{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:11:00Z","timestamp":1789593060266,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Keyvan Virology Specialty Laboratory"},{"name":"Islamic Azad University, Science and Research Branch (SRBIAU), Tehran, Iran"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.micpath.2018.10.043","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T12:20:58Z","timestamp":1541161258000},"page":"149-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Protection against human papillomavirus type 16-induced tumors in C57BL\/6 mice by mucosal vaccination with Lactococcus lactis NZ9000 expressing E6 oncoprotein"],"prefix":"10.1016","volume":"126","author":[{"given":"Sedigheh","family":"Taghinezhad-S","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0320-9523","authenticated-orcid":false,"given":"Amir Hossein","family":"Mohseni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Keyvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-4427","authenticated-orcid":false,"given":"Vadood","family":"Razavilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2018.10.043_bib1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/2229-516X.179027","article-title":"Human papillomavirus-associated cancers: a growing global problem","volume":"6","author":"Bansal","year":"2016","journal-title":"Int. J. Appl. Basic Med. Res."},{"key":"10.1016\/j.micpath.2018.10.043_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/mthe.2001.0447","article-title":"Human papilloma virus E6 and E7 proteins support DNA replication of adenoviruses deleted for the E1A and E1B genes","volume":"4","author":"Steinwaerder","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.micpath.2018.10.043_bib3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF02255810","article-title":"Preventive and therapeutic vaccines for human papillomavirus-associated cervical cancers","volume":"7","author":"Ling","year":"2000","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.micpath.2018.10.043_bib4","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1093\/jnci\/81.22.1698","article-title":"Antibodies against the human papillomavirus type 16 early proteins in human sera: correlation of anti-E7 reactivity with cervical cancer","volume":"81","author":"Jochmus-Kudielka","year":"1989","journal-title":"JNCI (J. Natl. Cancer Inst.)"},{"key":"10.1016\/j.micpath.2018.10.043_bib5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/ijc.23502","article-title":"Skin reactions to human papillomavirus (HPV) 16 specific antigens intradermally injected in healthy subjects and patients with cervical neoplasia","volume":"123","author":"van den Hende","year":"2008","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.micpath.2018.10.043_bib6","doi-asserted-by":"crossref","DOI":"10.3851\/IMP1941","article-title":"New approaches to prophylactic human papillomavirus vaccines for cervical cancer prevention","volume":"17","author":"Gersch","year":"2012","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.micpath.2018.10.043_bib7","series-title":"Lactococci and Lactobacilli as Mucosal Delivery Vectors for Therapeutic Proteins and DNA Vaccines","first-page":"S4","author":"Berm\u00fadez-Humar\u00e1n","year":"2011"},{"key":"10.1016\/j.micpath.2018.10.043_bib8","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1271\/bbb.130157","article-title":"Lactococcus lactis anchoring avian infectious bronchitis virus multi-epitope peptide EpiC induced specific immune responses in chickens","volume":"77","author":"Cao","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.micpath.2018.10.043_bib9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF00395939","article-title":"Lactic acid bacteria as vaccine delivery vehicles","volume":"70","author":"Wells","year":"1996","journal-title":"Antonie Leeuwenhoek"},{"key":"10.1016\/j.micpath.2018.10.043_bib10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4161\/hv.5.4.7553","article-title":"Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins","volume":"5","author":"Berm\u00fadez-Humar\u00e1n","year":"2009","journal-title":"Hum. Vaccine"},{"key":"10.1016\/j.micpath.2018.10.043_bib11","doi-asserted-by":"crossref","first-page":"697","DOI":"10.2217\/fvl-2018-0026","article-title":"Extracellular overproduction of recombinant Iranian HPV-16 E6 oncoprotein in Lactococcus lactis using the NICE system","author":"Taghinezhad-S","year":"2018","journal-title":"Future Virol."},{"key":"10.1016\/j.micpath.2018.10.043_bib12","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s00253-005-0285-2","article-title":"Expression of Helicobacter pylori cag12 gene in Lactococcus lactis MG1363 and its oral administration to induce systemic anti-Cag12 immune response in mice","volume":"72","author":"Kim","year":"2006","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.micpath.2018.10.043_bib13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1574-695X.2009.00566.x","article-title":"Oral vaccination of mice against Helicobacter pylori with recombinant Lactococcus lactis expressing urease subunit B","volume":"56","author":"Gu","year":"2009","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.micpath.2018.10.043_bib14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nri1777","article-title":"Mucosal vaccines: the promise and the challenge","volume":"6","author":"Neutra","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.micpath.2018.10.043_bib15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2217\/fvl-2017-0032","article-title":"Codon optimization of Iranian human papillomavirus Type 16 E6 oncogene for Lactococcus lactis subsp. cremoris MG1363","volume":"12","author":"Taghinezhad-S","year":"2017","journal-title":"Future Virol."},{"key":"10.1016\/j.micpath.2018.10.043_bib16","doi-asserted-by":"crossref","DOI":"10.5812\/jjm.31733","article-title":"Assessment of the human cytomegalovirus UL97 gene for immunosuppressed identification of resistance patients to ganciclovir in Iranian","volume":"9","author":"Keyvani","year":"2016","journal-title":"Jundishapur J. Microbiol."},{"key":"10.1016\/j.micpath.2018.10.043_bib17","doi-asserted-by":"crossref","DOI":"10.5812\/jjm.8849","article-title":"Construction and evaluation of a novel internal positive control (IPC) for detection of Coxiella burnetii by PCR","volume":"7","author":"Majidzadeh","year":"2014","journal-title":"Jundishapur J. Microbiol."},{"key":"10.1016\/j.micpath.2018.10.043_bib18","first-page":"783","article-title":"Codon usage optimization and construction of plasmid encoding Iranian human papillomavirus type 16 E7 oncogene for Lactococcus lactis Subsp. Cremoris MG1363","volume":"18","author":"Mohseni","year":"2017","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.micpath.2018.10.043_bib19","first-page":"2249","article-title":"Active expression of human tissue plasminogen activator (t-PA) c-DNA from pulmonary metastases in the methylotrophic yeast pichia pastoris KM71H strain","volume":"18","author":"Mohseni","year":"2017","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.micpath.2018.10.043_bib20","series-title":"Isolation of T Cells from the Gut. T-Helper Cells","first-page":"21","author":"Rei\u00dfig","year":"2014"},{"key":"10.1016\/j.micpath.2018.10.043_bib21","doi-asserted-by":"crossref","first-page":"6568","DOI":"10.1128\/JVI.76.13.6568-6576.2002","article-title":"Induction of CD8 T-cell-specific systemic and mucosal immunity against herpes simplex virus with CpG-peptide complexes","volume":"76","author":"Gierynska","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2018.10.043_bib22","first-page":"1","article-title":"Comparison of acyclovir and multistrain Lactobacillus brevis in women with recurrent genital herpes infections: a double-blind, randomized, controlled study","author":"Mohseni","year":"2017","journal-title":"Probiotics Antimicrobial Proteins"},{"key":"10.1016\/j.micpath.2018.10.043_bib23","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/bit.23130","article-title":"Nisin\u2010inducible secretion of a biologically active single\u2010chain insulin analog by Lactococcus lactis NZ9000","volume":"108","author":"Ng","year":"2011","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.micpath.2018.10.043_bib24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1475-2859-4-16","article-title":"Optimization of the Lactococcus lactis nisin-controlled gene expression system NICE for industrial applications","volume":"4","author":"Mierau","year":"2005","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.micpath.2018.10.043_bib25","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.4049\/jimmunol.167.11.6471","volume":"167","author":"Gunn","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2018.10.043_bib26","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1128\/IAI.01484-07","article-title":"Intravaginal immunization of mice with recombinant Salmonella enterica serovar Typhimurium expressing human papillomavirus type 16 antigens as a potential route of vaccination against cervical cancer","volume":"76","author":"Echchannaoui","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2018.10.043_bib27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/10611860400024219","article-title":"Cell-surface display of E7 antigen from human papillomavirus type-16 in Lactococcus lactis and in Lactobacillus plantarum using a new cell-wall anchor from lactobacilli","volume":"13","author":"Cortes-Perez","year":"2005","journal-title":"J. Drug Target."},{"key":"10.1016\/j.micpath.2018.10.043_bib28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrmicro1840","article-title":"Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria","volume":"6","author":"Wells","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micpath.2018.10.043_bib29","article-title":"Oral immunization with recombinant Lactococcus lactis NZ9000 expressing human papillomavirus type 16 E7 antigen and evaluation of its immune effects in female C57BL\/6 mice","author":"Mohseni","year":"2018","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.micpath.2018.10.043_bib30","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1016\/j.vaccine.2008.03.024","article-title":"Innate inflammatory responses to the Gram-positive bacterium Lactococcus lactis","volume":"26","author":"Yam","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2018.10.043_bib31","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.1016\/j.vaccine.2007.09.024","article-title":"Induction of mucosal and systemic immune responses following oral immunization of mice with Lactococcus lactis expressing human papillomavirus type 16 L1","volume":"25","author":"Cho","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2018.10.043_bib32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0929-6646(10)60017-4","article-title":"Perspectives for preventive and therapeutic HPV vaccines","volume":"109","author":"Lin","year":"2010","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.micpath.2018.10.043_bib33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s12026-009-8141-6","article-title":"Therapeutic Hpv Dna vaccines","volume":"47","author":"Lin","year":"2010","journal-title":"Immunol. Res."},{"key":"10.1016\/j.micpath.2018.10.043_bib34","first-page":"66","article-title":"Human papillomavirus type 16 E6\/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignancies","volume":"36","author":"Ramos","year":"2013","journal-title":"J. Immunotherapy (Hagerstown, Md: 1997)"},{"key":"10.1016\/j.micpath.2018.10.043_bib35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/sj.bjc.6602679","article-title":"T-cell responses to human papillomavirus type 16 among women with different grades of cervical neoplasia","volume":"93","author":"Steele","year":"2005","journal-title":"Br. J. Canc."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240101830888X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240101830888X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T03:28:34Z","timestamp":1662348514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088240101830888X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":35,"alternative-id":["S088240101830888X"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2018.10.043","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protection against human papillomavirus type 16-induced tumors in C57BL\/6 mice by mucosal vaccination with Lactococcus lactis NZ9000 expressing E6 oncoprotein","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2018.10.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}