{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:06:51Z","timestamp":1759936011880},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Education, Basic Science Research Program, National Research Foundation, Korea","award":["2015-0885"],"award-info":[{"award-number":["2015-0885"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.micpath.2016.11.028","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T08:16:41Z","timestamp":1482481001000},"page":"87-93","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Nocodazole treatment interrupted Brucella abortus invasion in RAW 264.7 cells, and successfully attenuated splenic proliferation with enhanced inflammatory response in mice"],"prefix":"10.1016","volume":"103","author":[{"given":"Alisha Wehdnesday Bernardo","family":"Reyes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huynh Tan","family":"Hop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren Togonon","family":"Arayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Xuan Ngoc","family":"Huy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wongi","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu Jang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Hee","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2016.11.028_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13567-016-0311-7","article-title":"Expression of cytokine and apoptosis-related genes in bovine peripheral blood mononuclear cells stimulated with Brucella abortus recombinant proteins","volume":"47","author":"Im","year":"2016","journal-title":"Vet. Res."},{"key":"10.1016\/j.micpath.2016.11.028_bib2","first-page":"537","article-title":"Epidemiology of brucellosis among cattle in Korea from 2001 to 2011","volume":"15","author":"Yoon","year":"2014","journal-title":"J.\u00a0Vet. Sci."},{"key":"10.1016\/j.micpath.2016.11.028_bib3","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1128\/IAI.66.12.5711-5724.1998","article-title":"Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes","volume":"66","author":"Pizarro-Cerd\u00e1","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2016.11.028_bib4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11515-012-1196-0","article-title":"Progress in Brucella vaccine development","volume":"8","author":"Yang","year":"2013","journal-title":"Front. Biol."},{"key":"10.1016\/j.micpath.2016.11.028_bib5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.micinf.2011.08.012","article-title":"Identification of a unique gene cluster of Brucella spp. that mediates adhesion to host cells","volume":"14","author":"Czibener","year":"2012","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micpath.2016.11.028_bib6","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.ajpath.2015.03.003","article-title":"Pathogenesis and immunobiology of brucellosis: review of Brucella\u2013host interactions","volume":"185","author":"de Figueiredo","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.micpath.2016.11.028_bib7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fcimb.2016.00030","article-title":"Establishment of chronic infection: Brucella's stealth strategy","volume":"6","author":"Ahmed","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2016.11.028_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1042\/BJ20110577","article-title":"Modulation of microtubule dynamics by a TIR domain protein from the intracellular pathogen Brucella melitensis","volume":"439","author":"Radhakrishnan","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.micpath.2016.11.028_bib9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/cm.20134","article-title":"Effects of acrylamide, latrunculin, and nocodazole on intracellular transport and cytoskeletal organization in melanophores","volume":"63","author":"Aspengren","year":"2006","journal-title":"Cell Motil. Cytoskelet."},{"key":"10.1016\/j.micpath.2016.11.028_bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00709-005-0121-7","article-title":"Nocodazole inhibits macronuclear infection with Holospora obtusa in Paramecium caudatum","volume":"226","author":"Sabaneyeva","year":"2005","journal-title":"Protoplasma"},{"key":"10.1016\/j.micpath.2016.11.028_bib11","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1128\/IAI.01151-08","article-title":"Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection","volume":"77","author":"Pasquevich","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2016.11.028_bib12","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.micpath.2015.10.024","article-title":"Dextran sulfate sodium upregulates MAPK signaling for the uptake and subsequent intracellular survival of Brucella abortus in murine macrophages","volume":"91","author":"Reyes","year":"2016","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2016.11.028_bib13","doi-asserted-by":"crossref","first-page":"fnv070","DOI":"10.1093\/femsle\/fnv070","article-title":"The effects of red ginseng saponin fraction-A (RGSF-A) on phagocytosis and intracellular signaling in Brucella abortus infected RAW 264.7 cells","volume":"362","author":"Arayan","year":"2015","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micpath.2016.11.028_bib14","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/jam.13019","article-title":"Methyl gallate limits infection in mice challenged with Brucella abortus while enhancing the inflammatory response","volume":"120","author":"Reyes","year":"2016","journal-title":"J.\u00a0Appl. Microbiol."},{"key":"10.1016\/j.micpath.2016.11.028_bib15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1297-9716-43-29","article-title":"What have we learned from brucellosis in the mouse model","volume":"43","author":"Grill\u00f3","year":"2012","journal-title":"Vet. Res."},{"key":"10.1016\/j.micpath.2016.11.028_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1155\/1995\/42412","article-title":"Cytokine production in the serum and spleen of mice from day 6 to 14 of gestation: cytokines\/placenta\/spleen\/serum","volume":"4","author":"Athanassakis","year":"1996","journal-title":"Dev. Immunol."},{"key":"10.1016\/j.micpath.2016.11.028_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cimid.2012.10.002","article-title":"Redundant effects of ketamine on the pathogenesis and severity of Brucella abortus infection","volume":"36","author":"Lee","year":"2013","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.micpath.2016.11.028_bib18","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/cmi.12526","article-title":"BigA is a novel adhesin of Brucella that mediates adhesion to epithelial cells","volume":"18","author":"Czibener","year":"2016","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.micpath.2016.11.028_bib19","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.tim.2009.05.006","article-title":"Brucella regulators: self-control in a hostile environment","volume":"17","author":"Rambow-Larsen","year":"2009","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micpath.2016.11.028_bib20","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1006\/bbrc.1998.8536","article-title":"Effect of microtubule disruption on cell adhesion and spreading","volume":"246","author":"Kadi","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.micpath.2016.11.028_bib21","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1128\/IAI.01811-06","article-title":"An in\u00a0vitro model system used to study adherence and invasion of Francisella tularensis live vaccine strain in nonphagocytic cells","volume":"75","author":"Lindemann","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2016.11.028_bib22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1574-6968.1998.tb12895.x","article-title":"The microtubule depolymerizing drugs nocodazole and colchicine inhibit the uptake of Listeria monocytogenes by P388D1 macrophages","volume":"160","author":"Kuhn","year":"1998","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micpath.2016.11.028_bib23","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1242\/jcs.00949","article-title":"Microtubule motors control membrane dynamics of Salmonella-containing vacuoles","volume":"117","author":"Guignot","year":"2004","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.micpath.2016.11.028_bib24","series-title":"Trafficking of Intracellular Membranes: from Molecular Sorting to Membrane Fusion","first-page":"216","year":"2013"},{"key":"10.1016\/j.micpath.2016.11.028_bib25","doi-asserted-by":"crossref","first-page":"16147","DOI":"10.1074\/jbc.272.26.16147","article-title":"Reconstitution of phagosome-lysosome fusion in streptolysin O-permeabilized cells","volume":"272","author":"Funato","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.micpath.2016.11.028_bib26","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.micinf.2008.07.005","article-title":"The role of innate immune receptors in the control of Brucella abortus infection: toll-like receptors and beyond","volume":"10","author":"Oliveira","year":"2008","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micpath.2016.11.028_bib27","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/S0960-9822(98)70321-5","article-title":"Endoplasmic reticulum membrane tubules are distributed by microtubules in living cells using three distinct mechanisms","volume":"8","author":"Waterman-Storer","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.micpath.2016.11.028_bib28","series-title":"The Role of Microtubules in Cell Biology, Neurobiology, and Oncology","first-page":"499","year":"2009"},{"key":"10.1016\/j.micpath.2016.11.028_bib29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11010-012-1239-5","article-title":"Nocodazole increases the ERK activity to enhance MKP-1 expression which inhibits p38 activation induced by TNF-\u03b1","volume":"364","author":"Guo","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.micpath.2016.11.028_bib30","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1016\/j.vaccine.2015.05.057","article-title":"Immune response triggered by Brucella abortus following infection or vaccination","volume":"33","author":"Dorneles","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2016.11.028_bib31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1128\/CMR.16.1.65-78.2003","article-title":"Molecular host-pathogen interaction in brucellosis: current understanding and future approaches to vaccine development for mice and humans","volume":"16","author":"Ko","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micpath.2016.11.028_bib32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.20506\/rst.32.1.2190","article-title":"Immunity to brucellosis","volume":"32","author":"Skendros","year":"2013","journal-title":"Rev. Sci. Tech."},{"key":"10.1016\/j.micpath.2016.11.028_bib33","doi-asserted-by":"crossref","first-page":"e1003454","DOI":"10.1371\/journal.ppat.1003454","article-title":"CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function","volume":"9","author":"Xavier","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2016.11.028_bib34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tvjl.2009.04.010","article-title":"Pathogenesis of bovine brucellosis","volume":"184","author":"Neta","year":"2010","journal-title":"Vet. J."},{"key":"10.1016\/j.micpath.2016.11.028_bib35","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/icb.1993.32","article-title":"Interleukin-6 production during chronic experimental infection","volume":"71","author":"Saunders","year":"1993","journal-title":"Immunol. Cell Biol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401016306453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401016306453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T01:33:58Z","timestamp":1601256838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401016306453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":35,"alternative-id":["S0882401016306453"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2016.11.028","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nocodazole treatment interrupted Brucella abortus invasion in RAW 264.7 cells, and successfully attenuated splenic proliferation with enhanced inflammatory response in mice","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2016.11.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}