{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:13:51Z","timestamp":1761581631401,"version":"3.37.3"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":317,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES\/Brazil","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"FUNCAP\/Cear\u00e1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.micpath.2017.12.016","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T23:24:34Z","timestamp":1512775474000},"page":"32-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Action mechanism of naphthofuranquinones against fluconazole-resistant Candida tropicalis strains evidenced by proteomic analysis: The role of increased endogenous ROS"],"prefix":"10.1016","volume":"117","author":[{"given":"Jo\u00e3o Batista","family":"de Andrade Neto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cec\u00edlia Rocha","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana de Sousa","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca Bruna Stefany Aires","family":"do Nascimento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia Serpa","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson Ramos","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida Alexandre","family":"Josino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Odorico","family":"de Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Duarte Pinto","family":"Lobo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico Bruno Mendes Batista","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina de Oliveira Monteiro","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"de Azevedo Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thalles Barbosa","family":"Grangeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eufr\u00e2nio Nunes","family":"da Silva J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemerson Iuri Ferreira","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo Damasceno","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Co\u00ealho","family":"Cavalcanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lio Vitoriano Nobre","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2017.12.016_bib1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.riam.2013.10.001","article-title":"Epidemiology of candidaemia and invasive candidiasis. A changing face","volume":"31","author":"Quind\u00f3s","year":"2014","journal-title":"Rev. Iberoam. Micol."},{"key":"10.1016\/j.micpath.2017.12.016_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1099\/jmm.0.045054-0","article-title":"Candida species: current epidemiology, pathogenicity, biofilm formation,natural antifungal products and new therapeutic options","volume":"62","author":"Sardi","year":"2013","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.micpath.2017.12.016_bib3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1592\/phco.30.4.361","article-title":"Hospital resource utilization and costs of inappropriate treatment of candidemia","volume":"30","author":"Arnold","year":"2010","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.micpath.2017.12.016_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059373","article-title":"Epidemiology of candidemia in Latin America: a laboratory-based survey","volume":"8","author":"Nucci","year":"2013","journal-title":"PLoSOne"},{"key":"10.1016\/j.micpath.2017.12.016_bib5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1590\/S0074-02762013000300005","article-title":"Historical trends in the epidemiology of candidaemia: analysis of an 11-year period in a tertiary care hospital in Brazil","volume":"108","author":"Wille","year":"2013","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.micpath.2017.12.016_bib6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1590\/0037-8682-0074-2012","article-title":"Antifungal susceptibility and distribution of Candida spp. isolates from the university hospital in the municipality of dourados, state of Mato Grosso do Sul, Brazil","volume":"46","author":"Almeida","year":"2013","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.micpath.2017.12.016_bib7","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1099\/jmm.0.013227-0","article-title":"Candida tropicalis: its prevalence, pathogenicity and increasing resistance to fluconazole","volume":"59","author":"Kothavade","year":"2010","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.micpath.2017.12.016_bib8","first-page":"S3","article-title":"Antifungal drug resistance: mechanisms, epidemiology and consequences for treatment","volume":"125","author":"Pfaller","year":"2012","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.micpath.2017.12.016_bib9","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2217\/fmb.14.32","article-title":"Antifungal drug discovery: the process and outcomes","volume":"9","author":"Calderone","year":"2014","journal-title":"Future Microbiol."},{"key":"10.1016\/j.micpath.2017.12.016_bib10","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1128\/AAC.01728-09","article-title":"Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicans","volume":"54","author":"Gamarra","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2017.12.016_bib11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1439-0507.2011.02156.x","article-title":"Emergence of Candida spp. and exploration of natural bioactive molecules for anticandidal therapy\u2013status quo","volume":"55","author":"Rajeshkumar","year":"2012","journal-title":"Mycoses"},{"key":"10.1016\/j.micpath.2017.12.016_bib12","first-page":"62","article-title":"Semi-Synthesis: a solution to problems of pharmacological natural products","volume":"9","author":"Oliveira","year":"2009","journal-title":"Electron. J. Pharm."},{"key":"10.1016\/j.micpath.2017.12.016_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0924-8579(02)00349-7","article-title":"In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus","volume":"21","author":"Machado","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micpath.2017.12.016_bib14","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00284-010-9763-6","article-title":"Identification of nor-\u03b2-lapachone derivatives as potential antibacterial compounds against Enterococcus faecalis clinical strain","volume":"62","author":"Louren\u00e7o","year":"2011","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.micpath.2017.12.016_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1476-0711-5-5","article-title":"Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis","volume":"22","author":"Pereira","year":"2006","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"10.1016\/j.micpath.2017.12.016_bib16","article-title":"Antifungal activity of naphthoquinoidal compounds in vitro against fluconazole-resistant strains of different Candida species: a special emphasis on mechanisms of action on Candida tropicalis","volume":"9","author":"Andrade Neto","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2017.12.016_bib17","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ejmech.2005.12.006","article-title":"Synthesis of naphthofuranquinones with activity against Trypanosoma cruzi","volume":"41","author":"Silva","year":"2006","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.micpath.2017.12.016_bib18","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1128\/AAC.00966-12","article-title":"Synergistic effects of amiodarone and fluconazole on Candida tropicalis resistant to fluconazole","volume":"57","author":"Da Silva","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2017.12.016_bib19","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/pmic.200800562","article-title":"The detection, correlation, and comparison of peptide precursor and product ions from data independent LC-MS with data dependant LC-MS\/MS","volume":"9","author":"Geromanos","year":"2009","journal-title":"Proteomics"},{"key":"10.1016\/j.micpath.2017.12.016_bib20","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/pmic.200900698","article-title":"Investigation of solubilization and digestion methods for microsomal membrane proteome analysis using data-independent LC-MSE","volume":"11","author":"Mbeunkui","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.micpath.2017.12.016_bib21","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1021\/ac048455k","article-title":"Quantitative proteomic analysis by accurate mass retention time pairs","volume":"77","author":"Silva","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.micpath.2017.12.016_bib22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1074\/mcp.M500230-MCP200","article-title":"Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisition","volume":"5","author":"Silva","year":"2006","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.micpath.2017.12.016_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbrc.2011.03.125","article-title":"Induction of yeast apoptosis by an antimicrobial peptide","volume":"29","author":"Hwang","year":"2011","journal-title":"Papiliocin. Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.micpath.2017.12.016_bib24","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1021\/tx970086i","article-title":"Hypochlorous acid-induced base modifications in isolated calf thymus DNA","volume":"10","author":"Whiteman","year":"1997","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.micpath.2017.12.016_bib25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0891-5849(97)00104-4","article-title":"Protein carbonyl measurement by a sensitive Elisa method","volume":"23","author":"Buss","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.micpath.2017.12.016_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2017.12.016_bib27","article-title":"Cell cycle analysis of yeasts","volume":"11","author":"Fortuna","year":"2011","journal-title":"Curr. Protoc. Cytom. Chapter"},{"key":"10.1016\/j.micpath.2017.12.016_bib28","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2217\/fmb.14.17","article-title":"Honey flavonoids inhibit Candida albicans morphogenesis by affecting DNA behavior and mitochondrial function","volume":"9","author":"Canonico","year":"2014","journal-title":"Future Microbiol."},{"key":"10.1016\/j.micpath.2017.12.016_bib29","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1177\/002215540104900912","article-title":"A silver staining method for single-cell gel assay","volume":"49","author":"Nadin","year":"2001","journal-title":"J. Histochem Cytochem"},{"key":"10.1016\/j.micpath.2017.12.016_bib30","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1385\/MB:26:3:249","article-title":"The comet assay for DNA damage and repair: principles, applications, and limitations","volume":"26","author":"Collins","year":"1994","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.micpath.2017.12.016_bib31","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1128\/EC.05042-11","article-title":"Protein phosphatase Pph3 and its regulatory subunit Psy2 regulate Rad53 dephosphorylation and cell morphogenesis during recovery from DNA damage in Candida albicans","volume":"10","author":"Sun","year":"2011","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.micpath.2017.12.016_bib32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/978-1-61779-998-3_40","article-title":"Histone H2AX phosphorylation: a marker for DNA damage","volume":"920","author":"Sharma","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.micpath.2017.12.016_bib33","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2017.12.016_bib34","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micpath.2017.12.016_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2011.06.003","article-title":"Antifungal activity of novel synthetic peptides by accumulation of reactive oxygen species (ROS) and disruption of cell wall against Candida albicans","volume":"32","author":"Maurya","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.micpath.2017.12.016_bib36","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.freeradbiomed.2009.06.004","article-title":"The effects on Trypanosomacruziof novel synthetic naphthoquinones are mediated by mitochondrial dysfunction","volume":"47","author":"Menna-Barreto","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.micpath.2017.12.016_bib37","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cbi.2009.09.002","article-title":"Mechanism of action of novel naphthofuranquinones on rat liver microsomal peroxidation","volume":"182","author":"Elingold","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.micpath.2017.12.016_bib38","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.biochi.2011.07.011","article-title":"Oxidative stress by antimicrobial peptide pleurocidin triggers apoptosis in Candida albicans","volume":"93","author":"Cho","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.micpath.2017.12.016_bib39","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/EC.00303-10","article-title":"Enzymatic dysfunction of mitochondrial complex I of the Candida albicans Goa1 mutant is associated with increased reactive oxidants and cell death","volume":"10","author":"Li","year":"2011","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.micpath.2017.12.016_bib40","series-title":"Peroxiredoxin Systems","first-page":"61","author":"Floh\u00e9","year":"2007"},{"key":"10.1016\/j.micpath.2017.12.016_bib41","series-title":"Functions of Typical 2-cys Peroxiredoxins in Yeast","first-page":"61","author":"Morgan","year":"2007"},{"key":"10.1016\/j.micpath.2017.12.016_bib42","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1091\/mbc.e02-08-0546","article-title":"Stress-induced gene expression in Candida albicans: absence of a general stress response","volume":"14","author":"Enjalbert","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.micpath.2017.12.016_bib43","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/yea.1283","article-title":"Characterization of thiol-specific antioxidant 1 (TSA1) of Candida albicans","volume":"22","author":"Shin","year":"2005","journal-title":"Yeast"},{"key":"10.1016\/j.micpath.2017.12.016_bib44","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/1574-6968.12450","article-title":"Melittin triggers apoptosis in Candida albicans through the reactive oxygen species-mediated mitochondria\/caspasedependent pathway","volume":"355","author":"Lee","year":"2014","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micpath.2017.12.016_bib45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.micpath.2017.12.016_bib46","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.freeradbiomed.2012.03.012","article-title":"Coprisin-induced antifungal effects in Candida albicans correlate with apoptotic mechanisms","volume":"52","author":"Lee","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.micpath.2017.12.016_bib47","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/clinchem\/41.12.1819","article-title":"Lipid peroxidation and antioxidants as biomarkers of tissue damage","volume":"41","author":"Gutteridge","year":"1995","journal-title":"Clin. Chem."},{"key":"10.1016\/j.micpath.2017.12.016_bib48","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1128\/EC.00105-08","article-title":"Hydrogen peroxide induces hyphal differentiation in C. albicans","volume":"7","author":"Nasution","year":"2008","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.micpath.2017.12.016_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069316","article-title":"Mechanisms of the antifungal action of marine metagenome-derived peptide, MMGP1, against Candida albicans","volume":"8","author":"Pushpanathan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2017.12.016_bib50","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1007\/s11434-011-4760-0","article-title":"DNA Damage, Signaling and Repair: protecting genomic integrity and reducing the risk of human disease","volume":"56","author":"Zhou","year":"2011","journal-title":"Chin. Sci. Bull."},{"key":"10.1016\/j.micpath.2017.12.016_bib51","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bbagen.2010.01.001","article-title":"An antifungal active macrocyclic bis(bibenzyl), induced apoptosis in Candida albicans through a metacaspase-dependent apoptotic pathway","volume":"1800","author":"Wu","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.micpath.2017.12.016_bib52","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1042\/BST0391502","article-title":"Proteases and caspase-like activity in the yeast Saccharomyces cerevisiae","volume":"39","author":"Wilkinson","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.micpath.2017.12.016_bib53","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1093\/genetics\/160.4.1375","article-title":"A role for histone H2B during repair of UV-induced DNA damage in Saccharomyces cerevisiae","volume":"160","author":"Martini","year":"2002","journal-title":"Genetics"},{"key":"10.1016\/j.micpath.2017.12.016_bib54","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1139\/o04-034","article-title":"Histone modifications and DNA double-strand break repair","volume":"82","author":"Moore","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.micpath.2017.12.016_bib55","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1021\/pr9005074","article-title":"Proteomic analysis reveals a synergistic mechanism of fluconazole and berberine against fluconazole-resistant Candida albicans: endogenous ROS augmentation","volume":"8","author":"Xu","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.micpath.2017.12.016_bib56","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1021\/pr060656c","article-title":"Proteomic analysis reveals a metabolism shift in a laboratory fluconazole-resistant Candida albicans strain","volume":"6","author":"Yan","year":"2007","journal-title":"J. Proteome Res."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401017303595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401017303595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T03:39:50Z","timestamp":1660102790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401017303595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":56,"alternative-id":["S0882401017303595"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2017.12.016","relation":{},"ISSN":["0882-4010"],"issn-type":[{"type":"print","value":"0882-4010"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Action mechanism of naphthofuranquinones against fluconazole-resistant Candida tropicalis strains evidenced by proteomic analysis: The role of increased endogenous ROS","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2017.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}