{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:49:43Z","timestamp":1789213783607,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"University of Guanajuato, Mexico"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.micpath.2018.08.024","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T02:51:41Z","timestamp":1534301501000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Moonlighting proteins induce protection in a mouse model against Candida species"],"prefix":"10.1016","volume":"124","author":[{"given":"C\u00e9sar Luis","family":"Medrano-D\u00edaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Vega-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Ruiz-Baca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Cu\u00e9llar-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2018.08.024_bib1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M117.813741","article-title":"Aspartyl proteases in Candida glabrata are required for suppression of the host innate immune response","author":"Rasheed","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2018.08.024_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.micpath.2015.07.011","article-title":"Proteomic analysis of cell wall in four pathogenic species of Candida exposed to oxidative stress","volume":"87","author":"Ram\u00edrez-Quijas","year":"2015","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2018.08.024_bib3","series-title":"Candida and Candidiasis","author":"Calderone","year":"2002"},{"issue":"7","key":"10.1016\/j.micpath.2018.08.024_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0966-842X(01)02094-7","article-title":"Virulence factors of Candida albicans","volume":"9","author":"Calderone","year":"2001","journal-title":"Trends Microbiol."},{"issue":"6","key":"10.1016\/j.micpath.2018.08.024_bib5","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1462-5822.2005.00676.x","article-title":"Nichespecific regulation of central metabolic pathways in a fungal pathogen","volume":"8","author":"Barelle","year":"2006","journal-title":"Cell Microbiol."},{"issue":"21","key":"10.1016\/j.micpath.2018.08.024_bib6","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1002\/pmic.201200228","article-title":"Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans","volume":"12","author":"Ene","year":"2012","journal-title":"Proteomics"},{"issue":"8","key":"10.1016\/j.micpath.2018.08.024_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00631-17","article-title":"Initial treatment of cancer patients with fluconazole-susceptible dose-dependent Candida glabrata fungemia: better outcome with an echinocandin or polyene compared to an azole?","volume":"61","author":"Le","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2018.08.024_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2165\/11315530-000000000-00000","article-title":"Invasive fungal infections: the challenge continues","volume":"69","author":"Gullo","year":"2009","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.micpath.2018.08.024_bib9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4103\/0975-7406.72131","article-title":"Emerging fungal infections among children: a review on its clinical manifestations, diagnosis, and prevention","volume":"2","author":"Jain","year":"2010","journal-title":"J. Pharm. BioAllied Sci."},{"key":"10.1016\/j.micpath.2018.08.024_bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3410\/M3-14","article-title":"Emerging fungal infections in immunocompromised patients","volume":"3","author":"Low","year":"2011","journal-title":"F1000 Medicine Reports"},{"issue":"1","key":"10.1016\/j.micpath.2018.08.024_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00466-17","article-title":"Jjj1 is a negative regulator of Pdr1-Mediated fluconazole resistance in Candida glabrata","volume":"3","author":"Whaley","year":"2018","journal-title":"mSphere"},{"key":"10.1016\/j.micpath.2018.08.024_bib12","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3389\/fmicb.2015.01343","article-title":"Candida albicans shaving to profile human serum proteins on hyphal surface","volume":"6","author":"Mar\u00edn","year":"2015","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.micpath.2018.08.024_bib13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.diagmicrobio.2015.04.008","volume":"82","author":"Pfaller","year":"2015","journal-title":"Diagn. Microbiol. Infect. Dis."},{"issue":"1","key":"10.1016\/j.micpath.2018.08.024_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408410903241444","article-title":"Epidemiology of invasive mycoses in North America","volume":"36","author":"Pfaller","year":"2010","journal-title":"Crit. Rev. Microbiol."},{"issue":"11","key":"10.1016\/j.micpath.2018.08.024_bib15","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.3201\/eid2011.140685","article-title":"Drug-resistant Candida glabrata infection in cancer patients","volume":"20","author":"Farmakiotis","year":"2014","journal-title":"Emerg. Infect. Dis."},{"issue":"11","key":"10.1016\/j.micpath.2018.08.024_bib16","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1002\/cncr.23466","article-title":"The changing epidemiology of invasive candidiasis: Candida glabrata and Candida krusei as the leading causes of candidemia in hematologic malignancy","volume":"112","author":"Hachem","year":"2008","journal-title":"Cancer"},{"issue":"12","key":"10.1016\/j.micpath.2018.08.024_bib17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.tim.2014.09.001","article-title":"Candida albicans hyphal initiation and elongation","volume":"22","author":"Lu","year":"2014","journal-title":"Trends Microbiol."},{"issue":"7","key":"10.1016\/j.micpath.2018.08.024_bib18","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.micres.2013.02.008","article-title":"Disruption of the intestinal mucosal barrier in Candida albicans infections","volume":"168","author":"Yan","year":"2013","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.micpath.2018.08.024_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/456878","article-title":"Virulence Factors Contributing to pathogenicity of Candida tropicalis and its antifungal susceptibility profile","volume":"2014","author":"Deorukhkar","year":"2014","journal-title":"Int. J. Microbiol."},{"issue":"Pt 1","key":"10.1016\/j.micpath.2018.08.024_bib20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1099\/jmm.0.045054-0","article-title":"Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options","volume":"62","author":"Sardi","year":"2013","journal-title":"J. Med. Microbiol."},{"issue":"5","key":"10.1016\/j.micpath.2018.08.024_bib21","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/pmic.200600575","article-title":"Proteomic analysis of the oxidative stress response in Candida albicans","volume":"7","author":"Kusch","year":"2007","journal-title":"Proteomics"},{"issue":"2","key":"10.1016\/j.micpath.2018.08.024_bib22","first-page":"123","article-title":"Invasive fungal disease in patients from five hospitals in the Valpara\u00edso region, Chile: 2004 to 2009","volume":"28","author":"Cruz","year":"2011","journal-title":"Rev. Chilena Infectol."},{"issue":"2","key":"10.1016\/j.micpath.2018.08.024_bib23","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1574-6976.2011.00278.x","article-title":"Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance","volume":"36","author":"Silva","year":"2012","journal-title":"FEMS Microbiol. Rev."},{"issue":"7","key":"10.1016\/j.micpath.2018.08.024_bib24","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3109\/13693786.2012.672770","article-title":"Combinatorial stresses kill pathogenic Candida species","volume":"50","author":"Kaloriti","year":"2012","journal-title":"Med. Mycol."},{"issue":"7","key":"10.1016\/j.micpath.2018.08.024_bib25","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1567-1364.2009.00541.x","article-title":"Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence","volume":"9","author":"Klis","year":"2009","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.micpath.2018.08.024_bib26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.micpath.2015.10.001","article-title":"Moonlight-like proteins of the cell wall protect sessile cells of Candida from oxidative stress","volume":"90","author":"Serrano-Fujarte","year":"2016","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2018.08.024_bib27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.micpath.2017.04.009","article-title":"Identification of proteins involved in the adhesion of Candida species to different medical devices","volume":"107","author":"N\u00fa\u00f1ez-Beltr\u00e1n","year":"2017","journal-title":"Microb. Pathog."},{"issue":"1","key":"10.1016\/j.micpath.2018.08.024_bib28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tim.2005.11.009","article-title":"Non-conventional protein secretion in yeast","volume":"14","author":"Nombela","year":"2006","journal-title":"Trends Microbiol."},{"issue":"8","key":"10.1016\/j.micpath.2018.08.024_bib29","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1002\/pmic.200700594","article-title":"Proteomic analysis of cytoplasmic and surface proteins from yeast cells, hyphae, and biofilms of Candida albicans","volume":"9","author":"Mart\u00ednez-Gomariz","year":"2009","journal-title":"Proteomics"},{"issue":"3","key":"10.1016\/j.micpath.2018.08.024_bib30","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/MMBR.00032-07","article-title":"Candida albicans cell wall proteins","volume":"72","author":"Chaffin","year":"2008","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.micpath.2018.08.024_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/721950","article-title":"Use of recombinant antigens for the diagnosis of invasive candidiasis","volume":"2008","author":"La\u00edn","year":"2008","journal-title":"Clin. Dev. Immunol."},{"issue":"Pt8","key":"10.1016\/j.micpath.2018.08.024_bib32","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1099\/jmm.0.05060-0","article-title":"Binding of Candida albicans enolase to plasminogen results in enhanced invasion of human brain microvascular endothelial cells","volume":"52","author":"Jong","year":"2003","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.micpath.2018.08.024_bib33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1099\/00222615-27-4-227","article-title":"Characterisation and cellular localisation of the immunodominant 47-Kda antigen of Candida albicans","volume":"27","author":"Matthews","year":"1988","journal-title":"J. Med. Microbiol."},{"issue":"3","key":"10.1016\/j.micpath.2018.08.024_bib34","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1128\/IAI.43.3.1012-1018.1984","article-title":"Production and characterisation of three monoclonal antibodies to Candida albicans proteins","volume":"43","author":"Strockbine","year":"1984","journal-title":"Infect. Immun."},{"issue":"8","key":"10.1016\/j.micpath.2018.08.024_bib35","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1128\/IAI.64.8.3333-3340.1996","article-title":"Evidence for presence in the cell wall of Candida albicans of a protein related to the hsp70 family","volume":"64","author":"L\u00f3pez-Ribot","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2018.08.024_bib36","series-title":"Experiments in Molecular Genetics","first-page":"433","author":"Miller","year":"1972"},{"key":"10.1016\/j.micpath.2018.08.024_bib37","series-title":"Current Protocols in Molecular Biology","author":"Ausubel","year":"2003"},{"key":"10.1016\/j.micpath.2018.08.024_bib38","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.micpath.2018.08.024_bib39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1574-695X.2011.00802.x","article-title":"A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine","volume":"62","author":"Sandini","year":"2011","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"2","key":"10.1016\/j.micpath.2018.08.024_bib40","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1086\/504691","article-title":"Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis","volume":"194","author":"Spellberg","year":"2006","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.micpath.2018.08.024_bib41","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1128\/IAI.73.2.999-1005.2005","article-title":"Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity","volume":"73","author":"Ibrahim","year":"2005","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.micpath.2018.08.024_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148714","article-title":"A murine, bispecific monoclonal antibody simultaneously recognizing \u03b2-Glucan and MP65 determinants in Candida species","volume":"11","author":"Zito","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.micpath.2018.08.024_bib43","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/2049-632X.12068","article-title":"An oral vaccine against candidiasis generated by a yeast molecular display system","volume":"69","author":"Shibasaki","year":"2013","journal-title":"Pathog. Dis."},{"issue":"1","key":"10.1016\/j.micpath.2018.08.024_bib44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4265\/bio.19.51","article-title":"Evaluation of Mdh1 protein as an antigenic candidate for a vaccine against candidiasis","volume":"19","author":"Shibasaki","year":"2014","journal-title":"Biocontrol Sci."},{"issue":"3","key":"10.1016\/j.micpath.2018.08.024_bib45","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3797\/scipharm.1404-07","article-title":"Oral immunization against candidiasis using Lactobacillus casei displaying Enolase 1 from Candida albicans","volume":"82","author":"Shibasaki","year":"2014","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.micpath.2018.08.024_bib46","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.1128\/IAI.73.9.6191-6193.2005","article-title":"The anti-Candida albicans vaccine composed of the recombinant N terminus of Als1p reduces fungal burden and improves survival in both immunocompetent and immunocompromised mice","volume":"73","author":"Spellberg","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2018.08.024_bib47","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1128\/IAI.74.5.3039-3041.2006","article-title":"The anti-Candida vaccine based on the recombinant N-terminal domain of Als1p is broadly active against disseminated candidiasis","volume":"74","author":"Ibrahim","year":"2006","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.micpath.2018.08.024_bib48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF02931297","article-title":"Comparison of protective effect of protein and DNA vaccines hsp90 in murine model of systemic candidiasis","volume":"50","author":"Raska","year":"2005","journal-title":"Folia Microbiol."},{"issue":"10","key":"10.1016\/j.micpath.2018.08.024_bib49","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1128\/CVI.05215-11","article-title":"Vaccine and monoclonal anti-body that enhance mouse resistance to candidiasis","volume":"18","author":"Xin","year":"2011","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.micpath.2018.08.024_bib50","first-page":"241","article-title":"Double chimeric peptide vaccine and monoclonal antibodies that protect against disseminated candidiasis","volume":"5","author":"Xin","year":"2014","journal-title":"J. Vaccines Vaccin."},{"issue":"36","key":"10.1016\/j.micpath.2018.08.024_bib51","doi-asserted-by":"crossref","first-page":"13526","DOI":"10.1073\/pnas.0803195105","article-title":"Synthetic glycopeptide vaccines combining beta-mannan and peptide epitopes induce protection against candidiasis","volume":"105","author":"Xin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401018308519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401018308519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T20:03:41Z","timestamp":1604779421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401018308519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":51,"alternative-id":["S0882401018308519"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2018.08.024","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Moonlighting proteins induce protection in a mouse model against Candida species","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2018.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}