{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:16:14Z","timestamp":1786994174065,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.micpath.2018.06.026","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T00:35:27Z","timestamp":1528936527000},"page":"122-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Efficacy of whole-cell pneumococcal vaccine in mice: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"122","author":[{"given":"Mona","family":"Mohammadzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Pourakbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-8639","authenticated-orcid":false,"given":"Abbas","family":"Keshtkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Habibi-Anbouhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setareh","family":"Mamishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.micpath.2018.06.026_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/s-0029-1202938","article-title":"Streptococcus pneumoniae: epidemiology, risk factors, and strategies for prevention","volume":"30","author":"Lynch","year":"2009","journal-title":"Semin. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.micpath.2018.06.026_bib2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s12275-014-3583-5","article-title":"Serotype-independent protection against pneumococcal infections elicited by intranasal immunization with ethanol-killed pneumococcal strain, SPY1","volume":"52","author":"Xu","year":"2014","journal-title":"J. Microbiol."},{"issue":"11","key":"10.1016\/j.micpath.2018.06.026_bib3","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1086\/657144","article-title":"Efficacy of whole-cell killed bacterial vaccines in preventing pneumonia and death during the 1918 influenza pandemic","volume":"202","author":"Chien","year":"2010","journal-title":"J. Infect. Dis."},{"issue":"4","key":"10.1016\/j.micpath.2018.06.026_bib4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF03401572","article-title":"Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a desoxyribonucleic acid fraction isolated from Pneumococcus type III","volume":"1","author":"Avery","year":"1995","journal-title":"Mol. Med."},{"issue":"9","key":"10.1016\/j.micpath.2018.06.026_bib5","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.vaccine.2013.10.091","article-title":"Development of a whole cell pneumococcal vaccine: BPL inactivation, cGMP production, and stability","volume":"32","author":"Goncalves","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2018.06.026_bib6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2334-9-121","article-title":"Emerging pneumococcal carriage serotypes in a high-risk population receiving universal 7-valent pneumococcal conjugate vaccine and 23-valent polysaccharide vaccine since 2001","volume":"9","author":"Leach","year":"2009","journal-title":"BMC Infect. Dis."},{"issue":"8","key":"10.1016\/j.micpath.2018.06.026_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043445","article-title":"Identification of protective pneumococcal T(H)17 antigens from the soluble fraction of a killed whole cell vaccine","volume":"7","author":"Moffitt","year":"2012","journal-title":"PLoS One"},{"issue":"29","key":"10.1016\/j.micpath.2018.06.026_bib8","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1016\/j.vaccine.2012.01.034","article-title":"Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine","volume":"30","author":"Moffitt","year":"2012","journal-title":"Vaccine"},{"issue":"33","key":"10.1016\/j.micpath.2018.06.026_bib9","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1016\/j.vaccine.2014.05.019","article-title":"Mucosal and systemic immunization with a novel attenuated pneumococcal vaccine candidate confer serotype independent protection against Streptococcus pneumoniae in mice","volume":"32","author":"Wu","year":"2014","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.micpath.2018.06.026_bib10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.coi.2011.04.002","article-title":"Next generation pneumococcal vaccines","volume":"23","author":"Moffitt","year":"2011","journal-title":"Curr. Opin. Immunol."},{"issue":"8","key":"10.1016\/j.micpath.2018.06.026_bib11","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1128\/IAI.69.8.4870-4873.2001","article-title":"Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci","volume":"69","author":"Malley","year":"2001","journal-title":"Infect. Immun."},{"issue":"47","key":"10.1016\/j.micpath.2018.06.026_bib12","doi-asserted-by":"crossref","first-page":"7468","DOI":"10.1016\/j.vaccine.2010.09.031","article-title":"GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis","volume":"28","author":"Lu","year":"2010","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.micpath.2018.06.026_bib13","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1128\/IAI.72.7.4290-4292.2004","article-title":"Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant","volume":"72","author":"Malley","year":"2004","journal-title":"Infect. Immun."},{"issue":"18","key":"10.1016\/j.micpath.2018.06.026_bib14","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1007\/s00018-012-1234-8","article-title":"Serotype-independent pneumococcal vaccines","volume":"70","author":"Miyaji","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"issue":"13","key":"10.1016\/j.micpath.2018.06.026_bib15","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1073\/pnas.0501254102","article-title":"CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization","volume":"102","author":"Malley","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.micpath.2018.06.026_bib16","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/ilar\/ilu042","article-title":"Meta-analyses of animal studies: an introduction of a valuable instrument to further improve healthcare","volume":"55","author":"Hooijmans","year":"2014","journal-title":"ILAR J."},{"issue":"7","key":"10.1016\/j.micpath.2018.06.026_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001482","article-title":"Progress in using systematic reviews of animal studies to improve translational research","volume":"10","author":"Hooijmans","year":"2013","journal-title":"PLoS Med."},{"issue":"3","key":"10.1016\/j.micpath.2018.06.026_bib18","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/ilar\/ilu043","article-title":"The usefulness of systematic reviews of animal experiments for the design of preclinical and clinical studies","volume":"55","author":"de Vries","year":"2014","journal-title":"ILAR J."},{"issue":"7","key":"10.1016\/j.micpath.2018.06.026_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Medicine"},{"issue":"4","key":"10.1016\/j.micpath.2018.06.026_bib20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/BF00268516","article-title":"Destruction of low efficiency markers is a slow process occurring at a heteroduplex stage of transformation","volume":"128","author":"Shoemaker","year":"1974","journal-title":"Mol. Gen. Genet."},{"issue":"4","key":"10.1016\/j.micpath.2018.06.026_bib21","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.joca.2012.02.010","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"20","author":"Kilkenny","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.micpath.2018.06.026_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1177\/0023677213498717","article-title":"Scientists and the 3Rs: attitudes to animal use in biomedical research and the effect of mandatory training in laboratory animal science","volume":"48","author":"Franco","year":"2014","journal-title":"Lab. Anim"},{"issue":"7109","key":"10.1016\/j.micpath.2018.06.026_bib23","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.micpath.2018.06.026_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"issue":"8","key":"10.1016\/j.micpath.2018.06.026_bib25","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1128\/CVI.00118-15","article-title":"TH17-Mediated protection against pneumococcal carriage by a whole-cell vaccine is dependent on toll-like receptor 2 and surface lipoproteins","volume":"22","author":"Moffitt","year":"2015","journal-title":"Clin. Vaccine Immunol."},{"issue":"2","key":"10.1016\/j.micpath.2018.06.026_bib26","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/oxfordjournals.aje.a121662","article-title":"Respiratory immunity in rabbits. VII. Resistance to intranasal infection in the absence of demonstrable antibodies","volume":"9","author":"Bull","year":"1929","journal-title":"Am. J. Epidemiol."},{"issue":"6","key":"10.1016\/j.micpath.2018.06.026_bib27","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1084\/jem.48.6.791","article-title":"Active and passive immunity to pneumococcus infection induced in rabbits by immunization with R pneumococci","volume":"48","author":"Tillett","year":"1928","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.micpath.2018.06.026_bib28","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1128\/IAI.67.9.4320-4325.1999","article-title":"Intranasal immunization with heat-inactivated Streptococcus pneumoniae protects mice against systemic pneumococcal infection","volume":"67","author":"Hvalbye","year":"1999","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.micpath.2018.06.026_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/mpat.1997.0142","article-title":"Establishment of a Streptococcus pneumoniae nasopharyngeal colonization model in adult mice","volume":"23","author":"Wu","year":"1997","journal-title":"Microb. Pathog."},{"issue":"9","key":"10.1016\/j.micpath.2018.06.026_bib30","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.4049\/jimmunol.165.9.4778","article-title":"Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues","volume":"165","author":"van Ginkel","year":"2000","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.micpath.2018.06.026_bib31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1046\/j.1365-2249.1998.00477.x","article-title":"Effects of adjuvants on the immune response to allergens in a murine model of allergen inhalation: cholera toxin induces a Th1-like response to Bet v 1, the major birch pollen allergen","volume":"111","author":"Wiedermann","year":"1998","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"10.1016\/j.micpath.2018.06.026_bib32","first-page":"488","article-title":"Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization","volume":"75","author":"Vajdy","year":"1992","journal-title":"Immunology"},{"issue":"Suppl 2","key":"10.1016\/j.micpath.2018.06.026_bib33","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1097\/INF.0000000000000079","article-title":"Systematic review of the effect of pneumococcal conjugate vaccine dosing schedules on immunogenicity","volume":"33","author":"Deloria Knoll","year":"2014","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"52","key":"10.1016\/j.micpath.2018.06.026_bib34","doi-asserted-by":"crossref","first-page":"9600","DOI":"10.1016\/j.vaccine.2011.09.011","article-title":"Immunogenicity of pneumococcal conjugate vaccines in infants after two or three primary vaccinations: a systematic review and meta-analysis","volume":"29","author":"Ruckinger","year":"2011","journal-title":"Vaccine"},{"issue":"52","key":"10.1016\/j.micpath.2018.06.026_bib35","doi-asserted-by":"crossref","first-page":"9711","DOI":"10.1016\/j.vaccine.2011.07.042","article-title":"Comparing pneumococcal conjugate vaccine schedules based on 3 and 2 primary doses: systematic review and meta-analysis","volume":"29","author":"Scott","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2018.06.026_bib36","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1097\/INF.0000000000000076","article-title":"Dosing schedules for pneumococcal conjugate vaccine: considerations for policy makers","volume":"33","author":"Whitney","year":"2014","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"7","key":"10.1016\/j.micpath.2018.06.026_bib37","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a010215","article-title":"The pneumococcus: epidemiology, microbiology, and pathogenesis","volume":"3","author":"Henriques-Normark","year":"2013","journal-title":"Cold Spring Harbor. Perspect. Med."},{"issue":"3","key":"10.1016\/j.micpath.2018.06.026_bib38","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1473-3099(04)00938-7","article-title":"Streptococcus pneumoniae colonisation: the key to pneumococcal disease","volume":"4","author":"Bogaert","year":"2004","journal-title":"Lancet Infect. Dis."},{"issue":"6","key":"10.1016\/j.micpath.2018.06.026_bib39","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1128\/CVI.00036-10","article-title":"Options for inactivation, adjuvant, and route of topical administration of a killed, unencapsulated pneumococcal whole-cell vaccine","volume":"17","author":"Lu","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"issue":"5","key":"10.1016\/j.micpath.2018.06.026_bib40","first-page":"600","article-title":"Administration of substances to laboratory animals: routes of administration and factors to consider","volume":"50","author":"Turner","year":"2011","journal-title":"J Am Assoc Lab Anim Sci"},{"issue":"3","key":"10.1016\/j.micpath.2018.06.026_bib41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/bfgp\/4.3.241","article-title":"Susceptibility and resistance to pneumococcal disease in mice","volume":"4","author":"Kadioglu","year":"2005","journal-title":"Briefings Funct. Genomics Proteomics"},{"issue":"11","key":"10.1016\/j.micpath.2018.06.026_bib42","doi-asserted-by":"crossref","first-page":"5460","DOI":"10.1128\/IAI.00773-07","article-title":"Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins","volume":"75","author":"Basset","year":"2007","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.micpath.2018.06.026_bib43","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1128\/IAI.00871-08","article-title":"Impaired innate and adaptive immunity to Streptococcus pneumoniae and its effect on colonization in an infant mouse model","volume":"77","author":"Bogaert","year":"2009","journal-title":"Infect. Immun."},{"issue":"9","key":"10.1016\/j.micpath.2018.06.026_bib44","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1042\/CS20150699","article-title":"Intranasal vaccination with gamma-irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses","volume":"130","author":"Babb","year":"2016","journal-title":"Clin. Sci. (Lond.)"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401017315292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401017315292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T09:35:17Z","timestamp":1604396117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401017315292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":44,"alternative-id":["S0882401017315292"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2018.06.026","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of whole-cell pneumococcal vaccine in mice: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2018.06.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}