{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:19:49Z","timestamp":1789370389783,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graduate Program in Biochemistry Toxicology and Laboratory of Clinical and Toxicological Analysis (UFSM)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.micpath.2016.04.002","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T08:21:48Z","timestamp":1459844508000},"page":"166-174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Synergistic effects of resveratrol (free and inclusion complex) and sulfamethoxazole-trimetropim treatment on pathology, oxidant\/antioxidant status and behavior of mice infected with Toxoplasma gondii"],"prefix":"10.1016","volume":"95","author":[{"given":"Nathieli B.","family":"Bottari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus D.","family":"Baldissera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre A.","family":"Tonin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia C.","family":"Rech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catiane B.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"D'Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo R.","family":"Thom\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiara S.","family":"Guarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael N.","family":"Moresco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana","family":"Camillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda F.","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane","family":"Luchese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosa C.","family":"Schetinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera M.","family":"Morsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Tochetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Fighera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian S.K.","family":"Nishihira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandro S.","family":"Da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2016.04.002_bib1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1128\/MMBR.64.3.607-623.2000","article-title":"Lytic cycle of Toxoplasma gondii","volume":"64","author":"Black","year":"2000","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.micpath.2016.04.002_bib2","series-title":"Toxoplasmosis of Animals and Humans","author":"Dubey","year":"2012"},{"key":"10.1016\/j.micpath.2016.04.002_bib3","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: from animals to humans","volume":"30","author":"Tender","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.micpath.2016.04.002_bib4","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2307\/3285739","article-title":"Infection and immunity with the RH strain of Toxoplasma gondii in rats and mice","volume":"85","author":"Dubey","year":"1999","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.micpath.2016.04.002_bib5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.7326\/0003-4819-117-2-106","article-title":"Low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS","volume":"117","author":"Carr","year":"1992","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.micpath.2016.04.002_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jac\/dkl180","article-title":"Antiproliferative activities of two novel quinuclidine inhibitors against Toxoplasma gondii tachyzoites in\u00a0vitro","volume":"58","author":"De Souza","year":"2006","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2016.04.002_bib7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1590\/S1413-86702007000500011","article-title":"Toxoplasma gondii infection in pregnancy","volume":"11","author":"Lopes","year":"2007","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.micpath.2016.04.002_bib8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1645\/13-451.1","article-title":"A\u00a0thiazole derivative of artemisinin moderately reduces toxoplasma gondii cyst burden in infected mice","volume":"100","author":"Schultz","year":"2014","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.micpath.2016.04.002_bib9","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1017\/S0031182014001073","article-title":"Diphenyl diselenide and sodium selenite associated with chemotherapy in experimental toxoplasmosis: influence on oxidant\/antioxidant biomarkers and cytokine modulation","volume":"141","author":"Barbosa","year":"2014","journal-title":"Parasitol"},{"key":"10.1016\/j.micpath.2016.04.002_bib10","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1152\/ajpheart.01013.2001","article-title":"Pharmacological preconditioning with resveratrol: an insight with iNOS knockout mice","volume":"282","author":"Imamura","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.micpath.2016.04.002_bib11","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0024-3205(99)00410-5","article-title":"Biological effects of resveratrol","volume":"66","author":"Fr\u00e9mon","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.micpath.2016.04.002_bib12","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1042\/BST0351156","article-title":"Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications","volume":"35","author":"De la Lastra","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.micpath.2016.04.002_bib13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-1-62703-475-3_9","article-title":"Biomedical applications of nano-antioxidant","volume":"1028","author":"Watal","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.micpath.2016.04.002_bib14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/mabi.201300551","article-title":"Polymer micro- and nanocapsules as biological carriers with multifunctional properties","volume":"14","author":"Musyanovych","year":"2014","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.micpath.2016.04.002_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open: closed arm entries in an elevated plus maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1982","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.micpath.2016.04.002_bib16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbr.2005.07.018","article-title":"Light\/dark cycle manipulation influences mice behavior in the elevated plus maze","volume":"166","author":"Cl\u00e9net","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.micpath.2016.04.002_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejphar.2005.11.014","article-title":"Effects of systemic administration of beta-casomorphin-5 on learning and memory in mice","volume":"530","author":"Sakaguchi","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.micpath.2016.04.002_bib18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1037\/0033-2909.83.3.482","article-title":"The open-field test: a critical review","volume":"83","author":"Walsh","year":"1976","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.micpath.2016.04.002_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/jac\/34.1.111","article-title":"Evaluation of the efficacy of prolonged administration of azithromycin in a murine model of chronic toxoplasmosis","volume":"34","author":"Dumas","year":"1994","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2016.04.002_bib20","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.cca.2012.01.038","article-title":"Improved detection of advanced oxidation protein products in plasma","volume":"413","author":"Hanasand","year":"2012","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.micpath.2016.04.002_bib21","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A\u00a0new automated colorimetric method for measuring total oxidant status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.micpath.2016.04.002_bib22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","article-title":"A\u00a0novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation","volume":"37","author":"Erel","year":"2005","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.micpath.2016.04.002_bib23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"Ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.micpath.2016.04.002_bib24","series-title":"Carelton's Histological Techniques","author":"Durary","year":"1976"},{"key":"10.1016\/j.micpath.2016.04.002_bib25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.micinf.2010.03.004","article-title":"Activation of the P2X7 receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages","volume":"12","author":"Correa","year":"2010","journal-title":"Microb. Infect."},{"key":"10.1016\/j.micpath.2016.04.002_bib26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0301-0511(03)00075-9","article-title":"Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii dopamine, a missing link between schizophrenia and toxoplasmosis?","volume":"63","author":"Flegr","year":"2003","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.micpath.2016.04.002_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S003118200007774X","article-title":"Effect of Toxoplasma gondii upon neophobic behavior in wild brown rats, Rattus norvegicus","volume":"109","author":"Webster","year":"1993","journal-title":"Parasitology"},{"key":"10.1016\/j.micpath.2016.04.002_bib28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1590\/S0036-46652013000100009","article-title":"Behavioral changes in Rattus norvegicus coinfected by Toxocara canis and Toxoplasma gondii","volume":"55","author":"Queiroz","year":"2013","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.micpath.2016.04.002_bib29","doi-asserted-by":"crossref","first-page":"e28925","DOI":"10.1371\/journal.pone.0028925","article-title":"The distribution of Toxoplasma gondii cysts in the brain of a mouse with latent toxoplasmosis: implications for the behavioral manipulation hypothesis","volume":"6","author":"Berenreiterov\u00e1","year":"2011","journal-title":"Plos One"},{"key":"10.1016\/j.micpath.2016.04.002_bib30","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1166\/jbn.2013.1709","article-title":"Lipid-core nanocapsules improve the effects of resveratrol against Abeta-induced neuroinflammation","volume":"9","author":"Frozza","year":"2013","journal-title":"J.\u00a0Biomed. Nanotechnol."},{"key":"10.1016\/j.micpath.2016.04.002_bib31","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.1109893","article-title":"TLR11 activation of dendritic cells by a protozoan profilin-like protein","volume":"308","author":"Yarovisky","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.micpath.2016.04.002_bib32","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.147.3656.400","article-title":"Photochemical action spectrum of the terminal oxidase of mixed function oxidase systems","volume":"147","author":"Cooper","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.micpath.2016.04.002_bib33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1021\/tx700079z","article-title":"Cytochrome p450 and chemical toxicology","volume":"21","author":"Guengerich","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.micpath.2016.04.002_bib34","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1530-0277.2001.tb02259.x","article-title":"Removal of glutathione produces apoptosis and necrosis in HepG2 cells overexpressing CYP2E1","volume":"25","author":"Wu","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.micpath.2016.04.002_bib35","article-title":"Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats","volume":"69","author":"Csisz\u00e1r","year":"2014","journal-title":"J.\u00a0Gerontol. Biol. Sci. Med. Sci."},{"key":"10.1016\/j.micpath.2016.04.002_bib36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1365-2958.2003.03823.x","article-title":"The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury","volume":"51","author":"Kwok","year":"2014","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micpath.2016.04.002_bib37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1365-2958.2003.03823.x","article-title":"The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury","volume":"51","author":"Kwok","year":"2014","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micpath.2016.04.002_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1365-2958.2003.03823.x","article-title":"The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury","volume":"51","author":"Ding","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micpath.2016.04.002_bib39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.micpath.2015.01.001","article-title":"Sulfamethoxazole-trimethoprim associated with resveratrol for the treatment of toxoplasmosis in mice: influence on the activity of enzymes involved in brain neurotransmission","volume":"79","author":"Bottari","year":"2015","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2016.04.002_bib40","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.micpath.2015.07.013","article-title":"Effects of sulfamethoxazole-trimethoprim associated to resveratrol on its free form and complexed with 2-hydroxypropyl-\u03b2-cyclodextrin on cytokines levels of mice infected by Toxoplasma gondii","volume":"87","author":"Bottari","year":"2015","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2016.04.002_bib41","doi-asserted-by":"crossref","first-page":"e15099","DOI":"10.1371\/journal.pone.0015099","article-title":"Anti-Inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation","volume":"5","author":"Bereswill","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2016.04.002_bib42","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.exppara.2012.12.011","article-title":"Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model","volume":"133","author":"Martins-Duarte","year":"2013","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.micpath.2016.04.002_bib43","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1128\/AAC.9.2.222","article-title":"Trimethoprim-sulfamethoxazole in murine toxoplasmosis","volume":"9","author":"Remington","year":"1976","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401015302485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401015302485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T14:09:44Z","timestamp":1718460584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401015302485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":43,"alternative-id":["S0882401015302485"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2016.04.002","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic effects of resveratrol (free and inclusion complex) and sulfamethoxazole-trimetropim treatment on pathology, oxidant\/antioxidant status and behavior of mice infected with Toxoplasma gondii","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2016.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}