genotypes, host factors, and gastric mucosal histopathology in peptic ulcer disease","volume":"32","author":"Tham","year":"2001","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.micpath.2015.09.005_bib47","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/00365520310000528","article-title":"Impact of clinical symptoms and referral volume on endoscopy for detecting peptic ulcer and gastric neoplasms","volume":"38","author":"Voutilainen","year":"2003","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.micpath.2015.09.005_bib48","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1523-5378.2005.00360.x","article-title":"No correlation of babA2 with vacA and cagA genotypes of Helicobacter pylori and grading of gastritis from peptic ulcer disease patients in Brazil","volume":"10","author":"Mattar","year":"2005","journal-title":"Helicobacter"},{"key":"10.1016\/j.micpath.2015.09.005_bib49","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1523-5378.2012.00988.x","article-title":"The epidemiology, diagnosis, and cost of dyspepsia and Helicobacter pylori gastritis: a case-control analysis in the Southwestern United States","volume":"18","author":"Mapel","year":"2013","journal-title":"Helicobacter"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401015001515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401015001515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T20:35:13Z","timestamp":1599597313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401015001515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":49,"alternative-id":["S0882401015001515"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2015.09.005","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple repeats of Helicobacter pylori CagA EPIYA-C phosphorylation sites predict risk of gastric ulcer in Iran","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2015.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}