{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:37:07Z","timestamp":1789850227274,"version":"4.0.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.micpath.2017.01.022","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T20:00:49Z","timestamp":1484251249000},"page":"180-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Hepatic xanthine oxidase activity and purine nucleosides levels as physiological mediators to analyze a subcutaneous treatment with (PhSe)2 in mice infected by Toxoplasma gondii"],"prefix":"10.1016","volume":"104","author":[{"given":"Pedro H.","family":"Doleski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela B.R.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa S.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathieli B.","family":"Bottari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson A.","family":"Casali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar E.J.","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana","family":"Camillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda F.","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenita M.","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandro Schafer","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2017.01.022_bib1","series-title":"The Model Apicomplexan: Perspectives and Methods","first-page":"1","article-title":"The history and life cycle of Toxoplasma gondii","author":"Dubey","year":"2007"},{"key":"10.1016\/j.micpath.2017.01.022_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1128\/CMR.11.2.267","article-title":"Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts","volume":"2","author":"Dubey","year":"1998","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micpath.2017.01.022_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.exppara.2016.07.006","article-title":"Diphenyl diselenide supplementation in infected mice by Toxoplasma gondii: protective effect on behavior, neuromodulation and oxidative stress caused by disease","volume":"169","author":"Machado","year":"2016","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.micpath.2017.01.022_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2016.08.003","article-title":"Latent toxoplasmosis is associated with neurocognitive impairment in young adults with and without chronic HIV infection","volume":"299","author":"Ene","year":"2016","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.micpath.2017.01.022_bib5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.micpath.2015.07.013","article-title":"Effects of sulfamethoxazole-trimethoprim associated to resveratrol on its free form and complexed with 2-hydroxypropyl-\u03b2-cyclodextrin on cytokines levels of mice infected by Toxoplasma gondii","volume":"87","author":"Bottari","year":"2015","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2017.01.022_bib6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.apjtm.2015.09.003","article-title":"Is toxoplasmosis a potential risk factor for liver cirrhosis?","volume":"10","author":"El-Henawy","year":"2015","journal-title":"Asian Pac J. Trop. Med."},{"key":"10.1016\/j.micpath.2017.01.022_bib7","first-page":"13","article-title":"Functional anatomy and blood supply of the liver","author":"Mitra","year":"2012","journal-title":"Anaesth. intensive care Med."},{"key":"10.1016\/j.micpath.2017.01.022_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.exppara.2014.04.008","article-title":"Influence of infection by Toxoplasma gondii on purine levels and E-ADA activity in the brain of mice experimentally infected mice","volume":"142","author":"Tonin","year":"2014","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.micpath.2017.01.022_bib9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","article-title":"Receptors for purines and pyrimidines","volume":"50","author":"Ralevic","year":"1998","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.micpath.2017.01.022_bib10","first-page":"27","article-title":"Two sides of a single coin: a determinant of antioxidant system or a factor in metabolic syndrome","volume":"10","author":"Bagheri","year":"2016","journal-title":"J.\u00a0Clin. Diagnostic Res."},{"key":"10.1016\/j.micpath.2017.01.022_bib11","series-title":"Uric Acid Puzzle: Dual Role as Anti-oxidant and Pro-oxidant","first-page":"1","volume":"vol. 12","author":"Kang","year":"2014"},{"key":"10.1016\/j.micpath.2017.01.022_bib12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5604\/20831862.1120934","article-title":"Delayed uric acid accumulation in plasma provides additional anti-oxidant protection against iron-triggered oxidative stress after a wingate test","volume":"31","author":"Souza-Junior","year":"2014","journal-title":"Biol. Sport"},{"key":"10.1016\/j.micpath.2017.01.022_bib13","first-page":"1","article-title":"Hydroxysafflor yellow a inhibits LPS-induced NLRP3 inflammasome activation via binding to xanthine oxidase in mouse RAW264.7 macrophages","author":"Xu","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.micpath.2017.01.022_bib14","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1536\/ihj.16-192","article-title":"Hyperuricemia and Atrial Fibrillation: Possible underlying mechanisms","volume":"57","author":"Maharani","year":"2016","journal-title":"Int Heart J."},{"key":"10.1016\/j.micpath.2017.01.022_bib15","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1021\/cr0406559","article-title":"Organoselenium and organotellurium compounds: toxicology and pharmacology","volume":"104","author":"Nogueira","year":"2004","journal-title":"Chem. Rev."},{"key":"10.1016\/j.micpath.2017.01.022_bib16","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1590\/S0103-50532010001100006","article-title":"Diphenyl diselenide a janus-faced molecule","volume":"21","author":"Nogueira","year":"2010","journal-title":"J.\u00a0Braz. Chem. Soc."},{"key":"10.1016\/j.micpath.2017.01.022_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cyto.2014.09.006","article-title":"Swimming exercise and diphenyl diselenide-supplemented diet affect the serum levels of pro- and anti-inflammatory cytokines differently depending on the age of rats","volume":"71","author":"Leite","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.micpath.2017.01.022_bib18","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1017\/S0031182014001073","article-title":"Diphenyl diselenide and sodium selenite associated with chemotherapy in experimental toxoplasmosis: influence on oxidant\/antioxidant biomarkers and cytokine modulation","volume":"141","author":"Barbosa","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.micpath.2017.01.022_bib19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0021-9673(01)91386-X","article-title":"Determination of selected pyrimidines, purines and their metabolites in serum and urine by reversed phase ionpair chromatography","volume":"199","author":"Voelter","year":"1980","journal-title":"J.\u00a0Chromatogr."},{"key":"10.1016\/j.micpath.2017.01.022_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3181\/00379727-71-17125","article-title":"The xanthine oxidase activity of rat tissues","volume":"71","author":"Westerfeld","year":"1949","journal-title":"Proc. Soe. Exptl. Biol. Med."},{"key":"10.1016\/j.micpath.2017.01.022_bib21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S1471-4892(02)00143-1","article-title":"Uric acid and cardiovascular risk","volume":"2","author":"Alderman","year":"2002","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.micpath.2017.01.022_bib22","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1253\/circj.69.928","article-title":"Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome","volume":"69","author":"Tae","year":"2005","journal-title":"Circulation J."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401016305514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401016305514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T10:57:11Z","timestamp":1749898631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401016305514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":22,"alternative-id":["S0882401016305514"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2017.01.022","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic xanthine oxidase activity and purine nucleosides levels as physiological mediators to analyze a subcutaneous treatment with (PhSe)2 in mice infected by Toxoplasma gondii","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2017.01.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}