{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:30:26Z","timestamp":1794267026973,"version":"4.9.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.micpath.2017.01.049","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T07:45:32Z","timestamp":1485416732000},"page":"254-262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"special_numbering":"C","title":["Bacteremia and other body site infection caused by hypervirulent and classic Klebsiella pneumoniae"],"prefix":"10.1016","volume":"104","author":[{"given":"Hua","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingxia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.micpath.2017.01.049_bib1","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1128\/JCM.01716-07","article-title":"Capsular polysaccharide synthesis regions in Klebsiella pneumoniae serotype K57 and a new capsular serotype","volume":"46","author":"Pan","year":"2008","journal-title":"J.\u00a0Clin. Microbiol."},{"issue":"13","key":"10.1016\/j.micpath.2017.01.049_bib2","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.micinf.2004.06.003","article-title":"High prevalence of phagocytic-resistant capsular serotypes of Klebsiella pneumoniae in liver abscess","volume":"6","author":"Lin","year":"2004","journal-title":"Microbes Infect."},{"issue":"11","key":"10.1016\/j.micpath.2017.01.049_bib3","doi-asserted-by":"crossref","first-page":"e15005","DOI":"10.1371\/journal.pone.0015005","article-title":"Do neutrophils play a role in establishing liver abscesses and distant metastases caused by Klebsiella pneumoniae?","volume":"5","author":"Lin","year":"2010","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.micpath.2017.01.049_bib4","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S1473-3099(12)70205-0","article-title":"Klebsiella pneumoniae liver abscess: a new invasive syndrome","volume":"12","author":"Siu","year":"2012","journal-title":"Lancet Infect. Dis."},{"issue":"Pt 5","key":"10.1016\/j.micpath.2017.01.049_bib5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1099\/jmm.0.015198-0","article-title":"PCR characterization and typing of Klebsiella pneumoniae using capsular type-specific, variable number tandem repeat and virulence gene targets","volume":"59","author":"Turton","year":"2010","journal-title":"J.\u00a0Med. Microbiol."},{"issue":"11","key":"10.1016\/j.micpath.2017.01.049_bib6","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1128\/JCM.00977-11","article-title":"Molecular typing and virulence analysis of serotype K1 Klebsiella pneumoniae strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan","volume":"49","author":"Siu","year":"2011","journal-title":"J.\u00a0Clin. Microbiol."},{"issue":"3","key":"10.1016\/j.micpath.2017.01.049_bib7","doi-asserted-by":"crossref","first-page":"e4982","DOI":"10.1371\/journal.pone.0004982","article-title":"Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization","volume":"4","author":"Brisse","year":"2009","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.micpath.2017.01.049_bib8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1128\/IAI.72.1.54-61.2004","article-title":"A\u00a0gene, uge, is essential for Klebsiella pneumoniae virulence","volume":"72","author":"Regu\u00e9","year":"2004","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.micpath.2017.01.049_bib9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.patbio.2012.10.004","article-title":"Virulence profiles and antibiotic susceptibility patterns of Klebsiella pneumoniae strains isolated from different clinical specimens","volume":"61","author":"El Fertas-Aissani","year":"2013","journal-title":"Pathol. Biol. Paris."},{"issue":"7","key":"10.1016\/j.micpath.2017.01.049_bib10","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1128\/JCM.00088-14","article-title":"Expansion and evolution of a virulent, extensively drug-resistant (polymyxin B-resistant), QnrS1-, CTX-M-2-, and KPC-2-producing Klebsiella pneumoniae ST11 international high-risk clone","volume":"52","author":"Andrade","year":"2014","journal-title":"J.\u00a0Clin. Microbiol."},{"issue":"3","key":"10.1016\/j.micpath.2017.01.049_bib11","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/CMR.00001-07","article-title":"Carbapenemases: the versatile beta-lactamases","volume":"20","author":"Queenan","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.micpath.2017.01.049_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diagmicrobio.2008.04.007","article-title":"Comparison of prevalence of virulence factors for Klebsiella pneumonae liver absecsses between isolates with capsular K1\/K2 and non-K1\/K2 serotypes","volume":"62","author":"Yu","year":"2008","journal-title":"Diagn Microbiol. Infect. Dis."},{"key":"10.1016\/j.micpath.2017.01.049_bib13","doi-asserted-by":"crossref","DOI":"10.1089\/mdr.2016.0018","article-title":"Impacts of hypervirulence determinants on clinical features and outcomes of bacteremia caused by extended-spectrum \u03b2-lactamase-producing Klebsiella pneumoniae","author":"Yu","year":"2016","journal-title":"Microb. Drug Resist"},{"key":"10.1016\/j.micpath.2017.01.049_bib14","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3201\/eid1307.070187","article-title":"International Klebseilla Study Group. Virulence characteristics of Klebsiella and clinical manifestations of K.\u00a0pneumoniae bloodstream infections","volume":"13","author":"Yu","year":"2007","journal-title":"Emerg. Infect. Dis."},{"issue":"6","key":"10.1016\/j.micpath.2017.01.049_bib15","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1128\/IAI.01667-13","article-title":"Aerobactin mediates virulence and accounts for increased siderophore production under iron-limiting condition by hypervirulent (hypermucoviscous) Klebsiella pneumoniae","volume":"82","author":"Russo","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2017.01.049_bib16","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.3390\/ijerph10072720","article-title":"Optimization of pulse-field gel electrophoresis for subtyping of Klebsiella pneumoniae","volume":"10","author":"Han","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.micpath.2017.01.049_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2307\/1932409","article-title":"Measures of the amount of ecological association between species","volume":"26","author":"Dice","year":"1945","journal-title":"Ecology"},{"issue":"8","key":"10.1016\/j.micpath.2017.01.049_bib18","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1128\/JCM.43.8.4178-4182.2005","article-title":"Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates","volume":"43","author":"Diancourt","year":"2005","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.micpath.2017.01.049_bib19","series-title":"Performance Standards for Antimicrobial Susceptibility Testing: Twenty-sixth Informational Supplement M100\u2013s26","author":"Clinical and Laboratory Standards Institute","year":"2016"},{"key":"10.1016\/j.micpath.2017.01.049_bib20","doi-asserted-by":"crossref","unstructured":"Cheng HY, Chen YS, Wu CY, Chang HY, Lai YC, Peng HL. RmpA regulation of capsular polysaccharide biosynthesis in Klebsiella pneumoniae CG43. J. Bacteriol.. 192:3144\u20133158.","DOI":"10.1128\/JB.00031-10"},{"issue":"10","key":"10.1016\/j.micpath.2017.01.049_bib21","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1086\/503420","article-title":"Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan","volume":"42","author":"Yu","year":"2006","journal-title":"Clin. Infect. Dis."},{"issue":"2","key":"10.1016\/j.micpath.2017.01.049_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4161\/viru.22718","article-title":"Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed","volume":"4","author":"Shon","year":"2013","journal-title":"Virulence"},{"issue":"5","key":"10.1016\/j.micpath.2017.01.049_bib23","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S1473-3099(13)70068-9","article-title":"Klebsiella pneumoniae liver abscesses","volume":"13","author":"Shen","year":"2013","journal-title":"Lancet Infect. Dis."},{"issue":"6","key":"10.1016\/j.micpath.2017.01.049_bib24","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jinf.2006.11.008","article-title":"Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea","volume":"54","author":"Chung","year":"2007","journal-title":"J.\u00a0Infect."},{"issue":"5","key":"10.1016\/j.micpath.2017.01.049_bib25","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1128\/IAI.70.5.2583-2590.2002","article-title":"Molecular analysis of the contribution of the capsular poly-saccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine model of pneumonia","volume":"70","author":"Cort\u00e9s","year":"2002","journal-title":"Infect. Immun."},{"issue":"9","key":"10.1016\/j.micpath.2017.01.049_bib26","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1128\/IAI.00494-08","article-title":"Characterization of Klebsiella pneumoniae type 1 fimbriae by detection of phase variation during colonization and infection and impact on virulence","volume":"76","author":"Struve","year":"2008","journal-title":"Infect. Immun."},{"issue":"11","key":"10.1016\/j.micpath.2017.01.049_bib27","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1128\/IAI.00585-09","article-title":"Identification of a conserved chromosomal region encoding Klebsiella pneumoniae type 1 and type 3 fimbriae and assessment of the role of fimbriae in pathogenicity","volume":"77","author":"Struve","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2017.01.049_bib28","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/archinte.1991.00400080059010","article-title":"Septic metastatic lesions of pyogenic liver abscess. Their association with Klebsiella pneumoniae bacteremia in diabetic patients","volume":"151","author":"Cheng","year":"1991","journal-title":"Arch. Intern Med."},{"key":"10.1016\/j.micpath.2017.01.049_bib29","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1001\/archinte.1986.00360220057011","article-title":"Klebsiella pneumoniae liver abscess associated with septic endophthalmitis","volume":"146","author":"Liu","year":"1986","journal-title":"Arch. Intern Med."},{"issue":"1","key":"10.1016\/j.micpath.2017.01.049_bib30","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1186\/s12879-016-2011-3","article-title":"Two unusual cases of successful treatment of hypermucoviscous Klebsiella pnemoniae invasive syndrome","volume":"16","author":"Namikawa","year":"2016","journal-title":"BMC Infect. Dis."},{"issue":"4","key":"10.1016\/j.micpath.2017.01.049_bib31","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/jpids\/piu080","article-title":"Outbreak of KPC-3 producing carbapenem - resistant Klebsiella pneumoniae in a US Pediatric Hospital","volume":"4","author":"Stillwell","year":"2015","journal-title":"J.\u00a0Pediatr. Infect. Dis. Soc."},{"key":"10.1016\/j.micpath.2017.01.049_bib32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1186\/s12879-015-1152-0","article-title":"Trends in the annual incidence of carbapenem-resistant Klebsiella pneumoniae bloodstream infections: a 8-year retrospective study in a large teaching hospital in northern Italy","volume":"15","author":"Alicino","year":"2015","journal-title":"BMC Infect. Dis."},{"issue":"2","key":"10.1016\/j.micpath.2017.01.049_bib33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijantimicag.2015.04.001","article-title":"Interhospital spread of NDM-7-producing Klebsiella pneumoniae belonging to ST437 in Spain","volume":"46","author":"Seara","year":"2015","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micpath.2017.01.049_bib34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13756-015-0049-4","article-title":"An outbreak of carbapenem-resistant OXA-48- producing Klebsiella pneumoniae associated to duodenoscopy","volume":"4","author":"Kola","year":"2015","journal-title":"Antimicrob. Resist Infect. Control"},{"issue":"10","key":"10.1016\/j.micpath.2017.01.049_bib35","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s10096-016-2710-0","article-title":"Risk factors and clinical outcomes for carbapenem-resistant enterobacteriaceae nosocomial infections","volume":"35","author":"Wang","year":"2016","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.micpath.2017.01.049_bib36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/jac\/dkq431","article-title":"ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China","volume":"66","author":"Qi","year":"2011","journal-title":"J.\u00a0Antimicrob. Chemother."},{"issue":"2","key":"10.1016\/j.micpath.2017.01.049_bib37","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1128\/AAC.01269-07","article-title":"Community acquired liver abscess caused by serotype K1 Klebsiella pneumoniae with CTX-M-15-type extended-spectrum beta-lactamase [J]","volume":"52","author":"Su","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"issue":"9","key":"10.1016\/j.micpath.2017.01.049_bib38","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1128\/JCM.00726-14","article-title":"First isolate of KPC-2 producing Klebsiella pneumonaie sequence type 23 from the Americas [J]","volume":"52","author":"Cejas","year":"2014","journal-title":"J.\u00a0Clin. Microbiol."},{"issue":"6","key":"10.1016\/j.micpath.2017.01.049_bib39","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2217\/fmb.12.43","article-title":"Hypervirulent Klebsiella pneumoniae: the next superbug?","volume":"7","author":"Shon","year":"2012","journal-title":"Future Microbiol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401016306441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401016306441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T16:54:47Z","timestamp":1536080087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401016306441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":39,"alternative-id":["S0882401016306441"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2017.01.049","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bacteremia and other body site infection caused by hypervirulent and classic Klebsiella pneumoniae","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2017.01.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}