{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:02:07Z","timestamp":1789387327288,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"Department of Laboratory Sciences, College of Applied Medical Sciences, at King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.micpath.2017.07.002","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T21:30:26Z","timestamp":1499203826000},"page":"279-284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Chemically modified tetracyclines an emerging host modulator in chronic periodontitis patients: A randomized, double-blind, placebo-controlled, clinical trial"],"prefix":"10.1016","volume":"110","author":[{"given":"Abdullah A.","family":"Alyousef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshan Devang","family":"Divakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Muzaheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2017.07.002_bib1","series-title":"Polymicrobial Diseases","article-title":"Periodontal diseases","author":"Guthmiller","year":"2002"},{"issue":"1","key":"10.1016\/j.micpath.2017.07.002_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/138920009787048347","article-title":"The potential of p38 MAPK inhibitors to modulate periodontal infections","volume":"10","author":"Kirkwood","year":"2009","journal-title":"Curr. Drug Metab."},{"issue":"3","key":"10.1016\/j.micpath.2017.07.002_bib3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1034\/j.1600-0765.2002.00663.x","article-title":"Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures","volume":"37","author":"Chang","year":"2002","journal-title":"J.\u00a0Periodontal Res."},{"issue":"3","key":"10.1016\/j.micpath.2017.07.002_bib4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/2230-973X.104394","article-title":"Treatment modalities and evaluation models for periodontitis","volume":"2","author":"Mohammad","year":"2012","journal-title":"Int. J. Pharm. Investig."},{"issue":"3","key":"10.1016\/j.micpath.2017.07.002_bib5","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4103\/0972-124X.134559","article-title":"Host modulation therapy: an indispensable part of perioceutics","volume":"18","author":"Minkle Gulati","year":"2014","journal-title":"J.\u00a0Indian Soc. Periodontol."},{"issue":"2","key":"10.1016\/j.micpath.2017.07.002_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/0253-7613.93841","article-title":"Chemically modified tetracyclines: novel therapeutic agents in the management of chronic periodontitis","volume":"44","author":"Agnihotri","year":"2012","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.micpath.2017.07.002_bib7","first-page":"983","article-title":"Current and prospective pharmacotherapies in gastroesophageal reflux disease","volume":"1","author":"Nguyen","year":"2009","journal-title":"Clin. Med. Ther."},{"issue":"13","key":"10.1016\/j.micpath.2017.07.002_bib8","first-page":"1","article-title":"Chemically modified tetracyclines: an emerging host modulatory therapy","volume":"21","author":"Gupta","year":"2012","journal-title":"J.\u00a0Pharm. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.micpath.2017.07.002_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1046\/j.1524-475X.2002.10605.x","article-title":"Chemically modified tetracycline (CMT-8) and estrogen promote wound healing in ovariectomized rats: effects on matrix metalloproteinase-2, membrane type 1 matrix metalloproteinase, and laminin-5 gamma2-chain","volume":"10","author":"Piril\u00e4","year":"2002","journal-title":"Wound Repair Regen."},{"issue":"6","key":"10.1016\/j.micpath.2017.07.002_bib10","doi-asserted-by":"crossref","first-page":"739","DOI":"10.4103\/0972-124X.147410","article-title":"Comparative evaluation of C-reactive protein in peripheral blood of patients with healthy gingiva, gingivitis and chronic periodontitis: a clinical and particle-enhanced turbidimetric immuno-analysis","volume":"18","author":"Tushika","year":"2014","journal-title":"J.\u00a0Indian Soc. Periodontol."},{"issue":"4","key":"10.1016\/j.micpath.2017.07.002_bib11","doi-asserted-by":"crossref","first-page":"484","DOI":"10.4103\/0976-237X.142816","article-title":"Comparative evaluation of serum C-reactive protein levels in chronic and aggressive periodontitis patients and association with periodontal disease severity","volume":"5","author":"Lata","year":"2014","journal-title":"Contemp. Clin. Dent."},{"issue":"4","key":"10.1016\/j.micpath.2017.07.002_bib12","first-page":"47","article-title":"C-reactive protein as predict of increased carotid intima media thickness in patients with chronic periodontitis","volume":"6","author":"Tapashetti","year":"2014","journal-title":"J.\u00a0Int. Oral Health"},{"issue":"972313","key":"10.1016\/j.micpath.2017.07.002_bib13","first-page":"11","article-title":"Periodontal ligament stem cells: current status, concerns, and future prospects","volume":"2015","author":"Wenjun","year":"2015","journal-title":"Stem Cells Int."},{"issue":"9","key":"10.1016\/j.micpath.2017.07.002_bib14","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/S1567-5769(01)00100-X","article-title":"Anti-inflammatory effects of chemically modified tetracyclines by the inhibition of nitric oxide and interleukin-12 synthesis in J774 cell line","volume":"1","author":"D'Agostino","year":"2001","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.micpath.2017.07.002_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.phrs.2010.10.006","article-title":"Using tetracyclines to treat osteoporotic\/osteopenic bone loss: from the basic science laboratory to the clinic","volume":"63","author":"Jeffrey","year":"2011","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.micpath.2017.07.002_bib16","first-page":"S256","article-title":"Host modulation by therapeutic agents","volume":"4","author":"Sugumari","year":"2012","journal-title":"J.\u00a0Pharm. Bioallied Sci."},{"key":"10.1016\/j.micpath.2017.07.002_bib17","first-page":"111","article-title":"The nonantimicrobial properties of tetracycline for the treatment of periodontal disease","author":"Vernillo","year":"1994","journal-title":"Curr. Opin. Periodontol."},{"issue":"8","key":"10.1016\/j.micpath.2017.07.002_bib18","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1902\/jop.2007.070015","article-title":"Subantimicrobial dose incyclinide effects on osteopenic bone loss: microbiologic results","volume":"78","author":"Clay","year":"2007","journal-title":"J.\u00a0Periodontol."},{"issue":"3","key":"10.1016\/j.micpath.2017.07.002_bib19","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/0929867013373598","article-title":"Excessive matrix metalloproteinase activity in diabetes: inhibition by tetracycline analogues with zinc reactivity","volume":"8","author":"Ryan","year":"2001","journal-title":"Curr. Med. Chem."},{"issue":"8","key":"10.1016\/j.micpath.2017.07.002_bib20","first-page":"819","article-title":"Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs","volume":"64","author":"Barry","year":"1993","journal-title":"J.\u00a0Periodontol."},{"issue":"8","key":"10.1016\/j.micpath.2017.07.002_bib21","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1902\/jop.1993.64.8s.819","article-title":"Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs","volume":"64","author":"Rifkin","year":"1993","journal-title":"J.\u00a0Periodontol."},{"issue":"2","key":"10.1016\/j.micpath.2017.07.002_bib22","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/sj.bjp.0704068","article-title":"Effects of chemically modified tetracyclines (CMTs) in sensitive, multidrug resistant and apoptosis resistant leukaemia cell lines","volume":"133","author":"Tolomeo","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.micpath.2017.07.002_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/1874210601408010109","article-title":"Anti-inflammatory actions of adjunctive tetracyclines and other agents. In periodontitis and associated comorbidities","volume":"8","author":"Aruni","year":"2014","journal-title":"Open Dent. J."},{"issue":"2","key":"10.1016\/j.micpath.2017.07.002_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.5005\/jp-journals-10024-1305","article-title":"Effect of periodontal therapy on serum C-reactive protein levels in patients with gingivitis and chronic periodontitis: a clinicobiochemical study","volume":"14","author":"Patil","year":"2013","journal-title":"J.\u00a0Contemp. Dent. Pract."},{"issue":"4","key":"10.1016\/j.micpath.2017.07.002_bib25","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4103\/0972-124X.138688","article-title":"Effect of periodontal therapy on C-reactive protein levels in gingival crevicular fluid of patients with gingivitis and chronic periodontitis: a clinical and biochemical study","volume":"18","author":"Deepika","year":"2014","journal-title":"J.\u00a0Indian Soc. Periodontol."},{"issue":"3","key":"10.1016\/j.micpath.2017.07.002_bib26","first-page":"261","article-title":"Evaluation of serum C-reactive protein levels in subjects with aggressive and chronic periodontitis and comparison with healthy controls","volume":"9","author":"Aruna","year":"2012","journal-title":"Dent. Res. J. (Isfahan)"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401017305132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401017305132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T11:37:40Z","timestamp":1565350660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401017305132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":26,"alternative-id":["S0882401017305132"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2017.07.002","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemically modified tetracyclines an emerging host modulator in chronic periodontitis patients: A randomized, double-blind, placebo-controlled, clinical trial","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2017.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}