{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:16:12Z","timestamp":1786994172980,"version":"build-2736575974"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.micpath.2018.11.012","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T12:05:53Z","timestamp":1542197153000},"page":"298-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Determination of immunodominant scaffolds of Com1 and OmpH antigens of Coxiella burnetii"],"prefix":"10.1016","volume":"126","author":[{"given":"Amin","family":"Jaydari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6698-3503","authenticated-orcid":false,"given":"Ali","family":"Forouharmehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Nazifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2018.11.012_bib1","doi-asserted-by":"crossref","DOI":"10.5694\/j.1326-5377.1937.tb43743.x","article-title":"Q\" fever, a new fever entity: clinical features, diagnosis and laboratory investigation","volume":"2","author":"Derrick","year":"1937","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.micpath.2018.11.012_bib2","series-title":"Biohazard. The Chilling True Story of the Largest Biological Weapons Program in the World-told from inside by the Man Who Ran it","author":"Alibek","year":"1999"},{"key":"10.1016\/j.micpath.2018.11.012_bib3","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1128\/JCM.36.7.1823-1834.1998","article-title":"Diagnosis of Q fever","volume":"36","author":"Fournier","year":"1998","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2018.11.012_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/248418","article-title":"Q Fever: current state of knowledge and perspectives of research of a neglected zoonosis","volume":"2011","author":"Porter","year":"2011","journal-title":"International Journal of Microbiology"},{"key":"10.1016\/j.micpath.2018.11.012_bib5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1586\/14760584.3.5.577","article-title":"Vaccines against Coxiella infection","volume":"3","author":"Zhang","year":"2004","journal-title":"Expet Rev. Vaccine"},{"key":"10.1016\/j.micpath.2018.11.012_bib6","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1017\/S0950268810002621","article-title":"Antibiotic therapy for acute Q fever in The Netherlands in 2007 and 2008 and its relation to hospitalization","volume":"139","author":"Dijkstra","year":"2011","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.micpath.2018.11.012_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091764","article-title":"Characteristics of hospitalized acute Q fever patients during a large epidemic, The Netherlands","volume":"9","author":"Wielders","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2018.11.012_bib8","first-page":"67","article-title":"Antibodies against Rickettsia burneti in serum of animals at a slaughter house in Tuscany. VI","volume":"12","author":"Davoli","year":"1951","journal-title":"Ann. Sanita Pubblica"},{"key":"10.1016\/j.micpath.2018.11.012_bib9","first-page":"327","article-title":"Protective immunity induced by 67 K outer membrane protein of phase I Coxiella burnetii in mice and Guinea pigs","volume":"38","author":"Zhang","year":"1994","journal-title":"Acta Virol."},{"key":"10.1016\/j.micpath.2018.11.012_bib10","first-page":"526","article-title":"Immunoreactive Coxiella burnetii Nine Mile proteins separated by 2D electrophoresis and identified by tandem mass spectrometry","volume":"157","author":"Deringer","year":"2011","journal-title":"Microbiology (N. Y.)"},{"key":"10.1016\/j.micpath.2018.11.012_bib11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4149\/av_2017_320","article-title":"Coxiella burnetii immunogenic proteins as a basis for new Q fever diagnostic and vaccine development","volume":"61","author":"Gerlach","year":"2017","journal-title":"Acta Virol."},{"key":"10.1016\/j.micpath.2018.11.012_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3892\/etm.2013.1142","article-title":"Bioinformatic prediction of epitopes in the Emy162 antigen of Echinococcus multilocularis","volume":"6","author":"Li","year":"2013","journal-title":"Experimental and therapeutic medicine"},{"key":"10.1016\/j.micpath.2018.11.012_bib13","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/JVI.55.3.836-839.1985","article-title":"Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide","volume":"55","author":"Emini","year":"1985","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2018.11.012_bib14","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1021\/bi00367a013","article-title":"New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites","volume":"25","author":"Parker","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/j.micpath.2018.11.012_bib15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF01195768","article-title":"Prediction of chain flexibility in proteins","volume":"72","author":"Karplus","year":"1985","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.micpath.2018.11.012_bib16","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/bioinformatics\/11.6.681","article-title":"SOPMA: significant improvements in protein secondary structure prediction by consensus prediction from multiple alignments","volume":"11","author":"Geourjon","year":"1995","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2018.11.012_bib17","doi-asserted-by":"crossref","first-page":"i264","DOI":"10.1093\/bioinformatics\/btu281","article-title":"Tertiary structure-based prediction of conformational B-cell epitopes through B factors","volume":"30","author":"Ren","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2018.11.012_bib18","series-title":"Bioinformatics Analysis of Brucella Vaccines and Vaccine Targets Using VIOLIN","first-page":"S5","author":"He","year":"2010"},{"key":"10.1016\/j.micpath.2018.11.012_bib19","article-title":"Vaxign: the first web-based vaccine design program for reverse vaccinology and applications for vaccine development","volume":"2010","author":"He","year":"2010","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.micpath.2018.11.012_bib20","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1586\/14760584.6.6.939","article-title":"Epitope-based vaccine against influenza","volume":"6","author":"Ben-Yedidia","year":"2007","journal-title":"Expet Rev. Vaccine"},{"key":"10.1016\/j.micpath.2018.11.012_bib21","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1038\/jid.1984.31","article-title":"Peptide-elicited protein-reactive antibodies in molecular biology and medicine","volume":"83","author":"Shinnick","year":"1984","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.micpath.2018.11.012_bib22","doi-asserted-by":"crossref","first-page":"W469","DOI":"10.1093\/nar\/gkq406","article-title":"3DLigandSite: predicting ligand-binding sites using similar structures","volume":"38","author":"Wass","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2018.11.012_bib23","first-page":"1","article-title":"Optimization of human serum albumin periplasmic localization in Escherichia coli using in silico evaluation of different signal peptides","author":"Jahandar","year":"2018","journal-title":"Int. J. Pept. Res. Therapeut."},{"key":"10.1016\/j.micpath.2018.11.012_bib24","article-title":"B and T\u2010cell epitope prediction of the OMP25 antigen for developing Brucella melitensis vaccines for sheep","volume":"5","author":"Yousefi","year":"2015","journal-title":"Iran. J. Appl. Anim. Sci."},{"key":"10.1016\/j.micpath.2018.11.012_bib25","doi-asserted-by":"crossref","first-page":"W513","DOI":"10.1093\/nar\/gkn254","article-title":"Immune epitope database analysis resource (IEDB-AR)","volume":"36","author":"Zhang","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2018.11.012_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s002510050595","article-title":"SYFPEITHI: database for MHC ligands and peptide motifs","volume":"50","author":"Rammensee","year":"1999","journal-title":"Immunogenetics"},{"key":"10.1016\/j.micpath.2018.11.012_bib27","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1110\/ps.0239403","article-title":"Reliable prediction of T\u2010cell epitopes using neural networks with novel sequence representations","volume":"12","author":"Nielsen","year":"2003","journal-title":"Protein Sci."},{"key":"10.1016\/j.micpath.2018.11.012_bib28","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1002\/eji.200425811","article-title":"An integrative approach to CTL epitope prediction: a combined algorithm integrating MHC class I binding, TAP transport efficiency, and proteasomal cleavage predictions","volume":"35","author":"Larsen","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micpath.2018.11.012_bib29","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/9858","article-title":"Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices","volume":"17","author":"Sturniolo","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.micpath.2018.11.012_bib30","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/bioinformatics\/17.12.1236","article-title":"ProPred: prediction of HLA-DR binding sites","volume":"17","author":"Singh","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2018.11.012_bib31","series-title":"BcePred: Prediction of Continuous B-cell Epitopes in Antigenic Sequences Using Physico-chemical Properties","first-page":"197","author":"Saha","year":"2004"},{"key":"10.1016\/j.micpath.2018.11.012_bib32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/prot.21078","article-title":"Prediction of continuous B\u2010cell epitopes in an antigen using recurrent neural network","volume":"65","author":"Saha","year":"2006","journal-title":"Proteins: Structure, Function, and Bioinformatics"},{"key":"10.1016\/j.micpath.2018.11.012_bib33","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkx346","article-title":"BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes","volume":"45","author":"Jespersen","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2018.11.012_bib34","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00726-006-0485-9","article-title":"Prediction of linear B-cell epitopes using amino acid pair antigenicity scale","volume":"33","author":"Chen","year":"2007","journal-title":"Amino Acids"},{"key":"10.1016\/j.micpath.2018.11.012_bib35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jmr.893","article-title":"Predicting linear B\u2010cell epitopes using string kernels","volume":"21","author":"EL\u2010Manzalawy","year":"2008","journal-title":"J. Mol. Recogn.: An Interdisciplinary Journal"},{"key":"10.1016\/j.micpath.2018.11.012_bib36","first-page":"121","article-title":"Predicting flexible length linear B-cell epitopes","volume":"vol. 7","author":"El-manzalawy","year":"2008"},{"key":"10.1016\/j.micpath.2018.11.012_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045152","article-title":"SVMTriP: a method to predict antigenic epitopes using support vector machine to integrate tri-peptide similarity and propensity","volume":"7","author":"Yao","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2018.11.012_bib38","first-page":"45","article-title":"Prediction of the secondary structure of proteins from their amino acid sequence","volume":"47","author":"Chou","year":"1978","journal-title":"Adv. Enzymol. Relat. Area Mol. Biol."},{"key":"10.1016\/j.micpath.2018.11.012_bib39","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/JVI.55.3.836-839.1985","article-title":"Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide","volume":"55","author":"Emini","year":"1985","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2018.11.012_bib40","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1016\/j.vaccine.2011.01.111","article-title":"Coxiella burnetii DNA in goat milk after vaccination with Coxevac\u00ae","volume":"29","author":"Hermans","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2018.11.012_bib41","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11515-012-1196-0","article-title":"Progress in Brucella vaccine development","volume":"8","author":"Yang","year":"2013","journal-title":"Front. Biol."},{"key":"10.1016\/j.micpath.2018.11.012_bib42","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0167-7799(96)10037-8","article-title":"Bioinformatics\u2014principles and potential of a new multidisciplinary tool","volume":"14","author":"Benton","year":"1996","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.micpath.2018.11.012_bib43","first-page":"849","article-title":"B cell epitope prediction","author":"Ponomarenko","year":"2009","journal-title":"Structural bioinformatics"},{"key":"10.1016\/j.micpath.2018.11.012_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12250-011-3159-4","article-title":"Advances of bioinformatics tools applied in virus epitopes prediction","volume":"26","author":"Chen","year":"2011","journal-title":"Virol. Sin."},{"key":"10.1016\/j.micpath.2018.11.012_bib45","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1073\/pnas.78.6.3824","article-title":"Prediction of protein antigenic determinants from amino acid sequences","volume":"78","author":"Hopp","year":"1981","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.micpath.2018.11.012_bib46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","article-title":"A simple method for displaying the hydropathic character of a protein","volume":"157","author":"Kyte","year":"1982","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.micpath.2018.11.012_bib47","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1034\/j.1399-0039.2003.00112.x","article-title":"Sensitive quantitative predictions of peptide\u2010MHC binding by a \u2018Query by Committee\u2019artificial neural network approach","volume":"62","author":"Buus","year":"2003","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.micpath.2018.11.012_bib48","first-page":"3954","article-title":"B and T-cell epitopes prediction of the P40 antigen for developing mycoplasma agalactiae vaccine using Bioinformatic Tools","volume":"13","author":"Forouharmehr","year":"2015","journal-title":"Genet Millennium"},{"key":"10.1016\/j.micpath.2018.11.012_bib49","doi-asserted-by":"crossref","DOI":"10.5812\/iji.63255","article-title":"In silico B cell and T cell epitopes evaluation of lipL32 and OmpL1 proteins for designing a recombinant multi-epitope vaccine against leptospirosis","volume":"5","author":"Nazifi","year":"2018","journal-title":"Int. J. Infect."},{"key":"10.1016\/j.micpath.2018.11.012_bib50","article-title":"In silico prediction of B\u2010cell and T\u2010cell epitopes of protective antigen of Bacillus anthracis in development of vaccines against anthrax","volume":"7","author":"Tahmoorespur","year":"2017","journal-title":"Iran. J. Appl. Anim. Sci."},{"key":"10.1016\/j.micpath.2018.11.012_bib51","series-title":"Handbook of LC-MS Bioanalysis: Best Practices, Experimental Protocols, and Regulations","author":"Li","year":"2013"},{"key":"10.1016\/j.micpath.2018.11.012_bib52","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s12026-008-8059-4","article-title":"Adaptive immunity to the obligate intracellular pathogen Coxiella burnetii","volume":"43","author":"Shannon","year":"2009","journal-title":"Immunol. Res."},{"key":"10.1016\/j.micpath.2018.11.012_bib53","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/infdis\/157.4.781","article-title":"Markers of cell-mediated immunity after vaccination with an inactivated, whole-cell Q fever vaccine","volume":"157","author":"Izzo","year":"1988","journal-title":"JID (J. Infect. Dis.)"},{"key":"10.1016\/j.micpath.2018.11.012_bib54","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2249.1991.tb05689.x","article-title":"Analysis of the cells involved in the lymphoproliferative response to Coxiella burnetii antigens","volume":"85","author":"Izzo","year":"1991","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.micpath.2018.11.012_bib55","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1128\/IAI.01767-06","article-title":"T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice","volume":"75","author":"Andoh","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2018.11.012_bib56","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/oxfordjournals.aje.a120618","article-title":"Studies of latent Q fever infections. III. Effects of parturition upon latently infected Guinea pigs and white mice","volume":"84","author":"SIDWELL","year":"1966","journal-title":"AJE (Am. J. Epidemiol.)"},{"key":"10.1016\/j.micpath.2018.11.012_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(06)91001-3","article-title":"A reappraisal of humoral immunity based on mechanisms of antibody\u2010mediated protection against intracellular pathogens","volume":"91","author":"Casadevall","year":"2006","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.micpath.2018.11.012_bib58","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.5694\/j.1326-5377.1938.tb46026.x","article-title":"Q\" fever: factors affecting the appearance of rickettsiae in mice","volume":"2","author":"Burnet","year":"1938","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.micpath.2018.11.012_bib59","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1749-6632.2003.tb07420.x","article-title":"Identification and cloning potentially protective antigens of Coxiella burnetii using sera from mice experimentally infected with Nine Mile phase I","volume":"990","author":"Zhang","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.micpath.2018.11.012_bib60","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1196\/annals.1355.021","article-title":"Protective immunity against Q fever induced with a recombinant P1 antigen fused with HspB of Coxiella burnetii","volume":"1063","author":"Li","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401018313068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401018313068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T02:09:42Z","timestamp":1605406182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401018313068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":60,"alternative-id":["S0882401018313068"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2018.11.012","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination of immunodominant scaffolds of Com1 and OmpH antigens of Coxiella burnetii","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2018.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}