{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:36:34Z","timestamp":1791599794548,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.micpath.2016.10.022","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T16:00:23Z","timestamp":1478102423000},"page":"44-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Use of juglone as antibacterial and potential efflux pump inhibitors in Staphylococcus aureus isolated from the oral cavity"],"prefix":"10.1016","volume":"101","author":[{"given":"Tarek","family":"Zmantar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanene","family":"Miladi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bochra","family":"Kouidhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassine","family":"Chaabouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihab","family":"Ben Slama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Bakhrouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1138-0638","authenticated-orcid":false,"given":"Kacem","family":"Mahdouani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Chaieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2016.10.022_bib1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.archoralbio.2010.09.010","article-title":"Molecular investigation of macrolide and Tetracycline resistances in oral bacteria isolated from Tunisian children","volume":"56","author":"Kouidhi","year":"2011","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.micpath.2016.10.022_bib2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/jac\/dkh137","article-title":"Antibiotic resistance in general dental practice\u2014a cause for concern?","volume":"53","author":"Sweeney","year":"2004","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2016.10.022_bib3","first-page":"285","article-title":"Antibacterial efflux systems","volume":"13","author":"Marshall","year":"1997","journal-title":"Microbiol. Madr. Spain"},{"key":"10.1016\/j.micpath.2016.10.022_bib4","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1128\/AAC.43.4.988","article-title":"Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine","volume":"43","author":"Markham","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2016.10.022_bib5","first-page":"897","article-title":"Evolution of resistance to antibiotics and antiseptics of hospital Staphylococcus aureus strains isolated from 1980 to 1991","volume":"41","author":"Reverdy","year":"1993","journal-title":"Pathol. Biol."},{"key":"10.1016\/j.micpath.2016.10.022_bib6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1211\/0022357001773742","article-title":"Do biocides select for antibiotic resistance?","volume":"52","author":"Russell","year":"2000","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.micpath.2016.10.022_bib7","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1128\/AAC.46.11.3606-3612.2002","article-title":"Organization of the antiseptic resistance gene qacA and Tn552-related \u03b2-lactamase genes in multidrug-resistant Staphylococcus haemolyticus strains of animal and human origins","volume":"46","author":"Anthonisen","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2016.10.022_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-0500-4-453","article-title":"Detection of macrolide and disinfectant resistance genes in clinical Staphylococcus aureus and coagulase-negative staphylococci","volume":"4","author":"Zmantar","year":"2011","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.micpath.2016.10.022_bib9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrd1657","article-title":"The evolving role of natural products in drug discovery","volume":"4","author":"Koehn","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.micpath.2016.10.022_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jep.2003.09.035","article-title":"Evaluation of antiplaque activity of Azadirachta indica leaf extract gel-a 6-week clinical study","volume":"90","author":"Pai","year":"2004","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.micpath.2016.10.022_bib11","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1586\/eri.12.57","article-title":"Plant essential oils and their constituents in coping with multidrug-resistant bacteria","volume":"10","author":"Kon","year":"2012","journal-title":"Expert Rev. Anti-infective Ther."},{"key":"10.1016\/j.micpath.2016.10.022_bib12","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/j.fct.2008.03.017","article-title":"Total phenols, antioxidant potential and antimicrobial activity of walnut (Juglans regia L.) green husks","volume":"46","author":"Oliveira","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.micpath.2016.10.022_bib13","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.foodchem.2005.01.035","article-title":"Traditional walnut liqueur\u2013cocktail of phenolics","volume":"95","author":"Stampar","year":"2006","journal-title":"Food Chem."},{"key":"10.1016\/j.micpath.2016.10.022_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/157341209787314936","article-title":"Noteworthy secondary metabolites naphthoquinones-their occurrence, pharmacological properties and analysis","volume":"5","author":"Babula","year":"2009","journal-title":"Curr. Pharm. Anal."},{"key":"10.1016\/j.micpath.2016.10.022_bib15","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1089\/fpd.2009.0527","article-title":"Effect of subinhibitory concentrations of plant-derived molecules in increasing the sensitivity of multidrug-resistant Salmonella enterica serovar Typhimurium DT104 to antibiotics","volume":"7","author":"Johny","year":"2010","journal-title":"Foodborne Pathog. Dis."},{"key":"10.1016\/j.micpath.2016.10.022_bib16","series-title":"Approved Standard - Seventh Edition","article-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically","author":"CLSI","year":"2006"},{"key":"10.1016\/j.micpath.2016.10.022_bib17","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/jac\/dkt481","article-title":"Redundancy in the periplasmic adaptor proteins AcrA and AcrE provides resilience and an ability to export substrates of multidrug efflux","volume":"69","author":"Smith","year":"2014","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2016.10.022_bib18","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1016\/j.bmcl.2014.04.080","article-title":"Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives","volume":"24","author":"Sreelatha","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.micpath.2016.10.022_bib19","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3390\/ijms17060965","article-title":"Antibacterial activity of juglone against Staphylococcus aureus: from apparent to proteomic","volume":"17","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2016.10.022_bib20","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/10496475.2012.762818","article-title":"Cytotoxicity, antibacterial, antioxidant, and antibiofilm properties of Tunisian Juglans regia bark extract","volume":"19","author":"Chaieb","year":"2013","journal-title":"J.\u00a0Herbs Sp. Med. Plants"},{"key":"10.1016\/j.micpath.2016.10.022_bib21","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/CMR.19.2.382-402.2006","article-title":"Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria","volume":"19","author":"Piddock","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micpath.2016.10.022_bib22","doi-asserted-by":"crossref","DOI":"10.1086\/321834","article-title":"Development and spread of bacterial resistance to antimicrobial agents: an overview","volume":"33","author":"Tenover","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.micpath.2016.10.022_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jac\/dkg044","article-title":"A\u00a0novel inhibitor of multidrug efflux pumps in Staphylococcus aureus","volume":"51","author":"Gibbons","year":"2003","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2016.10.022_bib24","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/jac\/dkl460","article-title":"Bacterial efflux pump inhibitors from natural sources","volume":"59","author":"Stavri","year":"2007","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2016.10.022_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.archoralbio.2005.08.001","article-title":"In\u00a0vitro antimicrobial and resistance-modifying activities of aqueous crude khat extracts against oral microorganisms","volume":"51","author":"Al-hebshi","year":"2006","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.micpath.2016.10.022_bib26","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/ptr.2695","article-title":"Modulation of drug resistance in Staphylococcus aureus by a kaempferol glycoside from Herissantia tiubae (Malvaceae)","volume":"23","author":"Falc\u00e3o-Silva","year":"2009","journal-title":"Phytother. Res."},{"key":"10.1016\/j.micpath.2016.10.022_bib27","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1016\/j.phytochem.2004.10.009","article-title":"Antibacterial and resistance modifying activity of Rosmarinus officinalis","volume":"65","author":"Oluwatuyi","year":"2004","journal-title":"Phytochemistry"},{"key":"10.1016\/j.micpath.2016.10.022_bib28","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1128\/JB.182.15.4264-4267.2000","article-title":"Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli","volume":"182","author":"Zgurskaya","year":"2000","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.micpath.2016.10.022_bib29","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1093\/jac\/dks005","article-title":"Novel inhibitory activity of the Staphylococcus aureus NorA efflux pump by a kaempferol rhamnoside isolated from Persea lingue Nees","volume":"67","author":"Holler","year":"2012","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2016.10.022_bib30","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1139\/w05-022","article-title":"Synergic interaction between pomegranate extract and antibiotics against Staphylococcus aureus","volume":"51","author":"Braga","year":"2005","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.micpath.2016.10.022_bib31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ijantimicag.2010.09.011","article-title":"Inhibition of efflux pumps in meticillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina","volume":"37","author":"Ramalhete","year":"2011","journal-title":"Int. J. Antimicrob. Agents"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401016306386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401016306386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T03:00:16Z","timestamp":1568516416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401016306386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":31,"alternative-id":["S0882401016306386"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2016.10.022","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of juglone as antibacterial and potential efflux pump inhibitors in Staphylococcus aureus isolated from the oral cavity","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2016.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}